KEGG Modules

Carbohydrate metabolism
Central carbohydrate metabolism
M00001 Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate [PATH:sfl00010 sfl01200 sfl01100]
M00002 Glycolysis, core module involving three-carbon compounds [PATH:sfl00010 sfl01200 sfl01230 sfl01100]
M00003 Gluconeogenesis, oxaloacetate => fructose-6P [PATH:sfl00010 sfl00020 sfl01100]
M00307 Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:sfl00010 sfl00020 sfl00620 sfl00785 sfl01200 sfl01210 sfl01100]
M00009 Citrate cycle (TCA cycle, Krebs cycle) [PATH:sfl00020 sfl01200 sfl01100]
M00010 Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [PATH:sfl00020 sfl01200 sfl01210 sfl01230 sfl01100]
M00011 Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate [PATH:sfl00020 sfl01200 sfl01210 sfl01100]
M00004 Pentose phosphate pathway (Pentose phosphate cycle) [PATH:sfl00030 sfl01200 sfl01100 sfl01120]
M00006 Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5P [PATH:sfl00030 sfl01200 sfl01100 sfl01120]
M00007 Pentose phosphate pathway, non-oxidative phase, fructose 6P => ribose 5P [PATH:sfl00030 sfl01200 sfl01230 sfl01100 sfl01120]
M00005 PRPP biosynthesis, ribose 5P => PRPP [PATH:sfl00030 sfl00230 sfl01200 sfl01230 sfl01100]
M00008 Entner-Doudoroff pathway, glucose-6P => glyceraldehyde-3P + pyruvate [PATH:sfl00030 sfl01200 sfl01100 sfl01120]

Other carbohydrate metabolism
M00631 D-Galacturonate degradation (bacteria), D-galacturonate => pyruvate + D-glyceraldehyde 3P [PATH:sfl00040 sfl00030 sfl01100]
M00061 D-Glucuronate degradation, D-glucuronate => pyruvate + D-glyceraldehyde 3P [PATH:sfl00040 sfl00030 sfl01100]
M00632 Galactose degradation, Leloir pathway, galactose => alpha-D-glucose-1P [PATH:sfl00052 sfl01100]
M00552 D-galactonate degradation, De Ley-Doudoroff pathway, D-galactonate => glycerate-3P [PATH:sfl00052 sfl01100]
M00550 Ascorbate degradation, ascorbate => D-xylulose-5P [PATH:sfl00053 sfl01100 sfl01120]
M00854 Glycogen biosynthesis, glucose-1P => glycogen/starch [PATH:sfl00500 sfl01100]
M00855 Glycogen degradation, glycogen => glucose-6P [PATH:sfl00500 sfl01100]
M00549 Nucleotide sugar biosynthesis, glucose => UDP-glucose [PATH:sfl00520 sfl01250 sfl01100]
M00554 Nucleotide sugar biosynthesis, galactose => UDP-galactose [PATH:sfl00520 sfl00052 sfl01250 sfl01100]
M00909 UDP-N-acetyl-D-glucosamine biosynthesis, prokaryotes, glucose => UDP-GlcNAc [PATH:sfl00520 sfl01250 sfl01100]
M00012 Glyoxylate cycle [PATH:sfl00630 sfl01200 sfl01100 sfl01110]
M00741 Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA [PATH:sfl00280 sfl00630 sfl00640 sfl01200 sfl01100]

Energy metabolism
Carbon fixation
M00168 CAM (Crassulacean acid metabolism), dark [PATH:sfl00620 sfl01200 sfl01100 sfl01120]
M00169 CAM (Crassulacean acid metabolism), light [PATH:sfl00620 sfl01200 sfl01100 sfl01120]
M00579 Phosphate acetyltransferase-acetate kinase pathway, acetyl-CoA => acetate [PATH:sfl00430 sfl00620 sfl01200 sfl01100 sfl01120]

Methane metabolism
Nitrogen metabolism
M00531 Assimilatory nitrate reduction, nitrate => ammonia [PATH:sfl00910 sfl01100 sfl01120]
M00530 Dissimilatory nitrate reduction, nitrate => ammonia [PATH:sfl00910 sfl01100 sfl01120]

Sulfur metabolism
M00176 Assimilatory sulfate reduction, sulfate => H2S [PATH:sfl00920 sfl01100 sfl01120]

Photosynthesis
ATP synthesis
M00144 NADH:quinone oxidoreductase, prokaryotes [PATH:sfl00190 sfl01100]
M00149 Succinate dehydrogenase, prokaryotes [PATH:sfl00190 sfl01100]
M00150 Fumarate reductase, prokaryotes [PATH:sfl00190 sfl01100]
M00151 Cytochrome bc1 complex respiratory unit [PATH:sfl00190 sfl01100]
M00155 Cytochrome c oxidase, prokaryotes [PATH:sfl00190 sfl01100]
M00156 Cytochrome c oxidase, cbb3-type [PATH:sfl00190 sfl01100]
M00157 F-type ATPase, prokaryotes and chloroplasts [PATH:sfl00190 sfl01100]

