KEGG Orthology (KO)

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 Metabolism
 
 Genetic Information Processing
 
 Environmental Information Processing
 
 Cellular Processes
 
   Transport and catabolism
 
   Cell motility
     02030 Bacterial chemotaxis [PATH:ko02030]
     02035 Bacterial motility proteins [BR:ko02035]
     02040 Flagellar assembly [PATH:ko02040]
     04810 Regulation of actin cytoskeleton [PATH:ko04810]
       K01313  F2; coagulation factor II (thrombin) [EC:3.4.21.5]
       K03914  F2R, PAR1; coagulation factor II (thrombin) receptor
       K04391  CD14; CD14 antigen
       K04526  INS; insulin
       K04357  EGF; epidermal growth factor
       K04358  FGF; fibroblast growth factor
       K04359  PDGFA; platelet-derived growth factor subunit A
       K17386  PDGFB; platelet-derived growth factor subunit B
       K05450  PDGFC_D; platelet derived growth factor C/D
       K05086  INSRR; insulin receptor-related receptor [EC:2.7.10.1]
       K04361  EGFR, ERBB1; epidermal growth factor receptor [EC:2.7.10.1]
       K04362  FGFR1; fibroblast growth factor receptor 1 [EC:2.7.10.1]
       K05093  FGFR2; fibroblast growth factor receptor 2 [EC:2.7.10.1]
       K05094  FGFR3; fibroblast growth factor receptor 3 [EC:2.7.10.1]
       K05095  FGFR4; fibroblast growth factor receptor 4 [EC:2.7.10.1]
       K04363  PDGFRA; platelet-derived growth factor receptor alpha [EC:2.7.10.1]
       K05089  PDGFRB; platelet-derived growth factor receptor beta [EC:2.7.10.1]
       K05717  FN1; fibronectin 1
       K06480  ITGA1; integrin alpha 1
       K06481  ITGA2; integrin alpha 2
       K06476  ITGA2B; integrin alpha 2B
       K06482  ITGA3; integrin alpha 3
       K06483  ITGA4; integrin alpha 4
       K06484  ITGA5; integrin alpha 5
       K06485  ITGA6; integrin alpha 6
       K06583  ITGA7; integrin alpha 7
       K06584  ITGA8; integrin alpha 8
       K06585  ITGA9; integrin alpha 9
       K06586  ITGA10; integrin alpha 10
       K06587  ITGA11; integrin alpha 11
       K06487  ITGAV; integrin alpha V
       K05718  ITGAL; integrin alpha L
       K06461  ITGAM; integrin alpha M
       K06462  ITGAX; integrin alpha X
       K06594  ITGAD; integrin alpha D
       K06524  ITGAE; integrin alpha E
       K05719  ITGB1; integrin beta 1
       K06464  ITGB2; integrin beta 2
       K06493  ITGB3; integrin beta 3
       K06525  ITGB4; integrin beta 4
       K06588  ITGB5; integrin beta 5
       K06589  ITGB6; integrin beta 6
       K06590  ITGB7; integrin beta 7
       K06591  ITGB8; integrin beta 8
       K03915  BDKRB1; bradykinin receptor B1
       K03916  BDKRB2; bradykinin receptor B2
       K04129  CHRM1; muscarinic acetylcholine receptor M1
       K04130  CHRM2; muscarinic acetylcholine receptor M2
       K04131  CHRM3; muscarinic acetylcholine receptor M3
       K04132  CHRM4; muscarinic acetylcholine receptor M4
       K04133  CHRM5; muscarinic acetylcholine receptor M5
       K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
       K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
       K04347  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
       K05720  FGD1; FYVE, RhoGEF and PH domain containing 1
       K05722  FGD3; FYVE, RhoGEF and PH domain containing 3
       K05725  PTK2, FAK; focal adhesion kinase 1 [EC:2.7.10.2]
       K05726  BCAR1, CAS; breast cancer anti-estrogen resistance 1
       K04438  CRK, CRKII; proto-oncogene C-crk
       K13708  DOCK1; dedicator of cytokinesis protein 1
       K05704  SRC; tyrosine-protein kinase Src [EC:2.7.10.2]
       K03099  SOS; son of sevenless
       K02833  HRAS; GTPase HRas
       K07827  KRAS, KRAS2; GTPase KRas
       K07828  NRAS; GTPase NRas
       K07829  RRAS; Ras-related protein R-Ras
       K07830  RRAS2, TC21; Ras-related protein R-Ras2
       K07831  MRAS; Ras-related protein M-Ras
       K05729  ARHGEF6, PIXA; Rho guanine nucleotide exchange factor 6
       K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
       K02649  PIK3R; phosphoinositide-3-kinase, regulatory subunit
       K05730  VAV; guanine nucleotide exchange factor VAV
       K05731  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1
       K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04367  MOS; proto-oncogene serine/threonine-protein kinase mos [EC:2.7.11.1]
