KEGG Orthology (KO)

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 Metabolism
 
   Overview
 
   Carbohydrate metabolism
 
   Energy metabolism
 
   Lipid metabolism
 
   Nucleotide metabolism
 
   Amino acid metabolism
     00250 Alanine, aspartate and glutamate metabolism [PATH:ko00250]
     00260 Glycine, serine and threonine metabolism [PATH:ko00260]
     00270 Cysteine and methionine metabolism [PATH:ko00270]
     00280 Valine, leucine and isoleucine degradation [PATH:ko00280]
     00290 Valine, leucine and isoleucine biosynthesis [PATH:ko00290]
     00300 Lysine biosynthesis [PATH:ko00300]
     00310 Lysine degradation [PATH:ko00310]
       K00290  LYS1; saccharopine dehydrogenase (NAD+, L-lysine forming) [EC:1.5.1.7]
       K00291  E1.5.1.8; saccharopine dehydrogenase (NADP+, L-lysine forming) [EC:1.5.1.8]
       K00292  E1.5.1.9; saccharopine dehydrogenase (NAD+, L-glutamate forming) [EC:1.5.1.9]
       K14157  AASS; alpha-aminoadipic semialdehyde synthase [EC:1.5.1.8 1.5.1.9]
       K00293  LYS9; saccharopine dehydrogenase (NADP+, L-glutamate forming) [EC:1.5.1.10]
       K00143  LYS2; L-aminoadipate-semialdehyde dehydrogenase [EC:1.2.1.31]
       K14085  ALDH7A1; aldehyde dehydrogenase family 7 member A1 [EC:1.2.1.31 1.2.1.8 1.2.1.3]
       K00825  AADAT, KAT2; kynurenine/2-aminoadipate aminotransferase [EC:2.6.1.7 2.6.1.39]
       K00164  OGDH, sucA; 2-oxoglutarate dehydrogenase E1 component [EC:1.2.4.2]
       K00658  DLST, sucB; 2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase) [EC:2.3.1.61]
       K00252  GCDH, gcdH; glutaryl-CoA dehydrogenase [EC:1.3.8.6]
       K01692  paaF, echA; enoyl-CoA hydratase [EC:4.2.1.17]
       K01825  fadB; 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase [EC:1.1.1.35 4.2.1.17 5.1.2.3 5.3.3.8]
       K01782  fadJ; 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase [EC:1.1.1.35 4.2.1.17 5.1.2.3]
       K07515  HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.211]
       K07514  EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase [EC:4.2.1.17 1.1.1.35 5.3.3.8]
       K07511  ECHS1; enoyl-CoA hydratase [EC:4.2.1.17]
       K00022  HADH; 3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35]
       K00626  E2.3.1.9, atoB; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]
       K18201  AGPHD1; hydroxylysine kinase [EC:2.7.1.81]
       K18202  AGXT2L2; 5-phosphonooxy-L-lysine phospho-lyase [EC:4.2.3.134]
       K01582  E4.1.1.18, ldcC, cadA; lysine decarboxylase [EC:4.1.1.18]
       K14268  davT, gabT; 5-aminovalerate/4-aminobutyrate aminotransferase [EC:2.6.1.48 2.6.1.19]
       K00135  gabD; succinate-semialdehyde dehydrogenase / glutarate-semialdehyde dehydrogenase [EC:1.2.1.16 1.2.1.79 1.2.1.20]
       K03897  iucD; lysine N6-hydroxylase [EC:1.14.13.59]
       K03896  iucB; acetyl CoA:N6-hydroxylysine acetyl transferase [EC:2.3.1.102]
       K03894  iucA; N2-citryl-N6-acetyl-N6-hydroxylysine synthase [EC:6.3.2.38]
       K03895  iucC; aerobactin synthase [EC:6.3.2.39]
       K01843  kamA; lysine 2,3-aminomutase [EC:5.4.3.2]
       K01844  kamD; beta-lysine 5,6-aminomutase alpha subunit [EC:5.4.3.3]
       K18011  kamE; beta-lysine 5,6-aminomutase beta subunit [EC:5.4.3.3]
       K18012  kdd; L-erythro-3,5-diaminohexanoate dehydrogenase [EC:1.4.1.11]
