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 1. Oxidoreductases
 2. Transferases
 3. Hydrolases
   3.1  Acting on ester bonds
     3.1.1  Carboxylic-ester hydrolases
     3.1.2  Thioester hydrolases
     3.1.3  Phosphoric-monoester hydrolases  alkaline phosphatase  acid phosphatase  phosphoserine phosphatase  phosphatidate phosphatase  5'-nucleotidase  3'-nucleotidase  3'(2'),5'-bisphosphate nucleotidase  3-phytase  glucose-6-phosphatase  glucose-1-phosphatase  fructose-bisphosphatase  trehalose-phosphatase  bisphosphoglycerate phosphatase  methylphosphothioglycerate phosphatase  histidinol-phosphatase  protein-serine/threonine phosphatase  [phosphorylase] phosphatase  phosphoglycolate phosphatase  glycerol-2-phosphatase  phosphoglycerate phosphatase  glycerol-1-phosphatase  mannitol-1-phosphatase  sugar-phosphatase  sucrose-phosphate phosphatase  inositol-phosphate phosphatase  4-phytase  phosphatidylglycerophosphatase  ADP-phosphoglycerate phosphatase  N-acylneuraminate-9-phosphatase  nucleotidase  polynucleotide 3'-phosphatase  polynucleotide 5'-phosphatase  deoxynucleotide 3'-phosphatase  thymidylate 5'-phosphatase  phosphoinositide 5-phosphatase  sedoheptulose-bisphosphatase  3-phosphoglycerate phosphatase  streptomycin-6-phosphatase  guanidinodeoxy-scyllo-inositol-4-phosphatase  4-nitrophenylphosphatase  [glycogen-synthase-D] phosphatase  [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase  [acetyl-CoA carboxylase]-phosphatase  3-deoxy-manno-octulosonate-8-phosphatase  fructose-2,6-bisphosphate 2-phosphatase  [hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase  protein-tyrosine-phosphatase
         K01104  E3.1.3.48; protein-tyrosine phosphatase [EC:]
         K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:]
         K02555  MIH1; M-phase inducer tyrosine phosphatase [EC:]
         K04458  PTPRR; receptor-type tyrosine-protein phosphatase R [EC:]
         K04459  DUSP, MKP; dual specificity MAP kinase phosphatase [EC:]
         K05693  PTPRM; receptor-type tyrosine-protein phosphatase mu [EC:]
         K05694  PTPRB, PTPB; receptor-type tyrosine-protein phosphatase beta [EC:]
         K05695  PTPRF, LAR; receptor-type tyrosine-protein phosphatase F [EC:]
         K05696  PTPN1, PTP1B; tyrosine-protein phosphatase non-receptor type 1 [EC:]
         K05697  PTPN6, SHP-1; tyrosine-protein phosphatase non-receptor type 6 [EC:]
         K05698  PTPRJ, DEP1; receptor-type tyrosine-protein phosphatase eta [EC:]
         K05766  SSH; protein phosphatase slingshot [EC:]
         K05866  CDC25B; M-phase inducer phosphatase 2 [EC:]
         K05867  CDC25C; M-phase inducer phosphatase 3 [EC:]
         K06478  PTPRC, CD45; receptor-type tyrosine-protein phosphatase C [EC:]
         K06639  CDC14; cell division cycle 14 [EC:]
         K06645  CDC25A; M-phase inducer phosphatase 1 [EC:]
         K06776  PTPRK; receptor-type tyrosine-protein phosphatase kappa [EC:]
         K06777  PTPRD; receptor-type tyrosine-protein phosphatase delta [EC:]
         K06778  PTPRS; receptor-type tyrosine-protein phosphatase S [EC:]
         K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11 [EC:]
         K07817  PTPRN; receptor-type tyrosine-protein phosphatase N [EC:]
         K08114  PTPRZ; receptor-type tyrosine-protein phosphatase zeta [EC:]
