Drug metabolism - other enzymes
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Reference pathway
Reference pathway (KO)
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Homo sapiens (human)
Homo sapiens (human) + Disease/drug
Pan troglodytes (chimpanzee)
Pan paniscus (bonobo)
Gorilla gorilla gorilla (western lowland gorilla)
Pongo abelii (Sumatran orangutan)
Nomascus leucogenys (northern white-cheeked gibbon)
Macaca mulatta (rhesus monkey)
Macaca fascicularis (crab-eating macaque)
Chlorocebus sabaeus (green monkey)
Rhinopithecus roxellana (golden snub-nosed monkey)
Rhinopithecus bieti (black snub-nosed monkey)
Callithrix jacchus (white-tufted-ear marmoset)
Saimiri boliviensis boliviensis (Bolivian squirrel monkey)
Mus musculus (mouse)
Rattus norvegicus (rat)
Cricetulus griseus (Chinese hamster)
Nannospalax galili (Upper Galilee mountains blind mole rat)
Heterocephalus glaber (naked mole rat)
Castor canadensis (American beaver)
Oryctolagus cuniculus (rabbit)
Tupaia chinensis (Chinese tree shrew)
Canis familiaris (dog)
Ailuropoda melanoleuca (giant panda)
Ursus maritimus (polar bear)
Odobenus rosmarus divergens (Pacific walrus)
Felis catus (domestic cat)
Panthera tigris altaica (Amur tiger)
Acinonyx jubatus (cheetah)
Bos taurus (cow)
Bos mutus (wild yak)
Bos indicus (zebu cattle)
Pantholops hodgsonii (chiru)
Capra hircus (goat)
Ovis aries (sheep)
Sus scrofa (pig)
Camelus ferus (Wild Bactrian camel)
Camelus dromedarius (Arabian camel)
Balaenoptera acutorostrata scammoni (minke whale)
Lipotes vexillifer (Yangtze River dolphin)
Orcinus orca (killer whale)
Equus caballus (horse)
Equus przewalskii (Przewalski's horse)
Equus asinus (ass)
Myotis brandtii (Brandt's bat)
Myotis davidii
Hipposideros armiger (great roundleaf bat)
Rhinolophus sinicus (Chinese rufous horseshoe bat)
Pteropus alecto (black flying fox)
Loxodonta africana (African savanna elephant)
Trichechus manatus latirostris (Florida manatee)
Monodelphis domestica (opossum)
Sarcophilus harrisii (Tasmanian devil)
Ornithorhynchus anatinus (platypus)
Gallus gallus (chicken)
Meleagris gallopavo (turkey)
Coturnix japonica (Japanese quail)
Anas platyrhynchos (mallard)
Anser cygnoides domesticus (swan goose)
Taeniopygia guttata (zebra finch)
Geospiza fortis (medium ground-finch)
Ficedula albicollis (collared flycatcher)
Pseudopodoces humilis (Tibetan ground-tit)
Parus major (Great Tit)
Corvus cornix (hooded crow)
Falco peregrinus (peregrine falcon)
Falco cherrug (Saker falcon)
Columba livia (rock pigeon)
Egretta garzetta (little egret)
Apteryx australis mantelli (brown kiwi)
Alligator sinensis (Chinese alligator)
Alligator mississippiensis (American alligator)
Pelodiscus sinensis (Chinese soft-shelled turtle)
Chelonia mydas (green sea turtle)
Chrysemys picta (western painted turtle)
Anolis carolinensis (green anole)
Pogona vitticeps (central bearded dragon)
Python bivittatus (Burmese python)
Gekko japonicus
Xenopus laevis (African clawed frog)
Xenopus tropicalis (western clawed frog)
Nanorana parkeri
Danio rerio (zebrafish)
Sinocyclocheilus rhinocerous
Sinocyclocheilus anshuiensis
Sinocyclocheilus grahami
Cyprinus carpio (common carp)
Ictalurus punctatus (channel catfish)
Astyanax mexicanus (Mexican tetra)
