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KO |
 09100 Metabolism
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09120 Genetic Information Processing
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 09130 Environmental Information Processing
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09131 Membrane transport
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09132 Signal transduction
|
 02020 Two-component system
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04010 MAPK signaling pathway [PATH:ptr04010]
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04013 MAPK signaling pathway - fly
|
04016 MAPK signaling pathway - plant
|
04011 MAPK signaling pathway - yeast
|
04012 ErbB signaling pathway [PATH:ptr04012]
|
04014 Ras signaling pathway [PATH:ptr04014]
|
04015 Rap1 signaling pathway [PATH:ptr04015]
|
04310 Wnt signaling pathway [PATH:ptr04310]
|
04330 Notch signaling pathway [PATH:ptr04330]
|
04340 Hedgehog signaling pathway [PATH:ptr04340]
|
04341 Hedgehog signaling pathway - fly
|
04350 TGF-beta signaling pathway [PATH:ptr04350]
|
04390 Hippo signaling pathway [PATH:ptr04390]
|
04391 Hippo signaling pathway - fly
|
04392 Hippo signaling pathway - multiple species [PATH:ptr04392]
|
04370 VEGF signaling pathway [PATH:ptr04370]
|
04371 Apelin signaling pathway [PATH:ptr04371]
|
04630 JAK-STAT signaling pathway [PATH:ptr04630]
|
04064 NF-kappa B signaling pathway [PATH:ptr04064]
|
04668 TNF signaling pathway [PATH:ptr04668]
|
04066 HIF-1 signaling pathway [PATH:ptr04066]
|
04068 FoxO signaling pathway [PATH:ptr04068]
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456060 TGFB1; transforming growth factor beta-1 isoform X2
457742 TGFB2; transforming growth factor beta-2 isoform X1
453054 TGFB3; transforming growth factor beta-3 isoform X1
472992 TGFBR1; TGF-beta receptor type-1 isoform X2
460243 TGFBR2; TGF-beta receptor type-2 isoform X2
468537 SMAD4; mothers against decapentaplegic homolog 4 isoform X1
748161 SMAD3; mothers against decapentaplegic homolog 3 isoform X1
468641 STK11; serine/threonine-protein kinase STK11 isoform X1
741802 PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1
471564 PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1
452297 PRKAB1; 5'-AMP-activated protein kinase subunit beta-1
457245 PRKAB2; 5'-AMP-activated protein kinase subunit beta-2
470648 PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 isoform X1
451872 PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X3
463879 PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X7
739132 NLK; serine/threonine-protein kinase NLK isoform X1
471570 SKP2; S-phase kinase-associated protein 2 isoform X4
742141 MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1
737682 SETD7; histone-lysine N-methyltransferase SETD7
467891 CREBBP; CREB-binding protein isoform X4
458862 EP300; histone acetyltransferase p300
107966703 SIRT1; NAD-dependent protein deacetylase sirtuin-1 isoform X1
453907 USP7; ubiquitin carboxyl-terminal hydrolase 7 isoform X2
468443 SLC2A4; solute carrier family 2, facilitated glucose transporter member 4
450445 MAPK8; mitogen-activated protein kinase 8 isoform X1
461358 MAPK10; mitogen-activated protein kinase 10 isoform X3
462336 MAPK9; mitogen-activated protein kinase 9 isoform X1
458275 STK4; serine/threonine-protein kinase 4
741055 IGF1; insulin-like growth factor I isoform X6
453676 IGF1R; insulin-like growth factor 1 receptor isoform X1
449570 INS; insulin preproprotein
455649 INSR; insulin receptor isoform X1
459985 IRS1; insulin receptor substrate 1
452657 IRS2; insulin receptor substrate 2
473846 IRS4; insulin receptor substrate 4 isoform X1
460858 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
457922 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1
471079 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1
456565 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2
461836 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2
455855 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta
467875 PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1
112205915 LOW QUALITY PROTEIN: putative 3-phosphoinositide-dependent protein kinase 2
450673 CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
472749 IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1