       K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
       K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
       K04371  MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
       K12330  ARHGEF1; Rho guanine nucleotide exchange factor 1
       K07532  ARHGEF12, LARG; Rho guanine nucleotide exchange factor 12
       K05732  GRLF1; glucocorticoid receptor DNA-binding factor 1
       K04513  RHOA; Ras homolog gene family, member A
       K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
       K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
       K07861  RAC3; Ras-related C3 botulinum toxin substrate 3
       K04393  CDC42; cell division control protein 42
       K04409  PAK1; p21-activated kinase 1 [EC:2.7.11.1]
       K04410  PAK2; p21-activated kinase 2 [EC:2.7.11.1]
       K05733  PAK3, MRX30; p21-activated kinase 3 [EC:2.7.11.1]
       K05734  PAK4; p21-activated kinase 4 [EC:2.7.11.1]
       K05735  PAK6; p21-activated kinase 6 [EC:2.7.11.1]
       K05736  PAK7; p21-activated kinase 7 [EC:2.7.11.1]
       K13710  ARHGEF7, PIXB; Rho guanine nucleotide exchange factor 7
       K05737  GIT1; G protein-coupled receptor kinase interactor 1
       K04514  ROCK1; Rho-associated protein kinase 1 [EC:2.7.11.1]
       K17388  ROCK2; Rho-associated protein kinase 2 [EC:2.7.11.1]
       K00907  MYLK; myosin-light-chain kinase [EC:2.7.11.18]
       K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]
       K06270  PPP1R12A, MYPT1; protein phosphatase 1 regulatory subunit 12A
       K12329  PPP1R12B, MYPT2; protein phosphatase 1 regulatory subunit 12B
       K17457  PPP1R12C, MBS85; protein phosphatase 1 regulatory subunit 12C
       K10351  MYL2; myosin regulatory light chain 2
       K12753  MYL5; myosin regulatory light chain 5
       K12754  MYL7; myosin regulatory light chain 7
       K12755  MYL9; myosin regulatory light chain 9
       K12756  MYL10; myosin regulatory light chain 10
       K12757  MYL12; myosin regulatory light chain 12
       K12758  MYLPF; fast skeletal myosin light chain 2
       K05740  DIAPH1; diaphanous 1
       K05741  DIAPH2; diaphanous 2
       K05742  SLC9A1, NHE1; solute carrier family 9 (sodium/hydrogen exchanger), member 1
       K00889  E2.7.1.68, PIP5K; 1-phosphatidylinositol-4-phosphate 5-kinase [EC:2.7.1.68]
       K00920  E2.7.1.149, PIP4K; 1-phosphatidylinositol-5-phosphate 4-kinase [EC:2.7.1.149]
       K00921  PIKFYVE, FAB1; 1-phosphatidylinositol-3-phosphate 5-kinase [EC:2.7.1.150]
       K05743  LIMK1; LIM domain kinase 1 [EC:2.7.11.1]
       K05744  LIMK2; LIM domain kinase 2 [EC:2.7.11.1]
       K05745  DIAPH3, DRF3; diaphanous 3
       K05627  BAIAP2, IRSP53; BAI1-associated protein 2
       K05746  ENAH, MENA; enabled
       K05747  WAS; Wiskott-Aldrich syndrome protein
       K05748  WASF2; WAS protein family, member 2
       K05749  CYFIP; cytoplasmic FMR1 interacting protein
       K05750  NCKAP1, NAP125; NCK-associated protein 1
       K05751  ABI2; abl interactor 2
       K05752  C3ORF10, HSPC300; chromosome 3 open reading frame 10
       K05753  WASF1; WAS protein family, member 1
       K05754  ARPC5; actin related protein 2/3 complex, subunit 5
       K05755  ARPC4; actin related protein 2/3 complex, subunit 4
       K05756  ARPC3; actin related protein 2/3 complex, subunit 3
       K05757  ARPC1A_B; actin related protein 2/3 complex, subunit 1A/1B
       K05758  ARPC2; actin related protein 2/3 complex, subunit 2
       K05692  ACTB_G1; actin beta/gamma 1
       K05759  PFN; profilin
       K05760  PXN; paxillin
       K08007  VIL2; villin 2 (ezrin)
       K05762  RDX; radixin
       K05763  MSN; moesin
       K05764  TMSB4; thymosin, beta 4
       K05765  CFL; cofilin
       K05766  SSH; protein phosphatase slingshot [EC:3.1.3.16 3.1.3.48]
       K05700  VCL; vinculin
       K16848  IQGAP1; Ras GTPase-activating-like protein IQGAP1
       K05767  IQGAP2_3; Ras GTPase-activating-like protein IQGAP2/3
       K05768  GSN; gelsolin
       K05699  ACTN; actinin alpha
       K02085  APC; adenomatosis polyposis coli protein
       K05769  ARHGEF4, ASEF; Rho guanine nucleotide exchange factor 4
     04812 Cytoskeleton proteins [BR:ko04812]
 
