KEGG Orthology (KO)

[ Brite menu | Organism menu | Download htext ]
    

1st Level  2nd Level  3rd Level  4th Level 

 Metabolism
 
 Genetic Information Processing
 
 Environmental Information Processing
 
   Membrane transport
 
   Signal transduction
     02020 Two-component system [PATH:ko02020]
     02022 Two-component system [BR:ko02022]
     04014 Ras signaling pathway [PATH:ko04014]
     04015 Rap1 signaling pathway [PATH:ko04015]
     04010 MAPK signaling pathway [PATH:ko04010]
     04013 MAPK signaling pathway - fly [PATH:ko04013]
     04011 MAPK signaling pathway - yeast [PATH:ko04011]
     04012 ErbB signaling pathway [PATH:ko04012]
     04310 Wnt signaling pathway [PATH:ko04310]
     04330 Notch signaling pathway [PATH:ko04330]
     04340 Hedgehog signaling pathway [PATH:ko04340]
     04350 TGF-beta signaling pathway [PATH:ko04350]
     04390 Hippo signaling pathway [PATH:ko04390]
     04391 Hippo signaling pathway -fly [PATH:ko04391]
     04370 VEGF signaling pathway [PATH:ko04370]
     04630 Jak-STAT signaling pathway [PATH:ko04630]
     04064 NF-kappa B signaling pathway [PATH:ko04064]
     04668 TNF signaling pathway [PATH:ko04668]
     04066 HIF-1 signaling pathway [PATH:ko04066]
     04068 FoxO signaling pathway [PATH:ko04068]
       K13375  TGFB1; transforming growth factor beta-1
       K13376  TGFB2; transforming growth factor beta-2
       K13377  TGFB3; transforming growth factor beta-3
       K04674  TGFBR1, ALK5; TGF-beta receptor type-1 [EC:2.7.11.30]
       K04388  TGFBR2; TGF-beta receptor type-2 [EC:2.7.11.30]
       K04501  SMAD4; mothers against decapentaplegic homolog 4
       K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
       K07298  STK11, LKB1; serine/threonine-protein kinase 11
       K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.11]
       K07199  PRKAB; 5'-AMP-activated protein kinase, regulatory beta subunit
       K07200  PRKAG; 5'-AMP-activated protein kinase, regulatory gamma subunit
       K04468  NLK; nemo like kinase [EC:2.7.11.24]
       K03875  SKP2, FBXL1; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
       K06643  MDM2; E3 ubiquitin-protein ligase Mdm2 [EC:6.3.2.19]
       K11431  SETD7; histone-lysine N-methyltransferase SETD7 [EC:2.1.1.43]
       K04498  EP300, CREBBP, KAT3; E1A/CREB-binding protein [EC:2.3.1.48]
       K11411  SIRT1, SIR2L1; NAD-dependent deacetylase sirtuin 1 [EC:3.5.1.-]
       K11838  USP7, UBP15; ubiquitin carboxyl-terminal hydrolase 7 [EC:3.1.2.15]
       K07191  SLC2A4, GLUT4; MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 4
       K04440  JNK; c-Jun N-terminal kinase [EC:2.7.11.24]
       K04411  STK4, MST1; serine/threonine kinase 4
       K05459  IGF1; insulin-like growth factor 1
       K05087  IGF1R; insulin-like growth factor 1 receptor [EC:2.7.10.1]
       K04526  INS; insulin
       K04527  INSR; insulin receptor [EC:2.7.10.1]
       K16172  IRS1; insulin receptor substrate 1
       K07187  IRS2; insulin receptor substrate 2
       K17445  IRS3; insulin receptor substrate 3
       K17446  IRS4; insulin receptor substrate 4
       K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
       K02649  PIK3R; phosphoinositide-3-kinase, regulatory subunit
       K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]
       K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
       K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
       K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67]
       K04456  AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
       K13302  SGK1; serum/glucocorticoid-regulated kinase 1 [EC:2.7.11.1]
       K13303  SGK2; serum/glucocorticoid-regulated kinase 2 [EC:2.7.11.1]