466142 PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1
456035 AKT2; RAC-beta serine/threonine-protein kinase isoform X4
740898 AKT1; RAC-alpha serine/threonine-protein kinase isoform X1
100609583 AKT3; RAC-gamma serine/threonine-protein kinase
463011 SGK1; serine/threonine-protein kinase Sgk1
740699 SGK2; serine/threonine-protein kinase Sgk2 isoform X1
464217 serine/threonine-protein kinase Sgk3 isoform X1
467352 FOXO1; forkhead box protein O1
462921 FOXO3; forkhead box protein O3
107976547 FOXO6; forkhead box protein O6
463049 GRM1; metabotropic glutamate receptor 1 precursor
453597 HOMER2; homer protein homolog 2 isoform X1
471504 HOMER1; homer protein homolog 1 isoform X1
736171 HOMER3; homer protein homolog 3 isoform X2
452023 AGAP2; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2
458829 CSNK1E; casein kinase I isoform X1
463288 IL6; interleukin-6 isoform X1
469657 IL10; interleukin-10 precursor
454682 STAT3; signal transducer and activator of transcription 3 isoform X8
461435 EGF; pro-epidermal growth factor isoform X3
463415 EGFR; epidermal growth factor receptor isoform X2
737245 GRB2; growth factor receptor-bound protein 2
459171 SOS1; son of sevenless homolog 1 isoform X2
452897 SOS2; son of sevenless homolog 2 isoform X1
466302 HRAS; GTPase HRas isoform X1
473387 KRAS; GTPase KRas isoform X1
742713 NRAS; GTPase NRas
463781 BRAF; serine/threonine-protein kinase B-raf isoform X2
460182 RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2
100614256 ARAF; serine/threonine-protein kinase A-Raf isoform X1
450188 MAP2K1; dual specificity mitogen-activated protein kinase kinase 1
456390 MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1
454037 MAPK3; mitogen-activated protein kinase 3 isoform X1
458680 MAPK1; mitogen-activated protein kinase 1
450161 MAPK14; mitogen-activated protein kinase 14
462644 MAPK13; mitogen-activated protein kinase 13
747077 MAPK12; mitogen-activated protein kinase 12 isoform X1
104003820 MAPK11; mitogen-activated protein kinase 11
467032 CDK2; cyclin-dependent kinase 2 isoform X1
456214 PRMT1; protein arginine N-methyltransferase 1 isoform X1
467416 FOXG1; forkhead box protein G1
461835 CCNB1; G2/mitotic-specific cyclin-B1
453478 CCNB2; G2/mitotic-specific cyclin-B2
104002075 CCNB3; G2/mitotic-specific cyclin-B3 isoform X1
747442 CCND1; G1/S-specific cyclin-D1
747123 CCND2; G1/S-specific cyclin-D2
461229 CCNG2; cyclin-G2
473204 CDKN2B; cyclin-dependent kinase 4 inhibitor B
745942 CDKN2D; cyclin-dependent kinase 4 inhibitor D
104001067 CDKN1A; cyclin-dependent kinase inhibitor 1 isoform X2
466947 CDKN1B; cyclin-dependent kinase inhibitor 1B
467978 RBL2; retinoblastoma-like protein 2 isoform X1
453991 PLK1; serine/threonine-protein kinase PLK1
461861 PLK2; serine/threonine-protein kinase PLK2
456546 PLK3; serine/threonine-protein kinase PLK3 isoform X1
461480 PLK4; serine/threonine-protein kinase PLK4 isoform X1
464585 GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma
744311 GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta
456929 GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X2
469584 FASLG; tumor necrosis factor ligand superfamily member 6
459487 BCL2L11; bcl-2-like protein 11 isoform X9
460852 TNFSF10; tumor necrosis factor ligand superfamily member 10
460926 BCL6; B-cell lymphoma 6 protein
450831 BNIP3; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3
462011 ATG12; ubiquitin-like protein ATG12
112209231 LOW QUALITY PROTEIN: ubiquitin-like protein ATG12
454251 GABARAPL2; gamma-aminobutyric acid receptor-associated protein-like 2
748888 GABARAP; gamma-aminobutyric acid receptor-associated protein
467760 gamma-aminobutyric acid receptor-associated protein-like 3
737951 GABARAPL1; gamma-aminobutyric acid receptor-associated protein-like 1 isoform X2
451116 CAT; catalase
449634 SOD2; superoxide dismutase [Mn], mitochondrial
451530 ATM; serine-protein kinase ATM isoform X1
458362 PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] isoform X2
452807 PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X1
741431 G6PC2; glucose-6-phosphatase 2 isoform X1
454703 G6PC; glucose-6-phosphatase isoform X1
454720 G6PC3; glucose-6-phosphatase 3 isoform X2
461922 IL7R; interleukin-7 receptor subunit alpha
748298 KLF2; Krueppel-like factor 2
457063 S1PR1; sphingosine 1-phosphate receptor 1
455581 S1PR4; sphingosine 1-phosphate receptor 4
