KEGG Orthology (KO)

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 Metabolism
 
   Overview
 
   Carbohydrate metabolism
 
   Energy metabolism
 
   Lipid metabolism
 
   Nucleotide metabolism
 
   Amino acid metabolism
     00250 Alanine, aspartate and glutamate metabolism [PATH:ko00250]
     00260 Glycine, serine and threonine metabolism [PATH:ko00260]
     00270 Cysteine and methionine metabolism [PATH:ko00270]
     00280 Valine, leucine and isoleucine degradation [PATH:ko00280]
     00290 Valine, leucine and isoleucine biosynthesis [PATH:ko00290]
     00300 Lysine biosynthesis [PATH:ko00300]
     00310 Lysine degradation [PATH:ko00310]
       K00290  LYS1; saccharopine dehydrogenase (NAD+, L-lysine forming) [EC:1.5.1.7]
       K14157  AASS; alpha-aminoadipic semialdehyde synthase [EC:1.5.1.8 1.5.1.9]
       K00293  LYS9; saccharopine dehydrogenase (NADP+, L-glutamate forming) [EC:1.5.1.10]
       K00143  LYS2; L-aminoadipate-semialdehyde dehydrogenase [EC:1.2.1.31]
       K14085  ALDH7A1; aldehyde dehydrogenase family 7 member A1 [EC:1.2.1.31 1.2.1.8 1.2.1.3]
       K00825  AADAT, KAT2; kynurenine/2-aminoadipate aminotransferase [EC:2.6.1.7 2.6.1.39]
       K00164  OGDH, sucA; 2-oxoglutarate dehydrogenase E1 component [EC:1.2.4.2]
       K00658  DLST, sucB; 2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase) [EC:2.3.1.61]
       K00252  GCDH, gcdH; glutaryl-CoA dehydrogenase [EC:1.3.8.6]
       K01692  paaF, echA; enoyl-CoA hydratase [EC:4.2.1.17]
       K01825  fadB; 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase [EC:1.1.1.35 4.2.1.17 5.1.2.3 5.3.3.8]
       K01782  fadJ; 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase [EC:1.1.1.35 4.2.1.17 5.1.2.3]
       K07515  HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.211]
       K07514  EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase [EC:4.2.1.17 1.1.1.35 5.3.3.8]
       K07511  ECHS1; enoyl-CoA hydratase [EC:4.2.1.17]
       K00022  HADH; 3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35]
       K00626  E2.3.1.9, atoB; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]
       K18201  AGPHD1; hydroxylysine kinase [EC:2.7.1.81]
       K18202  AGXT2L2; 5-phosphonooxy-L-lysine phospho-lyase [EC:4.2.3.134]
       K01582  E4.1.1.18, ldcC, cadA; lysine decarboxylase [EC:4.1.1.18]
       K14268  davT, gabT; 5-aminovalerate/4-aminobutyrate aminotransferase [EC:2.6.1.48 2.6.1.19]
       K00135  gabD; succinate-semialdehyde dehydrogenase / glutarate-semialdehyde dehydrogenase [EC:1.2.1.16 1.2.1.79 1.2.1.20]
       K03897  iucD; lysine N6-hydroxylase [EC:1.14.13.59]
       K03896  iucB; acetyl CoA:N6-hydroxylysine acetyl transferase [EC:2.3.1.102]
       K03894  iucA; N2-citryl-N6-acetyl-N6-hydroxylysine synthase [EC:6.3.2.38]
       K03895  iucC; aerobactin synthase [EC:6.3.2.39]
       K01843  kamA; lysine 2,3-aminomutase [EC:5.4.3.2]
       K01844  kamD; beta-lysine 5,6-aminomutase alpha subunit [EC:5.4.3.3]
       K18011  kamE; beta-lysine 5,6-aminomutase beta subunit [EC:5.4.3.3]
       K18012  kdd; L-erythro-3,5-diaminohexanoate dehydrogenase [EC:1.4.1.11]
       K18013  kce; 3-keto-5-aminohexanoate cleavage enzyme [EC:2.3.1.247]
       K18014  kal; 3-aminobutyryl-CoA ammonia-lyase [EC:4.3.1.14]
       K01034  atoD; acetate CoA/acetoacetate CoA-transferase alpha subunit [EC:2.8.3.8 2.8.3.9]
       K01035  atoA; acetate CoA/acetoacetate CoA-transferase beta subunit [EC:2.8.3.8 2.8.3.9]
       K00824  dat; D-alanine transaminase [EC:2.6.1.21]
       K13609  dpkA; delta1-piperideine-2-carboxylate reductase [EC:1.5.1.21]
