 1. Oxidoreductases
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2. Transferases
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3. Hydrolases
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4. Lyases
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5. Isomerases
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 6. Ligases
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6.1 Forming carbon-oxygen bonds
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6.2 Forming carbon-sulfur bonds
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6.3 Forming carbon-nitrogen bonds
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6.4 Forming carbon-carbon bonds
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6.5 Forming phosphoric-ester bonds
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6.5.1 Ligases that form phosphoric-ester bonds (only sub-subclass identified to date)
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6.5.1.1 DNA ligase (ATP)
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 K01971 E6.5.1.1, lig; DNA ligase (ATP) [EC:6.5.1.1]
K07468 K07468; putative ATP-dependent DNA ligase [EC:6.5.1.1]
K10747 LIG1; DNA ligase 1 [EC:6.5.1.1]
K10776 LIG3; DNA ligase 3 [EC:6.5.1.1]
K10777 LIG4, DNL4; DNA ligase 4 [EC:6.5.1.1]
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6.5.1.2 DNA ligase (NAD+)
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6.5.1.3 RNA ligase (ATP)
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6.5.1.4 RNA-3'-phosphate cyclase
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6.5.1.-
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6.6 Forming nitrogen-D-metal bonds
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6.-
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Enzymes