Disease genes and drug targets in KEGG pathways

KEGG pathway maps

Metabolism

Carbohydrate metabolism

H D  00010  Glycolysis / Gluconeogenesis
H    00020  Citrate cycle (TCA cycle)
H    00030  Pentose phosphate pathway
H D  00040  Pentose and glucuronate interconversions
H D  00051  Fructose and mannose metabolism
H D  00052  Galactose metabolism
H D  00053  Ascorbate and aldarate metabolism
H D  00500  Starch and sucrose metabolism
H D  00520  Amino sugar and nucleotide sugar metabolism
H D  00620  Pyruvate metabolism
H    00630  Glyoxylate and dicarboxylate metabolism
H D  00640  Propanoate metabolism
H D  00650  Butanoate metabolism
H D  00562  Inositol phosphate metabolism

Energy metabolism

H D 00190 Oxidative phosphorylation
H 00920 Sulfur metabolism

Lipid metabolism

H    00062  Fatty acid elongation
H D  00071  Fatty acid metabolism
H    00072  Synthesis and degradation of ketone bodies
H D  00100  Steroid biosynthesis
H    00120  Primary bile acid biosynthesis
H D  00140  Steroid hormone biosynthesis
H D  00561  Glycerolipid metabolism
H D  00564  Glycerophospholipid metabolism
H D  00565  Ether lipid metabolism
H D  00600  Sphingolipid metabolism
H D  00590  Arachidonic acid metabolism
H D  00591  Linoleic acid metabolism
H D  00592  alpha-Linolenic acid metabolism
H    01040  Biosynthesis of unsaturated fatty acids

Nucleotide metabolism

H D 00230 Purine metabolism
H D 00240 Pyrimidine metabolism

Amino acid metabolism

H D  00250  Alanine, aspartate and glutamate metabolism
H D  00260  Glycine, serine and threonine metabolism
H D  00270  Cysteine and methionine metabolism
H D  00280  Valine, leucine and isoleucine degradation
H    00300  Lysine biosynthesis
H D  00310  Lysine degradation
H D  00330  Arginine and proline metabolism
H D  00340  Histidine metabolism
H D  00350  Tyrosine metabolism
H D  00360  Phenylalanine metabolism
H D  00380  Tryptophan metabolism
H    00400  Phenylalanine, tyrosine and tryptophan biosynthesis

Metabolism of other amino acids

H D  00410  beta-Alanine metabolism
H D  00430  Taurine and hypotaurine metabolism
H D  00450  Selenocompound metabolism
  D  00460  Cyanoamino acid metabolism
H    00471  D-Glutamine and D-glutamate metabolism
H D  00480  Glutathione metabolism

Glycan biosynthesis and metabolism

H    00510  N-Glycan biosynthesis
H    00512  Mucin type O-Glycan biosynthesis
H    00514  Other types of O-glycan biosynthesis
H    00532  Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
H    00534  Glycosaminoglycan biosynthesis - heparan sulfate / heparin
H    00533  Glycosaminoglycan biosynthesis - keratan sulfate
H    00531  Glycosaminoglycan degradation
H    00563  Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
H    00601  Glycosphingolipid biosynthesis - lacto and neolacto series
H    00603  Glycosphingolipid biosynthesis - globo series
H    00604  Glycosphingolipid biosynthesis - ganglio series
H    00511  Other glycan degradation

Metabolism of cofactors and vitamins

H D  00740  Riboflavin metabolism
H    00750  Vitamin B6 metabolism
H D  00760  Nicotinate and nicotinamide metabolism
H D  00770  Pantothenate and CoA biosynthesis
H    00780  Biotin metabolism
H D  00790  Folate biosynthesis
H D  00670  One carbon pool by folate
H D  00830  Retinol metabolism
H D  00860  Porphyrin and chlorophyll metabolism
H D  00130  Ubiquinone and other terpenoid-quinone biosynthesis

Metabolism of terpenoids and polyketides

H D 00900 Terpenoid backbone biosynthesis

Biosynthesis of other secondary metabolites

H D 00232 Caffeine metabolism
H D 00524 Butirosin and neomycin biosynthesis

Xenobiotics biodegradation and metabolism

H D  00980  Metabolism of xenobiotics by cytochrome P450
H D  00982  Drug metabolism - cytochrome P450
H D  00983  Drug metabolism - other enzymes