466489 RAG1; V(D)J recombination-activating protein 1 isoform X2
466490 RAG2; V(D)J recombination-activating protein 2
463956 FBXO25; F-box only protein 25 isoform X1
464371 FBXO32; F-box only protein 32 isoform X1
|
K13375 TGFB1; transforming growth factor beta-1
K13376 TGFB2; transforming growth factor beta-2
K13377 TGFB3; transforming growth factor beta-3
K04674 TGFBR1; TGF-beta receptor type-1 [EC:2.7.11.30]
K04388 TGFBR2; TGF-beta receptor type-2 [EC:2.7.11.30]
K04501 SMAD4; mothers against decapentaplegic homolog 4
K23605 SMAD3; mothers against decapentaplegic homolog 3
K07298 STK11; serine/threonine-protein kinase 11 [EC:2.7.11.1]
K07198 PRKAA; 5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.31]
K07198 PRKAA; 5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.31]
K07199 PRKAB; 5'-AMP-activated protein kinase, regulatory beta subunit
K07199 PRKAB; 5'-AMP-activated protein kinase, regulatory beta subunit
K07200 PRKAG; 5'-AMP-activated protein kinase, regulatory gamma subunit
K07200 PRKAG; 5'-AMP-activated protein kinase, regulatory gamma subunit
K07200 PRKAG; 5'-AMP-activated protein kinase, regulatory gamma subunit
K04468 NLK; nemo like kinase [EC:2.7.11.24]
K03875 SKP2; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
K06643 MDM2; E3 ubiquitin-protein ligase Mdm2 [EC:2.3.2.27]
K11431 SETD7; [histone H3]-lysine4 N-methyltransferase [EC:2.1.1.364]
K04498 EP300; E1A/CREB-binding protein [EC:2.3.1.48]
K04498 EP300; E1A/CREB-binding protein [EC:2.3.1.48]
K11411 SIRT1; NAD-dependent protein deacetylase sirtuin 1 [EC:2.3.1.286]
K11838 USP7; ubiquitin carboxyl-terminal hydrolase 7 [EC:3.4.19.12]
K07191 SLC2A4; MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 4
K04440 JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
K04440 JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
K04440 JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
K04411 STK4; serine/threonine kinase 4
K05459 IGF1; insulin-like growth factor 1
K05087 IGF1R; insulin-like growth factor 1 receptor [EC:2.7.10.1]
K04526 INS; insulin
K04527 INSR; insulin receptor [EC:2.7.10.1]
K16172 IRS1; insulin receptor substrate 1
K07187 IRS2; insulin receptor substrate 2
K17446 IRS4; insulin receptor substrate 4
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K06276 PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]
K06276 PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]
K04467 IKBKA; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
K07209 IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
K01110 PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K13302 SGK1; serum/glucocorticoid-regulated kinase 1 [EC:2.7.11.1]
K13303 SGK2; serum/glucocorticoid-regulated kinase 2 [EC:2.7.11.1]
K13304 SGK3; serum/glucocorticoid-regulated kinase 3 [EC:2.7.11.1]
K07201 FOXO1; forkhead box protein O1
K09408 FOXO3; forkhead box protein O3
K17847 FOXO6; forkhead box protein O6
K04603 GRM1; metabotropic glutamate receptor 1
K15010 HOMER; homer
K15010 HOMER; homer
K15010 HOMER; homer
K17848 AGAP2; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2
K08960 CSNK1E; casein kinase 1, epsilon [EC:2.7.11.1]
K05405 IL6; interleukin 6
K05443 IL10; interleukin 10
K04692 STAT3; signal transducer and activator of transcription 3
K04357 EGF; epidermal growth factor
K04361 EGFR; epidermal growth factor receptor [EC:2.7.10.1]
K04364 GRB2; growth factor receptor-bound protein 2
K03099 SOS; son of sevenless
K03099 SOS; son of sevenless
K02833 HRAS; GTPase HRas
K07827 KRAS; GTPase KRas
K07828 NRAS; GTPase NRas
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04366 RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K08845 ARAF; A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
K04371 ERK; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K04371 ERK; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K04441 P38; p38 MAP kinase [EC:2.7.11.24]
K04441 P38; p38 MAP kinase [EC:2.7.11.24]
K04441 P38; p38 MAP kinase [EC:2.7.11.24]
K04441 P38; p38 MAP kinase [EC:2.7.11.24]
K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
K11434 PRMT1; type I protein arginine methyltransferase [EC:2.1.1.319]
K09385 FOXG; forkhead box protein G
K05868 CCNB1; G2/mitotic-specific cyclin-B1
K21770 CCNB2; G2/mitotic-specific cyclin-B2
K21771 CCNB3; G2/mitotic-specific cyclin-B3
