KEGG Orthology (KO)

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 Metabolism
 
 Genetic Information Processing
 
   Transcription
 
   Translation
     03010 Ribosome [PATH:ko03010]
     03011 Ribosome [BR:ko03011]
     03016 Transfer RNA biogenesis [BR:ko03016]
     00970 Aminoacyl-tRNA biosynthesis [PATH:ko00970]
     03013 RNA transport [PATH:ko03013]
       K01164  POP1; ribonuclease P/MRP protein subunit POP1 [EC:3.1.26.5]
       K14522  POP3; ribonuclease P/MRP protein subunit POP3 [EC:3.1.26.5]
       K14523  RPP38; ribonucleases P/MRP protein subunit RPP38 [EC:3.1.26.5]
       K03538  POP4, RPP29; ribonuclease P protein subunit POP4 [EC:3.1.26.5]
       K03537  POP5; ribonuclease P/MRP protein subunit POP5 [EC:3.1.26.5]
       K14524  POP6; ribonuclease P/MRP protein subunit POP6 [EC:3.1.26.5]
       K14525  RPP25; ribonucleases P/MRP protein subunit RPP25 [EC:3.1.26.5]
       K14526  POP7, RPP2; ribonuclease P/MRP protein subunit POP7 [EC:3.1.26.5]
       K14527  RPP20, POP7; ribonuclease P/MRP protein subunit RPP20 [EC:3.1.26.5]
       K14528  POP8; ribonuclease P/MRP protein subunit POP8 [EC:3.1.26.5]
       K14529  RPP14; ribonuclease P protein subunit RPP14 [EC:3.1.26.5]
       K03539  RPP1, RPP30; ribonuclease P/MRP protein subunit RPP1 [EC:3.1.26.5]
       K03540  RPR2, RPP21; ribonuclease P protein subunit RPR2 [EC:3.1.26.5]
       K14530  RPP40; ribonucleases P/MRP protein subunit RPP40 [EC:3.1.26.5]
       K18213  PRORP; proteinaceous RNase P [EC:3.1.26.5]
       K14533  RPM2; ribonuclease P protein component, mitochondrial [EC:3.1.26.5]
       K00784  rnz; ribonuclease Z [EC:3.1.26.11]
       K00974  cca; tRNA nucleotidyltransferase (CCA-adding enzyme) [EC:2.7.7.72 3.1.3.- 3.1.4.-]
       K07936  RAN; GTP-binding nuclear protein Ran
       K14288  XPOT; exportin-T
       K14289  XPO5; exportin-5
       K03231  EEF1A; elongation factor 1-alpha
       K14290  XPO1, CRM1; exportin-1
       K14291  PHAX; phosphorylated adapter RNA export protein
       K12882  NCBP1, CBP80; nuclear cap-binding protein subunit 1
       K12883  NCBP2, CBP20; nuclear cap-binding protein subunit 2
       K05019  CLNS1A; chloride channel, nucleotide-sensitive, 1A
       K02516  PRMT5, HSL7; protein arginine N-methyltransferase 5 [EC:2.1.1.125]
       K14292  TGS1; trimethylguanosine synthase [EC:2.1.1.-]
       K14293  KPNB1; importin subunit beta-1
       K13151  SNUPN, RNUT1; snurportin-1
       K07562  NMD3; nonsense-mediated mRNA decay protein 3
       K14294  WIBG, PYM; partner of Y14 and mago
       K09291  TPR; nucleoprotein TPR
       K14295  NUP50, NPAP60; nuclear pore complex protein Nup50
       K14296  NUP153; nuclear pore complex protein Nup153
       K03345  SENP2, AXAM2; sentrin-specific protease 2 (axin associating molecule) [EC:3.4.22.68]
       K14297  NUP98, ADAR2; nuclear pore complex protein Nup98-Nup96
       K14298  RAE1; mRNA export factor
       K14004  SEC13; protein transport protein SEC13