       K19743  lhpI; 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H] [EC:1.5.1.1]
       K00306  PIPOX; sarcosine oxidase / L-pipecolate oxidase [EC:1.5.3.1 1.5.3.7]
       K18854  LYC1; lysine N-acetyltransferase [EC:2.3.1.32]
       K06101  ASH1L; histone-lysine N-methyltransferase ASH1L [EC:2.1.1.43]
       K11427  DOT1L, DOT1; histone-lysine N-methyltransferase, H3 lysine-79 specific [EC:2.1.1.43]
       K11420  EHMT; euchromatic histone-lysine N-methyltransferase [EC:2.1.1.43]
       K09186  MLL1; histone-lysine N-methyltransferase MLL1 [EC:2.1.1.43]
       K09187  MLL2, ALR; histone-lysine N-methyltransferase MLL2 [EC:2.1.1.43]
       K09188  MLL3; histone-lysine N-methyltransferase MLL3 [EC:2.1.1.43]
       K14959  MLL4; histone-lysine N-methyltransferase MLL4 [EC:2.1.1.43]
       K09189  MLL5; histone-lysine N-methyltransferase MLL5 [EC:2.1.1.43]
       K15588  NSD1; histone-lysine N-methyltransferase NSD1 [EC:2.1.1.43]
       K11424  WHSC1, MMSET, NSD2; histone-lysine N-methyltransferase NSD2 [EC:2.1.1.43]
       K11425  WHSC1L1, NSD3; histone-lysine N-methyltransferase NSD3 [EC:2.1.1.43]
       K11422  SETD1, SET1; histone-lysine N-methyltransferase SETD1 [EC:2.1.1.43]
       K11423  SETD2, SET2; histone-lysine N-methyltransferase SETD2 [EC:2.1.1.43]
       K19199  SETD3; histone-lysine N-methyltransferase SETD3 [EC:2.1.1.43]
       K11431  SETD7; histone-lysine N-methyltransferase SETD7 [EC:2.1.1.43]
       K11428  SETD8; histone-lysine N-methyltransferase SETD8 [EC:2.1.1.43]
       K11421  SETDB1; histone-lysine N-methyltransferase SETDB1 [EC:2.1.1.43]
       K18494  SETDB2; histone-lysine N-methyltransferase SETDB2 [EC:2.1.1.43]
       K11433  SETMAR; histone-lysine N-methyltransferase SETMAR [EC:2.1.1.43]
       K11419  SUV39H, CLR4; histone-lysine N-methyltransferase SUV39H [EC:2.1.1.43]
       K11429  SUV420H; histone-lysine N-methyltransferase SUV420H [EC:2.1.1.43]
       K17451  EZH1; histone-lysine N-methyltransferase EZH1 [EC:2.1.1.43]
       K11430  EZH2; histone-lysine N-methyltransferase EZH2 [EC:2.1.1.43]
       K11432  PRDM2, RIZ; histone-lysine N-methyltransferase PRDM2 [EC:2.1.1.43]
       K20795  PRDM6; histone-lysine N-methyltransferase PRDM6 [EC:2.1.1.43]
       K20796  PRDM7_9; histone-lysine N-methyltransferase PRDM7/9 [EC:2.1.1.43]
       K18804  CTM1; [cytochrome c]-lysine N-methyltransferase [EC:2.1.1.59]
       K18826  CAMKMT; calmodulin-lysine N-methyltransferase [EC:2.1.1.60]
       K00474  TMLHE; trimethyllysine dioxygenase [EC:1.14.11.8]
       K00128  ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]
       K00149  ALDH9A1; aldehyde dehydrogenase family 9 member A1 [EC:1.2.1.47 1.2.1.3]
       K00471  E1.14.11.1; gamma-butyrobetaine dioxygenase [EC:1.14.11.1]
       K00473  PLOD1; procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 [EC:1.14.11.4]
       K13645  PLOD2; procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 [EC:1.14.11.4]
       K13646  PLOD3; lysyl hydroxylase/galactosyltransferase/glucosyltransferase [EC:1.14.11.4 2.4.1.50 2.4.1.66]
       K13647  PLODN; procollagen-lysine,2-oxoglutarate 5-dioxygenase, invertebrate [EC:1.14.11.4]
       K11703  GLT25D; collagen beta-1,O-galactosyltransferase [EC:2.4.1.50]
     00220 Arginine biosynthesis [PATH:ko00220]
     00330 Arginine and proline metabolism [PATH:ko00330]
     00340 Histidine metabolism [PATH:ko00340]
     00350 Tyrosine metabolism [PATH:ko00350]
     00360 Phenylalanine metabolism [PATH:ko00360]
     00380 Tryptophan metabolism [PATH:ko00380]
     00400 Phenylalanine, tyrosine and tryptophan biosynthesis [PATH:ko00400]
     01007 Amino acid related enzymes [BR:ko01007]
 