         K11240  MSG5; tyrosine-protein phosphatase [EC:]
         K13297  PTPRT; receptor-type tyrosine-protein phosphatase T [EC:]
         K14165  K14165; atypical dual specificity phosphatase [EC:]
         K14167  CDKN3, KAP; cyclin-dependent kinase inhibitor 3 [EC:]
         K14394  ACP1; low molecular weight phosphotyrosine protein phosphatase [EC:]
         K14819  DUSP12, YVH1; dual specificity phosphatase 12 [EC:]
         K15616  EYA1; eyes absent homolog 1 [EC:]
         K16662  PTPRU; receptor-type tyrosine-protein phosphatase U [EC:]
         K16667  PTPRG; receptor-type tyrosine-protein phosphatase gamma [EC:]
         K16723  STG; M-phase inducer phosphatase [EC:]
         K16910  PTPRQ; receptor-type tyrosine-protein phosphatase Q [EC:]
         K17614  DUSP3, VHR; dual specificity phosphatase 3 [EC:]
         K17619  MDP1; magnesium-dependent phosphatase 1 [EC: 3.1.3.-]
         K17620  EYA2; eyes absent homolog 2 [EC:]
         K17621  EYA3; eyes absent homolog 3 [EC:]
         K17622  EYA4; eyes absent homolog 4 [EC:]
         K18018  PTPN5; tyrosine-protein phosphatase non-receptor type 5 [EC:]
         K18019  PTPN7; tyrosine-protein phosphatase non-receptor type 7 [EC:]
         K18024  PTPN12_18_22; tyrosine-protein phosphatase non-receptor type 12/18/22 [EC:]
         K18025  PTPN14_21; tyrosine-protein phosphatase non-receptor type 14/21 [EC:]
         K18026  PTPN2, PTPT; tyrosine-protein phosphatase non-receptor type 2 [EC:]
         K18027  PTPN3, PTPH1; tyrosine-protein phosphatase non-receptor type 3 [EC:]
         K18032  PTPRA; receptor-type tyrosine-protein phosphatase A [EC:]
         K18033  PTPRE; receptor-type tyrosine-protein phosphatase epsilon [EC:]
         K18034  PTPRH, SAP1; receptor-type tyrosine-protein phosphatase H [EC:]
         K18035  PTPRO; receptor-type tyrosine-protein phosphatase O [EC:]
         K18036  PTPRV, ESP; receptor-type tyrosine-protein phosphatase V [EC:]
         K18037  PTPN4, MEG; tyrosine-protein phosphatase non-receptor type 4 [EC:]
         K18038  PTPN9, MEG2; tyrosine-protein phosphatase non-receptor type 9 [EC:]
         K18039  PTPN20; tyrosine-protein phosphatase non-receptor type 20 [EC:]
         K18040  PTPN23; tyrosine-protein phosphatase non-receptor type 23 [EC:]
         K18041  PTP4A; protein tyrosine phosphatase type IVA [EC:]
         K18043  OCA1; tyrosine-protein phosphatase OCA1 [EC:]
         K18045  SIW14, OCA3; tyrosine-protein phosphatase SIW14 [EC:]
         K18046  OCA6; tyrosine-protein phosphatase OCA6 [EC:]
         K18065  CDC25; Cdc25 family phosphatase [EC: 1.20.4.-]
         K18082  MTMR3_4, ZFYVE10_11; myotubularin-related protein 3/4 [EC:]
         K18498  DUSP9, MKP4; dual specificity phosphatase 9 [EC:]
         K18993  UBASH3, STS; ubiquitin-associated and SH3 domain-containing protein [EC:]
