 Metabolism
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Genetic Information Processing
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Environmental Information Processing
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Cellular Processes
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 Organismal Systems
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Immune system
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Endocrine system
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04911 Insulin secretion [PATH:ko04911]
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04910 Insulin signaling pathway [PATH:ko04910]
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04920 Adipocytokine signaling pathway [PATH:ko04920]
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 K03156 TNFA; tumor necrosis factor superfamily, member 2
K03158 TNFRSF1A, TNFR1; tumor necrosis factor receptor superfamily member 1A
K03171 TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein
K05141 TNFRSF1B, TNFR2; tumor necrosis factor receptor superfamily member 1B
K03173 TRAF2; TNF receptor-associated factor 2
K07203 FRAP; FKBP12-rapamycin complex-associated protein
K04440 JNK; c-Jun N-terminal kinase [EC:2.7.11.24]
K04467 IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
K07209 IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
K07210 IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
K04734 NFKBIA; NF-kappa-B inhibitor alpha
K02581 NFKBIB; NF-kappa-B inhibitor beta
K05872 NFKBIE; NF-kappa-B inhibitor epsilon
K02580 NFKB1; nuclear factor NF-kappa-B p105 subunit
K04735 RELA; transcription factor p65
K04696 SOCS3, CIS3; suppressor of cytokine signaling 3
K16172 IRS1; insulin receptor substrate 1
K07187 IRS2_3_4; insulin receptor substrate 2/3/4
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K06259 CD36; CD36 antigen
K01897 ACSL, fadD; long-chain acyl-CoA synthetase [EC:6.2.1.3]
K15013 ACSBG; long-chain-fatty-acid--CoA ligase ACSBG [EC:6.2.1.3]
K05424 LEP; leptin
K05062 LEPR; leptin receptor
K04447 JAK2; Janus kinase 2 [EC:2.7.10.2]
K04692 STAT3; signal transducer and activator of transcription 3
K05228 POMC; proopiomelanocortin
K07198 PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.11]
K07199 PRKAB; 5'-AMP-activated protein kinase, regulatory beta subunit
K07200 PRKAG; 5'-AMP-activated protein kinase, regulatory gamma subunit
K05231 AGRP; agouti related protein
K05232 NPY; neuropeptide Y
K07202 PGC1; peroxisome proliferative activated receptor, gamma, coactivator 1, alpha
K01596 E4.1.1.32, pckA, PEPCK; phosphoenolpyruvate carboxykinase (GTP) [EC:4.1.1.32]
K01084 G6PC; glucose-6-phosphatase [EC:3.1.3.9]
K07293 PTPN11; tyrosine-protein phosphatase non-receptor type 11 [EC:3.1.3.48]
K07294 NR1C1, PPARA; peroxisome proliferator-activated receptor alpha
K08524 NR2B1, RXRA; retinoid X receptor alpha
K08525 NR2B2, RXRB; retinoid X receptor beta
K08526 NR2B3, RXRG; retinoid X receptor gamma
K07296 ACDC; adiponectin
K07297 ADIPOR; adiponectin receptor
K07298 STK11, LKB1; serine/threonine-protein kinase 11
K07359 CAMKK; calcium/calmodulin-dependent protein kinase kinase [EC:2.7.11.17]
K08765 CPT1; carnitine O-palmitoyltransferase 1 [EC:2.3.1.21]
K07299 SLC2A1, GLUT1; MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 1
K07191 SLC2A4, GLUT4; MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 4
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03320 PPAR signaling pathway [PATH:ko03320]
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K06259 CD36; CD36 antigen
K08745 SLC27A1_4, FATP1, FATP4; solute carrier family 27 (fatty acid transporter), member 1/4 [EC:6.2.1.-]
K08746 SLC27A2, FACVL1, FATP2; solute carrier family 27 (fatty acid transporter), member 2 [EC:6.2.1.- 6.2.1.3]
K08748 SLC27A5, FATP5; solute carrier family 27 (fatty acid transporter), member 5 [EC:6.2.1.7]
K08749 SLC27A6, FATP6; solute carrier family 27 (fatty acid transporter), member 6
K08750 FABP1, L-FABP; fatty acid-binding protein 1, liver
K08751 FABP2; fatty acid-binding protein 2, intestinal
K08752 FABP3; fatty acid-binding protein 3, muscle and heart
K08753 FABP4, aP2; fatty acid-binding protein 4, adipocyte
K08754 FABP5; fatty acid-binding protein 5, epidermal
K08755 FABP6; fatty acid-binding protein 6, ileal (gastrotropin)
K08756 FABP7; fatty acid-binding protein 7, brain
K07294 NR1C1, PPARA; peroxisome proliferator-activated receptor alpha
