KEGG Modules

Energy metabolism

 Carbon fixation

 Nitrogen metabolism
M00531 Assimilatory nitrate reduction, nitrate => ammonia [PATH: str00910]


 Methane metabolism
M00345 Formaldehyde assimilation, ribulose monophosphate pathway [PATH: str00680]


 Sulfur metabolism
Carbohydrate and lipid metabolism

 Central carbohydrate metabolism
M00001 Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate [PATH: str00010]
M00002 Glycolysis, core module involving three-carbon compounds [PATH: str00010]
M00003 Gluconeogenesis, oxaloacetate => fructose-6P [PATH: str00010 str00020]
M00307 Pyruvate oxidation, pyruvate => acetyl-CoA [PATH: str00010 str00020 str00620]
M00009 Citrate cycle (TCA cycle, Krebs cycle) [PATH: str00020]
M00010 Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [PATH: str00020]
M00011 Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate [PATH: str00020]
M00004 Pentose phosphate pathway (Pentose phosphate cycle) [PATH: str00030]
M00006 Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5P [PATH: str00030]
M00007 Pentose phosphate pathway, non-oxidative phase, fructose 6P => ribose 5P [PATH: str00030]
M00005 PRPP biosynthesis, ribose 5P => PRPP [PATH: str00030 str00230]


 Other carbohydrate metabolism

 Fatty acid metabolism
M00086 beta-Oxidation, acyl-CoA synthesis [PATH: str00071]


 Lipid metabolism
M00093 Phosphatidylethanolamine (PE) biosynthesis, PA => PS => PE [PATH: str00564]


 Lipopolysaccharide metabolism
M00063 CMP-KDO biosynthesis [PATH: str00540]


 Sugar metabolism
M00549 Nucleotide sugar biosynthesis, glucose => UDP-glucose [PATH: str00520]
M00554 Nucleotide sugar biosynthesis, galactose => UDP-galactose [PATH: str00520 str00052]


 Glycan metabolism

 Glycosaminoglycan metabolism

 Terpenoid backbone biosynthesis
M00096 C5 isoprenoid biosynthesis, non-mevalonate pathway [PATH: str00900]
M00364 C10-C20 isoprenoid biosynthesis, bacteria [PATH: str00900]


 Sterol biosynthesis

 Other terpenoid biosynthesis
Nucleotide and amino acid metabolism

 Purine metabolism
M00048 Inosine monophosphate biosynthesis, PRPP + glutamine => IMP [PATH: str00230]
M00049 Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH: str00230]
M00050 Guanine ribonucleotide biosynthesis IMP => GDP,GTP [PATH: str00230]
M00546 Purine degradation, xanthine => urea [PATH: str00230]


 Pyrimidine metabolism
M00051 Uridine monophosphate biosynthesis, glutamine (+ PRPP) => UMP [PATH: str00240]
M00052 Pyrimidine ribonucleotide biosynthesis, UMP => UDP/UTP,CDP/CTP [PATH: str00240]


 Serine and threonine metabolism
M00020 Serine biosynthesis, glycerate-3P => serine [PATH: str00260]
M00018 Threonine biosynthesis, apartate => homoserine => threonine [PATH: str00260]


 Cysteine and methionine metabolism
M00021 Cysteine biosynthesis, serine => cysteine [PATH: str00270]


 Branched-chain amino acid metabolism
M00019 Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH: str00290]
M00570 Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine [PATH: str00290]
M00432 Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH: str00290]


 Lysine metabolism
M00016 Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine [PATH: str00300]


 Arginine and proline metabolism
M00015 Proline biosynthesis, glutamate => proline [PATH: str00330]
M00028 Ornithine biosynthesis, glutamate => ornithine [PATH: str00330]


 Histidine metabolism
M00026 Histidine biosynthesis, PRPP => histidine [PATH: str00340]


 Aromatic amino acid metabolism
M00022 Shikimate pathway, phosphoenolpyruvate + erythrose-4P => chorismate [PATH: str00400]
M00023 Tryptophan biosynthesis, chorismate => tryptophan [PATH: str00400]


 Other amino acid metabolism
M00027 GABA (gamma-Aminobutyrate) shunt [PATH: str00250]