         K19269  PGP, PGLP; phosphoglycolate phosphatase [EC:]  [pyruvate kinase]-phosphatase  sorbitol-6-phosphatase  dolichyl-phosphatase  [3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)]-phosphatase  [myosin-light-chain] phosphatase  fructose-2,6-bisphosphate 6-phosphatase  caldesmon-phosphatase  inositol-polyphosphate 5-phosphatase  inositol-1,4-bisphosphate 1-phosphatase  sugar-terminal-phosphatase  alkylacetylglycerophosphatase  phosphoenolpyruvate phosphatase  multiple inositol-polyphosphate phosphatase  2-carboxy-D-arabinitol-1-phosphatase  phosphatidylinositol-3-phosphatase  phosphatidylinositol-3,4-bisphosphate 4-phosphatase  phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase  2-deoxyglucose-6-phosphatase  glucosylglycerol 3-phosphatase  mannosyl-3-phosphoglycerate phosphatase  2-phosphosulfolactate phosphatase  5-phytase  adenosylcobalamin/alpha-ribazole phosphatase  pyridoxal phosphatase  phosphoethanolamine/phosphocholine phosphatase  lipid-phosphate phosphatase  acireductone synthase  phosphatidylinositol-4,5-bisphosphate 4-phosphatase  mannosylfructose-phosphate phosphatase  2,3-bisphosphoglycerate 3-phosphatase  diacylglycerol diphosphate phosphatase  D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase  D-glycero-alpha-D-manno-heptose 1,7-bisphosphate 7-phosphatase  ADP-ribose 1''-phosphate phosphatase  glucosyl-3-phosphoglycerate phosphatase  phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase  2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase  5''-phosphoribostamycin phosphatase  5'-deoxynucleotidase  maltose 6'-phosphate phosphatase  7-methylguanosine nucleotidase  kanosamine-6-phosphate phosphatase  L-galactose 1-phosphate phosphatase  D-galactose 1-phosphate phosphatase  phosphatidylinositol-3,5-bisphosphate 3-phosphatase  pseudouridine 5'-phosphatase  3',5'-nucleoside bisphosphate phosphatase
     3.1.4  Phosphoric-diester hydrolases
     3.1.5  Triphosphoric-monoester hydrolases
     3.1.6  Sulfuric-ester hydrolases
     3.1.7  Diphosphoric-monoester hydrolases
     3.1.8  Phosphoric-triester hydrolases
     3.1.11  Exodeoxyribonucleases producing 5'-phosphomonoesters
     3.1.12  Exodeoxyribonucleases producing 3'-phosphomonoesters
     3.1.13  Exoribonucleases producing 5'-phosphomonoesters
     3.1.14  Exoribonucleases producing 3'-phosphomonoesters
     3.1.15  Exonucleases that are active with either ribo- or deoxyribonucleic acids and produce 5'-phosphomonoesters
     3.1.16  Exonucleases that are active with either ribo- or deoxyribonucleic acids and produce 3'-phosphomonoesters
     3.1.21  Endodeoxyribonucleases producing 5'-phosphomonoesters
     3.1.22  Endodeoxyribonucleases producing 3'-phosphomonoesters
     3.1.25  Site-specific endodeoxyribonucleases that are specific for altered bases
     3.1.26  Endoribonucleases producing 5'-phosphomonoesters
     3.1.27  Endoribonucleases producing 3'-phosphomonoesters
     3.1.30  Endoribonucleases that are active with either ribo- or deoxyribonucleic acids and produce 5'-phosphomonoesters
     3.1.31  Endoribonucleases that are active with either ribo- or deoxyribonucleic acids and produce 3'-phosphomonoesters
     3.1.-  Acting on ester bonds
   3.2  Glycosylases
   3.3  Acting on ether bonds
   3.4  Acting on peptide bonds (peptidases)
   3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.6  Acting on acid anhydrides
   3.7  Acting on carbon-carbon bonds
   3.8  Acting on halide bonds
   3.9  Acting on phosphorus-nitrogen bonds
   3.10  Acting on sulfur-nitrogen bonds
   3.11  Acting on carbon-phosphorus bonds
   3.12  Acting on sulfur-sulfur bonds
   3.13  Acting on carbon-sulfur bonds
 4. Lyases
 5. Isomerases
 6. Ligases