Protein Phosphatases and Associated Proteins

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 Protein serine/threonine phosphatases
   Phosphoprotein phosphatases (PPPs)
     Protein phosphatase-1
       Catalytic subunits
       PP1-interacting proteins (PIPs)
         K08050  PPP1R1A; protein phosphatase 1 regulatory subunit 1A
         K15494  PPP1R1B, DARPP32; protein phosphatase 1 regulatory subunit 1B
         K17549  PPP1R1C; protein phosphatase 1 regulatory subunit 1C
         K16833  PPP1R2, IPP2; protein phosphatase inhibitor 2
         K07189  PPP1R3; protein phosphatase 1 regulatory subunit 3A/B/C/D/E
         K17453  PPP1R3F, R3F; protein phosphatase 1 regulatory subunit 3F
         K17550  PPP1R7, SDS22; protein phosphatase 1 regulatory subunit 7
         K13216  PPP1R8, NIPP1; nuclear inhibitor of protein phosphatase 1 [EC:3.1.4.-]
         K17551  PPP1R9; neurabin
         K17552  PPP1R10; protein phosphatase 1 regulatory subunit 10
         K17553  PPP1R11; protein phosphatase 1 regulatory subunit 11
         K06270  PPP1R12A, MYPT1; protein phosphatase 1 regulatory subunit 12A
         K12329  PPP1R12B, MYPT2; protein phosphatase 1 regulatory subunit 12B
         K17457  PPP1R12C, MBS85; protein phosphatase 1 regulatory subunit 12C
         K16823  TP53BP2, ASPP2; apoptosis-stimulating of p53 protein 2
         K17554  PPP1R13B, ASPP1; apoptosis-stimulating of p53 protein 1
         K12328  PPP1R14A, CPI17; protein phosphatase 1 regulatory subunit 14A
         K17555  PPP1R14B; protein phosphatase 1 regulatory subunit 14B
         K17556  PPP1R14C, KEPI; protein phosphatase 1 regulatory subunit 14C
         K17557  PPP1R14D, GBPI; protein phosphatase 1 regulatory subunit 14D
         K14019  PPP1R15A, GADD34; protein phosphatase 1 regulatory subunit 15A
         K17558  PPP1R15B, CREP; protein phosphatase 1 regulatory subunit 15B
         K17458  PPP1R16A, MYPT3; protein phosphatase 1 regulatory subunit 16A
         K17459  PPP1R16B, TIMAP; protein phosphatase 1 regulatory inhibitor subunit 16B
         K08067  PPP1R17, GSBS; protein phosphatase 1 regulatory subunit 17
         K17559  PPP1R18; phostensin
         K17560  URI1; unconventional prefoldin RPB5 interactor 1
         K17561  CCDC8; coiled-coil domain-containing protein 8
         K17562  PPP1R21, CCDC128, KLRAQ1; protein phosphatase 1 regulatory subunit 21
         K17563  CHCHD3; MICOS complex subunit MIC19
         K17564  CHCHD6; MICOS complex subunit MIC25
         K17495  CSMD; CUB and sushi domain-containing protein
         K14806  DDX31, DBP7; ATP-dependent RNA helicase DDX31/DBP7 [EC:3.6.4.13]
         K17565  PPP1R26; protein phosphatase 1 regulatory subunit 26
         K17566  PPP1R27; protein phosphatase 1 regulatory subunit 27
         K17567  ELFN1; protein phosphatase 1 regulatory subunit 28
         K17568  ELFN2; protein phosphatase 1 regulatory subunit 29
         K17569  GPATCH2; G patch domain-containing protein 2
         K17570  HYDIN; hydrocephalus-inducing protein
         K17571  PPP1R32; protein phosphatase 1 regulatory subunit 32
         K17572  ARFGEF3, KEPI; brefeldin A-inhibited guanine nucleotide-exchange protein 3
         K17573  LKAP, MARF1; meiosis arrest female protein 1
         K17574  PPP1R35; protein phosphatase 1 regulatory subunit 35
         K17575  PPP1R36; protein phosphatase 1 regulatory subunit 36
         K17576  PPP1R37, LRRC68; protein phosphatase 1 regulatory subunit 37
         K17577  SH2D4A; SH2 domain-containing protein 4A
         K12171  SH3RF, POSH; E3 ubiquitin-protein ligase SH3RF [EC:2.3.2.27]
         K12018  TRIM42; tripartite motif-containing protein 42
         K17578  ZCCHC9; zinc finger CCHC domain-containing protein 9
         K17579  PPP1R42, LRRC67; protein phosphatase 1 regulatory subunit 42
         K16518  AKAP1; A-kinase anchor protein 1, mitochondrial