       K14299  SEH1; nucleoporin SEH1
       K14300  NUP133; nuclear pore complex protein Nup133
       K14301  NUP107; nuclear pore complex protein Nup107
       K14302  NUP37; nuclear pore complex protein Nup37
       K14303  NUP160; nuclear pore complex protein Nup160
       K14304  NUP85; nuclear pore complex protein Nup85
       K14305  NUP43; nuclear pore complex protein Nup43
       K14306  NUP62; nuclear pore complex protein Nup62
       K14307  NUPL1; nucleoporin p58/p45
       K14308  NUP54; nuclear pore complex protein Nup54
       K14309  NUP93; nuclear pore complex protein Nup93
       K14310  NUP205; nuclear pore complex protein Nup205
       K14311  NUP188; nuclear pore complex protein Nup188
       K14312  NUP155; nuclear pore complex protein Nup155
       K14313  NUP35, NUP53; nuclear pore complex protein Nup53
       K14314  NUP210, GP210; nuclear pore complex protein Nup210
       K14315  NDC1, TMEM48; nucleoporin NDC1
       K14316  POM121, NUP121; nuclear pore complex protein Nup121
       K14317  NUP214, CAN; nuclear pore complex protein Nup214
       K14318  NUP88; nuclear pore complex protein Nup88
       K12172  RANBP2, NUP358; E3 SUMO-protein ligase RanBP2
       K14319  RANGAP1; Ran GTPase-activating protein 1
       K10577  UBE2I, UBC9; ubiquitin-conjugating enzyme E2 I [EC:6.3.2.19]
       K12160  SUMO, SMT3; small ubiquitin-related modifier
       K14320  AAAS; aladin
       K14321  NUPL2, CG1; nucleoporin-like protein 2
       K13129  SMN; survival motor neuron protein
       K13130  SIP1, GEMIN2; survival of motor neuron protein-interacting protein 1
       K13131  DDX20, GEMIN3; ATP-dependent RNA helicase DDX20 [EC:3.6.4.13]
       K13132  GEMIN4; gem associated protein 4
       K13133  GEMIN5; gem associated protein 5
       K13134  GEMIN6, SIP2; gem associated protein 6
       K13135  GEMIN7, SIP3; gem associated protein 7
       K13136  GEMIN8; gem associated protein 8
       K13137  STRAP, UNRIP; serine-threonine kinase receptor-associated protein
       K03245  EIF3J; translation initiation factor 3 subunit J
       K03246  EIF3I; translation initiation factor 3 subunit I
       K03247  EIF3H; translation initiation factor 3 subunit H
       K03248  EIF3G; translation initiation factor 3 subunit G
       K03249  EIF3F; translation initiation factor 3 subunit F
       K03250  EIF3E, INT6; translation initiation factor 3 subunit E
       K03251  EIF3D; translation initiation factor 3 subunit D
       K03252  EIF3C; translation initiation factor 3 subunit C
       K03253  EIF3B; translation initiation factor 3 subunit B
       K03254  EIF3A; translation initiation factor 3 subunit A
       K03236  EIF1A; translation initiation factor 1A
       K03113  EIF1, SUI1; translation initiation factor 1
       K03262  EIF5; translation initiation factor 5
       K03237  EIF2S1; translation initiation factor 2 subunit 1
       K03238  EIF2S2; translation initiation factor 2 subunit 2
