Cell Adhesion Molecules and Their Ligands

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     Ligand type
 1. Immunoglobulin Superfamily
   Immune system
   Neural system
     5/2 subfamily
     5/3 subfamily
     6/5 subfamily
     6/4 subfamily
     4/6 subfamily
     10/6 subfamily
     6/13 subfamily
     1/1 subfamily
     N/0 subfamily
     Enzymatic CD
       FGFR1; fibroblast growth factor receptor 1 [KO:K04362]
       FGFR2; fibroblast growth factor receptor 2 [KO:K05093]
       FGFR3; fibroblast growth factor receptor [KO:K05094]
       FGFR4; fibroblast growth factor receptor 4 [KO:K05095]
       PDGFRA; platelet-derived growth factor receptor, alpha polypeptide [KO:K04363]
       PDGFRB; platelet-derived growth factor receptor, beta polypeptide [KO:K05089]
       EGFR, ERBB1; epidermal growth factor receptor [KO:K04361]
       PTPRF, LAR; receptor-type tyrosine-protein phosphatase F [KO:K05695]
         K05695 PTPRF, LAR; receptor-type tyrosine-protein phosphatase F [EC:3.1.3.48]
Cell adhesion molecules (CAMs)
         K16336 SDC2; syndecan 2
Cell adhesion molecules (CAMs)
         K16360 LRRC4B, NGL3; netrin-G3 ligand
Cell adhesion molecules (CAMs)
         K06792 AGC1, CSPG1; aggrecan 1
Cell adhesion molecules (CAMs)
         K06793 VCAN, CSPG2; versican core protein
Cell adhesion molecules (CAMs)
         K06794 NCAN, CSPG3; neurocan core protein
Cell adhesion molecules (CAMs)
         K08115 CSPG4; chondroitin sulfate proteoglycan 4
Cell adhesion molecules (CAMs)
         K06795 BCAN; brevican
Cell adhesion molecules (CAMs)
         K08114 PTPRZ; receptor-type tyrosine-protein phosphatase zeta [EC:3.1.3.48]
Cell adhesion molecules (CAMs)
         Laminin-1
Extracellular matrix (ECM) components
           ------ LAMA1; laminin, alpha 1 [HSA:284217] [KO:K05637]
           K05636 LAMB1; laminin, beta 1
           K05635 LAMC1; laminin, gamma 1
 
 
 
       PTPRK; receptor-type tyrosine-protein phosphatase kappa [KO:K06776]
       PTPRD; receptor-type tyrosine-protein phosphatase delta [KO:K06777]
       PTPRM; receptor-type tyrosine-protein phosphatase mu [KO:K05693]
       PTPRS; receptor-type tyrosine-protein phosphatase S [KO:K06778]
       PTPRT; receptor-type tyrosine-protein phosphatase T [KO:K13297]
       PTPRU; receptor-type tyrosine-protein phosphatase U [KO:K16662]
       PTPRB, PTPB; receptor-type tyrosine-protein phosphatase beta [KO:K05694]
   Others
     VCAM1; vascular cell adhesion molecule 1 [KO:K06527]
     PECAM1, CD31; platelet/endothelial cell adhesion molecule [KO:K06471]
     MADCAM1; mucosal vascular addressin cell adhesion molecule 1 [KO:K06779]
     PVRL1; poliovirus receptor-related 1 [KO:K06081]
     PVRL2; poliovirus receptor-related 2 [KO:K06531]
     PVRL3; poliovirus receptor-related 3 [KO:K06592]
     PVRL4; poliovirus receptor-related 4 [KO:K06593]
     CADM3, IGSF4B, NECL1, TSLL1; cell adhesion molecule 3 [KO:K06780]
     CADM1, IGSF4, NECL2, TSLC1; cell adhesion molecule 1 [KO:K06781]
     CADM2, IGSF4D, NECL3; cell adhesion molecule 2 [KO:K06782]
     CADM4, IGSF4C, TSLL2; cell adhesion molecule 4 [KO:K06783]
     PVR, NECL5; poliovirus receptor [KO:K06539]
     ICAM4; intercellular adhesion molecule 4 [KO:K06581]
     CEACAM; carcinoembryonic antigen-related cell adhesion molecule [KO:K06499]
     ROBO4; roundabout, axon guidance receptor, homolog 4 (Drosophila) [KO:K06784]
     LU; Lutheran blood group glycoprotein [KO:K06578]
       VLA-4
Cell adhesion molecules (CAMs)
       Laminin-10
Extracellular matrix (ECM) components
         ------ LAMA5; laminin, alpha 5 [HSA:3911] [KO:K06240]
         K05636 LAMB1; laminin, beta 1
         K05635 LAMC1; laminin, gamma 1
 