         K16527  AKAP11; A-kinase anchor protein 11
         K16551  AKAP9, AKAP350; A-kinase anchor protein 9
         K02085  APC; adenomatosis polyposis coli protein
         K11481  AURKA; aurora kinase A [EC:2.7.11.1]
         K11479  AURKB; aurora kinase B [EC:2.7.11.1]
         K02157  AXIN1; axin 1
         K02161  BCL2; apoptosis regulator Bcl-2
         K02163  BCLW; apoptosis regulator BCL-W
         K04570  BCL2L1, bcl-xL; Bcl-2-like 1 (apoptosis regulator Bcl-X)
         K10605  BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
         K17580  CASC1; cancer susceptibility candidate protein 1
         K11542  CASC5, KNL1; protein CASC5
         K04399  CASP9; caspase 9 [EC:3.4.22.62]
         K02186  CASP2; caspase 2 [EC:3.4.22.55]
         K12075  DLG2; discs large protein 2
         K21098  DLG3; discs large protein 3
         K13099  CD2BP2, PPP1R59; CD2 antigen cytoplasmic tail-binding protein 2
         K05867  CDC25C; M-phase inducer phosphatase 3 [EC:3.1.3.48]
         K11498  CENPE, KIF10; centromeric protein E
         K16725  CEP192; centrosomal protein CEP192
         K05016  CLCN7; chloride channel 7
         K17581  CNST; consortin
         K15502  ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
         K10642  DZIP3; E3 ubiquitin-protein ligase DZIP3 [EC:2.3.2.27]
         K03238  EIF2S2; translation initiation factor 2 subunit 2
         K15183  ELL; RNA polymerase II elongation factor ELL
         K04679  MADHIP, SARA; MAD, mothers against decapentaplegic interacting protein
         K11248  SH3GLB1; endophilin-B1
         K05725  PTK2, FAK; focal adhesion kinase 1 [EC:2.7.10.2]
         K17494  CSRNP; cysteine/serine-rich nuclear protein
         K08889  FER, TYK3; tyrosine-protein kinase Fer [EC:2.7.10.2]
         K17477  FARP1; FERM, RhoGEF and pleckstrin domain-containing protein 1
         K17478  FKBP15, WAFL; FK506-binding protein 15
         K03504  POLD3; DNA polymerase delta subunit 3
         K16198  YWHAG_H; 14-3-3 protein gamma/eta
         K04315  GPR12; G protein-coupled receptor 12
         K17479  GRXCR1; glutaredoxin domain-containing cysteine-rich protein 1
         K14966  HCFC1; host cell factor 1
         K11407  HDAC6; histone deacetylase 6 [EC:3.5.1.98]
         K09220  IKZF, ZNFN1A; IKAROS family zinc finger protein
         K06476  ITGA2B, CD41; integrin alpha 2B
         K04958  ITPR1; inositol 1,4,5-triphosphate receptor type 1
         K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
         K01251  AHCY, ahcY; adenosylhomocysteinase [EC:3.13.2.1]
         K11446  KDM5, JARID1; [histone H3]-trimethyl-L-lysine4 demethylase [EC:1.14.11.67]
         K04879  KCNA6, KV1.6; potassium voltage-gated channel Shaker-related subfamily A member 6
         K04920  KCNK10, K2P10.1; potassium channel subfamily K member 10
         K08898  LMTK2; lemur tyrosine kinase 2 [EC:2.7.10.1]
         K02932  RP-L5e, RPL5; large subunit ribosomal protein L5e
         K17480  AATK, LMTK1; lemur tyrosine kinase 1 [EC:2.7.10.1]
         K08899  LMTK3; lemur tyrosine kinase 3 [EC:2.7.10.1]
         K10429  MAP1; microtubule-associated protein 1
         K02210  MCM7, CDC47; DNA replication licensing factor MCM7 [EC:5.6.2.3]
         K04603  GRM1; metabotropic glutamate receptor 1
         K04608  GRM6; metabotropic glutamate receptor 6
         K04609  GRM7; metabotropic glutamate receptor 7
         K04610  GRM8; metabotropic glutamate receptor 8
         K17582  MKI67; antigen KI-67
         K14559  MPP10; U3 small nucleolar RNA-associated protein MPP10
         K10356  MYO1; myosin I
         K17481  MYO16; myosin XVI
         K04650  NCOR1, N-CoR; nuclear receptor co-repressor 1
         K20872  NEK2; serine/threonine-protein kinase Nek2 [EC:2.7.11.1]
         K04572  NEFL, NF-L; neurofilament light polypeptide