       K03242  EIF2S3; translation initiation factor 2 subunit 3
       K03239  EIF2B1; translation initiation factor eIF-2B subunit alpha
       K03754  EIF2B2; translation initiation factor eIF-2B subunit beta
       K03680  EIF2B4; translation initiation factor eIF-2B subunit delta
       K03241  EIF2B3; translation initiation factor eIF-2B subunit gamma
       K03240  EIF2B5; translation initiation factor eIF-2B subunit epsilon
       K03243  EIF5B; translation initiation factor 5B
       K03260  EIF4G; translation initiation factor 4G
       K03259  EIF4E; translation initiation factor 4E
       K03257  EIF4A; translation initiation factor 4A
       K03258  EIF4B; translation initiation factor 4B
       K13126  PABPC; polyadenylate-binding protein
       K14322  PAIP1; polyadenylate-binding protein-interacting protein 1
       K07205  EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1
       K14283  TACC3, maskin; transforming acidic coiled-coil-containing protein 3
       K05749  CYFIP; cytoplasmic FMR1 interacting protein
       K15516  FMR; fragile X mental retardation protein
       K12876  RBM8A, Y14; RNA-binding protein 8A
       K12877  MAGOH; protein mago nashi
       K14323  CASC3, MLN51; protein CASC3
       K13025  EIF4A3, FAL1; ATP-dependent RNA helicase [EC:3.6.4.13]
       K14324  SAP18; histone deacetylase complex subunit SAP18
       K13114  PNN; pinin
       K12875  ACIN1, ACINUS; apoptotic chromatin condensation inducer in the nucleus
       K14325  RNPS1; RNA-binding protein with serine-rich domain 1
       K12881  THOC4, ALY; THO complex subunit 4
       K12812  UAP56, BAT1, SUB2; ATP-dependent RNA helicase UAP56/SUB2 [EC:3.6.4.13]
       K12878  THOC1; THO complex subunit 1
       K12879  THOC2; THO complex subunit 2
       K13174  THOC5; THO complex subunit 5
       K13175  THOC6; THO complex subunit 6
       K13176  THOC7; THO complex subunit 7
       K12880  THOC3; THO complex subunit 3
       K13171  SRRM1, SRM160; serine/arginine repetitive matrix protein 1
       K14284  NXF1_2, TAP; nuclear RNA export factor 1/2
       K14285  NXT1_2, P15; NTF2-related export protein 1/2
       K14543  MTR2; mRNA transport regulator MTR2
       K14326  UPF1, RENT1; regulator of nonsense transcripts 1 [EC:3.6.4.-]
       K14327  UPF2, RENT2; regulator of nonsense transcripts 2
       K14328  UPF3, RENT3; regulator of nonsense transcripts 3
       K14276  U1snRNA; U1 spliceosomal RNA
       K14277  U2snRNA; U2 spliceosomal RNA
       K14278  U4snRNA; U4 spliceosomal RNA
       K14279  U5snRNA; U5 spliceosomal RNA
       K14280  U6snRNA; U6 spliceosomal RNA
       K14483  U3snoRNA, snR17; U3 small nucleolar RNA
     03015 mRNA surveillance pathway [PATH:ko03015]
     03008 Ribosome biogenesis in eukaryotes [PATH:ko03008]
     03009 Ribosome biogenesis [BR:ko03009]
     03029 Mitochondrial biogenesis [BR:ko03029]
     03012 Translation factors [BR:ko03012]
 