   Cell growth and death
 
   Cellular commiunity
 
 Organismal Systems
 
   Immune system
     04640 Hematopoietic cell lineage [PATH:ko04640]
     04610 Complement and coagulation cascades [PATH:ko04610]
     04611 Platelet activation [PATH:ko04611]
       K04264  TBXA2R; thromboxane A2 receptor
       K03914  F2R, PAR1; coagulation factor II (thrombin) receptor
       K04236  F2RL3, PAR4; coagulation factor II (thrombin) receptor-like 3
       K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
       K12330  ARHGEF1; Rho guanine nucleotide exchange factor 1
       K07532  ARHGEF12, LARG; Rho guanine nucleotide exchange factor 12
       K04513  RHOA; Ras homolog gene family, member A
       K04514  ROCK1; Rho-associated protein kinase 1 [EC:2.7.11.1]
       K17388  ROCK2; Rho-associated protein kinase 2 [EC:2.7.11.1]
       K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]
       K06270  PPP1R12A, MYPT1; protein phosphatase 1 regulatory subunit 12A
       K12757  MYL12; myosin regulatory light chain 12
       K05215  P2RX1; P2X purinoceptor 1
       K16056  ORAI1; calcium release-activated calcium channel protein 1
       K04958  ITPR1; inositol 1,4,5-triphosphate receptor type 1
       K04959  ITPR2; inositol 1,4,5-triphosphate receptor type 2
       K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
       K16059  STIM1; stromal interaction molecule 1
       K00907  MYLK; myosin-light-chain kinase [EC:2.7.11.18]
       K04270  P2RY1; purinergic receptor P2Y, G protein-coupled, 1
       K04634  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha
       K05858  PLCB; phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
       K06069  APKC; atypical protein kinase C [EC:2.7.11.13]
       K04350  RASGRP1; RAS guanyl-releasing protein 1
       K12361  RASGRP2; RAS guanyl-releasing protein 2
       K04353  RAP1A; Ras-related protein Rap-1A
       K07836  RAP1B; Ras-related protein Rap-1B
       K17704  APBB1IP, RIAM; amyloid beta A4 precursor protein-binding family B member 1-interacting protein
       K06271  TLN; talin
       K06476  ITGA2B; integrin alpha 2B
       K06493  ITGB3; integrin beta 3
       K17084  FERMT3, KIND3; kindlin 3
       K03903  FGA; fibrinogen alpha chain
       K03904  FGB; fibrinogen beta chain
       K03905  FGG; fibrinogen gamma chain
       K04298  P2RY12; purinergic receptor P2Y, G protein-coupled, 12
       K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
       K08041  ADCY1; adenylate cyclase 1 [EC:4.6.1.1]
       K08042  ADCY2; adenylate cyclase 2 [EC:4.6.1.1]
       K08043  ADCY3; adenylate cyclase 3 [EC:4.6.1.1]
       K08044  ADCY4; adenylate cyclase 4 [EC:4.6.1.1]
       K08045  ADCY5; adenylate cyclase 5 [EC:4.6.1.1]
       K08046  ADCY6; adenylate cyclase 6 [EC:4.6.1.1]
       K08047  ADCY7; adenylate cyclase 7 [EC:4.6.1.1]
       K08048  ADCY8; adenylate cyclase 8 [EC:4.6.1.1]
       K08049  ADCY9; adenylate cyclase 9 [EC:4.6.1.1]
       K04263  PTGIR; prostacyclin receptor
       K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
