KEGG Orthology (KO)

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 Human Diseases
 
   Cancers
     05200 Pathways in cancer [PATH:ko05200]
     05202 Transcriptional misregulation in cancers [PATH:ko05202]
     05206 MicroRNAs in cancer [PATH:ko05206]
     05205 Proteoglycans in cancer [PATH:ko05205]
     05204 Chemical carcinogenesis [PATH:ko05204]
     05203 Viral carcinogenesis [PATH:ko05203]
       K05704  SRC; tyrosine-protein kinase Src [EC:2.7.10.2]
       K02833  HRAS; GTPase HRas
       K07827  KRAS, KRAS2; GTPase KRas
       K07828  NRAS; GTPase NRas
       K04371  MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
       K05870  CREB1; cyclic AMP-responsive element-binding protein 1
       K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
       K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
       K09048  CREB3; cyclic AMP-responsive element-binding protein 3
       K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
       K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
       K10610  DDB1; DNA damage-binding protein 1
       K16197  YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
       K06630  YWHAE; 14-3-3 protein epsilon
       K16198  YWHAG_H; 14-3-3 protein gamma/eta
       K11217  JAK1; Janus kinase 1 [EC:2.7.10.2]
       K04692  STAT3; signal transducer and activator of transcription 3
       K11223  STAT5A; signal transducer and activator of transcription 5A
       K11224  STAT5B; signal transducer and activator of transcription 5B
       K02187  CASP3; caspase 3 [EC:3.4.22.56]
       K08665  HPN; hepsin (transmembrane protease, serine 1) [EC:3.4.21.-]
       K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
       K02649  PIK3R; phosphoinositide-3-kinase, regulatory subunit
       K04735  RELA; transcription factor p65
       K09254  REL; c-Rel proto-oncogene protein
       K04469  NFKB2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2
       K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
       K04451  TP53, P53; tumor protein p53
       K06626  CCNE; cyclin E
       K02206  CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
       K12496  EGR2; early growth response protein 2
       K12497  EGR3; early growth response protein 3
       K15041  VDAC3; voltage-dependent anion channel protein 3
       K03159  TNFRSF3, LTBR; lymphotoxin beta receptor TNFR superfamily member 3
       K15413  SP100; nuclear autoantigen Sp-100
       K12886  HNRNPK; heterogeneous nuclear ribonucleoprotein K
       K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
       K11594  DDX3X, bel; ATP-dependent RNA helicase DDX3X [EC:3.6.4.13]
       K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2 [EC:2.7.11.1]
       K04345  PKA; protein kinase A [EC:2.7.11.11]
       K11252  H2B; histone H2B
       K11254  H4; histone H4
       K02159  BAX; apoptosis regulator BAX
       K04364  GRB2; growth factor receptor-binding protein 2
       K03171  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein
       K02087  CDK1, CDC2; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]
       K03120  TBP, tbp; transcription initiation factor TFIID TATA-box-binding protein
       K11838  USP7, UBP15; ubiquitin carboxyl-terminal hydrolase 7 [EC:3.1.2.15]
       K06643  MDM2; E3 ubiquitin-protein ligase Mdm2 [EC:6.3.2.19]
       K06053  RBPSUH, RBPJK; recombining binding protein suppressor of hairless
       K06063  SNW1, SKIIP, SKIP; SNW domain-containing protein 1
       K03141  TFIIH1, GTF2H1, TFB1; transcription initiation factor TFIIH subunit 1
       K03142  TFIIH2, GTF2H2, SSL1; transcription initiation factor TFIIH subunit 2
       K03143  TFIIH3, GTF2H3, TFB4; transcription initiation factor TFIIH subunit 3
       K03144  TFIIH4, GTF2H4, TFB2; transcription initiation factor TFIIH subunit 4
       K03136  TFIIE1, GTF2E1, TFA1, tfe; transcription initiation factor TFIIE subunit alpha
       K03137  TFIIE2, GTF2E2, TFA2; transcription initiation factor TFIIE subunit beta
       K15979  SND1; staphylococcal nuclease domain-containing protein 1
       K04498  EP300, CREBBP, KAT3; E1A/CREB-binding protein [EC:2.3.1.48]
       K03124  TFIIB, GTF2B, SUA7, tfb; transcription initiation factor TFIIB
       K04503  CCND1; cyclin D1
       K10151  CCND2; cyclin D2
       K10152  CCND3; cyclin D3
       K02091  CDK6; cyclin-dependent kinase 6 [EC:2.7.11.22]
       K06627  CCNA; cyclin A
       K03875  SKP2, FBXL1; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
       K16174  MRPS18B, MRPS18-2; small subunit ribosomal protein S18b, mitochondrial