       K13304  SGK3; serum/glucocorticoid-regulated kinase 3 [EC:2.7.11.1]
       K07201  FOXO1; forkhead box protein O1
       K09408  FOXO3; forkhead box protein O3
       K12358  FOXO4; forkhead box protein O4
       K17847  FOXO6; forkhead box protein O6
       K04603  GRM1; metabotropic glutamate receptor 1
       K15010  HOMER; homer
       K17848  AGAP2; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2
       K08960  CSNK1E; casein kinase 1, epsilon [EC:2.7.11.1]
       K05405  IL6; interleukin 6
       K05443  IL10, CSIF; interleukin 10
       K04692  STAT3; signal transducer and activator of transcription 3
       K04357  EGF; epidermal growth factor
       K04361  EGFR, ERBB1; epidermal growth factor receptor [EC:2.7.10.1]
       K04364  GRB2; growth factor receptor-binding protein 2
       K03099  SOS; son of sevenless
       K02833  HRAS; GTPase HRas
       K07827  KRAS, KRAS2; GTPase KRas
       K07828  NRAS; GTPase NRas
       K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
       K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
       K04371  MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
       K04441  P38; p38 MAP kinase [EC:2.7.11.24]
       K02206  CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
       K11434  PRMT1; protein arginine N-methyltransferase 1 [EC:2.1.1.-]
       K09385  FOXG; forkhead box protein G
       K05868  CCNB; cyclin B
       K04503  CCND1; cyclin D1
       K10151  CCND2; cyclin D2
       K10146  CCNG2; cyclin G2
       K04685  CDKN2B, P15, INK4B; cyclin-dependent kinase inhibitor 2B
       K06623  CDKN2D, P19, INK4D; cyclin-dependent kinase inhibitor 2D
       K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
       K06624  CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
       K16332  RBL2; retinoblastoma-like protein 2
       K06631  PLK1; polo-like kinase 1 [EC:2.7.11.21]
       K08861  PLK2; polo-like kinase 2 [EC:2.7.11.21]
       K08862  PLK3, CNK; polo-like kinase 3 [EC:2.7.11.21]
       K08863  PLK4; polo-like kinase 4 [EC:2.7.11.21]
       K04402  GADD45; growth arrest and DNA-damage-inducible protein
       K04389  TNFSF6, FASL; tumor necrosis factor ligand superfamily member 6
       K16341  BCL2L11, BIM; Bcl-2-like protein 11
       K04721  TNFSF10, TRAIL; tumor necrosis factor ligand superfamily member 10
       K15618  BCL6; B-cell lymphoma 6 protein
       K15464  BNIP3; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3
       K08336  ATG12; ubiquitin-like protein ATG12
       K08341  GABARAP, ATG8, LC3; GABA(A) receptor-associated protein
       K03781  katE, CAT, catB, srpA; catalase [EC:1.11.1.6]
       K04564  SOD2; superoxide dismutase, Fe-Mn family [EC:1.15.1.1]
       K04728  ATM, TEL1; ataxia telangiectasia mutated family protein [EC:2.7.11.1]
       K01596  E4.1.1.32, pckA, PEPCK; phosphoenolpyruvate carboxykinase (GTP) [EC:4.1.1.32]
       K01084  G6PC; glucose-6-phosphatase [EC:3.1.3.9]
       K05072  IL7R; interleukin 7 receptor
       K17845  KLF2; krueppel-like factor 2
       K04288  S1PR1, EDG1; sphingosine 1-phosphate receptor 1
       K04293  S1PR4, EDG6; sphingosine 1-phosphate receptor 4
       K10628  RAG1; V(D)J recombination-activating protein 1 [EC:6.3.2.19]
       K10988  RAG2; recombination-activating protein 2
       K10305  FBXO25_32; F-box protein 25/32
     04020 Calcium signaling pathway [PATH:ko04020]
     04070 Phosphatidylinositol signaling system [PATH:ko04070]
     04022 cGMP - PKG signaling pathway [PATH:ko04022]
     04151 PI3K-Akt signaling pathway [PATH:ko04151]
     04152 AMPK signaling pathway [PATH:ko04152]
     04150 mTOR signaling pathway [PATH:ko04150]
     04075 Plant hormone signal transduction [PATH:ko04075]
 
