KEGG Orthology (KO)

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   Replication and repair
     03030 DNA replication [PATH:ko03030]
       K02345  DPO3T, holE; DNA polymerase III subunit theta [EC:2.7.7.7]
       K02342  DPO3E, dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
       K14159  rnhA-dnaQ; ribonuclease HI / DNA polymerase III subunit epsilon [EC:3.1.26.4 2.7.7.7]
       K02337  DPO3A1, dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
       K03763  DPO3A2, polC; DNA polymerase III subunit alpha, Gram-positive type [EC:2.7.7.7]
       K02343  DPO3G, dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
       K02341  DPO3D2, holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
       K02340  DPO3D1, holA; DNA polymerase III subunit delta [EC:2.7.7.7]
       K02344  DPO3P, holD; DNA polymerase III subunit psi [EC:2.7.7.7]
       K02339  DPO3C, holC; DNA polymerase III subunit chi [EC:2.7.7.7]
       K02338  DPO3B, dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
       K02314  dnaB; replicative DNA helicase [EC:3.6.4.12]
       K02316  dnaG; DNA primase [EC:2.7.7.-]
       K03111  ssb; single-strand DNA-binding protein
       K03469  E3.1.26.4A, RNASEH1, rnhA; ribonuclease HI [EC:3.1.26.4]
       K03470  rnhB; ribonuclease HII [EC:3.1.26.4]
       K03471  rnhC; ribonuclease HIII [EC:3.1.26.4]
       K02335  DPO1, polA; DNA polymerase I [EC:2.7.7.7]
       K01972  E6.5.1.2, ligA, ligB; DNA ligase (NAD+) [EC:6.5.1.2]
       K02320  POLA1; DNA polymerase alpha subunit A [EC:2.7.7.7]
       K02321  POLA2; DNA polymerase alpha subunit B
       K02684  PRI1; DNA primase small subunit [EC:2.7.7.-]
       K02685  PRI2; DNA primase large subunit [EC:2.7.7.-]
       K02327  POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
       K02328  POLD2; DNA polymerase delta subunit 2
       K03504  POLD3; DNA polymerase delta subunit 3
       K03505  POLD4; DNA polymerase delta subunit 4
       K02324  POLE1; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
       K02325  POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
       K02326  POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
       K03506  POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
       K02540  MCM2; DNA replication licensing factor MCM2 [EC:3.6.4.12]
       K02541  MCM3; DNA replication licensing factor MCM3 [EC:3.6.4.12]
       K02212  MCM4, CDC54; DNA replication licensing factor MCM4 [EC:3.6.4.12]
       K02209  MCM5, CDC46; DNA replication licensing factor MCM5 [EC:3.6.4.12]
       K02542  MCM6; DNA replication licensing factor MCM6 [EC:3.6.4.12]
       K02210  MCM7, CDC47; DNA replication licensing factor MCM7 [EC:3.6.4.12]
       K07466  RFA1, RPA1, rpa; replication factor A1
       K10739  RFA2, RPA2; replication factor A2
       K10741  RPA4; replication factor A4
       K10740  RPA3; replication factor A3
       K04802  PCNA; proliferating cell nuclear antigen
       K10754  RFC1; replication factor C subunit 1
       K10755  RFC2_4; replication factor C subunit 2/4
       K10756  RFC3_5; replication factor C subunit 3/5
       K10742  DNA2; DNA replication ATP-dependent helicase Dna2 [EC:3.6.4.12]
       K10743  RNASEH2A; ribonuclease H2 subunit A [EC:3.1.26.4]
       K10744  RNASEH2B; ribonuclease H2 subunit B
       K10745  RNASEH2C; ribonuclease H2 subunit C
       K04799  FEN1, RAD2; flap endonuclease-1 [EC:3.-.-.-]
       K10747  LIG1; DNA ligase 1 [EC:6.5.1.1]
     03032 DNA replication proteins [BR:ko03032]
     03036 Chromosome and associated proteins [BR:ko03036]
     03410 Base excision repair [PATH:ko03410]
     03420 Nucleotide excision repair [PATH:ko03420]
       K03723  mfd; transcription-repair coupling factor (superfamily II helicase) [EC:3.6.4.-]
       K03701  uvrA; excinuclease ABC subunit A
       K03702  uvrB; excinuclease ABC subunit B
       K03703  uvrC; excinuclease ABC subunit C
       K03657  uvrD, pcrA; DNA helicase II / ATP-dependent DNA helicase PcrA [EC:3.6.4.12]
       K02335  DPO1, polA; DNA polymerase I [EC:2.7.7.7]
       K01971  E6.5.1.1, lig; DNA ligase (ATP) [EC:6.5.1.1]
       K01972  E6.5.1.2, ligA, ligB; DNA ligase (NAD+) [EC:6.5.1.2]
       K03868  RBX1, ROC1; RING-box protein 1