       K03172  TRAF1; TNF receptor-associated factor 1
       K03173  TRAF2; TNF receptor-associated factor 2
       K03174  TRAF3; TNF receptor-associated factor 3
       K09849  TRAF5; TNF receptor-associated factor 5
       K11218  JAK3; Janus kinase 3 [EC:2.7.10.2]
       K05854  LYN; tyrosine-protein kinase Lyn [EC:2.7.10.2]
       K05855  SYK; spleen tyrosine kinase [EC:2.7.10.2]
       K02146  ATPeV0D, ATP6D; V-type H+-transporting ATPase subunit d
       K10587  UBE3A, E6AP; ubiquitin-protein ligase E3 A [EC:6.3.2.19]
       K12076  DLG1; disks large protein 1
       K16175  SCRIB; protein scribble
       K05760  PXN; paxillin
       K14021  BAK, BAK1; Bcl-2 homologous antagonist/killer
       K05411  IRF3; interferon regulatory factor 3
       K03062  PSMC1, RPT2; 26S proteasome regulatory subunit T2
       K06618  RB1; retinoblastoma-associated protein
       K04681  RBL1; retinoblastoma-like protein 1
       K16332  RBL2; retinoblastoma-like protein 2
       K06624  CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
       K10691  UBR4, ZUBR1; E3 ubiquitin-protein ligase UBR4 [EC:6.3.2.19]
       K04448  JUN; transcription factor AP-1
       K11643  CHD4, MI2B; chromodomain-helicase-DNA-binding protein 4 [EC:3.6.4.12]
       K06067  HDAC1_2; histone deacetylase 1/2 [EC:3.5.1.98]
       K11404  HDAC3; histone deacetylase 3 [EC:3.5.1.98]
       K11406  HDAC4_5; histone deacetylase 4/5 [EC:3.5.1.98]
       K11407  HDAC6_10; histone deacetylase 6/10 [EC:3.5.1.98]
       K11408  HDAC7; histone deacetylase 7 [EC:3.5.1.98]
       K11405  HDAC8; histone deacetylase 8 [EC:3.5.1.98]
       K11409  HDAC9; histone deacetylase 9 [EC:3.5.1.98]
       K11418  HDAC11; histone deacetylase 11 [EC:3.5.1.98]
       K00873  PK, pyk; pyruvate kinase [EC:2.7.1.40]
       K04693  IRF9, ISGF3G, P48; interferon regulatory factor 9
       K09504  DNAJA3; DnaJ homolog subfamily A member 3
       K06062  PCAF, KAT2, GCN5; histone acetyltransferase [EC:2.3.1.48]
       K03122  TFIIA1, GTF2A1, TOA1; transcription initiation factor TFIIA large subunit
       K03123  TFIIA2, GTF2A2, TOA2; transcription initiation factor TFIIA small subunit
       K04378  SRF; serum response factor
       K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
       K04734  NFKBIA; NF-kappa-B inhibitor alpha
       K08053  RASA2, GAP1M; Ras GTPase-activating protein 2
       K04393  CDC42; cell division control protein 42
       K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
       K04513  RHOA; Ras homolog gene family, member A
       K05768  GSN; gelsolin
       K05699  ACTN; actinin alpha
       K02089  CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
       K06621  CDKN2A, P16, INK4A; cyclin-dependent kinase inhibitor 2A
       K04685  CDKN2B, P15, INK4B; cyclin-dependent kinase inhibitor 2B
       K02216  CHK1; serine/threonine-protein kinase Chk1 [EC:2.7.11.1]
       K03363  CDC20; cell division cycle 20, cofactor of APC complex
       K06638  MAD1L; mitotic spindle assembly checkpoint protein MAD1
       K15305  VAC14, TAX1BP2; vacuole morphology and inheritance protein 14
       K15306  RANBP1; Ran-binding protein 1
       K02330  POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
       K09447  IRF7; interferon regulatory factor 7
       K05060  IL6ST, GP130; interleukin 6 signal transducer
       K04180  CCR5; C-C chemokine receptor type 5
       K04183  CCR8; C-C chemokine receptor type 8
       K04178  CCR3; C-C chemokine receptor type 3
       K04179  CCR4; C-C chemokine receptor type 4
       K04443  MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2 [EC:2.7.11.1]
       K04398  CASP8; caspase 8 [EC:3.4.22.61]
       K02158  BAD; BCL2-antagonist of cell death
       K10131  PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1
       K03990  C3; complement component 3
       K06751  MHC1; major histocompatibility complex, class I
     05210 Colorectal cancer [PATH:ko05210]
     05212 Pancreatic cancer [PATH:ko05212]
     05214 Glioma [PATH:ko05214]
     05216 Thyroid cancer [PATH:ko05216]
     05221 Acute myeloid leukemia [PATH:ko05221]
     05220 Chronic myeloid leukemia [PATH:ko05220]
     05217 Basal cell carcinoma [PATH:ko05217]
     05218 Melanoma [PATH:ko05218]
     05211 Renal cell carcinoma [PATH:ko05211]
     05219 Bladder cancer [PATH:ko05219]
     05215 Prostate cancer [PATH:ko05215]
     05213 Endometrial cancer [PATH:ko05213]
     05222 Small cell lung cancer [PATH:ko05222]
     05223 Non-small cell lung cancer [PATH:ko05223]
 
