KEGG Orthology (KO)

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 Metabolism
 
 Genetic Information Processing
 
 Environmental Information Processing
 
 Cellular Processes
 
 Organismal Systems
 
   Immune system
     04640 Hematopoietic cell lineage [PATH:ko04640]
     04610 Complement and coagulation cascades [PATH:ko04610]
     04611 Platelet activation [PATH:ko04611]
     04620 Toll-like receptor signaling pathway [PATH:ko04620]
     04621 NOD-like receptor signaling pathway [PATH:ko04621]
     04622 RIG-I-like receptor signaling pathway [PATH:ko04622]
     04623 Cytosolic DNA-sensing pathway [PATH:ko04623]
     04650 Natural killer cell mediated cytotoxicity [PATH:ko04650]
       K06751  MHC1; major histocompatibility complex, class I
       K07980  KIR3DL; killer cell immunoglobulin-like receptor 3DL
       K07981  KIR2DL; killer cell immunoglobulin-like receptor 2DL
       K06541  KLRC; killer cell lectin-like receptor subfamily C
       K06516  KLRD1, CD94; killer cell lectin-like receptor subfamily D member 1
       K05697  PTPN6, SHP-1; tyrosine-protein phosphatase non-receptor type 6 [EC:3.1.3.48]
       K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11 [EC:3.1.3.48]
       K06490  ICAM1; intercellular adhesion molecule 1
       K06523  ICAM2; intercellular adhesion molecule 2
       K05718  ITGAL; integrin alpha L
       K06464  ITGB2; integrin beta 2
       K05871  PTK2B, FAK2; focal adhesion kinase 2 [EC:2.7.10.2]
       K05730  VAV; guanine nucleotide exchange factor VAV
       K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
       K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
       K07861  RAC3; Ras-related C3 botulinum toxin substrate 3
       K04409  PAK1; p21-activated kinase 1 [EC:2.7.11.1]
       K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
       K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
       K04371  MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
       K03156  TNFA; tumor necrosis factor superfamily, member 2
       K05427  CSF2, GMCSF; granulocyte-macrophage colony-stimulating factor
       K04687  IFNG; interferon gamma
       K07982  KIR2DS; killer cell immunoglobulin-like receptor 2DS
       K06742  NCR2; natural cytotoxicity triggering receptor 2
       K07992  TYROBP, DAP12; TYRO protein tyrosine kinase binding protein
       K05856  LCK; lymphocyte cell-specific protein tyrosine kinase [EC:2.7.10.2]
       K06856  IGH; immunoglobulin heavy chain
       K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc region receptor III
       K06741  NCR1; natural cytotoxicity triggering receptor 1
       K06743  NCR3; natural cytotoxicity triggering receptor 3
       K07983  FCER1G; Fc receptor, IgE, high affinity I, gamma polypeptide
       K06453  CD3Z; CD3Z antigen, zeta polypeptide
       K07360  ZAP70; tyrosine-protein kinase ZAP-70 [EC:2.7.10.2]
       K05855  SYK; spleen tyrosine kinase [EC:2.7.10.2]
       K07361  LCP2; lymphocyte cytosolic protein 2
       K07362  LAT; linker for activation of T cells