K08524 NR2B1, RXRA; retinoid X receptor alpha
K08525 NR2B2, RXRB; retinoid X receptor beta
K08526 NR2B3, RXRG; retinoid X receptor gamma
K04504 NR1C2, PPARD; peroxisome proliferator-activated receptor delta
K08530 NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
K08757 APOA1; apolipoprotein A-I
K08758 APOA2; apolipoprotein A-II
K08759 APOC3; apolipoprotein C-III
K09025 APOA5; apolipoprotein A-V
K08761 PLTP; phospholipid transfer protein
K10226 FADS2; fatty acid desaturase 2 (delta-6 desaturase) [EC:1.14.19.-]
K00507 SCD, desC; stearoyl-CoA desaturase (delta-9 desaturase) [EC:1.14.19.1]
K00489 CYP7A1; cytochrome P450, family 7, subfamily A (cholesterol 7alpha-monooxygenase) [EC:1.14.13.17]
K07431 CYP8B; cytochrome P450, family 8, subfamily B (sterol 12-alpha-hydroxylase) [EC:1.14.13.95]
K08536 NR1H3, LXRA; liver X receptor alpha
K00488 CYP27A; cytochrome P450, family 27, subfamily A (cholestanetriol 26-monooxygenase) [EC:1.14.13.15]
K08762 DBI, ACBP; diazepam-binding inhibitor (GABA receptor modulator, acyl-CoA-binding protein)
K01059 LPL; lipoprotein lipase [EC:3.1.1.34]
K01897 ACSL, fadD; long-chain acyl-CoA synthetase [EC:6.2.1.3]
K15013 ACSBG; long-chain-fatty-acid--CoA ligase ACSBG [EC:6.2.1.3]
K08763 OLR1; oxidised low-density lipoprotein receptor 1
K07514 EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase [EC:4.2.1.17 1.1.1.35 5.3.3.8]
K07425 CYP4A; cytochrome P450, family 4, subfamily A [EC:1.14.15.3]
K07513 ACAA1; acetyl-CoA acyltransferase 1 [EC:2.3.1.16]
K08764 SCP2, SCPX; sterol carrier protein 2 [EC:2.3.1.176]
K00232 E1.3.3.6, ACOX1, ACOX3; acyl-CoA oxidase [EC:1.3.3.6]
K10214 ACOX2; 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase [EC:1.17.99.3]
K08765 CPT1; carnitine O-palmitoyltransferase 1 [EC:2.3.1.21]
K08766 CPT2; carnitine O-palmitoyltransferase 2 [EC:2.3.1.21]
K00255 ACADL; long-chain-acyl-CoA dehydrogenase [EC:1.3.8.8]
K00249 ACADM, acd; acyl-CoA dehydrogenase [EC:1.3.8.7]
K08767 ANGPTL4, PGAR; angiopoietin-like 4
K06086 SORBS1, SH3D5, PONSIN, CAP; sorbin and SH3 domain containing 1
K08768 PLIN; perilipin
K07296 ACDC; adiponectin
K01388 MMP1; matrix metalloproteinase-1 (interstitial collagenase) [EC:3.4.24.7]
K08769 UCP1, SLC25A7; solute carrier family 25 (mitochondrial uncoupling protein), member 7
K06272 ILK; integrin-linked kinase [EC:2.7.11.1]
K06276 PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]
K08770 UBC; ubiquitin C
K01596 E4.1.1.32, pckA, PEPCK; phosphoenolpyruvate carboxykinase (GTP) [EC:4.1.1.32]
K00864 E2.7.1.30, glpK; glycerol kinase [EC:2.7.1.30]
K08771 AQP7; aquaporin-7
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04912 GnRH signaling pathway [PATH:ko04912]
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04913 Ovarian Steroidogenesis [PATH:ko04913]
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04915 Estrogen signaling pathway [PATH:ko04915]
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04914 Progesterone-mediated oocyte maturation [PATH:ko04914]
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04917 Prolactin signaling pathway [PATH:ko04917]
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04916 Melanogenesis [PATH:ko04916]
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04614 Renin-angiotensin system [PATH:ko04614]
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Circulatory system
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Digestive system
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Excretory system
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Nervous system
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Sensory system
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Development
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Environmental adaptation
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Human Diseases
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Cancers
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05200 Pathways in cancer [PATH:ko05200]
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K06765 DCC; deleted in colorectal carcinoma
K02187 CASP3; caspase 3 [EC:3.4.22.56]
K04399 CASP9; caspase 9 [EC:3.4.22.62]
K08733 APPL, DIP13A; DCC-interacting protein 13 alpha
K05689 CDHE, CDH1; cadherin 1, type 1, E-cadherin
K02105 CTNNB1; catenin beta 1
K05691 CTNNA; catenin alpha
K02157 AXIN1; axin 1
K04385 AXIN2; axin 2
K02085 APC; adenomatosis polyposis coli protein