   Immune diseases
 
   Neurodegenerative diseases
 
   Substance dependence
 
   Cardiovascular diseases
 
   Endocrine and metabolic diseases
 
   Infectious diseases
     05110 Vibrio cholerae infection [PATH:ko05110]
     05111 Vibrio cholerae pathogenic cycle [PATH:ko05111]
     05120 Epithelial cell signaling in Helicobacter pylori infection [PATH:ko05120]
     05130 Pathogenic Escherichia coli infection [PATH:ko05130]
     05132 Salmonella infection [PATH:ko05132]
     05131 Shigellosis [PATH:ko05131]
     05133 Pertussis [PATH:ko05133]
     05134 Legionellosis [PATH:ko05134]
     05150 Staphylococcus aureus infection [PATH:ko05150]
     05152 Tuberculosis [PATH:ko05152]
     05100 Bacterial invasion of epithelial cells [PATH:ko05100]
     05166 HTLV-I infection [PATH:ko05166]
     05162 Measles [PATH:ko05162]
     05164 Influenza A [PATH:ko05164]
     05161 Hepatitis B [PATH:ko05161]
       K06255  HSPG2; heparan sulfate proteoglycan 2 (perlecan)
       K04440  JNK; c-Jun N-terminal kinase [EC:2.7.11.24]
       K13375  TGFB1; transforming growth factor beta-1
       K13376  TGFB2; transforming growth factor beta-2
       K13377  TGFB3; transforming growth factor beta-3
       K04674  TGFBR1, ALK5; TGF-beta receptor type-1 [EC:2.7.11.30]
       K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
       K04377  MYC; Myc proto-oncogene protein
       K12496  EGR2; early growth response protein 2
       K12497  EGR3; early growth response protein 3
       K04498  EP300, CREBBP, KAT3; E1A/CREB-binding protein [EC:2.3.1.48]
       K04389  TNFSF6, FASL; tumor necrosis factor ligand superfamily member 6
       K04390  TNFRSF6, FAS; tumor necrosis factor receptor superfamily member 6
       K02373  FADD; FAS-associated death domain protein
       K04398  CASP8; caspase 8 [EC:3.4.22.61]
       K04400  CASP10; caspase 10 [EC:3.4.22.63]
       K10610  DDB1; DNA damage-binding protein 1
       K10140  DDB2; DNA damage-binding protein 2
       K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1 [EC:2.7.11.25]
       K16197  YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
       K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]
       K04734  NFKBIA; NF-kappa-B inhibitor alpha
       K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
       K04735  RELA; transcription factor p65
       K01403  MMP9; matrix metalloproteinase-9 (gelatinase B) [EC:3.4.24.35]
       K02161  BCL2; apoptosis regulator BCL-2
       K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
       K02649  PIK3R; phosphoinositide-3-kinase, regulatory subunit
       K04456  AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
       K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
       K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
       K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
       K02158  BAD; BCL2-antagonist of cell death
       K04451  TP53, P53; tumor protein p53
       K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67]
       K04741  CASP12; caspase 12 [EC:3.4.22.-]
       K02084  APAF1; apoptotic protease-activating factor
       K16344  HBXIP; hepatitis B virus X-interacting protein
       K08731  BIRC5; baculoviral IAP repeat-containing protein 5
       K02159  BAX; apoptosis regulator BAX
       K08738  CYC; cytochrome c
       K04399  CASP9; caspase 9 [EC:3.4.22.62]
       K02187  CASP3; caspase 3 [EC:3.4.22.56]
       K15041  VDAC3; voltage-dependent anion channel protein 3
       K04446  NFATC1, NFAT2, NFATC; nuclear factor of activated T-cells, cytoplasmic 1
       K17332  NFATC2, NFAT1, NFATP; nuclear factor of activated T-cells, cytoplasmic 2
       K17333  NFATC3, NFAT4; nuclear factor of activated T-cells, cytoplasmic 3
       K17334  NFATC4, NFAT3; nuclear factor of activated T-cells, cytoplasmic 4
       K03156  TNFA; tumor necrosis factor superfamily, member 2
       K05871  PTK2B, FAK2; focal adhesion kinase 2 [EC:2.7.10.2]
       K05704  SRC; tyrosine-protein kinase Src [EC:2.7.10.2]