   Folding, sorting and degradation
 
   Replication and repair
 
   RNA family
 
 Environmental Information Processing
 
 Cellular Processes
 
 Organismal Systems
 
 Human Diseases
 
   Cancers
 
   Immune diseases
 
   Neurodegenerative diseases
 
   Substance dependence
 
   Cardiovascular diseases
 
   Endocrine and metabolic diseases
 
   Infectious diseases
     05110 Vibrio cholerae infection [PATH:ko05110]
     05111 Vibrio cholerae pathogenic cycle [PATH:ko05111]
     05120 Epithelial cell signaling in Helicobacter pylori infection [PATH:ko05120]
     05130 Pathogenic Escherichia coli infection [PATH:ko05130]
     05132 Salmonella infection [PATH:ko05132]
     05131 Shigellosis [PATH:ko05131]
     05133 Pertussis [PATH:ko05133]
     05134 Legionellosis [PATH:ko05134]
     05150 Staphylococcus aureus infection [PATH:ko05150]
     05152 Tuberculosis [PATH:ko05152]
     05100 Bacterial invasion of epithelial cells [PATH:ko05100]
     05166 HTLV-I infection [PATH:ko05166]
     05162 Measles [PATH:ko05162]
     05164 Influenza A [PATH:ko05164]
       K01312  PRSS; trypsin [EC:3.4.21.4]
       K09633  TMPRSS2; transmembrane protease, serine 2
       K09635  TMPRSS4; transmembrane protease, serine 4
       K14216  OAS; 2'-5'-oligoadenylate synthetase
       K01165  RNASEL; ribonuclease L
       K09507  DNAJB1; DnaJ homolog subfamily B member 1
       K09523  DNAJC3; DnaJ homolog subfamily C member 3
       K03283  HSPA1_8; heat shock 70kDa protein 1/8
       K16194  EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 [EC:2.7.11.1]
       K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2 [EC:2.7.11.1]
       K08860  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [EC:2.7.11.1]
       K16196  EIF2AK4; eukaryotic translation initiation factor 2-alpha kinase 4 [EC:2.7.11.1]
       K03237  EIF2S1; translation initiation factor 2 subunit 1
       K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3 [EC:2.7.12.2]
       K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6 [EC:2.7.12.2]
       K04441  P38; p38 MAP kinase [EC:2.7.11.24]
       K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]
       K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7 [EC:2.7.12.2]
       K04440  JNK; c-Jun N-terminal kinase [EC:2.7.11.24]
       K04448  JUN; transcription factor AP-1
       K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
       K12646  DDX58, RIG-I; ATP-dependent RNA helicase DDX58 [EC:3.6.3.14]
       K12647  IFIH1, MDA5; interferon-induced helicase C domain-containing protein 1 [EC:3.6.4.13]
       K12648  MAVS, IPS1; mitochondrial antiviral-signaling protein
       K12653  NLRX1; NLR family member X1
       K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
       K02581  NFKBIB; NF-kappa-B inhibitor beta
       K04734  NFKBIA; NF-kappa-B inhibitor alpha
       K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
       K04735  RELA; transcription factor p65
       K10652  TRIM25, EFP; tripartite motif-containing protein 25 [EC:6.3.2.19]
       K05401  TLR3; toll-like receptor 3
       K05842  TRIF; toll-like receptor adapter molecule 1
       K05410  TBK1; TANK-binding kinase 1 [EC:2.7.11.10]
       K07211  IKBKE, IKKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [EC:2.7.11.10]
       K05411  IRF3; interferon regulatory factor 3
       K04498  EP300, CREBBP, KAT3; E1A/CREB-binding protein [EC:2.3.1.48]
       K02649  PIK3R; phosphoinositide-3-kinase, regulatory subunit
       K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
       K04456  AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
       K10160  TLR4; toll-like receptor 4
       K05404  TLR7; toll-like receptor 7
       K04729  MYD88; myeloid differentiation primary response protein MyD88
       K04733  IRAK4; interleukin-1 receptor-associated kinase 4 [EC:2.7.11.1]
       K09447  IRF7; interferon regulatory factor 7
       K04383  IL1A; interleukin 1 alpha
       K04519  IL1B; interleukin 1 beta
       K05405  IL6; interleukin 6
       K05406  IL12A; interleukin 12A
       K05425  IL12B; interleukin 12B
       K03156  TNFA; tumor necrosis factor superfamily, member 2
       K10030  IL8, CXCL8; interleukin 8