       K10609  CUL4; cullin 4
       K10610  DDB1; DNA damage-binding protein 1
       K10140  DDB2; DNA damage-binding protein 2
       K10838  XPC; xeroderma pigmentosum group C-complementing protein
       K10839  RAD23, HR23; UV excision repair protein RAD23
       K10840  CETN2; centrin-2
       K10570  ERCC8, CKN1, CSA; DNA excision repair protein ERCC-8
       K10841  ERCC6, CSB, RAD26; DNA excision repair protein ERCC-6
       K02202  CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
       K10842  MNAT1; CDK-activating kinase assembly factor MAT1
       K06634  CCNH; cyclin H
       K10843  ERCC3, XPB; DNA excision repair protein ERCC-3 [EC:3.6.4.12]
       K10844  ERCC2, XPD; DNA excision repair protein ERCC-2 [EC:3.6.4.12]
       K10845  TTDA, GTF2H5, TFB5; TFIIH basal transcription factor complex TTD-A subunit
       K03141  TFIIH1, GTF2H1, TFB1; transcription initiation factor TFIIH subunit 1
       K03142  TFIIH2, GTF2H2, SSL1; transcription initiation factor TFIIH subunit 2
       K03143  TFIIH3, GTF2H3, TFB4; transcription initiation factor TFIIH subunit 3
       K03144  TFIIH4, GTF2H4, TFB2; transcription initiation factor TFIIH subunit 4
       K10846  ERCC5, XPG, RAD2; DNA excision repair protein ERCC-5
       K10847  XPA; DNA-repair protein complementing XP-A cells
       K07466  RFA1, RPA1, rpa; replication factor A1
       K10739  RFA2, RPA2; replication factor A2
       K10740  RPA3; replication factor A3
       K10741  RPA4; replication factor A4
       K10848  ERCC4, XPF; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
       K10849  ERCC1; DNA excision repair protein ERCC-1
       K02327  POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
       K02328  POLD2; DNA polymerase delta subunit 2
       K03504  POLD3; DNA polymerase delta subunit 3
       K03505  POLD4; DNA polymerase delta subunit 4
       K02324  POLE1; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
       K02325  POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
       K02326  POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
       K03506  POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
       K04802  PCNA; proliferating cell nuclear antigen
       K10754  RFC1; replication factor C subunit 1
       K10755  RFC2_4; replication factor C subunit 2/4
       K10756  RFC3_5; replication factor C subunit 3/5
       K10747  LIG1; DNA ligase 1 [EC:6.5.1.1]
     03430 Mismatch repair [PATH:ko03430]
       K03555  mutS; DNA mismatch repair protein MutS
       K07456  mutS2; DNA mismatch repair protein MutS2
       K03572  mutL; DNA mismatch repair protein MutL
       K03573  mutH; DNA mismatch repair protein MutH
       K03657  uvrD, pcrA; DNA helicase II / ATP-dependent DNA helicase PcrA [EC:3.6.4.12]
       K01141  E3.1.11.1, sbcB; exodeoxyribonuclease I [EC:3.1.11.1]
       K03601  xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]
       K03602  xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]
       K10857  exoX; exodeoxyribonuclease X [EC:3.1.11.-]
       K07462  recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
       K03111  ssb; single-strand DNA-binding protein
       K02337  DPO3A1, dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
       K03763  DPO3A2, polC; DNA polymerase III subunit alpha, Gram-positive type [EC:2.7.7.7]
       K02338  DPO3B, dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
       K02343  DPO3G, dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
       K02340  DPO3D1, holA; DNA polymerase III subunit delta [EC:2.7.7.7]
       K02341  DPO3D2, holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
       K02342  DPO3E, dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
       K14159  rnhA-dnaQ; ribonuclease HI / DNA polymerase III subunit epsilon [EC:3.1.26.4 2.7.7.7]
       K02345  DPO3T, holE; DNA polymerase III subunit theta [EC:2.7.7.7]
       K02339  DPO3C, holC; DNA polymerase III subunit chi [EC:2.7.7.7]
       K02344  DPO3P, holD; DNA polymerase III subunit psi [EC:2.7.7.7]
       K01971  E6.5.1.1, lig; DNA ligase (ATP) [EC:6.5.1.1]
       K01972  E6.5.1.2, ligA, ligB; DNA ligase (NAD+) [EC:6.5.1.2]
       K06223  dam; DNA adenine methylase [EC:2.1.1.72]
