 1. Oxidoreductases
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2. Transferases
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3. Hydrolases
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 4. Lyases
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4.1 Carbon-carbon lyases
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4.2 Carbon-oxygen lyases
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4.3 Carbon-nitrogen lyases
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4.4 Carbon-sulfur lyases
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4.5 Carbon-halide lyases
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4.6 Phosphorus-oxygen lyases
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4.6.1 Phosphorus-oxygen lyases (only sub-subclass identified to date)
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4.6.1.1 adenylate cyclase
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 K01768 E4.6.1.1; adenylate cyclase [EC:4.6.1.1]
K05851 cyaA; adenylate cyclase, class 1 [EC:4.6.1.1]
K05873 cyaB; adenylate cyclase, class 2 [EC:4.6.1.1]
K08041 ADCY1; adenylate cyclase 1 [EC:4.6.1.1]
K08042 ADCY2; adenylate cyclase 2 [EC:4.6.1.1]
K08043 ADCY3; adenylate cyclase 3 [EC:4.6.1.1]
K08044 ADCY4; adenylate cyclase 4 [EC:4.6.1.1]
K08045 ADCY5; adenylate cyclase 5 [EC:4.6.1.1]
K08046 ADCY6; adenylate cyclase 6 [EC:4.6.1.1]
K08047 ADCY7; adenylate cyclase 7 [EC:4.6.1.1]
K08048 ADCY8; adenylate cyclase 8 [EC:4.6.1.1]
K08049 ADCY9; adenylate cyclase 9 [EC:4.6.1.1]
K11029 cyaA; anthrax edema toxin adenylate cyclase [EC:4.6.1.1]
K11265 ADCY10; adenylate cyclase 10 [EC:4.6.1.1]
K22944 cyaA; bifunctional hemolysin/adenylate cyclase [EC:4.6.1.1]
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4.6.1.2 guanylate cyclase
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4.6.1.6 cytidylate cyclase
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4.6.1.12 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
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4.6.1.13 phosphatidylinositol diacylglycerol-lyase
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4.6.1.14 glycosylphosphatidylinositol diacylglycerol-lyase
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4.6.1.15 FAD-AMP lyase (cyclizing)
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4.6.1.16 tRNA-intron lyase
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4.6.1.17 cyclic pyranopterin monophosphate synthase
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4.6.1.18 pancreatic ribonuclease
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4.6.1.19 ribonuclease T2
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4.6.1.20 ribonuclease U2
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4.6.1.21 Enterobacter ribonuclease
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4.6.1.22 Bacillus subtilis ribonuclease
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4.6.1.23 ribotoxin
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4.6.1.24 ribonuclease T1
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4.6.1.25 bacteriophage T4 restriction endoribonuclease RegB
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4.6.1.26 uridylate cyclase
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4.7 carbon-phosphorus lyases
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4.8 Nitrogen-oxygen lyases
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4.98 ATP-independent chelatases
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4.99 Other lyases
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5. Isomerases
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6. Ligases
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7. Translocases
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Enzymes