       K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
       K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
       K07984  SH3BP2; SH3-domain binding protein 2
       K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
       K02649  PIK3R; phosphoinositide-3-kinase, regulatory subunit
       K05703  FYN; tyrosine-protein kinase Fyn [EC:2.7.10.2]
       K06279  SHC1; SHC- transforming protein 1
       K17447  SHC2; SHC- transforming protein 2
       K17448  SHC3; SHC- transforming protein 3
       K17449  SHC4; SHC- transforming protein 4
       K04364  GRB2; growth factor receptor-binding protein 2
       K03099  SOS; son of sevenless
       K02833  HRAS; GTPase HRas
       K07827  KRAS, KRAS2; GTPase KRas
       K07828  NRAS; GTPase NRas
       K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K07985  MIC; MHC class I-related protein
       K07986  ULBP; UL16 binding protein
       K07987  RAET1; retinoic acid early transcript 1
       K06728  KLRK1; killer cell lectin-like receptor subfamily K member 1
       K07988  HCST, DAP10; hematopoietic cell signal transducer
       K06479  CD48, BCM1; CD48 antigen
       K06582  CD244; natural killer cell receptor 2B4
       K04348  PPP3C, CNA; serine/threonine-protein phosphatase 2B catalytic subunit [EC:3.1.3.16]
       K06268  PPP3R, CNB; serine/threonine-protein phosphatase 2B regulatory subunit
       K04446  NFATC1, NFAT2, NFATC; nuclear factor of activated T-cells, cytoplasmic 1
       K17332  NFATC2, NFAT1, NFATP; nuclear factor of activated T-cells, cytoplasmic 2
       K02677  CPKC; classical protein kinase C [EC:2.7.11.13]
       K07989  EAT2; EWS/FLI1 activated transcript 2
       K07990  SH2D1A, SAP; SH2 domain protein 1A
       K05132  IFNGR1, CD119; interferon gamma receptor 1
       K05133  IFNGR2; interferon gamma receptor 2
       K05414  IFNA; interferon alpha
       K05415  IFNB; interferon beta
       K05130  IFNAR1; interferon receptor 1
       K05131  IFNAR2; interferon receptor 2
       K04721  TNFSF10, TRAIL; tumor necrosis factor ligand superfamily member 10
       K04722  TNFRSF10, TRAILR; tumor necrosis factor receptor superfamily member 10
       K04389  TNFSF6, FASL; tumor necrosis factor ligand superfamily member 6
       K04390  TNFRSF6, FAS; tumor necrosis factor receptor superfamily member 6
       K01353  GZMB; granzyme B [EC:3.4.21.79]
       K07818  PRF1; perforin 1
       K02187  CASP3; caspase 3 [EC:3.4.22.56]
       K04726  BID; BH3 interacting domain death agonist
     04612 Antigen processing and presentation [PATH:ko04612]
     04660 T cell receptor signaling pathway [PATH:ko04660]
     04662 B cell receptor signaling pathway [PATH:ko04662]
     04664 Fc epsilon RI signaling pathway [PATH:ko04664]
     04666 Fc gamma R-mediated phagocytosis [PATH:ko04666]
     04670 Leukocyte transendothelial migration [PATH:ko04670]
     04672 Intestinal immune network for IgA production [PATH:ko04672]
     04062 Chemokine signaling pathway [PATH:ko04062]
 
