KEGG Orthology (KO)

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 Metabolism
 
   Overview
 
   Carbohydrate metabolism
 
   Energy metabolism
 
   Lipid metabolism
 
   Nucleotide metabolism
 
   Amino acid metabolism
     00250 Alanine, aspartate and glutamate metabolism [PATH:ko00250]
     00260 Glycine, serine and threonine metabolism [PATH:ko00260]
     00270 Cysteine and methionine metabolism [PATH:ko00270]
     00280 Valine, leucine and isoleucine degradation [PATH:ko00280]
     00290 Valine, leucine and isoleucine biosynthesis [PATH:ko00290]
     00300 Lysine biosynthesis [PATH:ko00300]
     00310 Lysine degradation [PATH:ko00310]
       K00290  LYS1; saccharopine dehydrogenase (NAD+, L-lysine forming) [EC:1.5.1.7]
       K00291  E1.5.1.8; saccharopine dehydrogenase (NADP+, L-lysine forming) [EC:1.5.1.8]
       K00292  E1.5.1.9; saccharopine dehydrogenase (NAD+, L-glutamate forming) [EC:1.5.1.9]
       K14157  AASS; alpha-aminoadipic semialdehyde synthase [EC:1.5.1.8 1.5.1.9]
       K00293  LYS9; saccharopine dehydrogenase (NADP+, L-glutamate forming) [EC:1.5.1.10]
       K00143  LYS2; L-aminoadipate-semialdehyde dehydrogenase [EC:1.2.1.31]
       K14085  ALDH7A1; aldehyde dehydrogenase family 7 member A1 [EC:1.2.1.31 1.2.1.8 1.2.1.3]
       K00825  AADAT, KAT2; kynurenine/2-aminoadipate aminotransferase [EC:2.6.1.7 2.6.1.39]
       K00164  OGDH, sucA; 2-oxoglutarate dehydrogenase E1 component [EC:1.2.4.2]
       K00658  DLST, sucB; 2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase) [EC:2.3.1.61]
       K00252  GCDH, gcdH; glutaryl-CoA dehydrogenase [EC:1.3.8.6]
       K01692  paaF, echA; enoyl-CoA hydratase [EC:4.2.1.17]
       K01825  fadB; 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase [EC:1.1.1.35 4.2.1.17 5.1.2.3 5.3.3.8]
       K01782  fadJ; 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase [EC:1.1.1.35 4.2.1.17 5.1.2.3]
       K07515  HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.211]
       K07514  EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase [EC:4.2.1.17 1.1.1.35 5.3.3.8]
       K07511  ECHS1; enoyl-CoA hydratase [EC:4.2.1.17]
       K00022  HADH; 3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35]
       K00626  E2.3.1.9, atoB; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]
       K18201  AGPHD1; hydroxylysine kinase [EC:2.7.1.81]
       K18202  AGXT2L2; 5-phosphonooxy-L-lysine phospho-lyase [EC:4.2.3.134]
       K01582  E4.1.1.18, ldcC, cadA; lysine decarboxylase [EC:4.1.1.18]
       K14268  davT, gabT; 5-aminovalerate/4-aminobutyrate aminotransferase [EC:2.6.1.48 2.6.1.19]
       K00135  gabD; succinate-semialdehyde dehydrogenase / glutarate-semialdehyde dehydrogenase [EC:1.2.1.16 1.2.1.79 1.2.1.20]
       K03897  iucD; lysine N6-hydroxylase [EC:1.14.13.59]
       K03896  iucB; acetyl CoA:N6-hydroxylysine acetyl transferase [EC:2.3.1.102]
       K03894  iucA; N2-citryl-N6-acetyl-N6-hydroxylysine synthase [EC:6.3.2.38]
       K03895  iucC; aerobactin synthase [EC:6.3.2.39]
       K01843  kamA; lysine 2,3-aminomutase [EC:5.4.3.2]
       K01844  kamD; beta-lysine 5,6-aminomutase alpha subunit [EC:5.4.3.3]
       K18011  kamE; beta-lysine 5,6-aminomutase beta subunit [EC:5.4.3.3]
       K18012  kdd; L-erythro-3,5-diaminohexanoate dehydrogenase [EC:1.4.1.11]