Takifugu rubripes (torafugu)
Tetraodon nigroviridis (spotted green pufferfish)
Larimichthys crocea (large yellow croaker)
Notothenia coriiceps (black rockcod)
Maylandia zebra (zebra mbuna)
Oryzias latipes (Japanese medaka)
Xiphophorus maculatus (southern platyfish)
Poecilia reticulata (guppy)
Nothobranchius furzeri (turquoise killifish)
Cynoglossus semilaevis (tongue sole)
Lates calcarifer (barramundi perch)
Hippocampus comes (tiger tail seahorse)
Boleophthalmus pectinirostris (great blue-spotted mudskipper)
Salmo salar (Atlantic salmon)
Esox lucius (northern pike)
Scleropages formosus (Asian bonytongue)
Latimeria chalumnae (coelacanth)
Callorhinchus milii (elephant shark)
Branchiostoma floridae (Florida lancelet)
Ciona intestinalis (sea squirt)
Strongylocentrotus purpuratus (purple sea urchin)
Acanthaster planci (crown-of-thorns starfish)
Saccoglossus kowalevskii (acorn worm)
Drosophila melanogaster (fruit fly)
Drosophila pseudoobscura pseudoobscura
Drosophila ananassae
Drosophila erecta
Drosophila persimilis
Drosophila sechellia
Drosophila simulans
Drosophila willistoni
Drosophila yakuba
Drosophila grimshawi
Drosophila mojavensis
Drosophila virilis
Musca domestica (house fly)
Anopheles gambiae (mosquito)
Aedes aegypti (yellow fever mosquito)
Culex quinquefasciatus (southern house mosquito)
Apis mellifera (honey bee)
Bombus impatiens (common eastern bumble bee)
Bombus terrestris (buff-tailed bumblebee)
Solenopsis invicta (red fire ant)
Acromyrmex echinatior (Panamanian leafcutter ant)
Atta cephalotes (leaf cutting ant)
Pogonomyrmex barbatus (red harvester ant)
Harpegnathos saltator (Jerdon's jumping ant)
Camponotus floridanus (Florida carpenter ant)
Linepithema humile (Argentine ant)
Pseudomyrmex gracilis
Nasonia vitripennis (jewel wasp)
Tribolium castaneum (red flour beetle)
Dendroctonus ponderosae (mountain pine beetle)
Nicrophorus vespilloides
Bombyx mori (domestic silkworm)
Danaus plexippus (monarch butterfly)
Papilio machaon (common yellow swallowtail)
Pieris rapae (cabbage white)
Plutella xylostella (diamondback moth)
Acyrthosiphon pisum (pea aphid)
Diuraphis noxia (Russian wheat aphid)
Pediculus humanus corporis (human body louse)
Zootermopsis nevadensis
Folsomia candida
Daphnia pulex (common water flea)
Ixodes scapularis (black-legged tick)
Tetranychus urticae (two-spotted spider mite)
Caenorhabditis elegans (nematode)
Caenorhabditis briggsae
Necator americanus
Brugia malayi (filaria)
Loa loa (eye worm)
Trichinella spiralis
Helobdella robusta
Lottia gigantea (owl limpet)
Crassostrea gigas (Pacific oyster)
Mizuhopecten yessoensis (Yesso scallop)
Octopus bimaculoides
Lingula anatina
Schistosoma mansoni
Schistosoma haematobium
Opisthorchis viverrini
Nematostella vectensis (sea anemone)
Exaiptasia pallida
Acropora digitifera (stony coral)
Hydra vulgaris
Trichoplax adhaerens
Amphimedon queenslandica (sponge)
Mycobacterium tuberculosis H37Rv
Mycobacterium tuberculosis H37Rv
Mycobacterium tuberculosis CDC1551
Mycobacterium tuberculosis H37Ra
Mycobacterium tuberculosis F11
Mycobacterium tuberculosis KZN 1435
Mycobacterium tuberculosis KZN 4207
Mycobacterium tuberculosis KZN 605
Mycobacterium tuberculosis RGTB327
Mycobacterium tuberculosis RGTB423