       K18013  kce; 3-keto-5-aminohexanoate cleavage enzyme
       K18014  kal; 3-aminobutyryl-CoA ammonia-lyase [EC:4.3.1.14]
       K01034  atoD; acetate CoA/acetoacetate CoA-transferase alpha subunit [EC:2.8.3.8 2.8.3.9]
       K01035  atoA; acetate CoA/acetoacetate CoA-transferase beta subunit [EC:2.8.3.8 2.8.3.9]
       K00824  dat; D-alanine transaminase [EC:2.6.1.21]
       K13609  dpkA; delta1-piperideine-2-carboxylate reductase [EC:1.5.1.21]
       K00306  PIPOX; sarcosine oxidase / L-pipecolate oxidase [EC:1.5.3.1 1.5.3.7]
       K06101  ASH1L; histone-lysine N-methyltransferase ASH1L [EC:2.1.1.43]
       K11427  DOT1L, DOT1; histone-lysine N-methyltransferase, H3 lysine-79 specific [EC:2.1.1.43]
       K11420  EHMT; euchromatic histone-lysine N-methyltransferase [EC:2.1.1.43]
       K15588  NSD1; histone-lysine N-methyltransferase NSD1 [EC:2.1.1.43]
       K11424  WHSC1, MMSET, NSD2; histone-lysine N-methyltransferase NSD2 [EC:2.1.1.43]
       K11425  WHSC1L1, NSD3; histone-lysine N-methyltransferase NSD3 [EC:2.1.1.43]
       K11422  SETD1, SET1; histone-lysine N-methyltransferase SETD1 [EC:2.1.1.43]
       K11423  SETD2, SET2; histone-lysine N-methyltransferase SETD2 [EC:2.1.1.43]
       K11431  SETD7; histone-lysine N-methyltransferase SETD7 [EC:2.1.1.43]
       K11428  SETD8; histone-lysine N-methyltransferase SETD8 [EC:2.1.1.43]
       K11421  SETDB1; histone-lysine N-methyltransferase SETDB1 [EC:2.1.1.43]
       K18494  SETDB2; histone-lysine N-methyltransferase SETDB2 [EC:2.1.1.43]
       K11433  SETMAR; histone-lysine N-methyltransferase SETMAR [EC:2.1.1.43]
       K11419  SUV39H, CLR4; histone-lysine N-methyltransferase SUV39H [EC:2.1.1.43]
       K11429  SUV420H; histone-lysine N-methyltransferase SUV420H [EC:2.1.1.43]
       K09186  MLL1; histone-lysine N-methyltransferase MLL1 [EC:2.1.1.43]
       K09187  MLL2, ALR; histone-lysine N-methyltransferase MLL2 [EC:2.1.1.43]
       K09188  MLL3; histone-lysine N-methyltransferase MLL3 [EC:2.1.1.43]
       K14959  MLL4; histone-lysine N-methyltransferase MLL4 [EC:2.1.1.43]
       K09189  MLL5; histone-lysine N-methyltransferase MLL5 [EC:2.1.1.43]
       K01423  E3.4.-.-;  [EC:3.4.-.-]
       K00474  E1.14.11.8; trimethyllysine dioxygenase [EC:1.14.11.8]
       K00128  E1.2.1.3; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]
       K00149  ALDH9A1; aldehyde dehydrogenase family 9 member A1 [EC:1.2.1.47 1.2.1.3]
       K00471  E1.14.11.1; gamma-butyrobetaine dioxygenase [EC:1.14.11.1]
       K00473  PLOD1; procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 [EC:1.14.11.4]
       K13645  PLOD2; procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 [EC:1.14.11.4]
       K13646  PLOD3; lysyl hydroxylase/galactosyltransferase/glucosyltransferase [EC:1.14.11.4 2.4.1.50 2.4.1.66]
       K13647  PLODN; procollagen-lysine,2-oxoglutarate 5-dioxygenase, invertebrate [EC:1.14.11.4]
       K11703  GLT25D; collagen beta-1,O-galactosyltransferase [EC:2.4.1.50]
     00330 Arginine and proline metabolism [PATH:ko00330]
     00340 Histidine metabolism [PATH:ko00340]
     00350 Tyrosine metabolism [PATH:ko00350]
     00360 Phenylalanine metabolism [PATH:ko00360]
     00380 Tryptophan metabolism [PATH:ko00380]
     00400 Phenylalanine, tyrosine and tryptophan biosynthesis [PATH:ko00400]
     01007 Amino acid related enzymes [BR:ko01007]
 