   Metabolism of other amino acids
 
   Glycan biosynthesis and metabolism
 
   Metabolism of cofactors and vitamins
 
   Metabolism of terpenoids and polyketides
 
   Biosynthesis of other secondary metabolites
 
   Xenobiotics biodegradation and metabolism
 
   Enzyme families
 
 Genetic Information Processing
 
 Environmental Information Processing
 
 Cellular Processes
 
 Organismal Systems
 
   Immune system
 
   Endocrine system
 
   Circulatory system
 
   Digestive system
 
   Excretory system
 
   Nervous system
 
   Sensory system
 
   Development
 
   Aging
     04211 Longevity regulating pathway - mammal [PATH:ko04211]
       K04526  INS; insulin
       K04527  INSR, CD220; insulin receptor [EC:2.7.10.1]
       K05459  IGF1; insulin-like growth factor 1
       K05087  IGF1R, CD221; insulin-like growth factor 1 receptor [EC:2.7.10.1]
       K16172  IRS1; insulin receptor substrate 1
       K07187  IRS2; insulin receptor substrate 2
       K17445  IRS3; insulin receptor substrate 3
       K17446  IRS4; insulin receptor substrate 4
       K02833  HRAS; GTPase HRas
       K07827  KRAS, KRAS2; GTPase KRas
       K07828  NRAS; GTPase NRas
       K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
       K02649  PIK3R; phosphoinositide-3-kinase, regulatory subunit
       K04456  AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
       K08041  ADCY1; adenylate cyclase 1 [EC:4.6.1.1]
       K08042  ADCY2; adenylate cyclase 2 [EC:4.6.1.1]
       K08043  ADCY3; adenylate cyclase 3 [EC:4.6.1.1]
       K08044  ADCY4; adenylate cyclase 4 [EC:4.6.1.1]
       K08045  ADCY5; adenylate cyclase 5 [EC:4.6.1.1]
       K08046  ADCY6; adenylate cyclase 6 [EC:4.6.1.1]
       K08047  ADCY7; adenylate cyclase 7 [EC:4.6.1.1]
       K08048  ADCY8; adenylate cyclase 8 [EC:4.6.1.1]
       K08049  ADCY9; adenylate cyclase 9 [EC:4.6.1.1]
       K04345  PKA; protein kinase A [EC:2.7.11.11]
       K05870  CREB1; cyclic AMP-responsive element-binding protein 1
       K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
       K09048  CREB3; cyclic AMP-responsive element-binding protein 3
       K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
       K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
       K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
       K11420  EHMT; euchromatic histone-lysine N-methyltransferase [EC:2.1.1.43]
       K07201  FOXO1; forkhead box protein O1
       K09408  FOXO3; forkhead box protein O3
       K04564  SOD2; superoxide dismutase, Fe-Mn family [EC:1.15.1.1]
       K03781  katE, CAT, catB, srpA; catalase [EC:1.11.1.6]
       K08339  ATG5; autophagy-related protein 5
       K14756  KL; klotho [EC:3.2.1.31]
       K07206  TSC1; tuberous sclerosis 1
       K07207  TSC2; tuberous sclerosis 2
       K07208  RHEB; Ras homolog enriched in brain
       K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
       K07204  RAPTOR; regulatory associated protein of mTOR
       K16184  AKT1S1, PRAS40; proline-rich AKT1 substrate 1
       K08269  ULK1_2_3, ATG1; serine/threonine-protein kinase ULK/ATG1 [EC:2.7.11.1]
       K08331  ATG13; autophagy-related protein 13
       K17589  RB1CC1; RB1-inducible coiled-coil protein 1
       K19730  ATG101; autophagy-related protein 101
       K04688  RPS6KB; ribosomal protein S6 kinase beta [EC:2.7.11.1]
       K07205  EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1
       K03259  EIF4E; translation initiation factor 4E
       K07296  ACDC; adiponectin
       K07297  ADIPOR; adiponectin receptor
       K08733  APPL1, DIP13A; DCC-interacting protein 13 alpha
       K07359  CAMKK; calcium/calmodulin-dependent protein kinase kinase [EC:2.7.11.17]
       K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.11]
       K07199  PRKAB; 5'-AMP-activated protein kinase, regulatory beta subunit
       K07200  PRKAG; 5'-AMP-activated protein kinase, regulatory gamma subunit
       K11411  SIRT1, SIR2L1; NAD-dependent deacetylase sirtuin 1 [EC:3.5.1.-]
       K02159  BAX; apoptosis regulator BAX
       K04451  TP53, P53; tumor protein p53
       K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
       K04735  RELA; transcription factor p65
       K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
       K07202  PPARGC1A, PGC1A; alpha peroxisome proliferator-activated receptor gamma coactivator 1-alpha
       K07298  STK11, LKB1; serine/threonine-protein kinase 11
       K10141  SESN1_3; sestrin 1/3
       K20394  SESN2; sestrin 2
       K05869  CAMK4; calcium/calmodulin-dependent protein kinase IV [EC:2.7.11.17]
     04212 Longevity regulating pathway - worm [PATH:ko04212]
     04213 Longevity regulating pathway - multiple species [PATH:ko04213]
 
   Environmental adaptation
 
 Human Diseases

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Last updated: December 2, 2016