   Signaling molecules and interaction
 
 Cellular Processes
 
   Transport and catabolism
 
   Cell motility
 
   Cell growth and death
     04110 Cell cycle [PATH:ko04110]
       K04503  CCND1; cyclin D1
       K10151  CCND2; cyclin D2
       K10152  CCND3; cyclin D3
       K02089  CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
       K02091  CDK6; cyclin-dependent kinase 6 [EC:2.7.11.22]
       K06618  RB1; retinoblastoma-associated protein
       K04681  RBL1; retinoblastoma-like protein 1
       K16332  RBL2; retinoblastoma-like protein 2
       K06619  ABL1; abelson tyrosine-protein kinase 1 [EC:2.7.10.2]
       K06067  HDAC1_2; histone deacetylase 1/2 [EC:3.5.1.98]
       K17454  E2F1; transcription factor E2F1
       K09389  E2F2; transcription factor E2F2
       K06620  E2F3; transcription factor E2F3
       K04682  E2F4_5; transcription factor E2F4/5
       K04683  TFDP1; transcription factor Dp-1
       K09392  TFDP2; transcription factor Dp-2
       K03083  GSK3B; glycogen synthase kinase 3 beta [EC:2.7.11.26]
       K13375  TGFB1; transforming growth factor beta-1
       K13376  TGFB2; transforming growth factor beta-2
       K13377  TGFB3; transforming growth factor beta-3
       K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
       K04501  SMAD4; mothers against decapentaplegic homolog 4
       K04377  MYC; Myc proto-oncogene protein
       K10500  ZBTB17, MIZ1; zinc finger and BTB domain-containing protein 17
       K06621  CDKN2A, P16, INK4A; cyclin-dependent kinase inhibitor 2A
       K04685  CDKN2B, P15, INK4B; cyclin-dependent kinase inhibitor 2B
       K06622  CDKN2C, P18, INK4C; cyclin-dependent kinase inhibitor 2C
       K06623  CDKN2D, P19, INK4D; cyclin-dependent kinase inhibitor 2D
       K06624  CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
       K09993  CDKN1C, P57, KIP2; cyclin-dependent kinase inhibitor 1C
       K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
       K06626  CCNE; cyclin E
       K02206  CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
       K03094  SKP1, CBF3D; S-phase kinase-associated protein 1
       K03347  CUL1, CDC53; cullin 1
       K03868  RBX1, ROC1; RING-box protein 1
       K03875  SKP2, FBXL1; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
       K06627  CCNA; cyclin A
       K02213  CDC6; cell division control protein 6
       K06628  CDC45; cell division control protein 45
       K02214  CDC7; cell division control protein 7 [EC:2.7.11.1]
       K06629  ASK, DBF4; activator of S phase kinase
       K02087  CDK1, CDC2; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]
       K05868  CCNB; cyclin B
       K05866  CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
       K05867  CDC25C; M-phase inducer phosphatase 3 [EC:3.1.3.48]
       K16197  YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
       K06630  YWHAE; 14-3-3 protein epsilon
       K16198  YWHAG_H; 14-3-3 protein gamma/eta
       K06631  PLK1; polo-like kinase 1 [EC:2.7.11.21]
       K06632  WEE1; wee1-like protein kinase [EC:2.7.11.1]
       K06633  PKMYT; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase [EC:2.7.11.1]
       K06634  CCNH; cyclin H
       K02202  CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
       K03348  APC1; anaphase-promoting complex subunit 1
       K03349  APC2; anaphase-promoting complex subunit 2
       K03350  APC3, CDC27; anaphase-promoting complex subunit 3
       K03351  APC4; anaphase-promoting complex subunit 4
       K03352  APC5; anaphase-promoting complex subunit 5