       K18013  kce; 3-keto-5-aminohexanoate cleavage enzyme
       K18014  kal; 3-aminobutyryl-CoA ammonia-lyase [EC:4.3.1.14]
       K01034  atoD; acetate CoA/acetoacetate CoA-transferase alpha subunit [EC:2.8.3.8 2.8.3.9]
       K01035  atoA; acetate CoA/acetoacetate CoA-transferase beta subunit [EC:2.8.3.8 2.8.3.9]
       K00824  dat; D-alanine transaminase [EC:2.6.1.21]
       K13609  dpkA; delta1-piperideine-2-carboxylate reductase [EC:1.5.1.21]
       K00306  PIPOX; sarcosine oxidase / L-pipecolate oxidase [EC:1.5.3.1 1.5.3.7]
       K06101  ASH1L; histone-lysine N-methyltransferase ASH1L [EC:2.1.1.43]
       K11427  DOT1L, DOT1; histone-lysine N-methyltransferase, H3 lysine-79 specific [EC:2.1.1.43]
       K11420  EHMT; euchromatic histone-lysine N-methyltransferase [EC:2.1.1.43]
       K15588  NSD1; histone-lysine N-methyltransferase NSD1 [EC:2.1.1.43]
       K11424  WHSC1, MMSET, NSD2; histone-lysine N-methyltransferase NSD2 [EC:2.1.1.43]
       K11425  WHSC1L1, NSD3; histone-lysine N-methyltransferase NSD3 [EC:2.1.1.43]
       K11422  SETD1, SET1; histone-lysine N-methyltransferase SETD1 [EC:2.1.1.43]
       K11423  SETD2, SET2; histone-lysine N-methyltransferase SETD2 [EC:2.1.1.43]
       K11431  SETD7; histone-lysine N-methyltransferase SETD7 [EC:2.1.1.43]
       K11428  SETD8; histone-lysine N-methyltransferase SETD8 [EC:2.1.1.43]
       K11421  SETDB1; histone-lysine N-methyltransferase SETDB1 [EC:2.1.1.43]
       K18494  SETDB2; histone-lysine N-methyltransferase SETDB2 [EC:2.1.1.43]
       K11433  SETMAR; histone-lysine N-methyltransferase SETMAR [EC:2.1.1.43]
       K11419  SUV39H, CLR4; histone-lysine N-methyltransferase SUV39H [EC:2.1.1.43]
       K11429  SUV420H; histone-lysine N-methyltransferase SUV420H [EC:2.1.1.43]
       K09186  MLL1; histone-lysine N-methyltransferase MLL1 [EC:2.1.1.43]
       K09187  MLL2, ALR; histone-lysine N-methyltransferase MLL2 [EC:2.1.1.43]
       K09188  MLL3; histone-lysine N-methyltransferase MLL3 [EC:2.1.1.43]
       K14959  MLL4; histone-lysine N-methyltransferase MLL4 [EC:2.1.1.43]
       K09189  MLL5; histone-lysine N-methyltransferase MLL5 [EC:2.1.1.43]
       K01423  E3.4.-.-;  [EC:3.4.-.-]
       K00474  E1.14.11.8; trimethyllysine dioxygenase [EC:1.14.11.8]
       K00128  E1.2.1.3; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]
       K00149  ALDH9A1; aldehyde dehydrogenase family 9 member A1 [EC:1.2.1.47 1.2.1.3]
       K00471  E1.14.11.1; gamma-butyrobetaine dioxygenase [EC:1.14.11.1]
       K00473  PLOD1; procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 [EC:1.14.11.4]
       K13645  PLOD2; procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 [EC:1.14.11.4]
       K13646  PLOD3; lysyl hydroxylase/galactosyltransferase/glucosyltransferase [EC:1.14.11.4 2.4.1.50 2.4.1.66]
       K13647  PLODN; procollagen-lysine,2-oxoglutarate 5-dioxygenase, invertebrate [EC:1.14.11.4]
       K11703  GLT25D; collagen beta-1,O-galactosyltransferase [EC:2.4.1.50]
     00330 Arginine and proline metabolism [PATH:ko00330]
     00340 Histidine metabolism [PATH:ko00340]
     00350 Tyrosine metabolism [PATH:ko00350]
     00360 Phenylalanine metabolism [PATH:ko00360]
     00380 Tryptophan metabolism [PATH:ko00380]
     00400 Phenylalanine, tyrosine and tryptophan biosynthesis [PATH:ko00400]
     01007 Amino acid related enzymes [BR:ko01007]
 