       K04364  GRB2; growth factor receptor-binding protein 2
       K02833  HRAS; GTPase HRas
       K07827  KRAS, KRAS2; GTPase KRas
       K07828  NRAS; GTPase NRas
       K04448  JUN; transcription factor AP-1
       K04501  SMAD4; mothers against decapentaplegic homolog 4
       K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
       K10030  IL8, CXCL8; interleukin 8
       K04802  PCNA; proliferating cell nuclear antigen
       K11217  JAK1; Janus kinase 1 [EC:2.7.10.2]
       K11220  STAT1; signal transducer and activator of transcription 1
       K11221  STAT2; signal transducer and activator of transcription 2
       K04692  STAT3; signal transducer and activator of transcription 3
       K11222  STAT4; signal transducer and activator of transcription 4
       K11223  STAT5A; signal transducer and activator of transcription 5A
       K11224  STAT5B; signal transducer and activator of transcription 5B
       K11225  STAT6; signal transducer and activator of transcription 6
       K03662  ATPeVS1, ATP6S1; V-type H+-transporting ATPase S1 subunit
       K02677  CPKC; classical protein kinase C [EC:2.7.11.13]
       K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
       K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
       K04371  MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
       K05870  CREB1; cyclic AMP-responsive element-binding protein 1
       K09048  CREB3; cyclic AMP-responsive element-binding protein 3
       K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
       K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
       K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
       K04379  FOS; proto-oncogene protein c-fos
       K04375  ELK1; ETS domain-containing protein Elk-1
       K11594  DDX3X, bel; ATP-dependent RNA helicase DDX3X [EC:3.6.4.13]
       K05414  IFNA; interferon alpha
       K05130  IFNAR1; interferon receptor 1
       K05401  TLR3; toll-like receptor 3
       K05842  TRIF; toll-like receptor adapter molecule 1
       K12646  DDX58, RIG-I; ATP-dependent RNA helicase DDX58 [EC:3.6.3.14]
       K12647  IFIH1, MDA5; interferon-induced helicase C domain-containing protein 1 [EC:3.6.4.13]
       K12648  MAVS, IPS1; mitochondrial antiviral-signaling protein
       K07211  IKBKE, IKKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [EC:2.7.11.10]
       K05410  TBK1; TANK-binding kinase 1 [EC:2.7.11.10]
       K05411  IRF3; interferon regulatory factor 3
       K09447  IRF7; interferon regulatory factor 7
       K10160  TLR4; toll-like receptor 4
       K05409  TIRP, TRAM; TRIF-related adaptor molecule
       K05415  IFNB; interferon beta
       K10159  TLR2; toll-like receptor 2
       K05403  TIRAP; toll-interleukin 1 receptor (TIR) domain-containing adaptor protein
       K04729  MYD88; myeloid differentiation primary response protein MyD88
       K05405  IL6; interleukin 6
       K04503  CCND1; cyclin D1
       K02089  CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
       K02091  CDK6; cyclin-dependent kinase 6 [EC:2.7.11.22]
       K06618  RB1; retinoblastoma-associated protein
       K17454  E2F1; transcription factor E2F1
       K09389  E2F2; transcription factor E2F2
       K06620  E2F3; transcription factor E2F3
       K06624  CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
       K06626  CCNE; cyclin E
       K02206  CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
       K06627  CCNA; cyclin A
     05160 Hepatitis C [PATH:ko05160]
     05168 Herpes simplex infection [PATH:ko05168]
     05169 Epstein-Barr virus infection [PATH:ko05169]
     05146 Amoebiasis [PATH:ko05146]
     05144 Malaria [PATH:ko05144]
     05145 Toxoplasmosis [PATH:ko05145]
     05140 Leishmaniasis [PATH:ko05140]
     05142 Chagas disease (American trypanosomiasis) [PATH:ko05142]
     05143 African trypanosomiasis [PATH:ko05143]
 
   Drug resistance

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Last updated: July 11, 2014