   Metabolism of other amino acids
 
   Glycan biosynthesis and metabolism
 
   Metabolism of cofactors and vitamins
 
   Metabolism of terpenoids and polyketides
 
   Biosynthesis of other secondary metabolites
 
   Xenobiotics biodegradation and metabolism
 
   Enzyme families
 
 Genetic Information Processing
 
 Environmental Information Processing
 
   Membrane transport
 
   Signal transduction
     02020 Two-component system [PATH:ko02020]
     02022 Two-component system [BR:ko02022]
     04014 Ras signaling pathway [PATH:ko04014]
     04015 Rap1 signaling pathway [PATH:ko04015]
     04010 MAPK signaling pathway [PATH:ko04010]
     04013 MAPK signaling pathway - fly [PATH:ko04013]
     04011 MAPK signaling pathway - yeast [PATH:ko04011]
     04012 ErbB signaling pathway [PATH:ko04012]
     04310 Wnt signaling pathway [PATH:ko04310]
     04330 Notch signaling pathway [PATH:ko04330]
     04340 Hedgehog signaling pathway [PATH:ko04340]
     04350 TGF-beta signaling pathway [PATH:ko04350]
     04390 Hippo signaling pathway [PATH:ko04390]
     04391 Hippo signaling pathway -fly [PATH:ko04391]
     04370 VEGF signaling pathway [PATH:ko04370]
     04630 Jak-STAT signaling pathway [PATH:ko04630]
     04064 NF-kappa B signaling pathway [PATH:ko04064]
     04668 TNF signaling pathway [PATH:ko04668]
     04066 HIF-1 signaling pathway [PATH:ko04066]
     04068 FoxO signaling pathway [PATH:ko04068]
       K13375  TGFB1; transforming growth factor beta-1
       K13376  TGFB2; transforming growth factor beta-2
       K13377  TGFB3; transforming growth factor beta-3
       K04674  TGFBR1, ALK5; TGF-beta receptor type-1 [EC:2.7.11.30]
       K04388  TGFBR2; TGF-beta receptor type-2 [EC:2.7.11.30]
       K04501  SMAD4; mothers against decapentaplegic homolog 4
       K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
       K07298  STK11, LKB1; serine/threonine-protein kinase 11
       K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.11]
       K07199  PRKAB; 5'-AMP-activated protein kinase, regulatory beta subunit
       K07200  PRKAG; 5'-AMP-activated protein kinase, regulatory gamma subunit
       K04468  NLK; nemo like kinase [EC:2.7.11.24]
       K03875  SKP2, FBXL1; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
       K06643  MDM2; E3 ubiquitin-protein ligase Mdm2 [EC:6.3.2.19]
       K11431  SETD7; histone-lysine N-methyltransferase SETD7 [EC:2.1.1.43]
       K04498  EP300, CREBBP, KAT3; E1A/CREB-binding protein [EC:2.3.1.48]
       K11411  SIRT1, SIR2L1; NAD-dependent deacetylase sirtuin 1 [EC:3.5.1.-]
       K11838  USP7, UBP15; ubiquitin carboxyl-terminal hydrolase 7 [EC:3.1.2.15]
       K07191  SLC2A4, GLUT4; MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 4
       K04440  JNK; c-Jun N-terminal kinase [EC:2.7.11.24]
       K04411  STK4, MST1; serine/threonine kinase 4
       K05459  IGF1; insulin-like growth factor 1
       K05087  IGF1R; insulin-like growth factor 1 receptor [EC:2.7.10.1]
       K04526  INS; insulin
       K04527  INSR; insulin receptor [EC:2.7.10.1]
       K16172  IRS1; insulin receptor substrate 1
       K07187  IRS2; insulin receptor substrate 2
       K17445  IRS3; insulin receptor substrate 3
       K17446  IRS4; insulin receptor substrate 4
       K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
       K02649  PIK3R; phosphoinositide-3-kinase, regulatory subunit
       K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]
       K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
       K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
       K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67]
       K04456  AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
       K13302  SGK1; serum/glucocorticoid-regulated kinase 1 [EC:2.7.11.1]
       K13303  SGK2; serum/glucocorticoid-regulated kinase 2 [EC:2.7.11.1]
       K13304  SGK3; serum/glucocorticoid-regulated kinase 3 [EC:2.7.11.1]