 
 
       Laminin-11
Extracellular matrix (ECM) components
         ------ LAMA5; laminin, alpha 5 [HSA:3911] [KO:K06240]
         K06243 LAMB2; laminin, beta 2
         K05635 LAMC1; laminin, gamma 1
 
 
 
       Laminin-14
Extracellular matrix (ECM) components
     MCAM, CD146; melanoma cell adhesion molecule [KO:K06534]
       K06534 MCAM, CD146; melanoma cell adhesion molecule
Cell adhesion molecules (CAMs)
       Laminin-8
Extracellular matrix (ECM) components
         K06241 LAMA4; laminin, alpha 4
         K05636 LAMB1; laminin, beta 1
         K05635 LAMC1; laminin, gamma 1
 
 
 
       K06828 MDK; midkine
Soluble ligands
     F11R, JAM1; junctional adhesion molecule 1 [KO:K06089]
     JAM2; junctional adhesion molecule 2 [KO:K06735]
     JAM3; junctional adhesional molecule 3 [KO:K06785]
     JAM4, JCAM; junctional adhesion molecule 4 [KO:K06786]
     ESAM; endothelial cell adhesion molecule [KO:K06787]
     CXADR, CAR; coxsackievirus and adenovirus receptor [KO:K06788]
       K06788 CXADR, CAR; coxsackievirus and adenovirus receptor
Cell adhesion molecules (CAMs)
       Laminin-1
Extracellular matrix (ECM) components
         ------ LAMA1; laminin, alpha 1 [HSA:284217] [KO:K05637]
         K05636 LAMB1; laminin, beta 1
         K05635 LAMC1; laminin, gamma 1
 
 
 
       K05717 FN1; fibronectin 1
Extracellular matrix (ECM) components
       K06252 TN; tenascin
Extracellular matrix (ECM) components
       K06254 AGRN; agrin
Extracellular matrix (ECM) components
       Coxsackievirus B1 (strain Japan), VP1, 2, 3
Viruses
       Coxsackievirus B2 (strain Ohio-1), VP1, 2, 3
Viruses
       Coxsackievirus B3 (strain Nancy), VP1, 2, 3
Viruses
       Coxsackievirus B3 (strain Woodruff), VP1, 2, 3
Viruses
       Coxsackievirus B4 (strain E2), VP1, 2, 3
Viruses
       Coxsackievirus B4 (strain JVB / Benschoten / New York/51), VP1, 2, 3
Viruses
       Coxsackievirus B5 (strain Peterborough / 1954/UK/85), VP1, 2, 3
Viruses
       Coxsackievirus B6 (strain Schmitt), VP1, 2, 3
Viruses
       Human adenovirus type 12, fiber protein
Viruses
       Human adenovirus type 5, fiber protein
Viruses
       Human adenovirus type 9, fiber protein
Viruses
       Human adenovirus type 41, fiber protein
Viruses
       Canine adenovirus [VGNM:NC_001734]
Viruses
       Fowl adenovirus A [VGNM:NC_001720]
Viruses
       Swine vesicular disease virus (STRAIN H/3 '76), VP1, 2, 3
Viruses
       Swine vesicular disease virus (STRAIN UKG/27/72), VP1, 2, 3
Viruses
     ASAM, CLMP; adipocyte-specific adhesion molecule [KO:K06789]
     GPA33; glycoprotein A33 (transmembrane) [KO:K06790]
     IGSF11; immunoglobulin superfamily, member 11 [KO:K06791]
     CRTAM; cytotoxic and regulatory T-cell molecule [KO:K16361]
     UNC5; netrin receptor unc-5 [KO:K07521]
 