       K14624  CCL2, MCP1; C-C motif chemokine 2
       K12499  CCL5; C-C motif chemokine 5
       K12671  CXCL10, IP10; C-X-C motif chemokine 10
       K06490  ICAM1; intercellular adhesion molecule 1
       K05414  IFNA; interferon alpha
       K05415  IFNB; interferon beta
       K05130  IFNAR1; interferon receptor 1
       K05131  IFNAR2; interferon receptor 2
       K11217  JAK1; Janus kinase 1 [EC:2.7.10.2]
       K11219  TYK2; non-receptor tyrosine-protein kinase TYK2 [EC:2.7.10.2]
       K11220  STAT1; signal transducer and activator of transcription 1
       K11221  STAT2; signal transducer and activator of transcription 2
       K04693  IRF9, ISGF3G, P48; interferon regulatory factor 9
       K04696  SOCS3, CIS3; suppressor of cytokine signaling 3
       K14754  MX1; interferon-induced GTP-binding protein Mx1
       K12968  ADAR, ADAR1; double-stranded RNA-specific adenosine deaminase [EC:3.5.4.37]
       K10054  PML, TRIM19; probable transcription factor PML
       K04687  IFNG; interferon gamma
       K05132  IFNGR1, CD119; interferon gamma receptor 1
       K05133  IFNGR2; interferon gamma receptor 2
       K04447  JAK2; Janus kinase 2 [EC:2.7.10.2]
       K08060  CIITA; class II, major histocompatibility complex, transactivator
       K06752  MHC2; major histocompatibility complex, class II
       K12800  NLRP3, PYPAF1; NACHT, LRR and PYD domains-containing protein 3
       K12799  PYCARD, ASC; apoptosis-associated speck-like protein containing a CARD
       K01370  CASP1; caspase 1 [EC:3.4.22.36]
       K05482  IL18, IL1F4; interleukin 18
       K12967  IL33; interleukin 33
       K04721  TNFSF10, TRAIL; tumor necrosis factor ligand superfamily member 10
       K04722  TNFRSF10, TRAILR; tumor necrosis factor receptor superfamily member 10
       K04389  TNFSF6, FASL; tumor necrosis factor ligand superfamily member 6
       K04390  TNFRSF6, FAS; tumor necrosis factor receptor superfamily member 6
       K03158  TNFRSF1A, TNFR1; tumor necrosis factor receptor superfamily member 1A
       K05862  VDAC1; voltage-dependent anion channel protein 1
       K08738  CYC; cytochrome c
       K04399  CASP9; caspase 9 [EC:3.4.22.62]
       K03083  GSK3B; glycogen synthase kinase 3 beta [EC:2.7.11.26]
       K15042  KPNA1; importin subunit alpha-1
       K15043  KPNA2; importin subunit alpha-2
       K12812  UAP56, BAT1, SUB2; ATP-dependent RNA helicase UAP56/SUB2 [EC:3.6.4.13]
       K14290  XPO1, CRM1; exportin-1
       K15044  AGFG1; Arf-GAP domain and FG repeats-containing protein 1
       K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
       K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
       K04371  MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
       K15045  RSAD2; radical S-adenosyl methionine domain-containing protein 2
       K00787  FDPS; farnesyl diphosphate synthase [EC:2.5.1.1 2.5.1.10]
       K05692  ACTB_G1; actin beta/gamma 1
       K15046  NS1BP; influenza virus NS1A-binding protein
       K14404  CPSF4, YTH1; cleavage and polyadenylation specificity factor subunit 4
       K14396  PABPN1, PABP2; polyadenylate-binding protein 2
       K14284  NXF1_2, TAP; nuclear RNA export factor 1/2
       K14285  NXT1_2, P15; NTF2-related export protein 1/2
       K14298  RAE1; mRNA export factor
       K15047  HNRNPUL1, E1BAP5; heterogeneous nuclear ribonucleoprotein U-like protein 1
       K14297  NUP98, ADAR2; nuclear pore complex protein Nup98-Nup96
       K01349  FURIN, PCSK3; furin [EC:3.4.21.75]
       K09643  TMPRSS13, TMPRSS11; transmembrane protease, serine 13
       K01315  PLG; plasminogen [EC:3.4.21.7]
     05161 Hepatitis B [PATH:ko05161]
     05160 Hepatitis C [PATH:ko05160]
     05168 Herpes simplex infection [PATH:ko05168]
     05169 Epstein-Barr virus infection [PATH:ko05169]
     05146 Amoebiasis [PATH:ko05146]
     05144 Malaria [PATH:ko05144]
     05145 Toxoplasmosis [PATH:ko05145]
     05140 Leishmaniasis [PATH:ko05140]
     05142 Chagas disease (American trypanosomiasis) [PATH:ko05142]
     05143 African trypanosomiasis [PATH:ko05143]
 
   Drug resistance

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Last updated: September 22, 2014