K03083 GSK3B; glycogen synthase kinase 3 beta [EC:2.7.11.26]
K02620 TCF7; transcription factor 7
K04490 TCF7L1; transcription factor 7-like 1
K04491 TCF7L2; transcription factor 7-like 2
K04492 LEF1; lymphoid enhancer-binding factor 1
K08731 BIRC5; baculoviral IAP repeat-containing protein 5
K04377 MYC; Myc proto-oncogene protein
K04503 CCND1; cyclin D1
K03209 WNT1; wingless-type MMTV integration site family, member 1
K00182 WNT2; wingless-type MMTV integration site family, member 2
K00312 WNT3; wingless-type MMTV integration site family, member 3
K00408 WNT4; wingless-type MMTV integration site family, member 4
K00444 WNT5; wingless-type MMTV integration site family, member 5
K00445 WNT6; wingless-type MMTV integration site family, member 6
K00572 WNT7; wingless-type MMTV integration site family, member 7
K00714 WNT8; wingless-type MMTV integration site family, member 8
K01064 WNT9; wingless-type MMTV integration site family, member 9
K01357 WNT10; wingless-type MMTV integration site family, member 10
K01384 WNT11; wingless-type MMTV integration site family, member 11
K01558 WNT16; wingless-type MMTV integration site family, member 16
K02432 FZD1_7, fz; frizzled 1/7
K02235 FZD2; frizzled 2
K02329 FZD3; frizzled 3
K02354 FZD4, fz4; frizzled 4
K02375 FZD5_8, fz2; frizzled 5/8
K02376 FZD6; frizzled 6
K02842 FZD9_10; frizzled 9/10
K02353 DVL; segment polarity protein dishevelled
K06237 COL4A; collagen, type IV, alpha
K05637 LAMA1_2; laminin, alpha 1/2
K06240 LAMA3_5; laminin, alpha 3/5
K06241 LAMA4; laminin, alpha 4
K05636 LAMB1; laminin, beta 1
K06243 LAMB2; laminin, beta 2
K06244 LAMB3; laminin, beta 3
K06245 LAMB4; laminin, beta 4
K05635 LAMC1; laminin, gamma 1
K06246 LAMC2; laminin, gamma 2
K06247 LAMC3; laminin, gamma 3
K05717 FN1; fibronectin 1
K06481 ITGA2; integrin alpha 2
K06476 ITGA2B; integrin alpha 2B
K06482 ITGA3; integrin alpha 3
K06485 ITGA6; integrin alpha 6
K06487 ITGAV; integrin alpha V
K05719 ITGB1; integrin beta 1
K05725 PTK2, FAK; focal adhesion kinase 1 [EC:2.7.10.2]
K00922 PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
K02649 PIK3R; phosphoinositide-3-kinase, regulatory subunit
K01110 PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67]
K09348 NKX3-1; homeobox protein Nkx-3.1
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04467 IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
K07209 IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
K07210 IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
K04734 NFKBIA; NF-kappa-B inhibitor alpha
K02580 NFKB1; nuclear factor NF-kappa-B p105 subunit
K04469 NFKB2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2
K04735 RELA; transcription factor p65
K11987 PTGS2, COX2; prostaglandin-endoperoxide synthase 2 [EC:1.14.99.1]
K13241 NOS2; nitric-oxide synthase, inducible [EC:1.14.13.39]
K02161 BCL2; apoptosis regulator BCL-2
K16060 BIRC2_3; baculoviral IAP repeat-containing protein 2/3
K04725 XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
K16061 BIRC7_8; baculoviral IAP repeat-containing protein 7/8
K04570 BCL2L1, bcl-xL; BCL2-like 1 (apoptosis regulator Bcl-X)
K03172 TRAF1; TNF receptor-associated factor 1
K03173 TRAF2; TNF receptor-associated factor 2
K03174 TRAF3; TNF receptor-associated factor 3
K09848 TRAF4; TNF receptor-associated factor 4
K09849 TRAF5; TNF receptor-associated factor 5
K03175 TRAF6; TNF receptor-associated factor 6
K07203 FRAP; FKBP12-rapamycin complex-associated protein
K02158 BAD; BCL2-antagonist of cell death
K07201 FOXO1; forkhead box protein O1
K06643 MDM2; E3 ubiquitin-protein ligase Mdm2 [EC:6.3.2.19]
K04451 TP53, P53; tumor protein p53
K06624 CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
K06625 CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
K08878 BCR1, BCR; breakpoint cluster region protein [EC:2.7.11.1]
K06619 ABL1; abelson tyrosine-protein kinase 1 [EC:2.7.10.2]
K04438 CRK, CRKII; proto-oncogene C-crk
K04707 CBL; E3 ubiquitin-protein ligase CBL [EC:6.3.2.19]
K11223 STAT5A; signal transducer and activator of transcription 5A
K11224 STAT5B; signal transducer and activator of transcription 5B
K11217 JAK1; Janus kinase 1 [EC:2.7.10.2]
K04692 STAT3; signal transducer and activator of transcription 3
K11220 STAT1; signal transducer and activator of transcription 1
K05448 VEGFA; vascular endothelial growth factor A
K16858 VEGFB; vascular endothelial growth factor B
K16859 PGF; placenta growth factor
K05449 VEGFC_D; vascular endothelial growth factor C/D