   Endocrine system
 
   Circulatory system
 
   Digestive system
 
   Excretory system
 
   Nervous system
 
   Sensory system
 
   Development
 
   Environmental adaptation
 
 Human Diseases
 
   Cancers
 
   Immune diseases
     05310 Asthma [PATH:ko05310]
     05322 Systemic lupus erythematosus [PATH:ko05322]
     05323 Rheumatoid arthritis [PATH:ko05323]
     05320 Autoimmune thyroid disease [PATH:ko05320]
       K05414  IFNA; interferon alpha
       K06538  CTLA4, CD152; cytotoxic T-lymphocyte-associated protein 4
       K00431  TPO; thyroid peroxidase [EC:1.11.1.8]
       K10809  TG; thyroglobulin
       K06752  MHC2; major histocompatibility complex, class II
       K10784  TRAV; T cell receptor alpha chain V region
       K10785  TRBV; T-cell receptor beta chain V region
       K05412  CD80; CD80 antigen
       K05413  CD86; CD86 antigen
       K06470  CD28; CD28 antigen
       K05429  IL2; interleukin 2
       K06751  MHC1; major histocompatibility complex, class I
       K04389  TNFSF6, FASL; tumor necrosis factor ligand superfamily member 6
       K04390  TNFRSF6, FAS; tumor necrosis factor receptor superfamily member 6
       K07818  PRF1; perforin 1
       K01353  GZMB; granzyme B [EC:3.4.21.79]
       K03161  TNFSF5, CD40L; tumor necrosis factor ligand superfamily member 5
       K03160  TNFRSF5, CD40; tumor necrosis factor receptor superfamily member 5
       K05430  IL4; interleukin 4
       K05428  IL5; interleukin 5
       K05443  IL10, CSIF; interleukin 10
       K06856  IGH; immunoglobulin heavy chain
       K04249  TSHR; thyroid stimulating hormone receptor
       K08522  CGA; glycoprotein hormones, alpha polypeptide
       K05251  TSHB; thyroid stimulating hormone, beta
     05321 Inflammatiory bowel disease (IBD) [PATH:ko05321]
     05330 Allograft rejection [PATH:ko05330]
       K06751  MHC1; major histocompatibility complex, class I
       K10784  TRAV; T cell receptor alpha chain V region
       K10785  TRBV; T-cell receptor beta chain V region
       K05412  CD80; CD80 antigen
       K05413  CD86; CD86 antigen
       K06470  CD28; CD28 antigen
       K05406  IL12A; interleukin 12A
       K05425  IL12B; interleukin 12B
       K04389  TNFSF6, FASL; tumor necrosis factor ligand superfamily member 6
       K04390  TNFRSF6, FAS; tumor necrosis factor receptor superfamily member 6
       K07818  PRF1; perforin 1
       K01353  GZMB; granzyme B [EC:3.4.21.79]
       K06752  MHC2; major histocompatibility complex, class II
       K05429  IL2; interleukin 2
       K03161  TNFSF5, CD40L; tumor necrosis factor ligand superfamily member 5
       K03160  TNFRSF5, CD40; tumor necrosis factor receptor superfamily member 5
       K04687  IFNG; interferon gamma
       K03156  TNFA; tumor necrosis factor superfamily, member 2
       K05430  IL4; interleukin 4
       K05428  IL5; interleukin 5
       K05443  IL10, CSIF; interleukin 10
       K06856  IGH; immunoglobulin heavy chain
     05332 Graft-versus-host disease [PATH:ko05332]
       K05405  IL6; interleukin 6
       K04383  IL1A; interleukin 1 alpha
       K04519  IL1B; interleukin 1 beta
       K03156  TNFA; tumor necrosis factor superfamily, member 2
       K06752  MHC2; major histocompatibility complex, class II
       K10784  TRAV; T cell receptor alpha chain V region
       K10785  TRBV; T-cell receptor beta chain V region
       K05412  CD80; CD80 antigen
       K05413  CD86; CD86 antigen
       K06470  CD28; CD28 antigen
       K05429  IL2; interleukin 2
       K06751  MHC1; major histocompatibility complex, class I
       K04389  TNFSF6, FASL; tumor necrosis factor ligand superfamily member 6
       K04390  TNFRSF6, FAS; tumor necrosis factor receptor superfamily member 6
       K07818  PRF1; perforin 1
       K01353  GZMB; granzyme B [EC:3.4.21.79]
       K04687  IFNG; interferon gamma
       K06516  KLRD1, CD94; killer cell lectin-like receptor subfamily D member 1
     05340 Primary immunodeficiency [PATH:ko05340]
 
