Messenger RNA Biogenesis - Pan paniscus (bonobo)

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     KO 
 Eukaryotic type

   mRNA processing factors

   mRNA surveillance and transport factors

     Transport factors

       EJC complex

       TREX complex

       TREX-2 complex

       Nuclear pore complex

       Ran-mediated transport factors

       eIF4F and regulatory proteins

         100992392 EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1
         100967756 EIF4E; eukaryotic translation initiation factor 4E isoform X3
         100987712 EIF4E1B; eukaryotic translation initiation factor 4E type 1B isoform X1
         117976254 eukaryotic translation initiation factor 4E
         100968316 eukaryotic translation initiation factor 4E-like
         100994770 EIF4A2; eukaryotic initiation factor 4A-II isoform X4
         100975612 eukaryotic initiation factor 4A-I
         103782634 EIF4A1; eukaryotic initiation factor 4A-I isoform X2
         100972290 EIF4G1; eukaryotic translation initiation factor 4 gamma 1 isoform X4
         100970189 EIF4G3; eukaryotic translation initiation factor 4 gamma 3 isoform X17
         100989137 EIF4G2; eukaryotic translation initiation factor 4 gamma 2 isoform X1
         117974328 LOW QUALITY PROTEIN: eukaryotic translation initiation factor 4 gamma 2-like
         100977376 eukaryotic translation initiation factor 4B-like
         100981855 EIF4B; eukaryotic translation initiation factor 4B isoform X1
         100972473 EIF4H; eukaryotic translation initiation factor 4H
         100972246 EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1
         100973060 EIF4EBP2; eukaryotic translation initiation factor 4E-binding protein 2
         100982004 LOW QUALITY PROTEIN: eukaryotic translation initiation factor 4E-binding protein 2
         100994292 EIF4ENIF1; eukaryotic translation initiation factor 4E transporter isoform X2
         100995614 ANGEL2; protein angel homolog 2 isoform X1
         100989532 ANGEL1; protein angel homolog 1 isoform X3
         100977612 FMR1; synaptic functional regulator FMR1 isoform X1
         100973513 FXR1; fragile X mental retardation syndrome-related protein 1 isoform X4
         100977519 FXR2; fragile X mental retardation syndrome-related protein 2
         100968966 CYFIP1; cytoplasmic FMR1-interacting protein 1 isoform X2
         100982761 CYFIP2; cytoplasmic FMR1-interacting protein 2 isoform X2
         100979106 GEMIN5; gem-associated protein 5 isoform X3
         100992962 TACC3; transforming acidic coiled-coil-containing protein 3 isoform X2
         100984532 CPEB4; cytoplasmic polyadenylation element-binding protein 4 isoform X1
         100993920 CPEB1; cytoplasmic polyadenylation element-binding protein 1 isoform X7
         100988298 CPEB3; cytoplasmic polyadenylation element-binding protein 3 isoform X2
         100992028 CPEB2; cytoplasmic polyadenylation element-binding protein 2 isoform X1
         100970420 DDX3X; ATP-dependent RNA helicase DDX3X isoform X1
         100989566 GIGYF2; GRB10-interacting GYF protein 2 isoform X1
         100982178 GIGYF1; GRB10-interacting GYF protein 1 isoform X1
         100976307 PABPC5; polyadenylate-binding protein 5
         100978235 PABPC3; polyadenylate-binding protein 3
         100991725 PABPC4; polyadenylate-binding protein 4 isoform X1
         100982483 PABPC1L; polyadenylate-binding protein 1-like isoform X4
         100973046 PABPC4L; polyadenylate-binding protein 4-like isoform X1
         100977147 PABPC1; polyadenylate-binding protein 1
         100976163 PABPC1L2B; polyadenylate-binding protein 1-like 2
         117977691 PABPC1L2A; polyadenylate-binding protein 1-like 2
         100990005 PAIP1; polyadenylate-binding protein-interacting protein 1 isoform X1
         100986520 PAIP2; polyadenylate-binding protein-interacting protein 2
         100985603 PAIP2B; polyadenylate-binding protein-interacting protein 2B
         100988793 SKIV2L; helicase SKI2W isoform X1
         100970817 DEAF1; deformed epidermal autoregulatory factor 1 homolog isoform X1
         100970138 MCTS1; malignant T-cell-amplified sequence 1 isoform X2
         103784137 malignant T-cell-amplified sequence 1-like
         103785055 DENR; density-regulated protein

