KEGG GLYCAN Composite Structure Map

About CSM The Composite Structure Map (CSM) is a merged tree of GLYCAN structures containing all possible variations of carbohydrate structures. Push the 'Go' button to display the map. The most right node is the root of the structures, representing a carbohydrate structure of one monosaccharide, say glucose. This root node is connected to the nodes to its left at the 2nd level from the right, which represent possible structures of two monosaccharides containing glucose as the single core. Nodes connected at each consecutive level represent these variations iteratively. Because every type of glycosidic linkage is distinguished, different glycosidic linkages are represented by different edges even if the attached monosaccharides are the same. For example, when a Gal can be attached to Glc by a b1-3 and a b1-4 glycosidic linkage, the CSM will contain two different edges 'Gal(b1-3)Glc' and 'Gal(b1-4)Glc.
Selecting organism Selecting an organism from the pull-down menu at the top changes the hyperlinks to the edges on the map. For example, after selecting 'All organisms in KEGG' and pushing the 'Go' button, edges that (1) correspond to glycosyltransferases that catalyze the synthesis of that structure and (2) have references in KO will be hyperlinked to its corresponding KO entry. On the other hand, if a particular organism is selected under the same pull-down menu, the edges will be hyperlinked to the genes corresponding to the selected organism.
Display options Selecting three monosaccharides in the three pull-down menus labeled 'Root,' 'Next1,' 'Next2' will display the CSM that containing the designated chain of monosaccharides as its core. Other parameters to adjust the visualized contents in the tree are also available. For example, a "Threshold" value may be specified to indicate the minimum number of times a particular edge should appear in the tree in order to be displayed. The "Position" may be adjusted to display the CSM with the root at the top, the right (default), the left, or the bottom. The "Node size" may be adjusted to increase the displayed size of the nodes in the CSM from the default minimum value of 5.
Superimposing
microarray data
Moreover, other functionality such as visualizing microarray results is under development. Download and then upload the sample data at the bottom and see the coloring of edges.