DNA Repair and Recombination Proteins

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 Eukaryotic type
   SSBR (single strand breaks repair)
   DSBR (double strand breaks repair)
     HR (homologous recombination)
       MRN(MRX) complex
       BRCA1-core complex
       BRCA1-A complex
       BRCA1-B complex
       BRCA1-C complex
       BRCA complex
       RecA family proteins
       Rad52 family proteins
       Rad54 family proteins
       RecQ family DNA helicases
       Bloom's syndrome complex (BTR)
       RPA (replication factor A)
       Protein phosphatase 4
       AP-5 complex
       SMC5-SMC6 complex
       Other HR factors
         K10882  EME1, MMS4; crossover junction endonuclease EME1 [EC:3.1.22.-]
         K10883  EME2; crossover junction endonuclease EME2
         K20777  EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
         K08991  MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
         K10881  SHFM1, DSS1, RPN15; 26 proteasome complex subunit DSS1
         K10991  SWI5, SAE3; DNA repair protein Swi5/Sae3
         K10992  SFR1; Swi5-dependent recombination DNA repair protein 1
         K15078  SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
         K10484  BTBD12, SLX4; structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)
         K15079  SLX4; structure-specific endonuclease subunit SLX4
         K15338  GEN1, YEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
         K19026  SPG11; spatacsin
         K19027  ZFYVE26; zinc finger FYVE domain-containing protein 26
         K20778  RAD51AP1; RAD51-associated protein 1
         K11339  MORF4L1, MRG15, EAF3; mortality factor 4-like protein 1
         K22544  SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
         K22766  FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
         K22806  SPIDR; DNA repair-scaffolding protein
         K22810  FAM84B; protein FAM84B
         K23112  BRAT1; BRCA1-associated ATM activator 1
         K23456  CFAP410, C21ORF2; cilla- and flagella-associated protein
         K25065  HDGFL2; hepatoma-derived growth factor-related protein 2
         K25770  ZSWIM7, SWS1; zinc finger SWIM domain-containing protein 7
         K25771  SWSAP1; ATPase SWSAP1
         K25790  EMSY; BRCA2-interacting transcriptional repressor EMSY
         K25791  HSF2BP; heat shock factor 2-binding protein
         K26125  MMS22L; protein MMS22-like
         K09257  NFKBIL2; NF-kappa-B inhibitor-like protein 2
         K27262  BOD1L1; biorientation of chromosomes in cell division protein 1-like 1
         K27412  PARPBP; PCNA-interacting partner
         K22807  WRNexo; werner syndrome-like exonuclease [EC:3.1.11.-]
         K22685  WSS1; DNA-dependent metalloprotease WSS1 [EC:3.4.24.-]
         K26559  WHY1; single-stranded DNA-binding protein WHY1
         K26561  WHY2; single-stranded DNA-binding protein WHY2
         K26560  WHY3; single-stranded DNA-binding protein WHY3
         K14635  MPH1; ATP-dependent DNA helicase MPH1 [EC:5.6.2.4]
         K15080  SAW1; single-strand annealing weakened protein 1
         K26124  RTT101, CUL8; cullin 8
         K26122  MMS22; E3 ubiquitin-protein ligase substrate receptor MMS22
         K26123  MMS1; E3 ubiquitin-protein ligase linker protein MMS1
     NHEJ (non-homologous end-joining)
     FA (Fanconi anemia) pathway
     Other DSBR factors
   TLS (translesion DNA synthesis) factors
   Check point factors
   Other factors with a suspected DNA repair function
 
 Prokaryotic type

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Last updated: March 29, 2024