 Cofactor and vitamin biosynthesis
M00115 NAD biosynthesis, aspartate => NAD [PATH: str00760]
M00119 Pantothenate biosynthesis, valine/L-aspartate => pantothenate [PATH: str00770]
M00120 Coenzyme A biosynthesis, pantothenate => CoA [PATH: str00770]
M00123 Biotin biosynthesis, pimeloyl-ACP/CoA => biotin [PATH: str00780]
M00126 Tetrahydrofolate biosynthesis, GTP => THF [PATH: str00790 str00670]
M00121 Heme biosynthesis, glutamate => protoheme/siroheme [PATH: str00860]
M00140 C1-unit interconversion, prokaryotes [PATH: str00670]


 Polyamine biosynthesis

 Phenylpropanoid and flavonoid biosynthesis

 Alkaloid and other secondary metabolite biosynthesis
M00033 Ectoine biosynthesis [PATH: str00260]

Secondary metabolism

 Aromatics degradataion

Energy metabolism

 Photosynthesis

 ATP synthesis
M00144 NADH:quinone oxidoreductase, prokaryotes [PATH: str00190]
M00149 Succinate dehydrogenase, prokaryotes [PATH: str00190]
M00151 Cytochrome bc1 complex respiratory unit [PATH: str00190]
M00155 Cytochrome c oxidase, prokaryotes [PATH: str00190]
M00153 Cytochrome d ubiquinol oxidase [PATH: str00190]
M00157 F-type ATPase, bacteria [PATH: str00190]

Carbohydrate and lipid metabolism

 Carbohydrate metabolism

 Glycan metabolism
Genetic information processing

 DNA polymerase
M00260 DNA polymerase III complex, bacteria [BR:ko03032 ko03400][PATH: str03030 str03430 str03440]


 Replication system

 Repair system

 RNA polymerase
M00183 RNA polymerase, bacteria [BR:ko03021 ko03400][PATH: str03020]


 Spliceosome

 RNA processing

 Ribosome
M00178 Ribosome, bacteria [BR:ko03011][PATH: str03010]


 Proteasome

 Ubiquitin system

 Protein processing
Environmental information processing

 Mineral and organic ion transport system
M00189 Molybdate transport system [BR:ko02000][PATH: str02010]
M00186 Tungstate transport system [BR:ko02000][PATH: str02010]
M00188 NitT/TauT family transport system [BR:ko02000]
M00435 Taurine transport system [BR:ko02000][PATH: str02010]
M00191 Thiamine transport system [BR:ko02000][PATH: str02010]
M00299 Spermidine/putrescine transport system [BR:ko02000][PATH: str02010]
M00193 Putative spermidine/putrescine transport system [BR:ko02000]
M00208 Glycine betaine/proline transport system [BR:ko02000][PATH: str02010]
M00209 Osmoprotectant transport system [BR:ko02000][PATH: str02010]


 Saccharide and polyol transport system
M00205 N-Acetylglucosamine transport system [BR:ko02000][PATH: str02010]
M00206 Cellobiose transport system [BR:ko02000][PATH: str02010]
M00214 Methyl-galactoside transport system [BR:ko02000][PATH: str02010]
M00215 D-Xylose transport system [BR:ko02000][PATH: str02010]
M00216 Multiple sugar transport system [BR:ko02000][PATH: str02010]
M00217 D-Allose transport system [BR:ko02000][PATH: str02010]
M00220 Rhamnose transport system [BR:ko02000][PATH: str02010]
M00212 Ribose transport system [BR:ko02000][PATH: str02010]
M00200 Putative sorbitol/mannitol transport system [BR:ko02000][PATH: str02010]
M00207 Putative multiple sugar transport system [BR:ko02000]
M00210 Putative ABC transport system [BR:ko02000]


 Phosphate and amino acid transport system
M00222 Phosphate transport system [BR:ko02000][PATH: str02010]
M00233 Glutamate transport system [BR:ko02000][PATH: str02010]
M00589 Putative lysine transport system [BR:ko02000][PATH: str02010]
M00237 Branched-chain amino acid transport system [BR:ko02000][PATH: str02010]
M00238 D-Methionine transport system [BR:ko02000][PATH: str02010]
M00236 Putative polar amino acid transport system [BR:ko02000]