Reaction module maps

H 01210 2-Oxocarboxylic acid metabolism
H 01230 Biosynthesis of amino acids

Genetic Information Processing

Transcription
- H    03020  RNA polymerase
  H    03022  Basal transcription factors
  H    03040  Spliceosome
Translation
- H    03010  Ribosome
  H D  00970  Aminoacyl-tRNA biosynthesis
  H    03013  RNA transport
  H    03015  mRNA surveillance pathway
  H    03008  Ribosome biogenesis in eukaryotes
Folding, sorting and degradation
- H    03060  Protein export
  H D  04141  Protein processing in endoplasmic reticulum
  H D  04130  SNARE interactions in vesicular transport
  H    04120  Ubiquitin mediated proteolysis
  H    04122  Sulfur relay system
  H D  03050  Proteasome
  H    03018  RNA degradation
Replication and repair
- H    03030  DNA replication
  H D  03410  Base excision repair
  H    03420  Nucleotide excision repair
  H    03430  Mismatch repair
  H    03440  Homologous recombination
  H    03450  Non-homologous end-joining
  H    03460  Fanconi anemia pathway

Environmental Information Processing

Membrane transport
- H D 02010 ABC transporters
Signal transduction
- H D  04010  MAPK signaling pathway
  H D  04012  ErbB signaling pathway
  H D  04310  Wnt signaling pathway
  H D  04330  Notch signaling pathway
  H D  04340  Hedgehog signaling pathway
  H D  04350  TGF-beta signaling pathway
  H D  04390  Hippo signaling pathway
  H D  04370  VEGF signaling pathway
  H D  04630  Jak-STAT signaling pathway
  H D  04064  NF-kappa B signaling pathway
  H D  04668  TNF signaling pathway
  H D  04066  HIF-1 signaling pathway
  H D  04020  Calcium signaling pathway
  H D  04070  Phosphatidylinositol signaling system
  H D  04151  PI3K-Akt signaling pathway
  H D  04150  mTOR signaling pathway
Signaling molecules and interaction
- H D  04080  Neuroactive ligand-receptor interaction
  H D  04060  Cytokine-cytokine receptor interaction
  H D  04512  ECM-receptor interaction
  H D  04514  Cell adhesion molecules (CAMs)

Cellular Processes

Transport and catabolism
- H D  04144  Endocytosis
  H D  04145  Phagosome
  H D  04142  Lysosome
  H D  04146  Peroxisome
  H D  04140  Regulation of autophagy
Cell motility
- H D 04810 Regulation of actin cytoskeleton
Cell growth and death
- H D  04110  Cell cycle
  H D  04114  Oocyte meiosis
  H D  04210  Apoptosis
  H D  04115  p53 signaling pathway
Cell communication
- H D  04510  Focal adhesion
  H D  04520  Adherens junction
  H D  04530  Tight junction
  H D  04540  Gap junction

Organismal Systems

Immune system
- H D  04640  Hematopoietic cell lineage
  H D  04610  Complement and coagulation cascades
  H D  04620  Toll-like receptor signaling pathway
  H D  04621  NOD-like receptor signaling pathway
  H D  04622  RIG-I-like receptor signaling pathway
  H D  04623  Cytosolic DNA-sensing pathway
  H D  04650  Natural killer cell mediated cytotoxicity
  H D  04612  Antigen processing and presentation
  H D  04660  T cell receptor signaling pathway
  H D  04662  B cell receptor signaling pathway
  H D  04664  Fc epsilon RI signaling pathway
  H D  04666  Fc gamma R-mediated phagocytosis
  H D  04670  Leukocyte transendothelial migration
  H D  04672  Intestinal immune network for IgA production
  H D  04062  Chemokine signaling pathway
Endocrine system
- H D  04911  Insulin secretion
  H D  04910  Insulin signaling pathway
  H D  04920  Adipocytokine signaling pathway
  H D  03320  PPAR signaling pathway
  H D  04912  GnRH signaling pathway
  H D  04913  Ovarian steroidogenesis
  H D  04915  Estrogen signaling pathway
  H D  04914  Progesterone-mediated oocyte maturation
  H D  04917  Prolactin signaling pathway
  H D  04916  Melanogenesis
  H D  04614  Renin-angiotensin system
Circulatory system
- H D 04260 Cardiac muscle contraction
  H D 04270 Vascular smooth muscle contraction
Digestive system
- H D  04970  Salivary secretion
  H D  04971  Gastric acid secretion
  H D  04972  Pancreatic secretion
  H D  04976  Bile secretion
  H D  04973  Carbohydrate digestion and absorption
  H D  04974  Protein digestion and absorption
  H D  04975  Fat digestion and absorption
  H D  04977  Vitamin digestion and absorption
  H D  04978  Mineral absorption
Excretory system
- H D  04962  Vasopressin-regulated water reabsorption
  H D  04960  Aldosterone-regulated sodium reabsorption
  H D  04961  Endocrine and other factor-regulated calcium reabsorption
  H D  04964  Proximal tubule bicarbonate reclamation
  H D  04966  Collecting duct acid secretion
Nervous system
- H D  04724  Glutamatergic synapse
  H D  04727  GABAergic synapse
  H D  04725  Cholinergic synapse
  H D  04728  Dopaminergic synapse
  H D  04726  Serotonergic synapse
  H D  04720  Long-term potentiation
  H D  04730  Long-term depression
  H D  04723  Retrograde endocannabinoid signaling
  H D  04721  Synaptic vesicle cycle
  H D  04722  Neurotrophin signaling pathway
Sensory system
- H    04744  Phototransduction
  H D  04740  Olfactory transduction
  H D  04742  Taste transduction
Development
- H D  04320  Dorso-ventral axis formation
  H D  04360  Axon guidance
  H D  04380  Osteoclast differentiation
Environmental adaptation
- H D 04710 Circadian rhythm
  H D 04713 Circadian entrainment

