Cancer pathways

• Overview maps:
     Signaling network (Pathways in cancer)
     Transcriptional network (Transcriptional misregulation in cancer)
     microRNAs (in preparation)
     Glycans (Proteoglycans in cancer) New!
     Carcinogens (Chemical carcinogenesis)
     Viruses (Viral carcinogenesis)
• KEGG pathway maps (14 specific cancer types)

Cancer-associated genes

• KEGG DISEASE entries (55 different cancers)

Environmental factors

• KEGG COMPOUND entries in BRITE classifications (Carcinogens, Endocrine disrupting compounds, Pesticides, etc.)
• Overview maps (Chemical carcinogenesis and Viral carcinogenesis)

Drugs

• KEGG DRUG entries in BRITE classifications (Antineoplastics and other drug classifications)
• KEGG DRUG structure maps (Chronology: Antineoplastics)

The KEGG pathway maps for 14 cancers contain oncogenes and tumor suppressor genes with genetic alterations summarized in the gray box and also marked in red in the pathway. This is based on literature data. In contrast, the Sanger Institute's COSMIC (Catalogue Of Somatic Mutations In Cancer) database contains actual observations of genetic alterations in cancer genomes. Here the COSMIC data for 27 cancers (see detail of selecting COSMIC site and histology) are mapped against KEGG pathways using one of the tools of KEGG Mapper. The result can be viewed from the follwing link:

KEGG Atlas 3D viewer

To analyze your own data, use this KEGG mapper tool:

Color Pathway 3D

Note that this tool is based on WebGL and runs on Firefox, Chrome, and WebGL-enabled Safari browsers.

The KEGG pathway maps for 14 cancers are drawn in a stage-dependent manner; how different signaling pathways and cancer-related genes are involved at different stages of oncogenesis. This is summarized in the following BRITE hierarchy file:

Cancer stages

together with links to the snapshots of involved pathways in the signaling overview map and the individual maps.