 Peptide and nickel transport system
M00439 Oligopeptide transport system [BR:ko02000][PATH: str02010]
M00239 Peptides/nickel transport system [BR:ko02000][PATH: str02010]


 Metallic cation, iron-siderophore and vitamin B12 transport system
M00240 Iron complex transport system [BR:ko02000][PATH: str02010]
M00242 Zinc transport system [BR:ko02000][PATH: str02010]
M00319 Manganese/zinc/iron transport system [BR:ko02000][PATH: str02010]
M00245 Cobalt transport system [BR:ko02000][PATH: str02010]
M00582 Energy-coupling factor transport system [BR:ko02000][PATH: str02010]
M00247 Putative ABC transport system [BR:ko02000]


 ABC-2 type and other transport systems
M00250 Lipopolysaccharide transport system [BR:ko02000][PATH: str02010]
M00320 Lipopolysaccharide export system [BR:ko02000][PATH: str02010]
M00255 Lipoprotein-releasing system [BR:ko02000][PATH: str02010]
M00256 Cell division transport system [BR:ko02000][PATH: str02010]
M00248 Putative antibiotic transport system [BR:ko02000][PATH: str02010]
M00258 Putative ABC transport system [BR:ko02000]
M00254 ABC-2 type transport system [BR:ko02000]


 Phosphotransferase system (PTS)
M00266 PTS system, maltose and glucose-specific II component [BR:ko02000][PATH: str00010 str00500 str02060]
M00282 PTS system, D-glucosamine-specific II component [BR:ko02000][PATH: str00520 str02060]
M00271 PTS system, beta-glucosides-specific II component [BR:ko02000][PATH: str02060]
M00270 PTS system, trehalose-specific II component [BR:ko02000][PATH: str00500 str02060]
M00268 PTS system, arbutin-like II component [BR:ko02000][PATH: str00010 str02060]
M00273 PTS system, fructose-specific II component [BR:ko02000][PATH: str00051 str02060]
M00274 PTS system, mannitol-specific II component [BR:ko02000][PATH: str00051 str02060]
M00305 PTS system, 2-O-A-mannosyl-D-glycerate-specific II component [BR:ko02000][PATH: str02060]
M00281 PTS system, lactose-specific II component [BR:ko02000][PATH: str00052 str02060]
M00275 PTS system, cellobiose-specific II component [BR:ko02000][PATH: str02060]
M00280 PTS system, glucitol/sorbitol-specific II component [BR:ko02000][PATH: str00051 str02060]
M00279 PTS system, galactitol-specific II component [BR:ko02000][PATH: str00052 str02060]
M00276 PTS system, mannose-specific II component [BR:ko02000][PATH: str00051 str02060]
M00287 PTS system, galactosamine-specific II component [BR:ko02000][PATH: str00052 str02060]
M00283 PTS system, ascorbate-specific II component [BR:ko02000][PATH: str00053 str02060]


 Bacterial secretion system
M00335 Sec (secretion) system [BR:ko02044][PATH: str03070]
M00336 Twin-arginine translocation (Tat) system [BR:ko02044][PATH: str03070]

Metabolism

 Aminoacyl tRNA
M00360 Aminoacyl-tRNA biosynthesis, prokaryotes [PATH: str00970]


 Nucleotide sugar
M00362 Nucleotide sugar biosynthesis, prokaryotes [PATH: str00520]

Environmental information processing

 Two-component regulatory system
M00443 SenX3-RegX3 (phosphate starvation response) two-component regulatory system [BR:ko02022][PATH: str02020]
M00454 KdpD-KdpE (potassium transport) two-component regulatory system [BR:ko02022][PATH: str02020]
M00460 MprB-MprA (maintenance of persistent infection) two-component regulatory system [BR:ko02022][PATH: str02020]
M00461 MtrB-MtrA (osmotic stress response) two-component regulatory system [BR:ko02022][PATH: str02020]
M00479 DesK-DesR (membrane lipid fluidity regulation) two-component regulatory system [BR:ko02022][PATH: str02020]

Genotypic signature

 Pathogenicity