Ubiquitin System

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 Ubiquitins and Ubiquitin-like proteins
 
 Ubiquitin-activating enzymes (E1)
 
 Ubiquitin-conjugating enzymes (E2)
 
 Ubiquitin ligases (E3)
   HECT type E3
   U-box type E3
   single Ring-finger type E3
     BRE1 protein
     CBL protein
     SINA (Seven in absentia) proteins
     Ligand of Numb proteins
     March proteins
     MDM2/MDM4 proteins
     NFX1 proteins
     Pellino proteins
     Peripheral membrane proteins
     RBR proteins
     TRAF proteins
     TRIM/RBCC proteins
     UBR box proteins
     Other single Ring-finger type E3
       K10636  AMFR, GP78; autocrine motility factor receptor [EC:6.3.2.19]
       K10603  AIRE; autoimmune regulator
       K15684  BFAR; bifunctional apoptosis regulator
       K16060  BIRC2_3; baculoviral IAP repeat-containing protein 2/3
       K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
       K16061  BIRC7_8; baculoviral IAP repeat-containing protein 7/8
       K10632  BRAP; BRCA1-associated protein [EC:6.3.2.19]
       K10605  BRCA1; breast cancer type 1 susceptibility protein
       K15685  CBLL1; E3 ubiquitin-protein ligase Hakai [EC:6.3.2.19]
       K10639  CCNB1IP1, HEI10; E3 ubiquitin-protein ligase CCNP1IP1 [EC:6.3.2.19]
       K10644  CHFR; E3 ubiquitin-protein ligase CHFR [EC:6.3.2.19]
       K10643  CNOT4, NOT4, MOT2; CCR4-NOT transcription complex subunit 4 [EC:6.3.2.19]
       K06058  DTX; deltex
       K10642  DZIP3; E3 ubiquitin-protein ligase DZIP3 [EC:6.3.2.19]
       K10606  FANCL, PHF9; E3 ubiquitin-protein ligase FANCL [EC:6.3.2.19]
       K10641  LRSAM1; E3 ubiquitin-protein ligase LRSAM1 [EC:6.3.2.19]
       K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1 [EC:2.7.11.25]
       K15686  MEX3, RKHD; RNA-binding protein MEX3
       K10604  MGRN1; E3 ubiquitin-protein ligase MGRN1 [EC:6.3.2.19]
       K10645  MIB; E3 ubiquitin-protein ligase mind-bomb [EC:6.3.2.19]
       K15687  MKRN; E3 ubiquitin-protein ligase makorin [EC:6.3.2.19]
       K15688  MUL1; E3 ubiquitin-protein ligase MUL1 [EC:6.3.2.19]
       K10693  MYCBP2, PAM; E3 ubiquitin-protein ligase MYCBP2 [EC:6.3.2.19]
       K10637  MYLIP, MIR; E3 ubiquitin-protein ligase MYLIP [EC:6.3.2.19]
       K01931  NEUR; protein neuralized [EC:6.3.2.19]
       K15689  NEURL3, LINCR; E3 ubiquitin-protein ligase NEURL3 [EC:6.3.2.19]
       K10602  NHLRC1; E3 ubiquitin-protein ligase NHLRC1 [EC:6.3.2.19]
       K10633  PJA1; E3 ubiquitin-protein ligase Praja1 [EC:6.3.2.19]
       K10634  PJA2; E3 ubiquitin-protein ligase Praja2 [EC:6.3.2.19]
       K10627  RAD18; E3 ubiquitin-protein ligase RAD18 [EC:6.3.2.19]
       K10628  RAG1; V(D)J recombination-activating protein 1 [EC:6.3.2.19]
       K10144  RCHY1, PIRH2; RING finger and CHY zinc finger domain-containing protein 1 [EC:6.3.2.19]
       K15690  RC3H; RING finger and CCCH-type zinc finger domain-containing protein
       K10143  RFWD2, COP1; E3 ubiquitin-protein ligase RFWD2 [EC:6.3.2.19]
       K15691  RFWD3; E3 ubiquitin-protein ligase RFWD3 [EC:6.3.2.19]
       K10695  RNF1_2; E3 ubiquitin-protein ligase RNF1/2 [EC:6.3.2.19]
       K10666  RNF5; E3 ubiquitin-protein ligase RNF5 [EC:6.3.2.19]
       K10667  RNF8; E3 ubiquitin-protein ligase RNF8 [EC:6.3.2.19]
       K11980  RNF11; E3 ubiquitin-protein ligase RNF11
       K16271  RLIM, RNF12; E3 ubiquitin-protein ligase RLIM [EC:6.3.2.19]
       K15692  RNF13, RZF; E3 ubiquitin-protein ligase RNF13 [EC:6.3.2.19]
       K10640  RNF25, AO7; E3 ubiquitin-protein ligase RNF25 [EC:6.3.2.19]
       K15693  RNF26; RING finger protein 26
       K11981  RNF41, NRDP1; E3 ubiquitin-protein ligase NRDP1 [EC:6.3.2.19]
       K15694  RNF43; RING finger protein 43
       K15695  RNF103, KF1; E3 ubiquitin-protein ligase RNF103 [EC:6.3.2.19]