       K03353  APC6, CDC16; anaphase-promoting complex subunit 6
       K03354  APC7; anaphase-promoting complex subunit 7
       K03355  APC8, CDC23; anaphase-promoting complex subunit 8
       K03356  APC9; anaphase-promoting complex subunit 9
       K03357  APC10, DOC1; anaphase-promoting complex subunit 10
       K03358  APC11; anaphase-promoting complex subunit 11
       K03359  APC12, CDC26; anaphase-promoting complex subunit 12
       K12456  APC13; anaphase-promoting complex subunit 13
       K03363  CDC20; cell division cycle 20, cofactor of APC complex
       K06635  PTTG; securin
       K02365  ESP1; separase [EC:3.4.22.49]
       K06636  SMC1; structural maintenance of chromosome 1
       K06669  SMC3, CSPG6; structural maintenance of chromosome 3 (chondroitin sulfate proteoglycan 6)
       K06671  STAG1_2, SCC3, IRR1; cohesin complex subunit SA-1/2
       K06670  SCC1, MCD1, RAD21; cohesin complex subunit SCC1
       K08866  TTK, MPS1; serine/threonine-protein kinase TTK/MPS1 [EC:2.7.12.1]
       K02178  BUB1; checkpoint serine/threonine-protein kinase [EC:2.7.11.1]
       K02180  BUB3; cell cycle arrest protein BUB3
       K06637  BUB1B, BUBR1, MAD3L; mitotic checkpoint serine/threonine-protein kinase BUB1 beta [EC:2.7.11.1]
       K06638  MAD1L; mitotic spindle assembly checkpoint protein MAD1
       K02537  MAD2; mitotic spindle assembly checkpoint protein MAD2
       K13728  MAD2L2; mitotic spindle assembly checkpoint protein MAD2B
       K03364  CDH1; cell division cycle 20-like protein 1, cofactor of APC complex
       K06639  CDC14; cell division cycle 14 [EC:3.1.3.16 3.1.3.48]
       K06640  ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
       K04728  ATM, TEL1; ataxia telangiectasia mutated family protein [EC:2.7.11.1]
       K04451  TP53, P53; tumor protein p53
       K02216  CHK1; serine/threonine-protein kinase Chk1 [EC:2.7.11.1]
       K06641  CHK2; serine/threonine-protein kinase Chk2 [EC:2.7.11.1]
       K04498  EP300, CREBBP, KAT3; E1A/CREB-binding protein [EC:2.3.1.48]
       K06642  PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
       K06643  MDM2; E3 ubiquitin-protein ligase Mdm2 [EC:6.3.2.19]
       K04402  GADD45; growth arrest and DNA-damage-inducible protein
       K04802  PCNA; proliferating cell nuclear antigen
       K06644  SFN; stratifin
       K06645  CDC25A; M-phase inducer phosphatase 1 [EC:3.1.3.48]
       K02603  ORC1; origin recognition complex subunit 1
       K02604  ORC2; origin recognition complex subunit 2
       K02605  ORC3; origin recognition complex subunit 3
       K02606  ORC4; origin recognition complex subunit 4
       K02607  ORC5; origin recognition complex subunit 5
       K02608  ORC6; origin recognition complex subunit 6
       K02540  MCM2; DNA replication licensing factor MCM2 [EC:3.6.4.12]
       K02541  MCM3; DNA replication licensing factor MCM3 [EC:3.6.4.12]
       K02212  MCM4, CDC54; DNA replication licensing factor MCM4 [EC:3.6.4.12]
       K02209  MCM5, CDC46; DNA replication licensing factor MCM5 [EC:3.6.4.12]
       K02542  MCM6; DNA replication licensing factor MCM6 [EC:3.6.4.12]
       K02210  MCM7, CDC47; DNA replication licensing factor MCM7 [EC:3.6.4.12]
     04111 Cell cycle - yeast [PATH:ko04111]
     04112 Cell cycle - Caulobacter [PATH:ko04112]
     04113 Meiosis - yeast [PATH:ko04113]
     04114 Oocyte meiosis [PATH:ko04114]
     04210 Apoptosis [PATH:ko04210]
     04115 p53 signaling pathway [PATH:ko04115]
 
   Cell communication
 
 Organismal Systems
 
 Human Diseases

[ BRITE | KEGG2 | KEGG ]
Last updated: July 24, 2014