         K17493  CAMSAP; calmodulin-regulated spectrin-associated protein
         K05742  SLC9A1, NHE1; solute carrier family 9 (sodium/hydrogen exchanger), member 1
         K10951  SLC12A2, NKCC1; solute carrier family 12 (sodium/potassium/chloride transporter), member 2
         K17583  NOM1; nucleolar MIF4G domain-containing protein 1
         K06088  OCLN; occludin
         K04256  OPN3; c-opsin
         K02607  ORC5; origin recognition complex subunit 5
         K04237  PARD3; partitioning defective protein 3
         K17584  PCIF1; phosphorylated CTD-interacting factor 1
         K00850  pfkA, PFK; 6-phosphofructokinase 1 [EC:2.7.1.11]
         K17594  PHACTR; phosphatase and actin regulator
         K17586  PHRF1; PHD and RING finger domain-containing protein 1
         K06633  PKMYT; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase [EC:2.7.11.1]
         K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2 [EC:2.7.11.1]
         K17587  TMEM225; transmembrane protein 225
         K17588  PREX2; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein
         K15375  PLCL1, PRIP; inactive phospholipase C-like protein 1
         K16498  PCDHD1; protocadherin delta 1
         K13219  SFPQ, PSF; splicing factor, proline- and glutamine-rich
         K06618  RB1; retinoblastoma-associated protein
         K17589  RB1CC1; RB1-inducible coiled-coil protein 1
         K13192  RBM26; RNA-binding protein 26
         K17590  CDCA2; cell division cycle-associated protein 2
         K17591  RIMBP2; RIMS-binding protein 2
         K16550  RPGRIP1L; protein fantom
         K14849  RRP1; ribosomal RNA-processing protein 1
         K04961  RYR1; ryanodine receptor 1
         K17592  SACS; sacsin
         K17593  ANKRD42, SARP; ankyrin repeat domain-containing protein 42
         K12866  WBP11, NPWBP; WW domain-binding protein 11
         K11648  SMARCB1, SNF5, INI1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
         K13871  SLC7A14; solute carrier family 7 (cationic amino acid transporter), member 14
         K17595  SPATA2; spermatogenesis-associated protein 2
         K17596  SPOCD1; SPOC domain-containing protein 1
         K04703  SPRED; sprouty-related, EVH1 domain-containing protein
         K17482  SPZ1; spermatogenic leucine zipper protein 1
         K12900  SRSF10, FUSIP1; serine/arginine-rich splicing factor 10
         K17597  STAU; double-stranded RNA-binding protein Staufen
         K17598  SYTL; synaptotagmin-like protein
         K04380  MAPT, TAU; microtubule-associated protein tau
         K17599  TMEM132; transmembrane protein 132
         K12897  TRA2; transformer-2 protein
         K11796  TRPC4AP; Trpc4-associated protein
         K04968  TRPC5; transient receptor potential cation channel subfamily C member 5
         K07207  TSC2; tuberous sclerosis 2
         K16492  TSKS; testis-specific serine kinase substrate
         K17492  UBN; ubinuclein
         K08539  VDR, NR1I1; vitamin D3 receptor
         K17600  VPS54; vacuolar protein sorting-associated protein 54
         K17601  WDR81; WD repeat-containing protein 81
         K08867  WNK, PRKWNK; WNK lysine deficient protein kinase [EC:2.7.11.1]
         K17602  YLPM1; YLP motif-containing protein 1
         K10510  ZBTB38; zinc finger and BTB domain-containing protein 38
         K17603  ZFYVE1; zinc finger FYVE domain-containing protein 1
         K17604  ZSWIM3; zinc finger SWIM domain-containing protein 3
     Protein phosphatase-2 (PP2A)
     Calcineurin (PPP3/ PP2B)
     Protein phosphatase-4
     Protein phosphatase-5
     Protein phosphatase-6
     PPEF/PP7 protein phosphatases
   Mg2+- or Mn2+- dependent protein phosphatases (PPMs)
 
 Protein tyrosine phosphatases (PTPs)
 
 HAD phosphatases

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Last updated: December 3, 2020