Lipid metabolism
Fatty acid metabolism
M00082 Fatty acid biosynthesis, initiation [PATH:sfl00061 sfl01212 sfl01100]
M00083 Fatty acid biosynthesis, elongation [PATH:sfl00061 sfl01212 sfl01100]
M00086 beta-Oxidation, acyl-CoA synthesis [PATH:sfl00061 sfl00071 sfl01212 sfl01100]
M00087 beta-Oxidation [PATH:sfl00071 sfl01212 sfl01100]

Sterol biosynthesis
Lipid metabolism
M00098 Acylglycerol degradation [PATH:sfl00561 sfl01100]
M00091 Phosphatidylcholine (PC) biosynthesis, PE => PC [PATH:sfl00564 sfl01100]
M00093 Phosphatidylethanolamine (PE) biosynthesis, PA => PS => PE [PATH:sfl00564 sfl01100]

Nucleotide metabolism
Purine metabolism
M00048 De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:sfl00230 sfl01100]
M00049 Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:sfl00230 sfl01232 sfl01240 sfl01100]
M00050 Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:sfl00230 sfl01232 sfl01100]
M00053 Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:sfl00230 sfl00240 sfl01232 sfl01100]
M00958 Adenine ribonucleotide degradation, AMP => Urate [PATH:sfl00230 sfl01232 sfl01100]

Pyrimidine metabolism
M00051 De novo pyrimidine biosynthesis, glutamine (+ PRPP) => UMP [PATH:sfl00240 sfl01240 sfl01100]
M00052 Pyrimidine ribonucleotide biosynthesis, UMP => UDP/UTP,CDP/CTP [PATH:sfl00240 sfl01232 sfl01240 sfl01100]
M00938 Pyrimidine deoxyribonucleotide biosynthesis, UDP => dTTP [PATH:sfl00240 sfl01232 sfl01100]
M00939 Pyrimidine degradation, uracil => 3-hydroxypropanoate [PATH:sfl00240 sfl01100]

Amino acid metabolism
Serine and threonine metabolism
M00020 Serine biosynthesis, glycerate-3P => serine [PATH:sfl00260 sfl00680 sfl01200 sfl01230 sfl01100]
M00018 Threonine biosynthesis, aspartate => homoserine => threonine [PATH:sfl00260 sfl01230 sfl01100 sfl01110]
M00621 Glycine cleavage system [PATH:sfl00260 sfl00630 sfl00785 sfl01200 sfl01100]

Cysteine and methionine metabolism
M00021 Cysteine biosynthesis, serine => cysteine [PATH:sfl00270 sfl00920 sfl01200 sfl01230 sfl01100 sfl01110]

Branched-chain amino acid metabolism
M00019 Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:sfl00290 sfl00770 sfl01210 sfl01230 sfl01100 sfl01110]
M00570 Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine [PATH:sfl00290 sfl01230 sfl01100]
M00432 Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:sfl00290 sfl01210 sfl01230 sfl01100 sfl01110]

Lysine metabolism
M00016 Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine [PATH:sfl00300 sfl01230 sfl01100]

Arginine and proline metabolism
M00028 Ornithine biosynthesis, glutamate => ornithine [PATH:sfl00220 sfl01210 sfl01230 sfl01100]
M00844 Arginine biosynthesis, ornithine => arginine [PATH:sfl00220 sfl01230 sfl01100]
M00015 Proline biosynthesis, glutamate => proline [PATH:sfl00330 sfl01230 sfl01100]
M00970 Proline degradation, proline => glutamate [PATH:sfl00330 sfl01100]

Polyamine biosynthesis
M00133 Polyamine biosynthesis, arginine => agmatine => putrescine => spermidine [PATH:sfl00330 sfl01100]
M00136 GABA biosynthesis, prokaryotes, putrescine => GABA [PATH:sfl00330 sfl01100]

Histidine metabolism
M00026 Histidine biosynthesis, PRPP => histidine [PATH:sfl00340 sfl01230 sfl01100 sfl01110]
M00045 Histidine degradation, histidine => N-formiminoglutamate => glutamate [PATH:sfl00340 sfl01100]

Aromatic amino acid metabolism
M00022 Shikimate pathway, phosphoenolpyruvate + erythrose-4P => chorismate [PATH:sfl00400 sfl01230 sfl01100 sfl01110]
M00023 Tryptophan biosynthesis, chorismate => tryptophan [PATH:sfl00400 sfl01230 sfl01100 sfl01110]
M00024 Phenylalanine biosynthesis, chorismate => phenylpyruvate => phenylalanine [PATH:sfl00400 sfl01230 sfl01100 sfl01110]
M00025 Tyrosine biosynthesis, chorismate => HPP => tyrosine [PATH:sfl00400 sfl01230 sfl01100]
M00044 Tyrosine degradation, tyrosine => homogentisate [PATH:sfl00350 sfl01100]
M00533 Homoprotocatechuate degradation, homoprotocatechuate => 2-oxohept-3-enedioate [PATH:sfl00350 sfl01220 sfl01100 sfl01120]