K04503 CCND1; G1/S-specific cyclin-D1
K10151 CCND2; G1/S-specific cyclin-D2
K10146 CCNG2; cyclin G2
K04685 CDKN2B; cyclin-dependent kinase inhibitor 2B
K06623 CDKN2D; cyclin-dependent kinase inhibitor 2D
K06625 CDKN1A; cyclin-dependent kinase inhibitor 1A
K06624 CDKN1B; cyclin-dependent kinase inhibitor 1B
K16332 RBL2; retinoblastoma-like protein 2
K06631 PLK1; polo-like kinase 1 [EC:2.7.11.21]
K08861 PLK2; polo-like kinase 2 [EC:2.7.11.21]
K08862 PLK3; polo-like kinase 3 [EC:2.7.11.21]
K08863 PLK4; polo-like kinase 4 [EC:2.7.11.21]
K04402 GADD45; growth arrest and DNA-damage-inducible protein
K04402 GADD45; growth arrest and DNA-damage-inducible protein
K04402 GADD45; growth arrest and DNA-damage-inducible protein
K04389 TNFSF6; tumor necrosis factor ligand superfamily member 6
K16341 BCL2L11; Bcl-2-like protein 11
K04721 TNFSF10; tumor necrosis factor ligand superfamily member 10
K15618 BCL6; B-cell lymphoma 6 protein
K15464 BNIP3; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3
K08336 ATG12; ubiquitin-like protein ATG12
K08336 ATG12; ubiquitin-like protein ATG12
K08341 GABARAP; GABA(A) receptor-associated protein
K08341 GABARAP; GABA(A) receptor-associated protein
K08341 GABARAP; GABA(A) receptor-associated protein
K08341 GABARAP; GABA(A) receptor-associated protein
K03781 katE; catalase [EC:1.11.1.6]
K04564 SOD2; superoxide dismutase, Fe-Mn family [EC:1.15.1.1]
K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
K01596 E4.1.1.32; phosphoenolpyruvate carboxykinase (GTP) [EC:4.1.1.32]
K01596 E4.1.1.32; phosphoenolpyruvate carboxykinase (GTP) [EC:4.1.1.32]
K01084 G6PC; glucose-6-phosphatase [EC:3.1.3.9]
K01084 G6PC; glucose-6-phosphatase [EC:3.1.3.9]
K01084 G6PC; glucose-6-phosphatase [EC:3.1.3.9]
K05072 IL7R; interleukin 7 receptor
K17845 KLF2; krueppel-like factor 2
K04288 S1PR1; sphingosine 1-phosphate receptor 1
K04293 S1PR4; sphingosine 1-phosphate receptor 4
K10628 RAG1; V(D)J recombination-activating protein 1 [EC:2.3.2.27]
K10988 RAG2; recombination-activating protein 2
K10305 FBXO25_32; F-box protein 25/32
K10305 FBXO25_32; F-box protein 25/32
|
04020 Calcium signaling pathway [PATH:ptr04020]
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04070 Phosphatidylinositol signaling system [PATH:ptr04070]
|
04072 Phospholipase D signaling pathway [PATH:ptr04072]
|
04071 Sphingolipid signaling pathway [PATH:ptr04071]
|
04024 cAMP signaling pathway [PATH:ptr04024]
|
04022 cGMP-PKG signaling pathway [PATH:ptr04022]
|
04151 PI3K-Akt signaling pathway [PATH:ptr04151]
|
04152 AMPK signaling pathway [PATH:ptr04152]
|
04150 mTOR signaling pathway [PATH:ptr04150]
|
04075 Plant hormone signal transduction
|
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09133 Signaling molecules and interaction
|
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09140 Cellular Processes
|
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09141 Transport and catabolism
|
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09143 Cell growth and death
|
04110 Cell cycle [PATH:ptr04110]
|
747442 CCND1; G1/S-specific cyclin-D1
747123 CCND2; G1/S-specific cyclin-D2
462689 CCND3; G1/S-specific cyclin-D3 isoform X1
452025 CDK4; cyclin-dependent kinase 4
746968 CDK6; cyclin-dependent kinase 6 isoform X1
452715 RB1; retinoblastoma-associated protein isoform X2
735916 RBL1; retinoblastoma-like protein 1 isoform X1
467978 RBL2; retinoblastoma-like protein 2 isoform X1
107976801 ABL1; tyrosine-protein kinase ABL1 isoform X1
748850 histone deacetylase 1 isoform X1
462950 HDAC2; histone deacetylase 2 isoform X2
107966150 HDAC1; histone deacetylase 1 isoform X3
107969994 E2F1; transcription factor E2F1
469153 E2F2; transcription factor E2F2 isoform X2
471865 E2F3; transcription factor E2F3 isoform X1
747256 E2F5; transcription factor E2F5 isoform X1
454158 E2F4; transcription factor E2F4 isoform X1
100608003 TFDP1; transcription factor Dp-1
460743 TFDP2; transcription factor Dp-2
100616510 GSK3B; glycogen synthase kinase-3 beta isoform X1
456060 TGFB1; transforming growth factor beta-1 isoform X2
457742 TGFB2; transforming growth factor beta-2 isoform X1
453054 TGFB3; transforming growth factor beta-3 isoform X1
455407 SMAD2; mothers against decapentaplegic homolog 2 isoform X1
748161 SMAD3; mothers against decapentaplegic homolog 3 isoform X1
468537 SMAD4; mothers against decapentaplegic homolog 4 isoform X1