       K10858  PMS2; DNA mismatch repair protein PMS2
       K08734  MLH1; DNA mismatch repair protein MLH1
       K08737  MSH6; DNA mismatch repair protein MSH6
       K08735  MSH2; DNA mismatch repair protein MSH2
       K08736  MSH3; DNA mismatch repair protein MSH3
       K08739  MLH3; DNA mismatch repair protein MLH3
       K10754  RFC1; replication factor C subunit 1
       K10755  RFC2_4; replication factor C subunit 2/4
       K10756  RFC3_5; replication factor C subunit 3/5
       K04802  PCNA; proliferating cell nuclear antigen
       K10746  EXO1; exonuclease 1 [EC:3.1.-.-]
       K07466  RFA1, RPA1, rpa; replication factor A1
       K10739  RFA2, RPA2; replication factor A2
       K10740  RPA3; replication factor A3
       K10741  RPA4; replication factor A4
       K02327  POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
       K02328  POLD2; DNA polymerase delta subunit 2
       K03504  POLD3; DNA polymerase delta subunit 3
       K03505  POLD4; DNA polymerase delta subunit 4
       K10747  LIG1; DNA ligase 1 [EC:6.5.1.1]
     03440 Homologous recombination [PATH:ko03440]
       K07462  recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
       K03111  ssb; single-strand DNA-binding protein
       K03629  recF; DNA replication and repair protein RecF
       K03584  recO; DNA repair protein RecO (recombination protein O)
       K06187  recR; recombination protein RecR
       K03553  recA; recombination protein RecA
       K02335  DPO1, polA; DNA polymerase I [EC:2.7.7.7]
       K03550  ruvA; holliday junction DNA helicase RuvA [EC:3.6.4.12]
       K03551  ruvB; holliday junction DNA helicase RuvB [EC:3.6.4.12]
       K01159  ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.22.4]
       K03655  recG; ATP-dependent DNA helicase RecG [EC:3.6.4.12]
       K03582  recB; exodeoxyribonuclease V beta subunit [EC:3.1.11.5]
       K03583  recC; exodeoxyribonuclease V gamma subunit [EC:3.1.11.5]
       K03581  recD; exodeoxyribonuclease V alpha subunit [EC:3.1.11.5]
       K02337  DPO3A1, dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
       K03763  DPO3A2, polC; DNA polymerase III subunit alpha, Gram-positive type [EC:2.7.7.7]
       K02338  DPO3B, dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
       K02343  DPO3G, dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
       K02340  DPO3D1, holA; DNA polymerase III subunit delta [EC:2.7.7.7]
       K02341  DPO3D2, holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
       K02342  DPO3E, dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
       K14159  rnhA-dnaQ; ribonuclease HI / DNA polymerase III subunit epsilon [EC:3.1.26.4 2.7.7.7]
       K02345  DPO3T, holE; DNA polymerase III subunit theta [EC:2.7.7.7]
       K02339  DPO3C, holC; DNA polymerase III subunit chi [EC:2.7.7.7]
       K02344  DPO3P, holD; DNA polymerase III subunit psi [EC:2.7.7.7]
       K04066  priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:3.6.4.-]
       K02686  priB; primosomal replication protein N
       K04067  priC; primosomal replication protein N''
       K02317  dnaT; DNA replication protein DnaT
       K10866  RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
       K10865  MRE11; double-strand break repair protein MRE11
       K10868  XRS2; DNA repair protein XRS2
       K10867  NBN, NBS1; nijmegen breakage syndrome protein 1
       K10957  RAD55; DNA repair protein RAD55
       K10958  RAD57; DNA repair protein RAD57
       K07466  RFA1, RPA1, rpa; replication factor A1
       K10739  RFA2, RPA2; replication factor A2
       K10740  RPA3; replication factor A3
       K10741  RPA4; replication factor A4
       K04482  RAD51; DNA repair protein RAD51
       K10873  RAD52; DNA repair and recombination protein RAD52
       K08775  BRCA2, FANCD1; breast cancer 2 susceptibility protein
       K10881  SHFM1, DSS1; 26 proteasome complex subunit DSS1
       K10869  RAD51L1, RAD51B; RAD51-like protein 1
       K10870  RAD51L2, RAD51C; RAD51-like protein 2
       K10871  RAD51L3, RAD51D; RAD51-like protein 3
       K10879  XRCC2; DNA-repair protein XRCC2
       K10880  XRCC3; DNA-repair protein XRCC3
       K10959  RAD59; DNA repair protein RAD59