       K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
       K02649  PIK3R; phosphoinositide-3-kinase, regulatory subunit
       K04345  PKA; protein kinase A [EC:2.7.11.11]
       K06274  VASP; vasodilator-stimulated phosphoprotein
       K05692  ACTB_G1; actin beta/gamma 1
       K05704  SRC; tyrosine-protein kinase Src [EC:2.7.10.2]
       K05732  GRLF1; glucocorticoid receptor DNA-binding factor 1
       K06472  FCGR2A, CD32; low affinity immunoglobulin gamma Fc region receptor II-a
       K05855  SYK; spleen tyrosine kinase [EC:2.7.10.2]
       K06236  COL1AS; collagen, type I/II/III/V/XI/XXIV/XXVII, alpha
       K06264  GP6; platelet glycoprotein VI
       K07983  FCER1G; Fc receptor, IgE, high affinity I, gamma polypeptide
       K05854  LYN; tyrosine-protein kinase Lyn [EC:2.7.10.2]
       K05703  FYN; tyrosine-protein kinase Fyn [EC:2.7.10.2]
       K06481  ITGA2; integrin alpha 2
       K05719  ITGB1; integrin beta 1
       K07361  LCP2; lymphocyte cytosolic protein 2
       K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
       K07370  BTK; Bruton agammaglobulinemia tyrosine kinase [EC:2.7.10.2]
       K03900  VWF; von Willebrand factor
       K06260  GP5; platelet glycoprotein V
       K06261  GP1BA; platelet glycoprotein Ib alpha chain
       K06262  GP1BB; platelet glycoprotein Ib beta chain
       K06263  GP9; platelet glycoprotein IX
       K04456  AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
       K13242  NOS3; nitric-oxide synthase, endothelial [EC:1.14.13.39]
       K12318  GUCY1A; guanylate cyclase soluble subunit alpha [EC:4.6.1.2]
       K12319  GUCY1B; guanylate cyclase soluble subunit beta [EC:4.6.1.2]
       K07376  PRKG; protein kinase, cGMP-dependent [EC:2.7.11.12]
       K04441  P38; p38 MAP kinase [EC:2.7.11.24]
       K04371  MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
       K16342  PLA2G4, CPLA2; cytosolic phospholipase A2 [EC:3.1.1.4]
       K00509  PTGS1, COX1; prostaglandin-endoperoxide synthase 1 [EC:1.14.99.1]
       K01832  TBXAS1, CYP5A; thromboxane-A synthase [EC:5.3.99.5]
       K08508  SNAP23; synaptosomal-associated protein 23
       K08512  VAMP8; vesicle-associated membrane protein 8
     04620 Toll-like receptor signaling pathway [PATH:ko04620]
     04621 NOD-like receptor signaling pathway [PATH:ko04621]
     04622 RIG-I-like receptor signaling pathway [PATH:ko04622]
     04623 Cytosolic DNA-sensing pathway [PATH:ko04623]
     04650 Natural killer cell mediated cytotoxicity [PATH:ko04650]
     04612 Antigen processing and presentation [PATH:ko04612]
     04660 T cell receptor signaling pathway [PATH:ko04660]
     04662 B cell receptor signaling pathway [PATH:ko04662]
     04664 Fc epsilon RI signaling pathway [PATH:ko04664]
     04666 Fc gamma R-mediated phagocytosis [PATH:ko04666]
     04670 Leukocyte transendothelial migration [PATH:ko04670]
     04672 Intestinal immune network for IgA production [PATH:ko04672]
     04062 Chemokine signaling pathway [PATH:ko04062]
 