   Neurodegenerative diseases
 
   Substance dependence
 
   Cardiovascular diseases
     05410 Hypertrophic cardiomyopathy (HCM) [PATH:ko05410]
     05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) [PATH:ko05412]
     05414 Dilated cardiomyopathy (DCM) [PATH:ko05414]
     05416 Viral myocarditis [PATH:ko05416]
       K06788  CXADR, CAR; coxsackievirus and adenovirus receptor
       K04006  DAF, CD55; decay accelerating factor
       K05703  FYN; tyrosine-protein kinase Fyn [EC:2.7.10.2]
       K06278  CAV1; caveolin 1
       K06619  ABL1; abelson tyrosine-protein kinase 1 [EC:2.7.10.2]
       K08887  ABL2; abelson tyrosine-protein kinase 2 [EC:2.7.10.2]
       K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
       K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
       K07861  RAC3; Ras-related C3 botulinum toxin substrate 3
       K12563  SGCD; delta-sarcoglycan
       K12564  SGCG; gamma-sarcoglycan
       K12565  SGCA; alpha-sarcoglycan
       K12566  SGCB; beta-sarcoglycan
       K06265  DAG1; dystroglycan 1
       K10366  DMD; dystrophin
       K05692  ACTB_G1; actin beta/gamma 1
       K03260  EIF4G; translation initiation factor 4G
       K04503  CCND1; cyclin D1
       K04398  CASP8; caspase 8 [EC:3.4.22.61]
       K04726  BID; BH3 interacting domain death agonist
       K08738  CYC; cytochrome c
       K04399  CASP9; caspase 9 [EC:3.4.22.62]
       K02187  CASP3; caspase 3 [EC:3.4.22.56]
       K17751  MYH6_7; myosin heavy chain 6/7
       K03161  TNFSF5, CD40L; tumor necrosis factor ligand superfamily member 5
       K03160  TNFRSF5, CD40; tumor necrosis factor receptor superfamily member 5
       K06752  MHC2; major histocompatibility complex, class II
       K10784  TRAV; T cell receptor alpha chain V region
       K10785  TRBV; T-cell receptor beta chain V region
       K06751  MHC1; major histocompatibility complex, class I
       K05412  CD80; CD80 antigen
       K05413  CD86; CD86 antigen
       K06470  CD28; CD28 antigen
       K07818  PRF1; perforin 1
       K05718  ITGAL; integrin alpha L
       K06464  ITGB2; integrin beta 2
       K06490  ICAM1; intercellular adhesion molecule 1
       K06856  IGH; immunoglobulin heavy chain
 
   Endocrine and metabolic diseases
     04940 Type I diabetes mellitus [PATH:ko04940]
       K04526  INS; insulin
       K01580  E4.1.1.15, gadB, gadA, GAD; glutamate decarboxylase [EC:4.1.1.15]
       K07817  PTPRN; receptor-type tyrosine-protein phosphatase N [EC:3.1.3.48]
       K01294  CPE; carboxypeptidase E [EC:3.4.17.10]
       K04077  groEL, HSPD1; chaperonin GroEL
       K06752  MHC2; major histocompatibility complex, class II
       K05412  CD80; CD80 antigen
       K05413  CD86; CD86 antigen
       K06470  CD28; CD28 antigen
       K05406  IL12A; interleukin 12A
       K05425  IL12B; interleukin 12B
       K05429  IL2; interleukin 2
       K04687  IFNG; interferon gamma
       K06751  MHC1; major histocompatibility complex, class I
       K10784  TRAV; T cell receptor alpha chain V region
       K10785  TRBV; T-cell receptor beta chain V region
       K04389  TNFSF6, FASL; tumor necrosis factor ligand superfamily member 6
       K04390  TNFRSF6, FAS; tumor necrosis factor receptor superfamily member 6
       K07818  PRF1; perforin 1
       K01353  GZMB; granzyme B [EC:3.4.21.79]
       K05468  LTA, TNFB; lymphotoxin alpha (TNF superfamily, member 1)
       K03156  TNFA; tumor necrosis factor superfamily, member 2
       K04383  IL1A; interleukin 1 alpha
       K04519  IL1B; interleukin 1 beta
     04930 Type II diabetes mellitus [PATH:ko04930]
     04950 Maturity onset diabetes of the young [PATH:ko04950]
     04932 Non-alcoholic fatty liver disease (NAFLD) [PATH:ko04932]
 
   Infectious diseases
 
   Drug resistance

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Last updated: July 11, 2014