Other amino acid metabolism
M00118 Glutathione biosynthesis, glutamate => glutathione [PATH:sfl00480 sfl01240 sfl01100]

Glycan metabolism
Glycan biosynthesis
Glycosaminoglycan metabolism
Lipopolysaccharide metabolism
M00060 KDO2-lipid A biosynthesis, Raetz pathway, LpxL-LpxM type [PATH:sfl00540 sfl01100]
M00063 CMP-KDO biosynthesis [PATH:sfl00540 sfl01250 sfl01100]
M00064 ADP-L-glycero-D-manno-heptose biosynthesis [PATH:sfl00540 sfl01250 sfl01100]

Metabolism of cofactors and vitamins
Cofactor and vitamin metabolism
M00899 Thiamine salvage pathway, HMP/HET => TMP [PATH:sfl00730 sfl01100]
M00125 Riboflavin biosynthesis, plants and bacteria, GTP => riboflavin/FMN/FAD [PATH:sfl00740 sfl01240 sfl01100 sfl01110]
M00124 Pyridoxal-P biosynthesis, erythrose-4P => pyridoxal-P [PATH:sfl00750 sfl01240 sfl01100]
M00115 NAD biosynthesis, aspartate => quinolinate => NAD [PATH:sfl00760 sfl01240 sfl01100]
M00119 Pantothenate biosynthesis, valine/L-aspartate => pantothenate [PATH:sfl00770 sfl01240 sfl01100 sfl01110]
M00120 Coenzyme A biosynthesis, pantothenate => CoA [PATH:sfl00770 sfl01240 sfl01100]
M00572 Pimeloyl-ACP biosynthesis, BioC-BioH pathway, malonyl-ACP => pimeloyl-ACP [PATH:sfl00780 sfl01240 sfl01100]
M00123 Biotin biosynthesis, pimeloyl-ACP/CoA => biotin [PATH:sfl00780 sfl01240 sfl01100]
M00881 Lipoic acid biosynthesis, plants and bacteria, octanoyl-ACP => dihydrolipoyl-E2/H [PATH:sfl00785 sfl01240 sfl01100]
M00126 Tetrahydrofolate biosynthesis, GTP => THF [PATH:sfl00790 sfl00670 sfl01240 sfl01100]
M00880 Molybdenum cofactor biosynthesis, GTP => molybdenum cofactor [PATH:sfl00790 sfl01240 sfl01100]
M00846 Siroheme biosynthesis, glutamyl-tRNA => siroheme [PATH:sfl00860 sfl01240 sfl01100 sfl01110]
M00121 Heme biosynthesis, plants and bacteria, glutamate => heme [PATH:sfl00860 sfl01240 sfl01100 sfl01110]
M00117 Ubiquinone biosynthesis, prokaryotes, chorismate (+ polyprenyl-PP) => ubiquinol [PATH:sfl00130 sfl01240 sfl01100 sfl01110]
M00116 Menaquinone biosynthesis, chorismate (+ polyprenyl-PP) => menaquinol [PATH:sfl00130 sfl01240 sfl01100 sfl01110]

Biosynthesis of terpenoids and polyketides
Terpenoid backbone biosynthesis
M00096 C5 isoprenoid biosynthesis, non-mevalonate pathway [PATH:sfl00900 sfl01100 sfl01110]
M00364 C10-C20 isoprenoid biosynthesis, bacteria [PATH:sfl00900 sfl01100 sfl01110]

Plant terpenoid biosynthesis
Macrolide biosynthesis
Enediyne biosynthesis
Type II polyketide biosynthesis
Polyketide sugar unit biosynthesis
M00793 dTDP-L-rhamnose biosynthesis [PATH:sfl00521 sfl00523 sfl00541 sfl01250 sfl01100 sfl01110]

Biosynthesis of other secondary metabolites
Biosynthesis of phytochemical compounds
Biosynthesis of beta-lactams
Biosynthesis of other antibiotics
Biosynthesis of other fungal compounds
Biosynthesis of other bacterial compounds
M00918 Aerobactin biosynthesis, lysine => aerobactin [PATH:sfl00997 sfl01100 sfl01110]

Xenobiotics biodegradation
Aromatics degradation

Gene set
Pathogenicity
Drug resistance
M00627 beta-Lactam resistance, Bla system [PATH:sfl01501]
M00746 Multidrug resistance, repression of porin OmpF

Plant pathogenicity
Symbiosis
Module set
Metabolic capacity
M00615 Nitrate assimilation