Search BRITE hierarchies

KEGG Orthology (KO) [BR:rno00001]
  09130 Environmental Information Processing
    09132 Signal transduction
      04151 PI3K-Akt signaling pathway [PATH:rno04151]
        94201 Cdk4; cyclin-dependent kinase 4 isoform 1	K02089 CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
  09140 Cellular Processes
    09143 Cell growth and death
      04110 Cell cycle [PATH:rno04110]
        94201 Cdk4; cyclin-dependent kinase 4 isoform 1	K02089 CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
      04115 p53 signaling pathway [PATH:rno04115]
        94201 Cdk4; cyclin-dependent kinase 4 isoform 1	K02089 CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
      04218 Cellular senescence [PATH:rno04218]
        94201 Cdk4; cyclin-dependent kinase 4 isoform 1	K02089 CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
    09144 Cellular community - eukaryotes
      04530 Tight junction [PATH:rno04530]
        94201 Cdk4; cyclin-dependent kinase 4 isoform 1	K02089 CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
  09150 Organismal Systems
    09151 Immune system
      04660 T cell receptor signaling pathway [PATH:rno04660]
        94201 Cdk4; cyclin-dependent kinase 4 isoform 1	K02089 CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
  09160 Human Diseases
    09161 Cancer: overview
      05200 Pathways in cancer [PATH:rno05200]
        94201 Cdk4; cyclin-dependent kinase 4 isoform 1	K02089 CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
      05203 Viral carcinogenesis [PATH:rno05203]
        94201 Cdk4; cyclin-dependent kinase 4 isoform 1	K02089 CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
    09162 Cancer: specific types
      05212 Pancreatic cancer [PATH:rno05212]
        94201 Cdk4; cyclin-dependent kinase 4 isoform 1	K02089 CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
      05225 Hepatocellular carcinoma [PATH:rno05225]
        94201 Cdk4; cyclin-dependent kinase 4 isoform 1	K02089 CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
      05214 Glioma [PATH:rno05214]
        94201 Cdk4; cyclin-dependent kinase 4 isoform 1	K02089 CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
      05220 Chronic myeloid leukemia [PATH:rno05220]
        94201 Cdk4; cyclin-dependent kinase 4 isoform 1	K02089 CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
      05218 Melanoma [PATH:rno05218]
        94201 Cdk4; cyclin-dependent kinase 4 isoform 1	K02089 CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
      05219 Bladder cancer [PATH:rno05219]
        94201 Cdk4; cyclin-dependent kinase 4 isoform 1	K02089 CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
      05224 Breast cancer [PATH:rno05224]
        94201 Cdk4; cyclin-dependent kinase 4 isoform 1	K02089 CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
      05222 Small cell lung cancer [PATH:rno05222]
        94201 Cdk4; cyclin-dependent kinase 4 isoform 1	K02089 CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
      05223 Non-small cell lung cancer [PATH:rno05223]
        94201 Cdk4; cyclin-dependent kinase 4 isoform 1	K02089 CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
    09172 Infectious disease: viral
      05166 Human T-cell leukemia virus 1 infection [PATH:rno05166]
        94201 Cdk4; cyclin-dependent kinase 4 isoform 1	K02089 CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
      05160 Hepatitis C [PATH:rno05160]
        94201 Cdk4; cyclin-dependent kinase 4 isoform 1	K02089 CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
      05164 Influenza A [PATH:rno05164]
        94201 Cdk4; cyclin-dependent kinase 4 isoform 1	K02089 CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
      05162 Measles [PATH:rno05162]
        94201 Cdk4; cyclin-dependent kinase 4 isoform 1	K02089 CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
      05163 Human cytomegalovirus infection [PATH:rno05163]
        94201 Cdk4; cyclin-dependent kinase 4 isoform 1	K02089 CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
      05167 Kaposi sarcoma-associated herpesvirus infection [PATH:rno05167]
        94201 Cdk4; cyclin-dependent kinase 4 isoform 1	K02089 CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
      05169 Epstein-Barr virus infection [PATH:rno05169]
        94201 Cdk4; cyclin-dependent kinase 4 isoform 1	K02089 CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
      05165 Human papillomavirus infection [PATH:rno05165]
        94201 Cdk4; cyclin-dependent kinase 4 isoform 1	K02089 CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
    09167 Endocrine and metabolic disease
      04933 AGE-RAGE signaling pathway in diabetic complications [PATH:rno04933]
        94201 Cdk4; cyclin-dependent kinase 4 isoform 1	K02089 CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
      04934 Cushing syndrome [PATH:rno04934]
        94201 Cdk4; cyclin-dependent kinase 4 isoform 1	K02089 CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
    09176 Drug resistance: antineoplastic
      01522 Endocrine resistance [PATH:rno01522]
        94201 Cdk4; cyclin-dependent kinase 4 isoform 1	K02089 CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
  09180 Brite Hierarchies
    09181 Protein families: metabolism
      01001 Protein kinases [BR:rno01001]
        94201 Cdk4; cyclin-dependent kinase 4 isoform 1	K02089 CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]

Enzymes [BR:rno01000]
  2. Transferases
    2.7  Transferring phosphorus-containing groups
      2.7.11  Protein-serine/threonine kinases
        2.7.11.22  cyclin-dependent kinase
          94201 Cdk4; cyclin-dependent kinase 4 isoform 1	K02089 CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22] 

Protein kinases [BR:rno01001]
  Serine/threonine kinases: CMGC group
    CDK family
      94201 Cdk4; cyclin-dependent kinase 4 isoform 1	K02089 CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]