K08774 TGFA; transforming growth factor, alpha
K04357 EGF; epidermal growth factor
K04361 EGFR, ERBB1; epidermal growth factor receptor [EC:2.7.10.1]
K05083 ERBB2, HER2; receptor tyrosine-protein kinase erbB-2 [EC:2.7.10.1]
K04359 PDGFA_B; platelet derived growth factor A/B
K04363 PDGFRA; platelet-derived growth factor receptor alpha [EC:2.7.10.1]
K05089 PDGFRB; platelet-derived growth factor receptor beta [EC:2.7.10.1]
K05459 IGF1; insulin-like growth factor 1
K05087 IGF1R; insulin-like growth factor 1 receptor [EC:2.7.10.1]
K05461 KITLG; KIT ligand
K05091 KIT, SCFR; proto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1]
K05454 FLT3LG; fms-related tyrosine kinase 3 ligand
K05092 FLT3, FLK2; fms-related tyrosine kinase 3 [EC:2.7.10.1]
K05460 HGF; hepatocyte growth factor
K05099 MET, HGFR; proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]
K04358 FGF; fibroblast growth factor
K04362 FGFR1; fibroblast growth factor receptor 1 [EC:2.7.10.1]
K05093 FGFR2; fibroblast growth factor receptor 2 [EC:2.7.10.1]
K05094 FGFR3; fibroblast growth factor receptor 3 [EC:2.7.10.1]
K04364 GRB2; growth factor receptor-binding protein 2
K03099 SOS; son of sevenless
K02833 HRAS; GTPase HRas
K07827 KRAS, KRAS2; GTPase KRas
K07828 NRAS; GTPase NRas
K08845 ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04366 RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04368 MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
K04369 MAP2K2, MEK2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
K04371 ERK1_2; extracellular signal-regulated kinase 1/2 [EC:2.7.11.24]
K04448 JUN; transcription factor AP-1
K04379 FOS; proto-oncogene protein c-fos
K01388 MMP1; matrix metalloproteinase-1 (interstitial collagenase) [EC:3.4.24.7]
K01398 MMP2; matrix metalloproteinase-2 (gelatinase A) [EC:3.4.24.24]
K01403 MMP9; matrix metalloproteinase-9 (gelatinase B) [EC:3.4.24.35]
K10030 IL8, CXCL8; interleukin 8
K02089 CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
K05126 RET; proto-oncogene tyrosine-protein kinase Ret [EC:2.7.10.1]
K09288 CCDC6, PTC; coiled-coil domain-containing protein 6
K09289 NCOA4, PTC3; nuclear receptor coactivator 4
K03176 NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1 [EC:2.7.10.1]
K09290 TPM3; tropomyosin 3
K09291 TPR; nucleoprotein TPR
K09292 TFG; protein TFG
K09850 RASSF1; Ras association domain-containing protein 1
K08015 RASSF5, RAPL; Ras association domain-containing protein 5
K04411 STK4, MST1; serine/threonine kinase 4
K08803 DAPK; death-associated protein kinase [EC:2.7.11.1]
K01116 PLCG1; phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
K05859 PLCG2; phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
K02677 CPKC; classical protein kinase C [EC:2.7.11.13]
K08732 RALGDS; ral guanine nucleotide dissociation stimulator
K07834 RALA; Ras-related protein Ral-A
K07835 RALB; Ras-related protein Ral-B
K08773 RALBP1; RalA-binding protein 1
K04393 CDC42; cell division control protein 42
K04392 RAC1; Ras-related C3 botulinum toxin substrate 1
K07860 RAC2; Ras-related C3 botulinum toxin substrate 2
K07861 RAC3; Ras-related C3 botulinum toxin substrate 3
K04513 RHOA, RHO1; Ras homolog gene family, member A
K04440 JNK; c-Jun N-terminal kinase [EC:2.7.11.24]
K09293 PAX8; paired box protein 8
K08530 NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
K08524 NR2B1, RXRA; retinoid X receptor alpha
K08525 NR2B2, RXRB; retinoid X receptor beta
K08526 NR2B3, RXRG; retinoid X receptor gamma
K08528 NR1B2, RARB; retinoic acid receptor beta
K04504 NR1C2, PPARD; peroxisome proliferator-activated receptor delta
K10056 JUP; junction plakoglobin
K10055 ZBTB16, PLZF; zinc finger and BTB domain-containing protein 16
K10054 PML, TRIM19; probable transcription factor PML
K08527 NR1B1, RARA; retinoic acid receptor alpha
K08367 RUNX1, AML1; runt-related transcription factor 1
K10053 RUNX1T1, CBFA2T1; runt-related transcription factor 1; translocated to, 1
K09438 SPI1; transcription factor PU.1
K09055 CEBPA; CCAAT/enhancer binding protein (C/EBP), alpha
K05066 CSF2RA, GMCSFR; granulocyte-macrophage colony-stimulating factor receptor alpha
K05061 CSF3R; granulocyte colony-stimulating factor receptor
K05090 CSF1R, FMS; macrophage colony-stimulating factor 1 receptor [EC:2.7.10.1]
K05405 IL6; interleukin 6
K06621 CDKN2A, P16, INK4A; cyclin-dependent kinase inhibitor 2A
K06620 E2F1_3; E2F transcription factor 1/3
K09389 E2F2; E2F transcription factor 2