       K10635  RNF111; E3 ubiquitin-protein ligase Arkadia [EC:6.3.2.19]
       K15696  RNF113B; RING finger protein 113B
       K15697  RNF114; RING finger protein 114
       K11982  RNF115_126; E3 ubiquitin-protein ligase RNF115/126 [EC:6.3.2.19]
       K15698  RNF121; RING finger protein 121
       K15699  RNF122; RING finger protein 122
       K12169  KPC1, RNF123; Kip1 ubiquitination-promoting complex protein 1 [EC:6.3.2.19]
       K12170  RNF125; E3 ubiquitin-protein ligase RNF125 [EC:6.3.2.19]
       K10629  RNF128, GRAIL; E3 ubiquitin-protein ligase RNF128 [EC:6.3.2.19]
       K15701  RNF130, GOLIATH; E3 ubiquitin-protein ligase RNF130 [EC:6.3.2.19]
       K15702  RNF133; E3 ubiquitin-protein ligase RNF133 [EC:6.3.2.19]
       K16272  RNF135; E3 ubiquitin-protein ligase RNF135 [EC:6.3.2.19]
       K10668  RNF138; E3 ubiquitin-protein ligase RNF138 [EC:6.3.2.19]
       K15703  RNF139, TRC8; E3 ubiquitin-protein ligase RNF139 [EC:6.3.2.19]
       K15700  RNF146; E3 ubiquitin-protein ligase RNF146 [EC:6.3.2.19]
       K15704  RNF149; E3 ubiquitin-protein ligase RNF149 [EC:6.3.2.19]
       K15705  RNF152; E3 ubiquitin-protein ligase RNF152 [EC:6.3.2.19]
       K17821  RNF165; RING finger protein 165
       K17044  RNF166; RING finger protein 166
       K15706  RNF167; E3 ubiquitin-protein ligase RNF167 [EC:6.3.2.19]
       K15707  RNF170; RING finger protein 170
       K15708  RNF180; E3 ubiquitin-protein ligase RNF180 [EC:6.3.2.19]
       K11983  RNF182; E3 ubiquitin-protein ligase RNF182 [EC:6.3.2.19]
       K15709  RNF187; E3 ubiquitin-protein ligase RNF187 [EC:6.3.2.19]
       K11984  SART1, HAF, SNU66; U4/U6.U5 tri-snRNP-associated protein 1
       K15710  SHPRH; E3 ubiquitin-protein ligase SHPRH [EC:3.6.4.- 6.3.2.19]
       K12171  SH3RF, POSH; E3 ubiquitin-protein ligase SH3RF [EC:6.3.2.19]
       K15711  SMARCA3, HLTF; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A3 [EC:3.6.4.- 6.3.2.19]
       K10601  SYVN1, HRD1; E3 ubiquitin-protein ligase synoviolin [EC:6.3.2.19]
       K10631  TOPORS; E3 ubiquitin-protein ligase Topors [EC:6.3.2.19]
       K11985  TRAIP, TRIP; TRAF-interacting protein
       K15712  TTC3; E3 ubiquitin-protein ligase TTC3 [EC:6.3.2.19]
       K10638  UHRF1, NP95; E3 ubiquitin-protein ligase UHRF1 [EC:6.3.2.19]
       K15713  UHRF2, NIRF; E3 ubiquitin-protein ligase UHRF2 [EC:6.3.2.19]
       K15714  ZNF645; E3 ubiquitin-protein ligase ZNF645 [EC:6.3.2.19]
       K10694  ZNRF1_2; E3 ubiquitin-protein ligase ZNRF1/2 [EC:6.3.2.19]
       K16273  ZNRF3; E3 ubiquitin-protein ligase ZNRF3 [EC:6.3.2.19]
       K15715  ZNRF4; Zinc/RING finger protein 4
       K15716  ZSWIM2; E3 ubiquitin-protein ligase ZSWIM2 [EC:6.3.2.19]
       K16274  AIP2; E3 ubiquitin-protein ligase AIP2 [EC:6.3.2.19]
       K16275  BAH, NLA; E3 ubiquitin-protein ligase BAH [EC:6.3.2.19]
       K16276  K16276, BTS; zinc finger protein-like protein
       K16277  DRIP; E3 ubiquitin-protein ligase DRIP [EC:6.3.2.19]
       K16278  K16278, HOS1; E3 ubiquitin-protein ligase HOS1 [EC:6.3.2.19]
       K16279  KEG; E3 ubiquitin-protein ligase KEG [EC:2.7.11.1 6.3.2.19]
       K16280  RGLG; E3 ubiquitin-protein ligase RGLG [EC:6.3.2.19]
       K16281  RHA1; RING-H2 zinc finger protein RHA1
       K16282  RHA2; E3 ubiquitin-protein ligase RHA2 [EC:6.3.2.19]
       K16283  SDIR1; E3 ubiquitin-protein ligase SDIR1 [EC:6.3.2.19]
       K16284  SIS3; E3 ubiquitin-protein ligase SIS3 [EC:6.3.2.19]
       K16285  XERICO; RING/U-box domain-containing protein
       K16286  EL5; E3 ubiquitin-protein ligase EL5 [EC:6.3.2.19]
   UBL E3 ligases
   multi subunit Ring-finger type E3
 
 Deubiquitinating enzyme (DUB)

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Last updated: June 12, 2014