464393 MYC; myc proto-oncogene protein
740453 ZBTB17; zinc finger and BTB domain-containing protein 17
465021 CDKN2A; cyclin-dependent kinase inhibitor 2A
473204 CDKN2B; cyclin-dependent kinase 4 inhibitor B
469319 CDKN2C; cyclin-dependent kinase 4 inhibitor C
745942 CDKN2D; cyclin-dependent kinase 4 inhibitor D
466947 CDKN1B; cyclin-dependent kinase inhibitor 1B
747666 CDKN1C; cyclin-dependent kinase inhibitor 1C isoform X1
104001067 CDKN1A; cyclin-dependent kinase inhibitor 1 isoform X2
464292 CCNE2; G1/S-specific cyclin-E2
455914 CCNE1; G1/S-specific cyclin-E1 isoform X2
467032 CDK2; cyclin-dependent kinase 2 isoform X1
462063 SKP1; S-phase kinase-associated protein 1
463821 CUL1; cullin-1
458860 RBX1; E3 ubiquitin-protein ligase RBX1
471570 SKP2; S-phase kinase-associated protein 2 isoform X4
467260 CCNA1; cyclin-A1
461467 CCNA2; cyclin-A2
468234 CDC6; cell division control protein 6 homolog
468072 CDT1; DNA replication factor Cdt1
456857 ORC1; origin recognition complex subunit 1 isoform X1
459868 ORC2; origin recognition complex subunit 2 isoform X1
462876 ORC3; origin recognition complex subunit 3 isoform X2
459647 ORC4; origin recognition complex subunit 4 isoform X1
463636 ORC5; origin recognition complex subunit 5 isoform X2
465140 ORC6; origin recognition complex subunit 6
460668 MCM2; DNA replication licensing factor MCM2 isoform X2
462763 MCM3; DNA replication licensing factor MCM3 isoform X3
472757 MCM4; DNA replication licensing factor MCM4
458790 MCM5; DNA replication licensing factor MCM5
741695 MCM6; DNA replication licensing factor MCM6
472460 MCM7; DNA replication licensing factor MCM7 isoform X2
458651 CDC45; cell division control protein 45 homolog isoform X4
453642 TICRR; treslin isoform X1
464361 MTBP; mdm2-binding protein isoform X1
469380 CDC7; cell division cycle 7-related protein kinase isoform X1
472668 DBF4; protein DBF4 homolog A isoform X1
454734 DBF4B; protein DBF4 homolog B isoform X4
450481 CDK1; cyclin-dependent kinase 1
461835 CCNB1; G2/mitotic-specific cyclin-B1
453478 CCNB2; G2/mitotic-specific cyclin-B2
104002075 CCNB3; G2/mitotic-specific cyclin-B3 isoform X1
458064 CDC25B; M-phase inducer phosphatase 2 isoform X3
746151 CDC25C; M-phase inducer phosphatase 3
472830 YWHAZ; 14-3-3 protein zeta/delta
458272 YWHAB; 14-3-3 protein beta/alpha
470302 YWHAQ; 14-3-3 protein theta
454409 YWHAE; 14-3-3 protein epsilon
454608 14-3-3 protein homolog 1-like
459638 14-3-3 protein epsilon-like
458778 YWHAH; 14-3-3 protein eta
463489 YWHAG; 14-3-3 protein gamma
453991 PLK1; serine/threonine-protein kinase PLK1
466440 WEE1; wee1-like protein kinase isoform X1
463870 WEE2; wee1-like protein kinase 2
467880 PKMYT1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
739351 CCNH; cyclin-H
462378 CDK7; cyclin-dependent kinase 7 isoform X1
459381 ANAPC1; anaphase-promoting complex subunit 1 isoform X3
107973078 anaphase-promoting complex subunit 1-like
465174 ANAPC2; anaphase-promoting complex subunit 2 isoform X1
454815 CDC27; cell division cycle protein 27 homolog isoform X10
461149 ANAPC4; anaphase-promoting complex subunit 4 isoform X2
452321 ANAPC5; anaphase-promoting complex subunit 5 isoform X3
452688 CDC16; cell division cycle protein 16 homolog isoform X1
467128 ANAPC7; anaphase-promoting complex subunit 7 isoform X2
462092 CDC23; cell division cycle protein 23 homolog
739629 ANAPC10; anaphase-promoting complex subunit 10 isoform X1
454972 ANAPC11; anaphase-promoting complex subunit 11 isoform X2
473026 CDC26; anaphase-promoting complex subunit CDC26
460984 ANAPC13; anaphase-promoting complex subunit 13
101058140 ANAPC15; anaphase-promoting complex subunit 15 isoform X2
736866 ANAPC16; anaphase-promoting complex subunit 16
456819 CDC20; cell division cycle protein 20 homolog
462238 PTTG1; securin
736475 PTTG2; securin-2
451937 ESPL1; separin isoform X1
458907 SMC1B; structural maintenance of chromosomes protein 1B isoform X2
473619 SMC1A; structural maintenance of chromosomes protein 1A isoform X1
450731 SMC3; structural maintenance of chromosomes protein 3 isoform X1
464346 RAD21; double-strand-break repair protein rad21 homolog
460717 STAG1; cohesin subunit SA-1 isoform X1
473766 STAG2; cohesin subunit SA-2 isoform X1
449625 ATRX; transcriptional regulator ATRX
465368 DDX11; ATP-dependent DNA helicase DDX11 isoform X1