   Endocrine system
 
   Circulatory system
     04260 Cardiac muscle contraction [PATH:ko04260]
     04261 Adrenergic signaling in cardiomyocytes [PATH:ko04261]
     04270 Vascular smooth muscle contraction [PATH:ko04270]
       K04135  ADRA1A; adrenergic receptor alpha-1A
       K04136  ADRA1B; adrenergic receptor alpha-1B
       K04137  ADRA1D; adrenergic receptor alpha-1D
       K09821  AGT; angiotensinogen
       K04166  AGTR1; angiotensin II receptor type 1
       K16366  EDN1; endothelin-1
       K16367  EDN2; endothelin-2
       K05227  EDN3; endothelin-3
       K04197  EDNRA; endothelin receptor type A
       K05242  AVP; arginine vasopressin
       K04226  AVPR1A; arginine vasopressin receptor 1A
       K04227  AVPR1B; arginine vasopressin receptor 1B
       K04634  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha
       K04635  GNA11; guanine nucleotide-binding protein subunit alpha-11
       K01047  PLA2G, SPLA2; secretory phospholipase A2 [EC:3.1.1.4]
       K16342  PLA2G4, CPLA2; cytosolic phospholipase A2 [EC:3.1.1.4]
       K16343  PLA2G6, IPLA2; calcium-independent phospholipase A2 [EC:3.1.1.4]
       K17687  CYP4A11; alkane 1-monooxygenase [EC:1.14.15.3]
       K17688  CYP4A22; alkane 1-monooxygenase [EC:1.14.15.3]
       K07425  CYP4A; alkane 1-monooxygenase [EC:1.14.15.3]
       K04936  KCNMA1; potassium large conductance calcium-activated channel subfamily M alpha member 1
       K05274  KCNMA3; potassium large conductance calcium-activated channel subfamily M alpha member 3
       K04937  KCNMB1; potassium large conductance calcium-activated channel subfamily M beta member 1
       K04938  KCNMB2; potassium large conductance calcium-activated channel subfamily M beta member 2
       K04939  KCNMB3; potassium large conductance calcium-activated channel subfamily M beta member 3
       K04941  KCNMB4; potassium large conductance calcium-activated channel subfamily M beta member 4
       K04850  CACNA1C; voltage-dependent calcium channel L type alpha-1C
       K04851  CACNA1D; voltage-dependent calcium channel L type alpha-1D
       K04853  CACNA1F; voltage-dependent calcium channel L type alpha-1F
       K04857  CACNA1S; voltage-dependent calcium channel L type alpha-1S
       K02183  CALM; calmodulin
       K00907  MYLK; myosin-light-chain kinase [EC:2.7.11.18]
       K12751  MYL6; myosin light chain 6
       K12755  MYL9; myosin regulatory light chain 9
       K05858  PLCB; phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
       K04958  ITPR1; inositol 1,4,5-triphosphate receptor type 1
       K04959  ITPR2; inositol 1,4,5-triphosphate receptor type 2
       K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
       K02677  CPKC; classical protein kinase C [EC:2.7.11.13]
       K06068  PRKCD; novel protein kinase C delta type [EC:2.7.11.13]
       K18050  PRKCE; novel protein kinase C epsilon type [EC:2.7.11.13]
       K18051  PRKCH; novel protein kinase C eta type [EC:2.7.11.13]
       K18052  PRKCQ; novel protein kinase C theta type [EC:2.7.11.13]
       K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
       K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
       K04371  MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
       K12327  CALD1; caldesmon
       K12313  ACTA2; actin, aortic smooth muscle
       K12315  ACTG2; actin, gamma-enteric smooth muscle
       K12328  PPP1R14A, CPI17; protein phosphatase 1 regulatory subunit 14A
       K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]
       K06270  PPP1R12A, MYPT1; protein phosphatase 1 regulatory subunit 12A
       K12329  PPP1R12B, MYPT2; protein phosphatase 1 regulatory subunit 12B
       K17457  PPP1R12C, MBS85; protein phosphatase 1 regulatory subunit 12C
       K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
       K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
       K07532  ARHGEF12, LARG; Rho guanine nucleotide exchange factor 12
       K12330  ARHGEF1; Rho guanine nucleotide exchange factor 1
       K12331  ARHGEF11; Rho guanine nucleotide exchange factor 11
       K04513  RHOA; Ras homolog gene family, member A
       K04514  ROCK1; Rho-associated protein kinase 1 [EC:2.7.11.1]
       K17388  ROCK2; Rho-associated protein kinase 2 [EC:2.7.11.1]
       K04266  ADORA2A, ADOR; adenosine receptor A2a
       K04267  ADORA2B; adenosine receptor A2b
       K04263  PTGIR; prostacyclin receptor
       K12332  CALCA; calcitonin
       K12333  ADM; adrenomedullin
       K04577  CALCRL; calcitonin receptor-like
       K08447  RAMP1; receptor activity modifying protein 1
       K08448  RAMP2; receptor activity modifying protein 2
       K08449  RAMP3; receptor activity modifying protein 3
       K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
       K08041  ADCY1; adenylate cyclase 1 [EC:4.6.1.1]
       K08042  ADCY2; adenylate cyclase 2 [EC:4.6.1.1]
       K08043  ADCY3; adenylate cyclase 3 [EC:4.6.1.1]
       K08044  ADCY4; adenylate cyclase 4 [EC:4.6.1.1]
       K08045  ADCY5; adenylate cyclase 5 [EC:4.6.1.1]
       K08046  ADCY6; adenylate cyclase 6 [EC:4.6.1.1]
       K08047  ADCY7; adenylate cyclase 7 [EC:4.6.1.1]
       K08048  ADCY8; adenylate cyclase 8 [EC:4.6.1.1]
       K08049  ADCY9; adenylate cyclase 9 [EC:4.6.1.1]
       K04345  PKA; protein kinase A [EC:2.7.11.11]
       K12334  NPPA; natriuretic peptide A
       K12335  NPPB; natriuretic peptide B
       K12323  ANPRA, NPR1; atrial natriuretic peptide receptor A [EC:4.6.1.2]
       K12336  NPPC; natriuretic peptide C
       K12324  ANPRB, NPR2; atrial natriuretic peptide receptor B [EC:4.6.1.2]
       K12337  MRVI1, IRAG; inositol 1,4,5-triphosphate receptor-associated cGMP kinase substrate
       K12318  GUCY1A; guanylate cyclase soluble subunit alpha [EC:4.6.1.2]
       K12319  GUCY1B; guanylate cyclase soluble subunit beta [EC:4.6.1.2]
 