K03259 EIF4E; translation initiation factor 4E 
K03259 EIF4E; translation initiation factor 4E 
K03259 EIF4E; translation initiation factor 4E 
K03259 EIF4E; translation initiation factor 4E 
K03259 EIF4E; translation initiation factor 4E 
K03257 EIF4A; translation initiation factor 4A 
K03257 EIF4A; translation initiation factor 4A 
K03257 EIF4A; translation initiation factor 4A 
K03260 EIF4G; translation initiation factor 4G 
K03260 EIF4G; translation initiation factor 4G 
K03260 EIF4G; translation initiation factor 4G 
K03260 EIF4G; translation initiation factor 4G 
K03258 EIF4B; translation initiation factor 4B 
K03258 EIF4B; translation initiation factor 4B 
K24086 EIF4H; translation initiation factor 4H 
K07205 EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1 
K18644 EIF4EBP2; eukaryotic translation initiation factor 4E binding protein 2 
K18644 EIF4EBP2; eukaryotic translation initiation factor 4E binding protein 2 
K18728 EIF4ENIF1; eukaryotic translation initiation factor 4E transporter 
K18729 ANGEL; protein angel 
K18729 ANGEL; protein angel 
K15516 FMR; fragile X mental retardation protein 
K15516 FMR; fragile X mental retardation protein 
K15516 FMR; fragile X mental retardation protein 
K05749 CYFIP; cytoplasmic FMR1 interacting protein 
K05749 CYFIP; cytoplasmic FMR1 interacting protein 
K13133 GEMIN5; gem associated protein 5 
K14283 TACC3; transforming acidic coiled-coil-containing protein 3 
K02602 CPEB; cytoplasmic polyadenylation element-binding protein 
K02602 CPEB; cytoplasmic polyadenylation element-binding protein 
K02602 CPEB; cytoplasmic polyadenylation element-binding protein 
K02602 CPEB; cytoplasmic polyadenylation element-binding protein 
K11594 DDX3X; ATP-dependent RNA helicase DDX3X [EC:5.6.2.7] 
K18730 GIGYF; PERQ amino acid-rich with GYF domain-containing protein 
K18730 GIGYF; PERQ amino acid-rich with GYF domain-containing protein 
K13126 PABPC; polyadenylate-binding protein 
K13126 PABPC; polyadenylate-binding protein 
K13126 PABPC; polyadenylate-binding protein 
K13126 PABPC; polyadenylate-binding protein 
K13126 PABPC; polyadenylate-binding protein 
K13126 PABPC; polyadenylate-binding protein 
K13126 PABPC; polyadenylate-binding protein 
K13126 PABPC; polyadenylate-binding protein 
K14322 PAIP1; polyadenylate-binding protein-interacting protein 1 
K27470 PAIP2; polyadenylate-binding protein-interacting protein 2 
K27470 PAIP2; polyadenylate-binding protein-interacting protein 2 
K12599 SKI2; antiviral helicase SKI2 [EC:5.6.2.6] 
K23041 DEAF1; deformed epidermal autoregulatory factor 1 
K07575 MCTS; malignant T-cell-amplified sequence 
K07575 MCTS; malignant T-cell-amplified sequence 
K24272 DENR; density-regulated protein 