K04453 MAX; Max protein
K16063 PIAS2; E3 SUMO-protein ligase PIAS2 [EC:6.3.2.-]
K04685 CDKN2B, P15, INK4B; cyclin-dependent kinase inhibitor 2B
K02091 CDK6; cyclin-dependent kinase 6 [EC:2.7.11.22]
K02219 CKS1; cyclin-dependent kinase regulatory subunit CKS1
K03875 SKP2, FBXL1; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
K06626 CCNE; cyclin E
K06618 RB1; retinoblastoma-associated protein
K09455 MITF; microphthalmia-associated transcription factor
K13375 TGFB1; transforming growth factor beta-1
K13376 TGFB2; transforming growth factor beta-2
K13377 TGFB3; transforming growth factor beta-3
K04674 TGFBR1, ALK5; TGF-beta receptor type-1 [EC:2.7.11.30]
K04388 TGFBR2; TGF-beta receptor type-2 [EC:2.7.11.30]
K04500 SMAD2_3; mothers against decapentaplegic homolog 2/3
K04501 SMAD4; mothers against decapentaplegic homolog 4
K04462 EVI1; ecotropic virus integration site 1 protein
K04496 CTBP; C-terminal binding protein
K06067 HDAC1_2; histone deacetylase 1/2 [EC:3.5.1.98]
K08734 MLH1; DNA mismatch repair protein MLH1
K08735 MSH2; DNA mismatch repair protein MSH2
K08736 MSH3; DNA mismatch repair protein MSH3
K08737 MSH6; DNA mismatch repair protein MSH6
K02159 BAX; apoptosis regulator BAX
K08775 BRCA2, FANCD1; breast cancer 2 susceptibility protein
K04482 RAD51; DNA repair protein RAD51
K04389 TNFSF6, FASL; tumor necrosis factor ligand superfamily member 6
K04390 TNFRSF6, FAS; tumor necrosis factor receptor superfamily member 6
K02373 FADD; FAS-associated death domain protein
K04398 CASP8; caspase 8 [EC:3.4.22.61]
K04726 BID; BH3 interacting domain death agonist
K08738 CYC; cytochrome c
K03871 VHL; von Hippel-Lindau disease tumor supressor
K03872 TCEB1; transcription elongation factor B, polypeptide 1
K03873 TCEB2; transcription elongation factor B, polypeptide 2
K03868 RBX1, ROC1; RING-box protein 1
K03870 CUL2; cullin 2
K09592 EGLN, HPH; hypoxia-inducible factor prolyl hydroxylase [EC:1.14.11.-]
K01679 E4.2.1.2B, fumC; fumarate hydratase, class II [EC:4.2.1.2]
K08268 HIF1A; hypoxia-inducible factor 1 alpha
K09095 HIF2A, EPAS1; hypoxia-inducible factor 2 alpha
K09097 ARNT; aryl hydrocarbon receptor nuclear translocator
K15589 ARNT2; aryl hydrocarbon receptor nuclear translocator 2
K04498 EP300, CREBBP, KAT3; E1A/CREB-binding protein [EC:2.3.1.48]
K07299 SLC2A1, GLUT1; MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 1
K11988 SHH; sonic hedgehog
K06225 PTCH1; patched 1
K06226 SMO; smoothened
K06227 COS2; costal 2
K06228 FU; fused [EC:2.7.11.1]
K06229 SUFU; suppressor of fused
K16797 GLI1; zinc finger protein GLI1
K16798 GLI2; zinc finger protein GLI2
K06230 GLI3; zinc finger protein GLI3
K04662 BMP2_4; bone morphogenetic protein 2/4
K06231 HHIP; hedgehog interacting protein
K11101 PTCH2; patched 2
K08557 NR3C4, AR; androgen receptor
K04079 htpG, HSP90A; molecular chaperone HtpG
K09487 HSP90B, TRA1; heat shock protein 90kDa beta
K01351 KLK3; semenogelase [EC:3.4.21.77]
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05202 Transcriptional misregulation in cancers [PATH:ko05202]
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K08367 RUNX1, AML1; runt-related transcription factor 1
K05090 CSF1R, FMS; macrophage colony-stimulating factor 1 receptor [EC:2.7.10.1]
K10789 MPO; myeloperoxidase [EC:1.11.2.2]
K05427 CSF2, GMCSF; granulocyte-macrophage colony-stimulating factor
K04736 IL3; interleukin 3
K10053 RUNX1T1, CBFA2T1; runt-related transcription factor 1; translocated to, 1
K06067 HDAC1_2; histone deacetylase 1/2 [EC:3.5.1.98]
K11644 SIN3A; paired amphipathic helix protein Sin3a
K04650 NCOR1, N-CoR; nuclear receptor co-repressor 1
K09055 CEBPA; CCAAT/enhancer binding protein (C/EBP), alpha
K09438 SPI1; transcription factor PU.1
K04391 CD14; CD14 antigen
K06461 ITGAM; integrin alpha M
K06498 FCGR1A, CD64; high affinity immunoglobulin gamma Fc receptor I
K10056 JUP; junction plakoglobin
K10054 PML, TRIM19; probable transcription factor PML
K08527 NR1B1, RARA; retinoic acid receptor alpha
K10051 CEBPE; CCAAT/enhancer binding protein (C/EBP), epsilon
K02162 BCL2A1; hematopoietic BCL2-related protein A1
K10055 ZBTB16, PLZF; zinc finger and BTB domain-containing protein 16
K04377 MYC; Myc proto-oncogene protein
K09063 TCF3, E2A; transcription factor E2-alpha
K09355 PBX1; pre-B-cell leukemia transcription factor 1
K01558 WNT16; wingless-type MMTV integration site family, member 16
K03211 ETV6_7, yan; ETS translocation variant 6/7