Mycobacterium tuberculosis CCDC5079
Mycobacterium tuberculosis CCDC5079
Mycobacterium tuberculosis CCDC5180
Mycobacterium tuberculosis CTRI-2
Mycobacterium tuberculosis UT205
Mycobacterium tuberculosis Erdman = ATCC 35801
Mycobacterium tuberculosis Beijing/NITR203
Mycobacterium tuberculosis 7199-99
Mycobacterium tuberculosis CAS/NITR204
Mycobacterium tuberculosis EAI5/NITR206
Mycobacterium tuberculosis EAI5
Mycobacterium tuberculosis Haarlem/NITR202
Mycobacterium tuberculosis Haarlem
Mycobacterium tuberculosis BT1
Mycobacterium tuberculosis BT2
Mycobacterium tuberculosis HKBS1
Mycobacterium bovis AF2122/97
Mycobacterium bovis BCG Pasteur 1173P2
Mycobacterium bovis BCG Tokyo 172
Mycobacterium bovis BCG Mexico
Mycobacterium bovis BCG Korea 1168P
Mycobacterium bovis BCG ATCC 35743
Mycobacterium bovis ATCC BAA-935
Mycobacterium africanum
Mycobacterium canettii CIPT 140010059
Mycobacterium canettii CIPT 140060008
Mycobacterium canettii CIPT 140070008
Mycobacterium canettii CIPT 140070010
Mycobacterium canettii CIPT 140070017
Mycobacterium microti
Mycobacterium leprae TN
Mycobacterium leprae Br4923
Mycobacterium avium subsp. paratuberculosis K-10
Mycobacterium avium subsp. paratuberculosis MAP4
Mycobacterium avium subsp. paratuberculosis E1
Mycobacterium avium subsp. paratuberculosis E93
Mycobacterium avium 104
Mycobacterium avium subsp. avium DJO-44271
Mycobacterium avium subsp. avium 2285 (R)
Mycobacterium avium subsp. avium 2285 (S)
Mycobacterium intracellulare MOTT-02
Mycobacterium intracellulare ATCC 13950
Mycobacterium intracellulare 1956
Mycobacterium paraintracellulare
Mycobacterium indicus pranii
Mycobacterium yongonense
Mycobacterium chimaera
Mycobacterium marseillense
Mycobacterium smegmatis MC2 155
Mycobacterium smegmatis MC2 155
Mycobacterium smegmatis MC2 155
Mycobacterium smegmatis INHR1
Mycobacterium smegmatis INHR2
Mycobacterium vanbaalenii
Mycobacterium gilvum PYR-GCK
Mycobacterium gilvum Spyr1
Mycobacterium chubuense
Mycobacterium neoaurum
Mycobacterium goodii
Mycobacterium fortuitum
Mycobacterium phlei
Mycobacterium vaccae
Mycobacterium litorale
Mycobacterium sp. JS623
Mycobacterium ulcerans
Mycobacterium abscessus ATCC 19977
Mycobacterium abscessus subsp. bolletii 50594
Mycobacterium abscessus subsp. bolletii GO 06
Mycobacterium abscessus subsp. bolletii MA 1948
Mycobacterium abscessus subsp. bolletii MC1518
Mycobacterium abscessus subsp. bolletii CCUG 48898 = JCM 15300
Mycobacterium abscessus subsp. bolletii 103
Mycobacterium abscessus subsp. abscessus
Mycobacterium abscessus DJO-44274
Mycobacterium abscessus 4529
Mycobacterium chelonae
Mycobacterium immunogenum
Mycobacterium stephanolepidis
Mycobacterium sp. MCS
Mycobacterium sp. KMS
Mycobacterium sp. JLS
Mycobacterium sinense
Mycobacterium marinum M
Mycobacterium marinum E11
Mycobacterium rhodesiae
Mycobacterium sp. MOTT36Y
Mycobacterium liflandii
Mycobacterium kansasii ATCC 12478
Mycobacterium kansasii 662
Mycobacterium kansasii 824
Mycobacterium sp. VKM Ac-1817D
Mycobacterium sp. EPa45
Mycobacterium haemophilum
Mycobacterium sp. NRRL B-3805
Mycobacterium dioxanotrophicus
184%
150%
122%
100%
82%
67%
55%
Drug metabolism - other enzymes
Drug metabolism - other enzymes