451825 LOW QUALITY PROTEIN: ATP-dependent DNA helicase DDX11-like
461917 NIPBL; nipped-B-like protein isoform X1
455875 MAU2; MAU2 chromatid cohesion factor homolog isoform X2
465712 HDAC8; histone deacetylase 8 isoform X13
468494 ESCO1; N-acetyltransferase ESCO1 isoform X1
472926 ESCO2; N-acetyltransferase ESCO2 isoform X2
471172 PDS5A; sister chromatid cohesion protein PDS5 homolog A isoform X1
452530 PDS5B; sister chromatid cohesion protein PDS5 homolog B isoform X1
450568 WAPL; wings apart-like protein homolog isoform X1
451310 CDCA5; sororin
107969261 AURKB; aurora kinase B isoform X1
460220 SGO1; shugoshin 1 isoform X3
464100 PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
471633 serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
100614247 PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
468983 PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
466778 PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
453170 PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
462705 PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform
457716 PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform
452962 PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform
451305 PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1
455320 NDC80; kinetochore protein NDC80 homolog
453338 KNL1; kinetochore scaffold 1 isoform X1
462844 TTK; dual specificity protein kinase TTK isoform X1
463223 MAD1L1; mitotic spindle assembly checkpoint protein MAD1 isoform X2
461661 MAD2L1; mitotic spindle assembly checkpoint protein MAD2A
457953 MAD2L2; mitotic spindle assembly checkpoint protein MAD2B isoform X3
453324 BUB1B; mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform X1
450800 BUB3; mitotic checkpoint protein BUB3 isoform X1
459484 BUB1; mitotic checkpoint serine/threonine-protein kinase BUB1
100609557 TRIP13; pachytene checkpoint protein 2 homolog
742208 pachytene checkpoint protein 2 homolog
462721 MAD2L1BP; MAD2L1-binding protein
468665 FZR1; fizzy-related protein homolog isoform X1
463083 FBXO5; F-box only protein 5 isoform X2
457058 CDC14A; dual specificity protein phosphatase CDC14A
465251 CDC14B; dual specificity protein phosphatase CDC14B
740571 dual specificity protein phosphatase CDC14C
743528 LOW QUALITY PROTEIN: dual specificity protein phosphatase CDC14C-like
467891 CREBBP; CREB-binding protein isoform X4
458862 EP300; histone acetyltransferase p300
464165 PRKDC; DNA-dependent protein kinase catalytic subunit isoform X2
460745 ATR; serine/threonine-protein kinase ATR isoform X1
451530 ATM; serine-protein kinase ATM isoform X1
742141 MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1
455214 TP53; cellular tumor antigen p53 isoform X2
464585 GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma
744311 GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta
456929 GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X2
458081 PCNA; proliferating cell nuclear antigen
737412 SFN; 14-3-3 protein sigma
739836 CHEK1; serine/threonine-protein kinase Chk1 isoform X1
458733 CHEK2; serine/threonine-protein kinase Chk2 isoform X1
460341 CDC25A; M-phase inducer phosphatase 1 isoform X3
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K04503 CCND1; G1/S-specific cyclin-D1
K10151 CCND2; G1/S-specific cyclin-D2
K10152 CCND3; G1/S-specific cyclin-D3
K02089 CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
K02091 CDK6; cyclin-dependent kinase 6 [EC:2.7.11.22]
K06618 RB1; retinoblastoma-associated protein
K04681 RBL1; retinoblastoma-like protein 1
K16332 RBL2; retinoblastoma-like protein 2
K06619 ABL1; abelson tyrosine-protein kinase 1 [EC:2.7.10.2]
K06067 HDAC1_2; histone deacetylase 1/2 [EC:3.5.1.98]
K06067 HDAC1_2; histone deacetylase 1/2 [EC:3.5.1.98]
K06067 HDAC1_2; histone deacetylase 1/2 [EC:3.5.1.98]
K17454 E2F1; transcription factor E2F1
K09389 E2F2; transcription factor E2F2
K06620 E2F3; transcription factor E2F3
K04682 E2F4_5; transcription factor E2F4/5
K04682 E2F4_5; transcription factor E2F4/5
K04683 TFDP1; transcription factor Dp-1
K09392 TFDP2; transcription factor Dp-2
K03083 GSK3B; glycogen synthase kinase 3 beta [EC:2.7.11.26]
K13375 TGFB1; transforming growth factor beta-1
K13376 TGFB2; transforming growth factor beta-2
K13377 TGFB3; transforming growth factor beta-3