       K07201  FOXO1; forkhead box protein O1
       K09408  FOXO3; forkhead box protein O3
       K12358  FOXO4; forkhead box protein O4
       K17847  FOXO6; forkhead box protein O6
       K04603  GRM1; metabotropic glutamate receptor 1
       K15010  HOMER; homer
       K17848  AGAP2; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2
       K08960  CSNK1E; casein kinase 1, epsilon [EC:2.7.11.1]
       K05405  IL6; interleukin 6
       K05443  IL10, CSIF; interleukin 10
       K04692  STAT3; signal transducer and activator of transcription 3
       K04357  EGF; epidermal growth factor
       K04361  EGFR, ERBB1; epidermal growth factor receptor [EC:2.7.10.1]
       K04364  GRB2; growth factor receptor-binding protein 2
       K03099  SOS; son of sevenless
       K02833  HRAS; GTPase HRas
       K07827  KRAS, KRAS2; GTPase KRas
       K07828  NRAS; GTPase NRas
       K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
       K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
       K04371  MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
       K04441  P38; p38 MAP kinase [EC:2.7.11.24]
       K02206  CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
       K11434  PRMT1; protein arginine N-methyltransferase 1 [EC:2.1.1.-]
       K09385  FOXG; forkhead box protein G
       K05868  CCNB; cyclin B
       K04503  CCND1; cyclin D1
       K10151  CCND2; cyclin D2
       K10146  CCNG2; cyclin G2
       K04685  CDKN2B, P15, INK4B; cyclin-dependent kinase inhibitor 2B
       K06623  CDKN2D, P19, INK4D; cyclin-dependent kinase inhibitor 2D
       K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
       K06624  CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
       K16332  RBL2; retinoblastoma-like protein 2
       K06631  PLK1; polo-like kinase 1 [EC:2.7.11.21]
       K08861  PLK2; polo-like kinase 2 [EC:2.7.11.21]
       K08862  PLK3, CNK; polo-like kinase 3 [EC:2.7.11.21]
       K08863  PLK4; polo-like kinase 4 [EC:2.7.11.21]
       K04402  GADD45; growth arrest and DNA-damage-inducible protein
       K04389  TNFSF6, FASL; tumor necrosis factor ligand superfamily member 6
       K16341  BCL2L11, BIM; Bcl-2-like protein 11
       K04721  TNFSF10, TRAIL; tumor necrosis factor ligand superfamily member 10
       K15618  BCL6; B-cell lymphoma 6 protein
       K15464  BNIP3; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3
       K08336  ATG12; ubiquitin-like protein ATG12
       K08341  GABARAP, ATG8, LC3; GABA(A) receptor-associated protein
       K03781  katE, CAT, catB, srpA; catalase [EC:1.11.1.6]
       K04564  SOD2; superoxide dismutase, Fe-Mn family [EC:1.15.1.1]
       K04728  ATM, TEL1; ataxia telangiectasia mutated family protein [EC:2.7.11.1]
       K01596  E4.1.1.32, pckA, PEPCK; phosphoenolpyruvate carboxykinase (GTP) [EC:4.1.1.32]
       K01084  G6PC; glucose-6-phosphatase [EC:3.1.3.9]
       K05072  IL7R; interleukin 7 receptor
       K17845  KLF2; krueppel-like factor 2
       K04288  S1PR1, EDG1; sphingosine 1-phosphate receptor 1
       K04293  S1PR4, EDG6; sphingosine 1-phosphate receptor 4
       K10628  RAG1; V(D)J recombination-activating protein 1 [EC:6.3.2.19]
       K10988  RAG2; recombination-activating protein 2
       K10305  FBXO25_32; F-box protein 25/32
     04020 Calcium signaling pathway [PATH:ko04020]
     04070 Phosphatidylinositol signaling system [PATH:ko04070]
     04024 cAMP signaling pathway [PATH:ko04024]
     04022 cGMP - PKG signaling pathway [PATH:ko04022]
     04151 PI3K-Akt signaling pathway [PATH:ko04151]
     04152 AMPK signaling pathway [PATH:ko04152]
     04150 mTOR signaling pathway [PATH:ko04150]
     04075 Plant hormone signal transduction [PATH:ko04075]
 
   Signaling molecules and interaction
 
 Cellular Processes
 
 Organismal Systems
 
 Human Diseases

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Last updated: August 28, 2014