   Metabolism of other amino acids
 
   Glycan biosynthesis and metabolism
 
   Metabolism of cofactors and vitamins
 
   Metabolism of terpenoids and polyketides
 
   Biosynthesis of other secondary metabolites
 
   Xenobiotics biodegradation and metabolism
 
   Enzyme families
 
 Genetic Information Processing
 
 Environmental Information Processing
 
 Cellular Processes
 
 Organismal Systems
 
 Human Diseases
 
   Cancers
     05200 Pathways in cancer [PATH:ko05200]
     05230 Central carbon metabolism in cancer [PATH:ko05230]
     05202 Transcriptional misregulation in cancers [PATH:ko05202]
       K08367  RUNX1, AML1; runt-related transcription factor 1
       K05090  CSF1R, FMS; macrophage colony-stimulating factor 1 receptor [EC:2.7.10.1]
       K10789  MPO; myeloperoxidase [EC:1.11.2.2]
       K05427  CSF2, GMCSF; granulocyte-macrophage colony-stimulating factor
       K04736  IL3; interleukin 3
       K10053  RUNX1T1, CBFA2T1; runt-related transcription factor 1; translocated to, 1
       K06067  HDAC1_2; histone deacetylase 1/2 [EC:3.5.1.98]
       K11644  SIN3A; paired amphipathic helix protein Sin3a
       K04650  NCOR1, N-CoR; nuclear receptor co-repressor 1
       K09055  CEBPA; CCAAT/enhancer binding protein (C/EBP), alpha
       K09438  SPI1; transcription factor PU.1
       K04391  CD14; CD14 antigen
       K06461  ITGAM; integrin alpha M
       K06498  FCGR1A, CD64; high affinity immunoglobulin gamma Fc receptor I
       K10056  JUP; junction plakoglobin
       K10054  PML, TRIM19; probable transcription factor PML
       K08527  NR1B1, RARA; retinoic acid receptor alpha
       K10051  CEBPE; CCAAT/enhancer binding protein (C/EBP), epsilon
       K02162  BCL2A1; hematopoietic BCL2-related protein A1
       K10055  ZBTB16, PLZF; zinc finger and BTB domain-containing protein 16
       K04377  MYC; Myc proto-oncogene protein
       K09063  TCF3, E2A; transcription factor E2-alpha
       K09355  PBX1; pre-B-cell leukemia transcription factor 1
       K01558  WNT16; wingless-type MMTV integration site family, member 16
       K03211  ETV6_7, yan; ETS translocation variant 6/7
       K10784  TRAV; T cell receptor alpha chain V region
       K10785  TRBV; T-cell receptor beta chain V region
       K01327  ELANE; leukocyte elastase [EC:3.4.21.37]
       K01353  GZMB; granzyme B [EC:3.4.21.79]
       K09186  MLL1; histone-lysine N-methyltransferase MLL1 [EC:2.1.1.43]
       K15184  AFF1; AF4/FMR2 family member 1
       K02211  CDK9; cyclin-dependent kinase 9 [EC:2.7.11.22 2.7.11.23]
       K15188  CCNT; cyclin T
       K15187  MLLT1_3, ENL, AF9; YEATS domain-containing protein 1/3
       K11427  DOT1L, DOT1; histone-lysine N-methyltransferase, H3 lysine-79 specific [EC:2.1.1.43]
       K15612  LMO2; rhombotin-2
       K15610  PBX3; pre-B-cell leukemia transcription factor 3
       K09278  RUNX2, AML3; runt-related transcription factor 2
       K04676  SMAD1; mothers against decapentaplegic homolog 1
       K15605  KLF3; krueppel-like factor 3
       K04454  MEF2C; MADS-box transcription enhancer factor 2C
       K11449  JMJD1C; jumonji domain-containing protein 1C [EC:1.14.11.-]
       K09283  HMGA2; high mobility group AT-hook protein 2
       K11447  UTX, UTY; histone demethylase [EC:1.14.11.-]
       K11313  SUPT3H, SPT3; transcription initiation protein SPT3
       K06532  PROM1; prominin 1