K04500 SMAD2; mothers against decapentaplegic homolog 2
K23605 SMAD3; mothers against decapentaplegic homolog 3
K04501 SMAD4; mothers against decapentaplegic homolog 4
K04377 MYC; Myc proto-oncogene protein
K10500 ZBTB17; zinc finger and BTB domain-containing protein 17
K06621 CDKN2A; cyclin-dependent kinase inhibitor 2A
K04685 CDKN2B; cyclin-dependent kinase inhibitor 2B
K06622 CDKN2C; cyclin-dependent kinase inhibitor 2C
K06623 CDKN2D; cyclin-dependent kinase inhibitor 2D
K06624 CDKN1B; cyclin-dependent kinase inhibitor 1B
K09993 CDKN1C; cyclin-dependent kinase inhibitor 1C
K06625 CDKN1A; cyclin-dependent kinase inhibitor 1A
K06626 CCNE; G1/S-specific cyclin-E1
K06626 CCNE; G1/S-specific cyclin-E1
K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
K03094 SKP1; S-phase kinase-associated protein 1
K03347 CUL1; cullin 1
K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
K03875 SKP2; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
K06627 CCNA; cyclin-A
K06627 CCNA; cyclin-A
K02213 CDC6; cell division control protein 6
K10727 CDT1; chromatin licensing and DNA replication factor 1
K02603 ORC1; origin recognition complex subunit 1
K02604 ORC2; origin recognition complex subunit 2
K02605 ORC3; origin recognition complex subunit 3
K02606 ORC4; origin recognition complex subunit 4
K02607 ORC5; origin recognition complex subunit 5
K02608 ORC6; origin recognition complex subunit 6
K02540 MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3]
K02541 MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3]
K02212 MCM4; DNA replication licensing factor MCM4 [EC:5.6.2.3]
K02209 MCM5; DNA replication licensing factor MCM5 [EC:5.6.2.3]
K02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]
K02210 MCM7; DNA replication licensing factor MCM7 [EC:5.6.2.3]
K06628 CDC45; cell division control protein 45
K26117 TICRR; Treslin
K26116 MTBP; Mdm2-binding protein
K02214 CDC7; cell division control protein 7 [EC:2.7.11.1]
K06629 DBF4; protein DBF4
K06629 DBF4; protein DBF4
K02087 CDK1; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]
K05868 CCNB1; G2/mitotic-specific cyclin-B1
K21770 CCNB2; G2/mitotic-specific cyclin-B2
K21771 CCNB3; G2/mitotic-specific cyclin-B3
K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
K05867 CDC25C; M-phase inducer phosphatase 3 [EC:3.1.3.48]
K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
K06630 YWHAE; 14-3-3 protein epsilon
K06630 YWHAE; 14-3-3 protein epsilon
K06630 YWHAE; 14-3-3 protein epsilon
K16198 YWHAG_H; 14-3-3 protein gamma/eta
K16198 YWHAG_H; 14-3-3 protein gamma/eta
K06631 PLK1; polo-like kinase 1 [EC:2.7.11.21]
K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
K06633 PKMYT; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase [EC:2.7.11.1]
K06634 CCNH; cyclin H
K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
K03348 APC1; anaphase-promoting complex subunit 1
K03348 APC1; anaphase-promoting complex subunit 1
K03349 APC2; anaphase-promoting complex subunit 2
K03350 APC3; anaphase-promoting complex subunit 3
K03351 APC4; anaphase-promoting complex subunit 4
K03352 APC5; anaphase-promoting complex subunit 5
K03353 APC6; anaphase-promoting complex subunit 6
K03354 APC7; anaphase-promoting complex subunit 7
K03355 APC8; anaphase-promoting complex subunit 8
K03357 APC10; anaphase-promoting complex subunit 10
K03358 APC11; anaphase-promoting complex subunit 11
K03359 APC12; anaphase-promoting complex subunit 12
K12456 APC13; anaphase-promoting complex subunit 13
K25228 APC15; anaphase-promoting complex subunit 15
K25229 APC16; anaphase-promoting complex subunit 16
K03363 CDC20; cell division cycle 20, cofactor of APC complex
K06635 PTTG; securin
K06635 PTTG; securin
K02365 ESP1; separase [EC:3.4.22.49]
K06636 SMC1; structural maintenance of chromosome 1
K06636 SMC1; structural maintenance of chromosome 1
K06669 SMC3; structural maintenance of chromosome 3 (chondroitin sulfate proteoglycan 6)
K06670 SCC1; cohesin complex subunit SCC1
K06671 STAG1_2; cohesin complex subunit SA-1/2
K06671 STAG1_2; cohesin complex subunit SA-1/2
K10779 ATRX; transcriptional regulator ATRX
K11273 DDX11; chromosome transmission fidelity protein 1 [EC:5.6.2.7]
K11273 DDX11; chromosome transmission fidelity protein 1 [EC:5.6.2.7]
K06672 SCC2; cohesin loading factor subunit SCC2
K11266 MAU2; MAternally affected uncoordination
K11405 HDAC8; histone deacetylase 8 [EC:3.5.1.98]