 2. Integrin Family
   Beta1 integrins
     VLA-1
       ITGA1; integrin alpha 1 [KO:K06480]
       ITGB1; integrin beta 1 [KO:K05719]
         K06236 COL1AS; collagen, type I/II/III/V/XI/XXIV/XXVII, alpha
Extracellular matrix (ECM) components
         K06237 COL4A; collagen, type IV, alpha
Extracellular matrix (ECM) components
         K06238 COL6A; collagen, type VI, alpha
Extracellular matrix (ECM) components
         Laminin-1
Extracellular matrix (ECM) components
           ------ LAMA1; laminin, alpha 1 [HSA:284217] [KO:K05637]
           K05636 LAMB1; laminin, beta 1
           K05635 LAMC1; laminin, gamma 1
 
 
 
         Laminin-2
Extracellular matrix (ECM) components
           ------ LAMA2; laminin, alpha 2 [HSA:3908] [KO:K05637]
           K05636 LAMB1; laminin, beta 1
           K05635 LAMC1; laminin, gamma 1
 
 
 
         K06529 SEMA7, CD108; semaphorin 7
Other cell surface / pericellular molecules
         enterotoxin type A, putative [SAC:SACOL1657]
Bacterial pathogens
         seb; staphylococcal enterotoxin B [SAC:SACOL0907]
Bacterial pathogens
         K11043 tst; toxic shock syndrome toxin-1
Bacterial pathogens
         sec3; enterotoxin typeC3 [SAV:SAV2009]
Bacterial pathogens
         speA3; exotoxin type A - phage associated [SPG:SpyM3_1301]
Bacterial pathogens
     VLA-2
       ITGA2; integrin alpha 2 [KO:K06481]
       ITGB1; integrin beta 1 [KO:K05719]
         VLA-3
Cell adhesion molecules (CAMs)
         K05689 CDHE, CDH1; cadherin 1, type 1, E-cadherin
Cell adhesion molecules (CAMs)
         K06236 COL1AS; collagen, type I/II/III/V/XI/XXIV/XXVII, alpha
Extracellular matrix (ECM) components
         K06237 COL4A; collagen, type IV, alpha
Extracellular matrix (ECM) components
         Laminin-1
Extracellular matrix (ECM) components
           ------ LAMA1; laminin, alpha 1 [HSA:284217] [KO:K05637]
           K05636 LAMB1; laminin, beta 1
           K05635 LAMC1; laminin, gamma 1
 
 
 
         Laminin-2
Extracellular matrix (ECM) components
           ------ LAMA2; laminin, alpha 2 [HSA:3908] [KO:K05637]
           K05636 LAMB1; laminin, beta 1
           K05635 LAMC1; laminin, gamma 1
 
 
 
         K06252 TN; tenascin
Extracellular matrix (ECM) components
         K06255 HSPG2; heparan sulfate proteoglycan 2 (perlecan)
Extracellular matrix (ECM) components
         K06248 CHAD; chondroadherin
Extracellular matrix (ECM) components
         K01388 MMP1; matrix metalloproteinase-1 (interstitial collagenase) [EC:3.4.24.7]
Soluble ligands
         enterotoxin type A, putative [SAC:SACOL1657]
Bacterial pathogens
         seb; staphylococcal enterotoxin B [SAC:SACOL0907]
Bacterial pathogens
         K11043 tst; toxic shock syndrome toxin-1
Bacterial pathogens
         sec3; enterotoxin typeC3 [SAV:SAV2009]
Bacterial pathogens
         speA3; exotoxin type A - phage associated [SPG:SpyM3_1301]
Bacterial pathogens
         Echovirus 1 (strain Farouk / ATCC VR-1038), VP1, 2, 3, 4
Viruses
     VLA-3
       ITGA3; integrin alpha 3 [KO:K06482]
       ITGB1; integrin beta 1 [KO:K05719]
         VLA-2
Cell adhesion molecules (CAMs)
         VLA-3
Cell adhesion molecules (CAMs)
         K06237 COL4A; collagen, type IV, alpha
Extracellular matrix (ECM) components
         Laminin-2
Extracellular matrix (ECM) components
           ------ LAMA2; laminin, alpha 2 [HSA:3908] [KO:K05637]
           K05636 LAMB1; laminin, beta 1
           K05635 LAMC1; laminin, gamma 1
 