K10784 TRAV; T cell receptor alpha chain V region
K10785 TRBV; T-cell receptor beta chain V region
K01327 ELANE; leukocyte elastase [EC:3.4.21.37]
K01353 GZMB; granzyme B [EC:3.4.21.79]
K09186 MLL1; histone-lysine N-methyltransferase MLL1 [EC:2.1.1.43]
K15184 AFF1; AF4/FMR2 family member 1
K02211 CDK9; cyclin-dependent kinase 9 [EC:2.7.11.22 2.7.11.23]
K15188 CCNT; cyclin T
K15187 MLLT1_3, ENL, AF9; YEATS domain-containing protein 1/3
K11427 DOT1L, DOT1; histone-lysine N-methyltransferase, H3 lysine-79 specific [EC:2.1.1.43]
K15612 LMO2; rhombotin-2
K15610 PBX3; pre-B-cell leukemia transcription factor 3
K09278 RUNX2, AML3; runt-related transcription factor 2
K04676 SMAD1; mothers against decapentaplegic homolog 1
K15605 KLF3; krueppel-like factor 3
K04454 MEF2C; MADS-box transcription enhancer factor 2C
K11449 JMJD1C; jumonji domain-containing protein 1C [EC:1.14.11.-]
K09283 HMGA2; high mobility group AT-hook protein 2
K11447 UTX, UTY; histone demethylase [EC:1.14.11.-]
K11313 SUPT3H, SPT3; transcription initiation protein SPT3
K06532 PROM1; prominin 1
K05092 FLT3, FLK2; fms-related tyrosine kinase 3 [EC:2.7.10.1]
K08854 BMP2K, BIKE; BMP2 inducible kinase [EC:2.7.11.1]
K05087 IGF1R; insulin-like growth factor 1 receptor [EC:2.7.10.1]
K06624 CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
K08821 CDK14, PFTK1; cyclin-dependent kinase 14 [EC:2.7.11.22]
K15613 MEIS1; homeobox protein Meis1
K15614 SIX1; homeobox protein SIX1
K15615 SIX4; homeobox protein SIX4
K15616 EYA1; eyes absent homolog 1 [EC:3.1.3.48]
K06622 CDKN2C, P18, INK4C; cyclin-dependent kinase inhibitor 2C
K00069 HPGD; 15-hydroxyprostaglandin dehydrogenase (NAD) [EC:1.1.1.141]
K05199 GRIA3; glutamate receptor 3
K00717 FUT8; glycoprotein 6-alpha-L-fucosyltransferase [EC:2.4.1.68]
K15607 TLX3, HOX11L2; T-cell leukemia homeobox protein 3
K09340 TLX1, HOX11; T-cell leukemia homeobox protein 1
K04182 CCR7; C-C chemokine receptor type 7
K15617 LDB1; LIM domain-binding protein 1
K15604 LYL1; protein lyl-1
K08024 HHEX, HEX, PRH; homeobox protein HEX
K06056 PTCRA; pre T-cell antigen receptor alpha
K09254 REL; c-Rel proto-oncogene protein
K03172 TRAF1; TNF receptor-associated factor 1
K04570 BCL2L1, bcl-xL; BCL2-like 1 (apoptosis regulator Bcl-X)
K05413 CD86; CD86 antigen
K03160 TNFRSF5, CD40; tumor necrosis factor receptor superfamily member 5
K15618 BCL6; B-cell lymphoma 6 protein
K06856 IGH; immunoglobulin heavy chain
K09035 CMAF, MAF; transcription factor Maf
K10151 CCND2; cyclin D2
K06590 ITGB7; integrin beta 7
K11424 WHSC1, MMSET, NSD2; histone-lysine N-methyltransferase NSD2 [EC:2.1.1.43]
K11253 H3; histone H3
K09383 PAX5; paired box protein 5
K09293 PAX8; paired box protein 8
K08530 NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
K08524 NR2B1, RXRA; retinoid X receptor alpha
K08525 NR2B2, RXRB; retinoid X receptor beta
K08526 NR2B3, RXRG; retinoid X receptor gamma
K13105 PRCC; proline-rich protein PRCC
K09105 TFE3; transcription factor E3
K06625 CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
K09633 TMPRSS2; transmembrane protease, serine 2
K09435 ERG; transcriptional regulator ERG
K01348 PLAU; urokinase plasminogen activator [EC:3.4.21.73]
K01343 PLAT; tissue plasminogen activator [EC:3.4.21.68]
K01394 MMP3; matrix metalloproteinase-3 (stromelysin 1, progelatinase) [EC:3.4.24.17]
K01403 MMP9; matrix metalloproteinase-9 (gelatinase B) [EC:3.4.24.35]
K15619 SPINT1; Kunitz-type protease inhibitor 1
K04387 IL1R2; interleukin 1 receptor type II
K09431 ETV1; ets translocation variant 1
K15592 ETV4; ets translocation variant 4
K15593 ETV5; ets translocation variant 5
K15379 SLC45A3; solute carrier family 45, member 3
K04376 ELK4, SAP1; ETS domain-containing protein Elk-4
K12823 DDX5, DBP2; ATP-dependent RNA helicase DDX5/DBP2 [EC:3.6.4.13]
K09109 NMYC, MYCN; N-myc proto-oncogene protein
K04453 MAX; Max protein
K06643 MDM2; E3 ubiquitin-protein ligase Mdm2 [EC:6.3.2.19]
K05725 PTK2, FAK; focal adhesion kinase 1 [EC:2.7.10.2]
K04451 TP53, P53; tumor protein p53
K11459 PCGF4, BMI1; polycomb group RING finger protein 4
K04684 SP1; transcription factor Sp1
K10500 ZBTB17, MIZ1; zinc finger and BTB domain-containing protein 17
K03176 NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1 [EC:2.7.10.1]
K02583 NGFR; nerve growth factor receptor (TNFR superfamily member 16)
K14970 MEN1, MNN1; menin
K13209 EWSR1; RNA-binding protein EWS
K09436 FLI1; friend leukemia integration 1 transcription factor