K11268 ESCO; N-acetyltransferase [EC:2.3.1.-]
K11268 ESCO; N-acetyltransferase [EC:2.3.1.-]
K11267 PDS5; sister chromatid cohesion protein PDS5
K11267 PDS5; sister chromatid cohesion protein PDS5
K25163 WAPL; wings apart-like protein
K17390 CDCA5; sororin
K11479 AURKB; aurora kinase B [EC:2.7.11.1]
K11580 SGOL1; shugoshin-like 1
K04382 PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]
K04382 PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]
K04382 PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]
K03456 PPP2R1; serine/threonine-protein phosphatase 2A regulatory subunit A
K03456 PPP2R1; serine/threonine-protein phosphatase 2A regulatory subunit A
K11584 PPP2R5; serine/threonine-protein phosphatase 2A regulatory subunit B'
K11584 PPP2R5; serine/threonine-protein phosphatase 2A regulatory subunit B'
K11584 PPP2R5; serine/threonine-protein phosphatase 2A regulatory subunit B'
K11584 PPP2R5; serine/threonine-protein phosphatase 2A regulatory subunit B'
K11584 PPP2R5; serine/threonine-protein phosphatase 2A regulatory subunit B'
K11547 NDC80; kinetochore protein NDC80
K11542 CASC5; protein CASC5
K08866 TTK; serine/threonine-protein kinase TTK/MPS1 [EC:2.7.12.1]
K06679 MAD1; mitotic spindle assembly checkpoint protein MAD1
K02537 MAD2; mitotic spindle assembly checkpoint protein MAD2
K13728 MAD2L2; mitotic spindle assembly checkpoint protein MAD2B
K06637 BUB1B; mitotic checkpoint serine/threonine-protein kinase BUB1 beta [EC:2.7.11.1]
K02180 BUB3; cell cycle arrest protein BUB3
K02178 BUB1; checkpoint serine/threonine-protein kinase [EC:2.7.11.1]
K22399 TRIP13; pachytene checkpoint protein 2
K22399 TRIP13; pachytene checkpoint protein 2
K26093 MAD2L1BP; MAD2L1-binding protein
K03364 CDH1; cell division cycle 20-like protein 1, cofactor of APC complex
K10292 FBXO5; F-box protein 5
K06639 CDC14; cell division cycle 14 [EC:3.1.3.16 3.1.3.48]
K06639 CDC14; cell division cycle 14 [EC:3.1.3.16 3.1.3.48]
K06639 CDC14; cell division cycle 14 [EC:3.1.3.16 3.1.3.48]
K06639 CDC14; cell division cycle 14 [EC:3.1.3.16 3.1.3.48]
K04498 EP300; E1A/CREB-binding protein [EC:2.3.1.48]
K04498 EP300; E1A/CREB-binding protein [EC:2.3.1.48]
K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
K06643 MDM2; E3 ubiquitin-protein ligase Mdm2 [EC:2.3.2.27]
K04451 TP53; tumor protein p53
K04402 GADD45; growth arrest and DNA-damage-inducible protein
K04402 GADD45; growth arrest and DNA-damage-inducible protein
K04402 GADD45; growth arrest and DNA-damage-inducible protein
K04802 PCNA; proliferating cell nuclear antigen
K06644 SFN; stratifin
K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
K06645 CDC25A; M-phase inducer phosphatase 1 [EC:3.1.3.48]
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04111 Cell cycle - yeast
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04112 Cell cycle - Caulobacter
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04113 Meiosis - yeast
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04114 Oocyte meiosis [PATH:ptr04114]
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04210 Apoptosis [PATH:ptr04210]
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04214 Apoptosis - fly
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04215 Apoptosis - multiple species [PATH:ptr04215]
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04216 Ferroptosis [PATH:ptr04216]
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04217 Necroptosis [PATH:ptr04217]
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04115 p53 signaling pathway [PATH:ptr04115]
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04218 Cellular senescence [PATH:ptr04218]
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09144 Cellular community - eukaryotes
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09145 Cellular community - prokaryotes
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09142 Cell motility
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09150 Organismal Systems
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09160 Human Diseases
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09180 Brite Hierarchies
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09190 Not Included in Pathway or Brite
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KEGG Orthology (KO) - Pan troglodytes (chimpanzee)