 
 
         Laminin-5
Extracellular matrix (ECM) components
         Laminin-10
Extracellular matrix (ECM) components
           ------ LAMA5; laminin, alpha 5 [HSA:3911] [KO:K06240]
           K05636 LAMB1; laminin, beta 1
           K05635 LAMC1; laminin, gamma 1
 
 
 
         Laminin-11
Extracellular matrix (ECM) components
           ------ LAMA5; laminin, alpha 5 [HSA:3911] [KO:K06240]
           K06243 LAMB2; laminin, beta 2
           K05635 LAMC1; laminin, gamma 1
 
 
 
         K16857 THBS1; thrombospondin 1
Extracellular matrix (ECM) components
         K04659 THBS2S; thrombospondin 2/3/4/5
Extracellular matrix (ECM) components
         K06249 RELN; reelin [EC:3.4.21.-]
Extracellular matrix (ECM) components
         K06826 NID; nidogen (entactin)
Extracellular matrix (ECM) components
         K06831 LGALS3; galectin-3
Other cell surface / pericellular molecules
         K06832 LGALS8; galectin-8
Other cell surface / pericellular molecules
         enterotoxin type A, putative [SAC:SACOL1657]
Bacterial pathogens
         seb; staphylococcal enterotoxin B [SAC:SACOL0907]
Bacterial pathogens
         K11043 tst; toxic shock syndrome toxin-1
Bacterial pathogens
         sec3; enterotoxin typeC3 [SAV:SAV2009]
Bacterial pathogens
         speA3; exotoxin type A - phage associated [SPG:SpyM3_1301]
Bacterial pathogens
         putative invasin [YPS:YPTB1572]
Bacterial pathogens
         putative invasin [YPS:YPTB1668]
Bacterial pathogens
         Human herpesvirus 8 [VGNM:NC_009333], gB
Viruses
     VLA-4
     VLA-5
     VLA-6
       ITGA6; integrin alpha 6 [KO:K06485]
       ITGB1; integrin beta 1 [KO:K05719]
         Laminin-1
Extracellular matrix (ECM) components
           ------ LAMA1; laminin, alpha 1 [HSA:284217] [KO:K05637]
           K05636 LAMB1; laminin, beta 1
           K05635 LAMC1; laminin, gamma 1
 
 
 
         Laminin-2
Extracellular matrix (ECM) components
           ------ LAMA2; laminin, alpha 2 [HSA:3908] [KO:K05637]
           K05636 LAMB1; laminin, beta 1
           K05635 LAMC1; laminin, gamma 1
 
 
 
         Laminin-5
Extracellular matrix (ECM) components
         Laminin-8
Extracellular matrix (ECM) components
           K06241 LAMA4; laminin, alpha 4
           K05636 LAMB1; laminin, beta 1
           K05635 LAMC1; laminin, gamma 1
 
 
 
         Laminin-10
Extracellular matrix (ECM) components
           ------ LAMA5; laminin, alpha 5 [HSA:3911] [KO:K06240]
           K05636 LAMB1; laminin, beta 1
           K05635 LAMC1; laminin, gamma 1
 
 
 
         Laminin-11
Extracellular matrix (ECM) components
           ------ LAMA5; laminin, alpha 5 [HSA:3911] [KO:K06240]
           K06243 LAMB2; laminin, beta 2
           K05635 LAMC1; laminin, gamma 1
 
 
 