       K05092  FLT3, FLK2; fms-related tyrosine kinase 3 [EC:2.7.10.1]
       K08854  BMP2K, BIKE; BMP2 inducible kinase [EC:2.7.11.1]
       K05087  IGF1R; insulin-like growth factor 1 receptor [EC:2.7.10.1]
       K06624  CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
       K08821  CDK14, PFTK1; cyclin-dependent kinase 14 [EC:2.7.11.22]
       K15613  MEIS1; homeobox protein Meis1
       K15614  SIX1; homeobox protein SIX1
       K15615  SIX4; homeobox protein SIX4
       K15616  EYA1; eyes absent homolog 1 [EC:3.1.3.48]
       K06622  CDKN2C, P18, INK4C; cyclin-dependent kinase inhibitor 2C
       K00069  HPGD; 15-hydroxyprostaglandin dehydrogenase (NAD) [EC:1.1.1.141]
       K05199  GRIA3; glutamate receptor 3
       K00717  FUT8; glycoprotein 6-alpha-L-fucosyltransferase [EC:2.4.1.68]
       K15607  TLX3, HOX11L2; T-cell leukemia homeobox protein 3
       K09340  TLX1, HOX11; T-cell leukemia homeobox protein 1
       K04182  CCR7; C-C chemokine receptor type 7
       K15617  LDB1; LIM domain-binding protein 1
       K15604  LYL1; protein lyl-1
       K08024  HHEX, HEX, PRH; homeobox protein HEX
       K06056  PTCRA; pre T-cell antigen receptor alpha
       K09254  REL; c-Rel proto-oncogene protein
       K03172  TRAF1; TNF receptor-associated factor 1
       K04570  BCL2L1, bcl-xL; BCL2-like 1 (apoptosis regulator Bcl-X)
       K05413  CD86; CD86 antigen
       K03160  TNFRSF5, CD40; tumor necrosis factor receptor superfamily member 5
       K15618  BCL6; B-cell lymphoma 6 protein
       K06856  IGH; immunoglobulin heavy chain
       K09035  CMAF, MAF; transcription factor Maf
       K10151  CCND2; cyclin D2
       K06590  ITGB7; integrin beta 7
       K11424  WHSC1, MMSET, NSD2; histone-lysine N-methyltransferase NSD2 [EC:2.1.1.43]
       K11253  H3; histone H3
       K09383  PAX5; paired box protein 5
       K09293  PAX8; paired box protein 8
       K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
       K08524  NR2B1, RXRA; retinoid X receptor alpha
       K08525  NR2B2, RXRB; retinoid X receptor beta
       K08526  NR2B3, RXRG; retinoid X receptor gamma
       K13105  PRCC; proline-rich protein PRCC
       K09105  TFE3; transcription factor E3
       K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
       K09633  TMPRSS2; transmembrane protease, serine 2
       K09435  ERG; transcriptional regulator ERG
       K01348  PLAU; urokinase plasminogen activator [EC:3.4.21.73]
       K01343  PLAT; tissue plasminogen activator [EC:3.4.21.68]
       K01394  MMP3; matrix metalloproteinase-3 (stromelysin 1, progelatinase) [EC:3.4.24.17]
       K01403  MMP9; matrix metalloproteinase-9 (gelatinase B) [EC:3.4.24.35]
       K15619  SPINT1; Kunitz-type protease inhibitor 1
       K04387  IL1R2; interleukin 1 receptor type II
       K09431  ETV1; ets translocation variant 1
       K15592  ETV4; ets translocation variant 4
       K15593  ETV5; ets translocation variant 5
       K15379  SLC45A3; solute carrier family 45, member 3
       K04376  ELK4, SAP1; ETS domain-containing protein Elk-4
       K12823  DDX5, DBP2; ATP-dependent RNA helicase DDX5/DBP2 [EC:3.6.4.13]
       K09109  NMYC, MYCN; N-myc proto-oncogene protein
       K04453  MAX; Max protein
       K06643  MDM2; E3 ubiquitin-protein ligase Mdm2 [EC:6.3.2.19]
       K05725  PTK2, FAK; focal adhesion kinase 1 [EC:2.7.10.2]
       K04451  TP53, P53; tumor protein p53