       K10875  RAD54L, RAD54; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:3.6.4.-]
       K10877  RAD54B; DNA repair and recombination protein RAD54B [EC:3.6.4.-]
       K02327  POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
       K02328  POLD2; DNA polymerase delta subunit 2
       K03504  POLD3; DNA polymerase delta subunit 3
       K03505  POLD4; DNA polymerase delta subunit 4
       K10901  BLM, RECQL3, SGS1; bloom syndrome protein [EC:3.6.4.12]
       K03165  TOP3; DNA topoisomerase III [EC:5.99.1.2]
       K08991  MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
       K10882  EME1, MMS4; crossover junction endonuclease EME1 [EC:3.1.22.-]
     03450 Non-homologous end-joining [PATH:ko03450]
     03460 Fanconi anemia pathway [PATH:ko03460]
       K10905  ATRIP; ATR interacting protein
       K06640  ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
       K10896  FANCM; fanconi anemia group M protein
       K10898  FAAP24; fanconi anemia-associated protein
       K11511  APITD1, CENPS, MHF1; centromere protein S
       K15360  STRA13, CENPX, MHF2; centromere protein X
       K11137  TELO2, TEL2; telomere length regulation protein
       K06054  HES1; hairy and enhancer of split 1
       K10993  FAAP100; fanconi anemia core complex 100 kDa subunit
       K10888  FANCA; fanconi anemia group A protein
       K10889  FANCB; fanconi anemia group B protein
       K10890  FANCC; fanconi anemia group C protein
       K10892  FANCE; fanconi anemia group E protein
       K10893  FANCF; fanconi anemia group F protein
       K10894  FANCG; fanconi anemia group G protein
       K10606  FANCL, PHF9; E3 ubiquitin-protein ligase FANCL [EC:6.3.2.19]
       K15361  WDR48, UAF1; WD repeat-containing protein 48
       K11832  USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.1.2.15]
       K13960  UBE2T, HSPC150; ubiquitin-conjugating enzyme E2 T [EC:6.3.2.19]
       K10895  FANCI; fanconi anemia group I protein
       K10891  FANCD2; fanconi anemia group D2 protein
       K08775  BRCA2, FANCD1; breast cancer 2 susceptibility protein
       K10897  PALB2, FANCN; partner and localizer of BRCA2
       K10870  RAD51L2, RAD51C; RAD51-like protein 2
       K04482  RAD51; DNA repair protein RAD51
       K10605  BRCA1; breast cancer type 1 susceptibility protein
       K15362  BRIP1, BACH1, FANCJ; fanconi anemia group J protein [EC:3.6.4.12]
       K15363  FAN1, MTMR15; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]
       K08734  MLH1; DNA mismatch repair protein MLH1
       K10858  PMS2; DNA mismatch repair protein PMS2
       K03515  REV1; DNA repair protein REV1 [EC:2.7.7.-]
       K02350  POLZ1, rev3; DNA polymerase zeta [EC:2.7.7.7]
       K03508  POLZ2, rev7; DNA polymerase zeta [EC:2.7.7.7]
       K03509  POLH; DNA polymerase eta [EC:2.7.7.7]
       K03510  POLI; DNA polymerase iota [EC:2.7.7.7]
       K03511  POLK; DNA polymerase kappa [EC:2.7.7.7]
       K16618  POLN; DNA polymerase nu [EC:2.7.7.7]
       K10990  RMI1, BRAP75; RecQ-mediated genome instability protein 1
       K15364  NCE4, RMI1; RecQ-mediated genome instability protein 1
       K15365  RMI2; RecQ-mediated genome instability protein 2
       K03165  TOP3; DNA topoisomerase III [EC:5.99.1.2]
       K10901  BLM, RECQL3, SGS1; bloom syndrome protein [EC:3.6.4.12]
       K07466  RFA1, RPA1, rpa; replication factor A1
       K10739  RFA2, RPA2; replication factor A2
       K10740  RPA3; replication factor A3
       K10741  RPA4; replication factor A4
       K08991  MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
       K10882  EME1, MMS4; crossover junction endonuclease EME1 [EC:3.1.22.-]
       K10883  EME2; crossover junction endonuclease EME2
       K10848  ERCC4, XPF; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
       K10849  ERCC1; DNA excision repair protein ERCC-1
       K15078  SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
       K10484  BTBD12, SLX4; structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)
       K15079  SLX4; structure-specific endonuclease subunit SLX4
     03400 DNA repair and recombination proteins [BR:ko03400]
 
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Last updated: April 17, 2014