         K06827 CTGF; connective tissue growth factor
Soluble ligands
         K06829 CYR61; cysteine rich protein 61
Soluble ligands
         K06828 MDK; midkine
Soluble ligands
         K06833 ADAM2; disintegrin and metalloproteinase domain-containing protein 2 [EC:3.4.24.-]
Other cell surface / pericellular molecules
         K06834 ADAM9; disintegrin and metalloproteinase domain-containing protein 9 [EC:3.4.24.-]
Other cell surface / pericellular molecules
         enterotoxin type A, putative [SAC:SACOL1657]
Bacterial pathogens
         seb; staphylococcal enterotoxin B [SAC:SACOL0907]
Bacterial pathogens
         K11043 tst; toxic shock syndrome toxin-1
Bacterial pathogens
         sec3; enterotoxin typeC3 [SAV:SAV2009]
Bacterial pathogens
         speA3; exotoxin type A - phage associated [SPG:SpyM3_1301]
Bacterial pathogens
         putative invasin [YPS:YPTB1572]
Bacterial pathogens
         putative invasin [YPS:YPTB1668]
Bacterial pathogens
         Human papillomavirus type 16 [VGNM:NC_001526], L1
Viruses
     VLA-7
       ITGA7; integrin alpha 7 [KO:K06583]
       ITGB1; integrin beta 1 [KO:K05719]
         Laminin-1
Extracellular matrix (ECM) components
           ------ LAMA1; laminin, alpha 1 [HSA:284217] [KO:K05637]
           K05636 LAMB1; laminin, beta 1
           K05635 LAMC1; laminin, gamma 1
 
 
 
         Laminin-2
Extracellular matrix (ECM) components
           ------ LAMA2; laminin, alpha 2 [HSA:3908] [KO:K05637]
           K05636 LAMB1; laminin, beta 1
           K05635 LAMC1; laminin, gamma 1
 
 
 
         K06830 LGALS1; galectin-1
Other cell surface / pericellular molecules
         enterotoxin type A, putative [SAC:SACOL1657]
Bacterial pathogens
         seb; staphylococcal enterotoxin B [SAC:SACOL0907]
Bacterial pathogens
         K11043 tst; toxic shock syndrome toxin-1
Bacterial pathogens
         sec3; enterotoxin typeC3 [SAV:SAV2009]
Bacterial pathogens
         speA3; exotoxin type A - phage associated [SPG:SpyM3_1301]
Bacterial pathogens
     VLA-8
     VLA-9
     alpha 10 beta 1
     alpha 11 beta 1
     alpha V beta 1
   Beta2 integrins
   Beta3 integrins
   Beta4 integrins
     alpha 6 beta 4
       ITGA6; integrin alpha 6 [KO:K06485]
       ITGB4; integrin beta 4 [KO:K06525]
         K06257 SDC1; syndecan 1
Cell adhesion molecules (CAMs)
         K16338 SDC4; syndecan 4
Cell adhesion molecules (CAMs)
         Laminin-1
Extracellular matrix (ECM) components
           ------ LAMA1; laminin, alpha 1 [HSA:284217] [KO:K05637]
           K05636 LAMB1; laminin, beta 1
           K05635 LAMC1; laminin, gamma 1
 
 
 
         Laminin-2
Extracellular matrix (ECM) components
           ------ LAMA2; laminin, alpha 2 [HSA:3908] [KO:K05637]
           K05636 LAMB1; laminin, beta 1
           K05635 LAMC1; laminin, gamma 1
 
 
 
         Laminin-5
Extracellular matrix (ECM) components
         Human papillomavirus type 16 [VGNM:NC_001526], L1
Viruses
   Beta5 integrins
   Beta6 integrins
   Beta7 integrins
   Beta8 integrins
 
 3. Selectin Family
 
 4. Link Protein Family
 
 5. Cadherin Family
 
 6. Sialomucin Family
 
 7. Others
   TNFRSF5, CD40; tumor necrosis factor receptor superfamily, member 5 [KO:K03160]
   TNFSF5, CD40L; tumor necrosis factor (ligand) superfamily, member 5 [KO:K03161]
   NRP1; neuropilin 1 [KO:K06724]
   NRP2; neuropilin 2 [KO:K06819]
   PLXNA; plexin A [KO:K06820]
   PLXNB; plexin B [KO:K06821]
   PLXNC; plexin C [KO:K06572]
   PLXND; plexin D [KO:K06822]
   SDC1; syndecan 1 [KO:K06257]
   SDC2; syndecan 2 [KO:K16336]
   SDC3; syndecan 3 [KO:K16337]
   SDC4; syndecan 4 [KO:K16338]
   CLDN; claudin [KO:K06087]
   OCLN; occludin [KO:K06088]
   CD99, MIC2; CD99 antigen [KO:K06520]
   NRXN; neurexin [KO:K07377]
   NLGN; neuroligin [KO:K07378]
   DAG1; dystroglycan 1 [KO:K06265]
     K07377 NRXN; neurexin
Cell adhesion molecules (CAMs)
     Laminin-1
Extracellular matrix (ECM) components
       ------ LAMA1; laminin, alpha 1 [HSA:284217] [KO:K05637]
       K05636 LAMB1; laminin, beta 1
       K05635 LAMC1; laminin, gamma 1
 