Human Diseases

Cancers: Overview
- H D  05200  Pathways in cancer
  H D  05202  Transcriptional misregulation in cancer
  H D  05205  Proteoglycans in cancer
  H D  05204  Chemical carcinogenesis
  H D  05203  Viral carcinogenesis
Cancers: Specific types
- H D  05210  Colorectal cancer
  H D  05212  Pancreatic cancer
  H D  05214  Glioma
  H D  05216  Thyroid cancer
  H D  05221  Acute myeloid leukemia
  H D  05220  Chronic myeloid leukemia
  H D  05217  Basal cell carcinoma
  H D  05218  Melanoma
  H D  05211  Renal cell carcinoma
  H D  05219  Bladder cancer
  H D  05215  Prostate cancer
  H D  05213  Endometrial cancer
  H D  05222  Small cell lung cancer
  H D  05223  Non-small cell lung cancer
Immune diseases
- H D  05310  Asthma
  H D  05322  Systemic lupus erythematosus
  H D  05323  Rheumatoid arthritis
  H D  05320  Autoimmune thyroid disease
  H D  05330  Allograft rejection
  H D  05332  Graft-versus-host disease
  H D  05340  Primary immunodeficiency
Neurodegenerative diseases
- H D  05010  Alzheimer's disease
  H D  05012  Parkinson's disease
  H D  05014  Amyotrophic lateral sclerosis (ALS)
  H D  05016  Huntington's disease
  H D  05020  Prion diseases
Substance dependence
- H D  05030  Cocaine addiction
  H D  05031  Amphetamine addiction
  H D  05032  Morphine addiction
  H D  05033  Nicotine addiction
  H D  05034  Alcoholism
Cardiovascular diseases
- H D  05410  Hypertrophic cardiomyopathy (HCM)
  H D  05412  Arrhythmogenic right ventricular cardiomyopathy (ARVC)
  H D  05414  Dilated cardiomyopathy
  H D  05416  Viral myocarditis
Endocrine and metabolic diseases
- H D  04940  Type I diabetes mellitus
  H D  04930  Type II diabetes mellitus
  H D  04950  Maturity onset diabetes of the young
Infectious diseases: Bacterial
- H D  05110  Vibrio cholerae infection
  H D  05120  Epithelial cell signaling in Helicobacter pylori infection
  H D  05130  Pathogenic Escherichia coli infection
  H D  05132  Salmonella infection
  H D  05131  Shigellosis
  H D  05133  Pertussis
  H D  05134  Legionellosis
  H D  05150  Staphylococcus aureus infection
  H D  05152  Tuberculosis
  H D  05100  Bacterial invasion of epithelial cells
Infectious diseases: Viral
- H D  05166  HTLV-I infection
  H D  05162  Measles
  H D  05164  Influenza A
  H D  05161  Hepatitis B
  H D  05160  Hepatitis C
  H D  05168  Herpes simplex infection
  H D  05169  Epstein-Barr virus infection
Infectious diseases: Parasitic
- H D  05146  Amoebiasis
  H D  05144  Malaria
  H D  05145  Toxoplasmosis
  H D  05140  Leishmaniasis
  H D  05142  Chagas disease (American trypanosomiasis)
  H D  05143  African trypanosomiasis

Last updated: June 19, 2013