K05459 IGF1; insulin-like growth factor 1
K04388 TGFBR2; TGF-beta receptor type-2 [EC:2.7.11.30]
K10138 IGFBP3; insulin-like growth factor-binding protein 3
K09437 FEV; ETS oncogene family protein FEV
K09053 ATF1; activating transcription factor 1
K15589 ARNT2; aryl hydrocarbon receptor nuclear translocator 2
K04728 ATM, TEL1; ataxia telangiectasia mutated family protein [EC:2.7.11.1]
K15620 GOLPH3, GPP34; golgi phosphoprotein 3
K09234 WT1; Wilms tumor protein 1
K04359 PDGFA_B; platelet derived growth factor A/B
K05069 IL2RB; interleukin 2 receptor beta
K15621 BAIAP3; BAI1-associated protein 3
K06571 TM4SF2, MXS1; transmembrane 4 superfamily member 2
K15622 MLF1; myeloid leukemia factor 1
K08559 NR4A3, NOR1; nuclear receptor subfamily 4 group A member 3
K14651 TAF15; transcription initiation factor TFIID subunit 15
K13098 TLS, FUS; RNA-binding protein FUS
K04452 DDIT3, GADD153; DNA damage-inducible transcript 3
K10048 CEBPB; CCAAT/enhancer binding protein (C/EBP), beta
K05405 IL6; interleukin 6
K14242 NFKBIZ; NF-kappa-B inhibitor zeta
K02580 NFKB1; nuclear factor NF-kappa-B p105 subunit
K04735 RELA; transcription factor p65
K10030 IL8, CXCL8; interleukin 8
K07201 FOXO1; forkhead box protein O1
K05096 FLT1, VEGFR1; FMS-like tyrosine kinase 1 [EC:2.7.10.1]
K15623 SS18, SSXT, SYT; protein SSXT
K15624 SSX1; protein SSX1
K15625 SSX2; protein SSX2
K15626 NUPR1, COM1; nuclear protein, 1
K15627 ASPSCR1, ASPL; tether containing UBX domain for GLUT4
K05099 MET, HGFR; proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]
|
05205 Proteoglycans in cancer [PATH:ko05205]
|
05204 Chemical carcinogenesis [PATH:ko05204]
|
05203 Viral carcinogenesis [PATH:ko05203]
|
05210 Colorectal cancer [PATH:ko05210]
|
05212 Pancreatic cancer [PATH:ko05212]
|
05214 Glioma [PATH:ko05214]
|
05216 Thyroid cancer [PATH:ko05216]
|
K05126 RET; proto-oncogene tyrosine-protein kinase Ret [EC:2.7.10.1]
K09288 CCDC6, PTC; coiled-coil domain-containing protein 6
K09289 NCOA4, PTC3; nuclear receptor coactivator 4
K03176 NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1 [EC:2.7.10.1]
K09290 TPM3; tropomyosin 3
K09291 TPR; nucleoprotein TPR
K09292 TFG; protein TFG
K02833 HRAS; GTPase HRas
K07828 NRAS; GTPase NRas
K07827 KRAS, KRAS2; GTPase KRas
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04368 MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
K04369 MAP2K2, MEK2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
K04371 ERK1_2; extracellular signal-regulated kinase 1/2 [EC:2.7.11.24]
K09293 PAX8; paired box protein 8
K08530 NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
K08524 NR2B1, RXRA; retinoid X receptor alpha
K08525 NR2B2, RXRB; retinoid X receptor beta
K08526 NR2B3, RXRG; retinoid X receptor gamma
K04451 TP53, P53; tumor protein p53
K05689 CDHE, CDH1; cadherin 1, type 1, E-cadherin
K02105 CTNNB1; catenin beta 1
K02620 TCF7; transcription factor 7
K04490 TCF7L1; transcription factor 7-like 1
K04491 TCF7L2; transcription factor 7-like 2
K04492 LEF1; lymphoid enhancer-binding factor 1
K04377 MYC; Myc proto-oncogene protein
K04503 CCND1; cyclin D1
|
05221 Acute myeloid leukemia [PATH:ko05221]
|
05220 Chronic myeloid leukemia [PATH:ko05220]
|
05217 Basal cell carcinoma [PATH:ko05217]
|
05218 Melanoma [PATH:ko05218]
|
05211 Renal cell carcinoma [PATH:ko05211]
|
05219 Bladder cancer [PATH:ko05219]
|
05215 Prostate cancer [PATH:ko05215]
|
05213 Endometrial cancer [PATH:ko05213]
|
05222 Small cell lung cancer [PATH:ko05222]
|
K01522 FHIT; bis(5'-adenosyl)-triphosphatase [EC:3.6.1.29]
K08528 NR1B2, RARB; retinoic acid receptor beta
K08524 NR2B1, RXRA; retinoid X receptor alpha
K08525 NR2B2, RXRB; retinoid X receptor beta
K08526 NR2B3, RXRG; retinoid X receptor gamma
K04451 TP53, P53; tumor protein p53
K02161 BCL2; apoptosis regulator BCL-2
K08738 CYC; cytochrome c
K02084 APAF1; apoptotic protease-activating factor
K04399 CASP9; caspase 9 [EC:3.4.22.62]
K04377 MYC; Myc proto-oncogene protein
K04453 MAX; Max protein
K16063 PIAS2; E3 SUMO-protein ligase PIAS2 [EC:6.3.2.-]
K04685 CDKN2B, P15, INK4B; cyclin-dependent kinase inhibitor 2B
K02089 CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
K02091 CDK6; cyclin-dependent kinase 6 [EC:2.7.11.22]
K04503 CCND1; cyclin D1
K02219 CKS1; cyclin-dependent kinase regulatory subunit CKS1
K03875 SKP2, FBXL1; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
K06626 CCNE; cyclin E
K06618 RB1; retinoblastoma-associated protein