 
 
     Laminin-2
Extracellular matrix (ECM) components
       ------ LAMA2; laminin, alpha 2 [HSA:3908] [KO:K05637]
       K05636 LAMB1; laminin, beta 1
       K05635 LAMC1; laminin, gamma 1
 
 
 
     K06255 HSPG2; heparan sulfate proteoglycan 2 (perlecan)
Extracellular matrix (ECM) components
     Mycobacterium leprae TN [GN:mle]
Bacterial pathogens
     Lymphocytic choriomeningitis virus [VGNM:NC_004291]
Viruses
     Lassa virus [VGNM:NC_004297]
Viruses
     Mobala virus [VGNM:NC_007903]
Viruses
     Oliveros virus [VGNM:NC_010248]
Viruses
   LRRTM1_2; leucine-rich repeat transmembrane neuronal protein 1/2 [KO:K16665]
   OMG; oligodendrocyte myelin glycoprotein [KO:K16666]
   APP; amyloid beta A4 protein [KO:K04520]
     K06236 COL1AS; collagen, type I/II/III/V/XI/XXIV/XXVII, alpha
Extracellular matrix (ECM) components
     K06237 COL4A; collagen, type IV, alpha
Extracellular matrix (ECM) components
     Laminin-1
Extracellular matrix (ECM) components
       ------ LAMA1; laminin, alpha 1 [HSA:284217] [KO:K05637]
       K05636 LAMB1; laminin, beta 1
       K05635 LAMC1; laminin, gamma 1
 
 
 
     K16659 RTN4R, NGR; reticulon-4 receptor
Other cell surface / pericellular molecules
     K16660 RTN4RL1, NGR3; reticulon-4 receptor-like 1
Other cell surface / pericellular molecules
     K16661 RTN4RL2, NGR2; reticulon-4 receptor-like 2
Other cell surface / pericellular molecules
   PTPRG; receptor-type tyrosine-protein phosphatase gamma [KO:K16667]
   NTNG1; netrin-G1 [KO:K07522]
   NTNG2; netrin-G2 [KO:K16359]
   FLRT; leucine-rich repeat transmembrane protein FLRT [KO:K16362]
   CD209; CD209 antigen [KO:K06563]
   CD81, TAPA1; CD81 antigen [KO:K06508]
   SCARB1; scavenger receptor class B, member 1 [KO:K13885]
   TMIGD2, IGPR-1; transmembrane and immunoglobulin domain-containing protein 2 [KO:K16668]
   EFNA; ephrin-A [KO:K05462]
   EPHA1, EPH; Eph receptor A1 [KO:K05102]
   EPHA2, ECK; Eph receptor A2 [KO:K05103]
   EPHA3, HEK, TYRO4; Eph receptor A3 [KO:K05104]
   EPHA4, SEK, TYRO1; Eph receptor A4 [KO:K05105]
   EPHA5, EHK1, TYRO4; Eph receptor A5 [KO:K05106]
   EPHA6, EHK2; Eph receptor A6 [KO:K05107]
   EPHA7, EHK3, HEK11; EphA7 [KO:K05108]
   EPHA8, EEK; Eph receptor A8 [KO:K05109]
   EPHA10; Eph receptor A10 [KO:K08897]
   EFNB; ephrin-B [KO:K05463]
   EPHB1, ELK, NET; Eph receptor B1 [KO:K05110]
   EPHB2, ERK, DRT; Eph receptor B2 [KO:K05111]
   EPHB3; EPHB3, HEK2, ETK2; Eph receptor B3 [KO:K05112]
   EPHB4; EPHB4, HTK; Eph receptor B4 [KO:K05113]
   EPHB6; Eph receptor B6 [KO:K05114]

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Last updated: August 29, 2014