       K11459  PCGF4, BMI1; polycomb group RING finger protein 4
       K04684  SP1; transcription factor Sp1
       K10500  ZBTB17, MIZ1; zinc finger and BTB domain-containing protein 17
       K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1 [EC:2.7.10.1]
       K02583  NGFR; nerve growth factor receptor (TNFR superfamily member 16)
       K14970  MEN1, MNN1; menin
       K13209  EWSR1; RNA-binding protein EWS
       K09436  FLI1; friend leukemia integration 1 transcription factor
       K05459  IGF1; insulin-like growth factor 1
       K17693  ID2; DNA-binding protein inhibitor ID2
       K04388  TGFBR2; TGF-beta receptor type-2 [EC:2.7.11.30]
       K10138  IGFBP3; insulin-like growth factor-binding protein 3
       K09437  FEV; ETS oncogene family protein FEV
       K09053  ATF1; activating transcription factor 1
       K15589  ARNT2; aryl hydrocarbon receptor nuclear translocator 2
       K04728  ATM, TEL1; ataxia telangiectasia mutated family protein [EC:2.7.11.1]
       K15620  GOLPH3, GPP34; golgi phosphoprotein 3
       K09234  WT1; Wilms tumor protein 1
       K04359  PDGFA; platelet-derived growth factor subunit A
       K05069  IL2RB; interleukin 2 receptor beta
       K15621  BAIAP3; BAI1-associated protein 3
       K06571  TSPAN7, TM4SF2, MXS1; tetraspanin-7
       K15622  MLF1; myeloid leukemia factor 1
       K08559  NR4A3, NOR1; nuclear receptor subfamily 4 group A member 3
       K14651  TAF15, NPL3; transcription initiation factor TFIID subunit 15
       K13098  TLS, FUS; RNA-binding protein FUS
       K04452  DDIT3, GADD153; DNA damage-inducible transcript 3
       K10048  CEBPB; CCAAT/enhancer binding protein (C/EBP), beta
       K05405  IL6; interleukin 6
       K14242  NFKBIZ; NF-kappa-B inhibitor zeta
       K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
       K04735  RELA; transcription factor p65
       K10030  IL8, CXCL8; interleukin 8
       K07201  FOXO1; forkhead box protein O1
       K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1 [EC:2.7.10.1]
       K15623  SS18, SSXT, SYT; protein SSXT
       K15624  SSX1; protein SSX1
       K15625  SSX2; protein SSX2
       K15626  NUPR1, COM1; nuclear protein, 1
       K15627  ASPSCR1, ASPL; tether containing UBX domain for GLUT4
       K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]
     05206 MicroRNAs in cancer [PATH:ko05206]
     05205 Proteoglycans in cancer [PATH:ko05205]
     05204 Chemical carcinogenesis [PATH:ko05204]
     05203 Viral carcinogenesis [PATH:ko05203]
     05210 Colorectal cancer [PATH:ko05210]
     05212 Pancreatic cancer [PATH:ko05212]
     05214 Glioma [PATH:ko05214]
     05216 Thyroid cancer [PATH:ko05216]
     05221 Acute myeloid leukemia [PATH:ko05221]
     05220 Chronic myeloid leukemia [PATH:ko05220]
     05217 Basal cell carcinoma [PATH:ko05217]
     05218 Melanoma [PATH:ko05218]
     05211 Renal cell carcinoma [PATH:ko05211]
     05219 Bladder cancer [PATH:ko05219]
     05215 Prostate cancer [PATH:ko05215]
     05213 Endometrial cancer [PATH:ko05213]
     05222 Small cell lung cancer [PATH:ko05222]
     05223 Non-small cell lung cancer [PATH:ko05223]
 
   Immune diseases
 
   Neurodegenerative diseases
 
   Substance dependence
 
   Cardiovascular diseases
 
   Endocrine and metabolic diseases
 
   Infectious diseases
 
   Drug resistance

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Last updated: November 26, 2014