       APOBEC1-ACF complex

       Other transport factors

     Surveillance factors

     Factors involved in mRNA localization

     mRNA cycle factors

       Common to processing body (P body) and stress granule

         100975490 XRN1; 5'-3' exoribonuclease 1 isoform X3
         100968333 AGO1; protein argonaute-1 isoform X2
         100968913 protein argonaute-3 isoform X1
         100977537 AGO4; protein argonaute-4 isoform X1
         100973657 AGO2; protein argonaute-2 isoform X1
         100992392 EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1
         100967756 EIF4E; eukaryotic translation initiation factor 4E isoform X3
         100987712 EIF4E1B; eukaryotic translation initiation factor 4E type 1B isoform X1
         117976254 eukaryotic translation initiation factor 4E
         100968316 eukaryotic translation initiation factor 4E-like
         100967567 UPF1; regulator of nonsense transcripts 1 isoform X1
         100970420 DDX3X; ATP-dependent RNA helicase DDX3X isoform X1
         100972170 DDX6; probable ATP-dependent RNA helicase DDX6
         100981823 MEX3C; RNA-binding E3 ubiquitin-protein ligase MEX3C
         100968273 MEX3A; RNA-binding protein MEX3A
         100995861 MEX3B; RNA-binding protein MEX3B
         100976138 MEX3D; RNA-binding protein MEX3D
         100978359 FASTK; fas-activated serine/threonine kinase isoform X2
         100986218 LSM14A; protein LSM14 homolog A isoform X1
         100972230 protein LSM14 homolog A-like
         100970379 LSM14B; protein LSM14 homolog B isoform X1
         100990131 PCBP1; poly(rC)-binding protein 1
         100983627 PCBP2; poly(rC)-binding protein 2 isoform X1
         100967524 YBX1; Y-box-binding protein 1 isoform X1
         100996139 LOW QUALITY PROTEIN: Y-box-binding protein 1-like
         100978333 LOW QUALITY PROTEIN: Y-box-binding protein 1-like
         100985823 AJUBA; LIM domain-containing protein ajuba isoform X1
         100978590 LIMD1; LIM domain-containing protein 1 isoform X1
         100982641 WTIP; Wilms tumor protein 1-interacting protein isoform X1
         100987748 APOBEC1; C->U-editing enzyme APOBEC-1 isoform X1
         100971498 APOBEC3B; DNA dC->dU-editing enzyme APOBEC-3B
         100983664 APOBEC3H; DNA dC->dU-editing enzyme APOBEC-3H isoform X1
         100982453 APOBEC3G; DNA dC->dU-editing enzyme APOBEC-3G isoform X3
         100983444 APOBEC3C; DNA dC->dU-editing enzyme APOBEC-3C isoform X1
         117977490 APOBEC3A; DNA dC->dU-editing enzyme APOBEC-3A
         117977491 APOBEC3D; DNA dC->dU-editing enzyme APOBEC-3D isoform X1
         100990514 APOBEC3F; DNA dC->dU-editing enzyme APOBEC-3F isoform X1
         100984051 MOV10; helicase MOV-10 isoform X1
         100988655 PNRC2; proline-rich nuclear receptor coactivator 2
         100970374 TNPO1; transportin-1 isoform X1
         103783260 LOW QUALITY PROTEIN: transportin-1-like
         117976448 LOW QUALITY PROTEIN: transportin-1-like
         103783967 serine/threonine-protein kinase SMG1
         100975351 SMG5; protein SMG5 isoform X2
         100983543 SMG6; telomerase-binding protein EST1A isoform X1
         100993466 SMG7; protein SMG7 isoform X6
         100974849 ZFP36; mRNA decay activator protein ZFP36
         100977950 ZFP36L1; mRNA decay activator protein ZFP36L1 isoform X1
         100973704 ZFP36L2; mRNA decay activator protein ZFP36L2
         100973467 LIN28A; protein lin-28 homolog A
         100982249 LIN28B; protein lin-28 homolog B isoform X4
         100976812 protein lin-28 homolog A
         100972075 LOW QUALITY PROTEIN: protein lin-28 homolog A-like
         100978882 HTT; huntingtin isoform X1
         100974188 IPO8; importin-8 isoform X1
         100981106 BICC1; protein bicaudal C homolog 1 isoform X1
         100990297 heterogeneous nuclear ribonucleoprotein A1-like
         100996041 heterogeneous nuclear ribonucleoprotein A1-like
         100984991 HNRNPA3; heterogeneous nuclear ribonucleoprotein A3 isoform X1
         100991815 heterogeneous nuclear ribonucleoprotein A1-like
         100969159 heterogeneous nuclear ribonucleoprotein A1-like
         100972823 heterogeneous nuclear ribonucleoprotein A1-like
         100970253 HNRNPA1; heterogeneous nuclear ribonucleoprotein A1 isoform X1
         100985527 HNRNPA1L2; LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein A1-like 2
         106635036 heterogeneous nuclear ribonucleoprotein A1-like
         100995391 heterogeneous nuclear ribonucleoprotein A3-like
         100981230 heterogeneous nuclear ribonucleoprotein A1-like
         100982589 PRKACG; cAMP-dependent protein kinase catalytic subunit gamma
         100970917 PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X5
         100968237 PRKACA; cAMP-dependent protein kinase catalytic subunit alpha
         100986595 LARP1B; la-related protein 1B isoform X9
         100980263 LARP1; la-related protein 1 isoform X2
         100993971 ATXN2L; ataxin-2-like protein isoform X14
         100971117 ATXN2; ataxin-2 isoform X1