   Digestive system
 
   Excretory system
 
   Nervous system
 
   Sensory system
 
   Development
 
   Environmental adaptation
 
 Human Diseases
 
   Cancers
     05200 Pathways in cancer [PATH:ko05200]
     05202 Transcriptional misregulation in cancers [PATH:ko05202]
     05206 MicroRNAs in cancer [PATH:ko05206]
     05205 Proteoglycans in cancer [PATH:ko05205]
       K06256  CD44; CD44 antigen
       K05704  SRC; tyrosine-protein kinase Src [EC:2.7.10.2]
       K06106  CTTN, EMS1; cortactin
       K05083  ERBB2, HER2; receptor tyrosine-protein kinase erbB-2 [EC:2.7.10.1]
       K04364  GRB2; growth factor receptor-binding protein 2
       K02833  HRAS; GTPase HRas
       K07827  KRAS, KRAS2; GTPase KRas
       K07828  NRAS; GTPase NRas
       K07829  RRAS; Ras-related protein R-Ras
       K07830  RRAS2, TC21; Ras-related protein R-Ras2
       K07831  MRAS; Ras-related protein M-Ras
       K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
       K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
       K04371  MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
       K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
       K16848  IQGAP1; Ras GTPase-activating-like protein IQGAP1
       K04393  CDC42; cell division control protein 42
       K04375  ELK1; ETS domain-containing protein Elk-1
       K08550  NR3A1, ESR1; estrogen receptor alpha
       K04503  CCND1; cyclin D1
       K05692  ACTB_G1; actin beta/gamma 1
       K04437  FLNA; filamin
       K04409  PAK1; p21-activated kinase 1 [EC:2.7.11.1]
       K05731  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1
       K12330  ARHGEF1; Rho guanine nucleotide exchange factor 1
       K04513  RHOA; Ras homolog gene family, member A
       K04514  ROCK1; Rho-associated protein kinase 1 [EC:2.7.11.1]
       K17388  ROCK2; Rho-associated protein kinase 2 [EC:2.7.11.1]
       K10380  ANK; ankyrin
       K09593  GAB1; GRB2-associated-binding protein 1
       K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
       K02649  PIK3R; phosphoinositide-3-kinase, regulatory subunit
       K04456  AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
       K05742  SLC9A1, NHE1; solute carrier family 9 (sodium/hydrogen exchanger), member 1
       K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]
       K06270  PPP1R12A, MYPT1; protein phosphatase 1 regulatory subunit 12A
       K12329  PPP1R12B, MYPT2; protein phosphatase 1 regulatory subunit 12B
       K17457  PPP1R12C, MBS85; protein phosphatase 1 regulatory subunit 12C
       K07532  ARHGEF12, LARG; Rho guanine nucleotide exchange factor 12
       K05860  PLCE; phosphatidylinositol phospholipase C, epsilon [EC:3.1.4.11]
       K04958  ITPR1; inositol 1,4,5-triphosphate receptor type 1
       K04959  ITPR2; inositol 1,4,5-triphosphate receptor type 2
       K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
       K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]
       K10164  NANOG; homeobox protein Nanog
       K12823  DDX5, DBP2; ATP-dependent RNA helicase DDX5/DBP2 [EC:3.6.4.13]
       K03685  rnc, DROSHA, RNT1; ribonuclease III [EC:3.1.26.3]
       K04692  STAT3; signal transducer and activator of transcription 3
       K16863  MIR21; microRNA 21
       K09069  TWIST; twist