K06620 E2F1_3; E2F transcription factor 1/3
K09389 E2F2; E2F transcription factor 2
K06237 COL4A; collagen, type IV, alpha
K05637 LAMA1_2; laminin, alpha 1/2
K06240 LAMA3_5; laminin, alpha 3/5
K06241 LAMA4; laminin, alpha 4
K05636 LAMB1; laminin, beta 1
K06243 LAMB2; laminin, beta 2
K06244 LAMB3; laminin, beta 3
K06245 LAMB4; laminin, beta 4
K05635 LAMC1; laminin, gamma 1
K06246 LAMC2; laminin, gamma 2
K06247 LAMC3; laminin, gamma 3
K05717 FN1; fibronectin 1
K06481 ITGA2; integrin alpha 2
K06476 ITGA2B; integrin alpha 2B
K06482 ITGA3; integrin alpha 3
K06485 ITGA6; integrin alpha 6
K06487 ITGAV; integrin alpha V
K05719 ITGB1; integrin beta 1
K05725 PTK2, FAK; focal adhesion kinase 1 [EC:2.7.10.2]
K00922 PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
K02649 PIK3R; phosphoinositide-3-kinase, regulatory subunit
K01110 PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04467 IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
K07209 IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
K07210 IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
K04734 NFKBIA; NF-kappa-B inhibitor alpha
K02580 NFKB1; nuclear factor NF-kappa-B p105 subunit
K04735 RELA; transcription factor p65
K16060 BIRC2_3; baculoviral IAP repeat-containing protein 2/3
K04725 XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
K16061 BIRC7_8; baculoviral IAP repeat-containing protein 7/8
K04570 BCL2L1, bcl-xL; BCL2-like 1 (apoptosis regulator Bcl-X)
K03172 TRAF1; TNF receptor-associated factor 1
K03173 TRAF2; TNF receptor-associated factor 2
K03174 TRAF3; TNF receptor-associated factor 3
K09848 TRAF4; TNF receptor-associated factor 4
K09849 TRAF5; TNF receptor-associated factor 5
K03175 TRAF6; TNF receptor-associated factor 6
K11987 PTGS2, COX2; prostaglandin-endoperoxide synthase 2 [EC:1.14.99.1]
K13241 NOS2; nitric-oxide synthase, inducible [EC:1.14.13.39]
|
05223 Non-small cell lung cancer [PATH:ko05223]
|
K01522 FHIT; bis(5'-adenosyl)-triphosphatase [EC:3.6.1.29]
K08528 NR1B2, RARB; retinoic acid receptor beta
K08524 NR2B1, RXRA; retinoid X receptor alpha
K08525 NR2B2, RXRB; retinoid X receptor beta
K08526 NR2B3, RXRG; retinoid X receptor gamma
K06621 CDKN2A, P16, INK4A; cyclin-dependent kinase inhibitor 2A
K02089 CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
K02091 CDK6; cyclin-dependent kinase 6 [EC:2.7.11.22]
K04503 CCND1; cyclin D1
K06618 RB1; retinoblastoma-associated protein
K06620 E2F1_3; E2F transcription factor 1/3
K09389 E2F2; E2F transcription factor 2
K07827 KRAS, KRAS2; GTPase KRas
K09850 RASSF1; Ras association domain-containing protein 1
K08015 RASSF5, RAPL; Ras association domain-containing protein 5
K04411 STK4, MST1; serine/threonine kinase 4
K00922 PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
K02649 PIK3R; phosphoinositide-3-kinase, regulatory subunit
K06276 PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K02158 BAD; BCL2-antagonist of cell death
K04399 CASP9; caspase 9 [EC:3.4.22.62]
K09408 FOXO3; forkhead box protein O3
K04357 EGF; epidermal growth factor
K08774 TGFA; transforming growth factor, alpha
K04361 EGFR, ERBB1; epidermal growth factor receptor [EC:2.7.10.1]
K05083 ERBB2, HER2; receptor tyrosine-protein kinase erbB-2 [EC:2.7.10.1]
K04364 GRB2; growth factor receptor-binding protein 2
K03099 SOS; son of sevenless
K02833 HRAS; GTPase HRas
K07828 NRAS; GTPase NRas
K08845 ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04366 RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04368 MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
K04369 MAP2K2, MEK2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
K04371 ERK1_2; extracellular signal-regulated kinase 1/2 [EC:2.7.11.24]
K01116 PLCG1; phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
K05859 PLCG2; phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
K02677 CPKC; classical protein kinase C [EC:2.7.11.13]
K04451 TP53, P53; tumor protein p53
|
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Immune diseases
|
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Neurodegenerative diseases
|
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Substance dependence
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Cardiovascular diseases
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Endocrine and metabolic diseases
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Infectious diseases
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KEGG Orthology (KO)