Drug metabolism - other enzymes
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Reference pathway
Reference pathway (KO)
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Homo sapiens (human)
Homo sapiens (human) + Disease/drug
Pan troglodytes (chimpanzee)
Pan paniscus (bonobo)
Gorilla gorilla gorilla (western lowland gorilla)
Pongo abelii (Sumatran orangutan)
Nomascus leucogenys (northern white-cheeked gibbon)
Macaca mulatta (rhesus monkey)
Macaca fascicularis (crab-eating macaque)
Chlorocebus sabaeus (green monkey)
Rhinopithecus roxellana (golden snub-nosed monkey)
Rhinopithecus bieti (black snub-nosed monkey)
Callithrix jacchus (white-tufted-ear marmoset)
Saimiri boliviensis boliviensis (Bolivian squirrel monkey)
Mus musculus (mouse)
Rattus norvegicus (rat)
Cricetulus griseus (Chinese hamster)
Nannospalax galili (Upper Galilee mountains blind mole rat)
Heterocephalus glaber (naked mole rat)
Castor canadensis (American beaver)
Oryctolagus cuniculus (rabbit)
Tupaia chinensis (Chinese tree shrew)
Canis familiaris (dog)
Ailuropoda melanoleuca (giant panda)
Ursus maritimus (polar bear)
Felis catus (domestic cat)
Panthera tigris altaica (Amur tiger)
Acinonyx jubatus (cheetah)
Bos taurus (cow)
Bos mutus (wild yak)
Bos indicus (zebu cattle)
Pantholops hodgsonii (chiru)
Capra hircus (goat)
Ovis aries (sheep)
Sus scrofa (pig)
Camelus ferus (Wild Bactrian camel)
Camelus dromedarius (Arabian camel)
Balaenoptera acutorostrata scammoni (minke whale)
Lipotes vexillifer (Yangtze River dolphin)
Equus caballus (horse)
Equus przewalskii (Przewalski's horse)
Equus asinus (ass)
Myotis brandtii (Brandt's bat)
Myotis davidii
Hipposideros armiger (great roundleaf bat)
Rhinolophus sinicus (Chinese rufous horseshoe bat)
Pteropus alecto (black flying fox)
Loxodonta africana (African savanna elephant)
Monodelphis domestica (opossum)
Sarcophilus harrisii (Tasmanian devil)
Ornithorhynchus anatinus (platypus)
Gallus gallus (chicken)
Meleagris gallopavo (turkey)
Coturnix japonica (Japanese quail)
Anas platyrhynchos (mallard)
Anser cygnoides domesticus (swan goose)
Taeniopygia guttata (zebra finch)
Geospiza fortis (medium ground-finch)
Ficedula albicollis (collared flycatcher)
Pseudopodoces humilis (Tibetan ground-tit)
Parus major (Great Tit)
Corvus cornix (hooded crow)
Falco peregrinus (peregrine falcon)
Falco cherrug (Saker falcon)
Columba livia (rock pigeon)
Apteryx australis mantelli (brown kiwi)
Alligator sinensis (Chinese alligator)
Alligator mississippiensis (American alligator)
Pelodiscus sinensis (Chinese soft-shelled turtle)
Chelonia mydas (green sea turtle)
Chrysemys picta (western painted turtle)
Anolis carolinensis (green anole)
Pogona vitticeps (central bearded dragon)
Python bivittatus (Burmese python)
Gekko japonicus
Xenopus laevis (African clawed frog)
Xenopus tropicalis (western clawed frog)
Nanorana parkeri
Danio rerio (zebrafish)
Sinocyclocheilus rhinocerous
Sinocyclocheilus anshuiensis
Sinocyclocheilus grahami
Ictalurus punctatus (channel catfish)
Astyanax mexicanus (Mexican tetra)
Takifugu rubripes (torafugu)
Tetraodon nigroviridis (spotted green pufferfish)
Larimichthys crocea (large yellow croaker)
Notothenia coriiceps (black rockcod)
Maylandia zebra (zebra mbuna)
Oryzias latipes (Japanese medaka)
Xiphophorus maculatus (southern platyfish)
Cynoglossus semilaevis (tongue sole)
Lates calcarifer (barramundi perch)
Hippocampus comes (tiger tail seahorse)
Boleophthalmus pectinirostris (great blue-spotted mudskipper)
Salmo salar (Atlantic salmon)
Esox lucius (northern pike)
Scleropages formosus (Asian bonytongue)
Latimeria chalumnae (coelacanth)
Callorhinchus milii (elephant shark)
Branchiostoma floridae (Florida lancelet)
Ciona intestinalis (sea squirt)
Strongylocentrotus purpuratus (purple sea urchin)
Acanthaster planci (crown-of-thorns starfish)
Saccoglossus kowalevskii (acorn worm)
Drosophila melanogaster (fruit fly)
Drosophila pseudoobscura pseudoobscura
Drosophila ananassae
Drosophila erecta
Drosophila persimilis
Drosophila sechellia
Drosophila simulans
Drosophila willistoni
Drosophila yakuba
Drosophila grimshawi
Drosophila mojavensis
Drosophila virilis
Musca domestica (house fly)
Anopheles gambiae (mosquito)
Aedes aegypti (yellow fever mosquito)
Culex quinquefasciatus (southern house mosquito)
Apis mellifera (honey bee)
Bombus impatiens (common eastern bumble bee)
Bombus terrestris (buff-tailed bumblebee)
Solenopsis invicta (red fire ant)
Acromyrmex echinatior (Panamanian leafcutter ant)
Atta cephalotes (leaf cutting ant)
Pogonomyrmex barbatus (red harvester ant)
Harpegnathos saltator (Jerdon's jumping ant)
Camponotus floridanus (Florida carpenter ant)
Linepithema humile (Argentine ant)
Pseudomyrmex gracilis
Nasonia vitripennis (jewel wasp)
Tribolium castaneum (red flour beetle)
Dendroctonus ponderosae (mountain pine beetle)
Nicrophorus vespilloides
Bombyx mori (domestic silkworm)
Danaus plexippus (monarch butterfly)
Plutella xylostella (diamondback moth)
Acyrthosiphon pisum (pea aphid)
Diuraphis noxia (Russian wheat aphid)
Pediculus humanus corporis (human body louse)
Folsomia candida
Daphnia pulex (common water flea)
Ixodes scapularis (black-legged tick)
Tetranychus urticae (two-spotted spider mite)
Caenorhabditis elegans (nematode)
Caenorhabditis briggsae
Necator americanus
Brugia malayi (filaria)
Loa loa (eye worm)
Trichinella spiralis
Helobdella robusta
Lottia gigantea (owl limpet)
Crassostrea gigas (Pacific oyster)
Octopus bimaculoides
Lingula anatina
Schistosoma mansoni
Schistosoma haematobium
Opisthorchis viverrini
Nematostella vectensis (sea anemone)
Acropora digitifera (stony coral)
Hydra vulgaris
Trichoplax adhaerens
Amphimedon queenslandica (sponge)
184%
150%
122%
100%
82%
67%
55%
Drug metabolism - other enzymes
Drug metabolism - other enzymes