       K16864  MIR10A; microRNA 10a
       K17393  MIR10B; microRNA 10b
       K09295  HOXD10; homrobox protein Hox-D10
       K04660  DCN; decorin
       K05459  IGF1; insulin-like growth factor 1
       K05087  IGF1R; insulin-like growth factor 1 receptor [EC:2.7.10.1]
       K07203  FRAP; FKBP12-rapamycin complex-associated protein
       K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]
       K04688  RPS6KB; p70 ribosomal S6 kinase [EC:2.7.11.1]
       K03258  EIF4B; translation initiation factor 4B
       K02991  RP-S6e, RPS6; small subunit ribosomal protein S6e
       K04361  EGFR, ERBB1; epidermal growth factor receptor [EC:2.7.10.1]
       K06278  CAV1; caveolin 1
       K12958  CAV2; caveolin 2
       K12959  CAV3; caveolin 3
       K06497  CD63, MLA1, TSPAN30; CD63 antigen
       K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
       K02187  CASP3; caspase 3 [EC:3.4.22.56]
       K13375  TGFB1; transforming growth factor beta-1
       K10159  TLR2; toll-like receptor 2
       K10160  TLR4; toll-like receptor 4
       K16865  PDCD4; programmed cell death protein 4
       K03156  TNFA; tumor necrosis factor superfamily, member 2
       K05425  IL12B; interleukin 12B
       K05084  ERBB3, HER3; receptor tyrosine-protein kinase erbB-3 [EC:2.7.10.1]
       K05085  ERBB4, HER4; receptor tyrosine-protein kinase erbB-4 [EC:2.7.10.1]
       K04377  MYC; Myc proto-oncogene protein
       K02105  CTNNB1; catenin beta 1
       K08268  HIF1A; hypoxia-inducible factor 1 alpha
       K09108  TFAP4; transcription factor AP-4
       K05448  VEGFA; vascular endothelial growth factor A
       K05098  KDR, VEGFR2; kinase insert domain protein receptor [EC:2.7.10.1]
       K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]
       K04707  CBL; E3 ubiquitin-protein ligase CBL [EC:6.3.2.19]
       K16866  TIMP3; metalloproteinase inhibitor 3
       K16857  THBS1; thrombospondin 1
       K01398  MMP2; matrix metalloproteinase-2 (gelatinase A) [EC:3.4.24.24]
       K01403  MMP9; matrix metalloproteinase-9 (gelatinase B) [EC:3.4.24.35]
       K08122  LUM; lumican
       K04389  TNFSF6, FASL; tumor necrosis factor ligand superfamily member 6
       K04390  TNFRSF6, FAS; tumor necrosis factor receptor superfamily member 6
       K06643  MDM2; E3 ubiquitin-protein ligase Mdm2 [EC:6.3.2.19]
       K04451  TP53, P53; tumor protein p53
       K13376  TGFB2; transforming growth factor beta-2
       K07964  HPSE; heparanase 1 [EC:3.2.1.166]
       K07965  HPSE2; heparanase 2 [EC:3.2.1.-]
       K06257  SDC1; syndecan 1
       K01348  PLAU; urokinase plasminogen activator [EC:3.4.21.73]
       K03985  PLAUR; plasminogen activator, urokinase receptor
       K06481  ITGA2; integrin alpha 2
       K05719  ITGB1; integrin beta 1
       K06251  VTN; vitronectin
       K06487  ITGAV; integrin alpha V
       K06493  ITGB3; integrin beta 3
       K05717  FN1; fibronectin 1
       K06588  ITGB5; integrin beta 5
       K05460  HGF; hepatocyte growth factor
       K03209  WNT1; wingless-type MMTV integration site family, member 1
       K02432  FZD1_7, fz; frizzled 1/7
       K02235  FZD2; frizzled 2
       K02329  FZD3; frizzled 3
       K02354  FZD4, fz4; frizzled 4
       K02375  FZD5_8, fz2; frizzled 5/8
       K02376  FZD6; frizzled 6