K12618 XRN1; 5'-3' exoribonuclease 1 [EC:3.1.13.-] 
K11593 ELF2C; eukaryotic translation initiation factor 2C 
K11593 ELF2C; eukaryotic translation initiation factor 2C 
K11593 ELF2C; eukaryotic translation initiation factor 2C 
K11593 ELF2C; eukaryotic translation initiation factor 2C 
K03259 EIF4E; translation initiation factor 4E 
K03259 EIF4E; translation initiation factor 4E 
K03259 EIF4E; translation initiation factor 4E 
K03259 EIF4E; translation initiation factor 4E 
K03259 EIF4E; translation initiation factor 4E 
K14326 UPF1; regulator of nonsense transcripts 1 [EC:5.6.2.5 5.6.2.3] 
K11594 DDX3X; ATP-dependent RNA helicase DDX3X [EC:5.6.2.7] 
K12614 DDX6; ATP-dependent RNA helicase DDX6/DHH1 [EC:5.6.2.7] 
K15686 MEX3; RNA-binding protein MEX3 [EC:2.3.2.27] 
K15686 MEX3; RNA-binding protein MEX3 [EC:2.3.2.27] 
K15686 MEX3; RNA-binding protein MEX3 [EC:2.3.2.27] 
K15686 MEX3; RNA-binding protein MEX3 [EC:2.3.2.27] 
K08290 FASTK; Fas-activated serine/threonine kinase [EC:2.7.11.8] 
K18749 LSM14; protein LSM14 
K18749 LSM14; protein LSM14 
K18749 LSM14; protein LSM14 
K12889 PCBP1; poly(rC)-binding protein 1 
K13162 PCBP2; poly(rC)-binding protein 2 
K09276 YBX1; Y-box-binding protein 1 
K09276 YBX1; Y-box-binding protein 1 
K09276 YBX1; Y-box-binding protein 1 
K16682 AJUBA; LIM domain-containing protein 
K16682 AJUBA; LIM domain-containing protein 
K16682 AJUBA; LIM domain-containing protein 
K16932 APOBEC1; C->U-editing enzyme APOBEC1 [EC:3.5.4.36] 
K18750 APOBEC3; C->U-editing enzyme APOBEC3 [EC:3.5.4.-] 
K18750 APOBEC3; C->U-editing enzyme APOBEC3 [EC:3.5.4.-] 
K18750 APOBEC3; C->U-editing enzyme APOBEC3 [EC:3.5.4.-] 
K18750 APOBEC3; C->U-editing enzyme APOBEC3 [EC:3.5.4.-] 
K18750 APOBEC3; C->U-editing enzyme APOBEC3 [EC:3.5.4.-] 
K18750 APOBEC3; C->U-editing enzyme APOBEC3 [EC:3.5.4.-] 
K18750 APOBEC3; C->U-editing enzyme APOBEC3 [EC:3.5.4.-] 
K18422 MOV10; helicase MOV-10 [EC:5.6.2.5] 
K18751 PNRC2; proline-rich nuclear receptor coactivator 2 
K18752 TNPO1; transportin-1 
K18752 TNPO1; transportin-1 
K18752 TNPO1; transportin-1 
K08873 SMG1; serine/threonine-protein kinase SMG1 [EC:2.7.11.1] 
K11125 SMG5; protein SMG5 
K11124 SMG6; protein SMG6 [EC:3.1.-.-] 
K14409 SMG7; protein SMG7 
K15308 TTP; tristetraprolin 
K18753 ZFP36L; butyrate response factor 
K18753 ZFP36L; butyrate response factor 
K18754 LIN28; protein lin-28 
K18754 LIN28; protein lin-28 
K18754 LIN28; protein lin-28 
K18754 LIN28; protein lin-28 
K04533 HD; huntingtin 
K18755 IPO8; importin-8 
K18756 BICC1; protein bicaudal C 
K12741 HNRNPA1_3; heterogeneous nuclear ribonucleoprotein A1/A3 
K12741 HNRNPA1_3; heterogeneous nuclear ribonucleoprotein A1/A3 
K12741 HNRNPA1_3; heterogeneous nuclear ribonucleoprotein A1/A3 
K12741 HNRNPA1_3; heterogeneous nuclear ribonucleoprotein A1/A3 
K12741 HNRNPA1_3; heterogeneous nuclear ribonucleoprotein A1/A3 
K12741 HNRNPA1_3; heterogeneous nuclear ribonucleoprotein A1/A3 
K12741 HNRNPA1_3; heterogeneous nuclear ribonucleoprotein A1/A3 
K12741 HNRNPA1_3; heterogeneous nuclear ribonucleoprotein A1/A3 
K12741 HNRNPA1_3; heterogeneous nuclear ribonucleoprotein A1/A3 
K12741 HNRNPA1_3; heterogeneous nuclear ribonucleoprotein A1/A3 
K12741 HNRNPA1_3; heterogeneous nuclear ribonucleoprotein A1/A3 
K04345 PKA; protein kinase A [EC:2.7.11.11] 
K04345 PKA; protein kinase A [EC:2.7.11.11] 
K04345 PKA; protein kinase A [EC:2.7.11.11] 
K18757 LARP1; la-related protein 1 
K18757 LARP1; la-related protein 1 
K23625 ATXN2_2L; ataxin 2/2L 
K23625 ATXN2_2L; ataxin 2/2L 

       P-body specific factors

       Stress granule specific factors

   mRNA degradation factors

 





 Prokaryotic type













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Last updated: April 9, 2024