       K02842  FZD9_10; frizzled 9/10
       K06484  ITGA5; integrin alpha 5
       K16336  SDC2; syndecan 2
       K08007  VIL2; villin 2 (ezrin)
       K05762  RDX; radixin
       K05763  MSN; moesin
       K16338  SDC4; syndecan 4
       K04358  FGF; fibroblast growth factor
       K04362  FGFR1; fibroblast growth factor receptor 1 [EC:2.7.10.1]
       K12461  FRS2; fibroblast growth factor receptor substrate 2
       K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11 [EC:3.1.3.48]
       K03099  SOS; son of sevenless
       K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
       K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
       K02677  CPKC; classical protein kinase C [EC:2.7.11.13]
       K16867  NUDT16L1, SDOS; NUDT16-like protein 1
       K05760  PXN; paxillin
       K05725  PTK2, FAK; focal adhesion kinase 1 [EC:2.7.10.2]
       K08523  HBEGF; heparin-binding EGF-like growth factor
       K08107  GPC1; glypican 1
       K13769  IGF2; insulin-like growth factor 2
       K08109  GPC3; glypican 3 (OCI-5)
       K00182  WNT2; wingless-type MMTV integration site family, member 2
       K00312  WNT3; wingless-type MMTV integration site family, member 3
       K00408  WNT4; wingless-type MMTV integration site family, member 4
       K00444  WNT5; wingless-type MMTV integration site family, member 5
       K00445  WNT6; wingless-type MMTV integration site family, member 6
       K00572  WNT7; wingless-type MMTV integration site family, member 7
       K00714  WNT8; wingless-type MMTV integration site family, member 8
       K01064  WNT9; wingless-type MMTV integration site family, member 9
       K01357  WNT10; wingless-type MMTV integration site family, member 10
       K01384  WNT11; wingless-type MMTV integration site family, member 11
       K01558  WNT16; wingless-type MMTV integration site family, member 16
       K06224  HH; hedgehog
       K06225  PTCH1; patched 1
       K06226  SMO; smoothened
       K06255  HSPG2; heparan sulfate proteoglycan 2 (perlecan)
       K01365  CTSL; cathepsin L [EC:3.4.22.15]
       K04345  PKA; protein kinase A [EC:2.7.11.11]
       K04441  P38; p38 MAP kinase [EC:2.7.11.24]
       K09543  HSPB2; heat shock protein beta-2
       K05697  PTPN6, SHP-1; tyrosine-protein phosphatase non-receptor type 6 [EC:3.1.3.48]
     05204 Chemical carcinogenesis [PATH:ko05204]
     05203 Viral carcinogenesis [PATH:ko05203]
     05210 Colorectal cancer [PATH:ko05210]
     05212 Pancreatic cancer [PATH:ko05212]
     05214 Glioma [PATH:ko05214]
     05216 Thyroid cancer [PATH:ko05216]
     05221 Acute myeloid leukemia [PATH:ko05221]
     05220 Chronic myeloid leukemia [PATH:ko05220]
     05217 Basal cell carcinoma [PATH:ko05217]
     05218 Melanoma [PATH:ko05218]
     05211 Renal cell carcinoma [PATH:ko05211]
     05219 Bladder cancer [PATH:ko05219]
     05215 Prostate cancer [PATH:ko05215]
     05213 Endometrial cancer [PATH:ko05213]
     05222 Small cell lung cancer [PATH:ko05222]
     05223 Non-small cell lung cancer [PATH:ko05223]
 
   Immune diseases
 
   Neurodegenerative diseases
 
   Substance dependence
 
   Cardiovascular diseases
 
   Endocrine and metabolic diseases
 
   Infectious diseases
 
   Drug resistance

[ BRITE | KEGG2 | KEGG ]
Last updated: August 25, 2014