KEGG image  Antifungals

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Class Generic name ATC KEGG Products (USA) Products (Japan) Indications Species
Cell membrane function inhibitor Polyene macrolide Amphotericin B J02AA01 D00203 AMBISOME
AMBISOME Fungal infection
Invasive aspergillosis
Cryptococcus, Aspergillus, Candida
Nystatin D01AA01 A07AA02 G01AA01 D00202 NYSTATIN NYSTATIN Cutaneous or mucocutaneous mycotic infections Candida albicans, Candida species
Natamycin D01AA02 A01AB10 A07AA03 G01AA02 S01AA10 D00884 NATACYN PIMARICIN Fungal blepharitis, conjunctivitis, and keratitis Fusarium solani
Pyridone derivatives Ciclopirox D01AE14 G01AX12 D03488 D01364 LOPROX
Seborrheic dermatitis
Dermal infections
Malassezia, Trichophyton, Candida
Combination of macrolide Nystatin - triamcinolone D07CB01 D10299 NYSTATIN AND TRIAMCINOLONE Cutaneous candidiasis Candida
Mitosis inhibitor Penicillium-derived Griseofulvin D01AA08 D01BA01 D00209 GRIS-PEG Ringworm infections Trichophyton
Ergosterol biosynthesis inhibitor Imidazole Miconazole J02AB01 D01AC02 A01AB09 A07AC01 G01AF04 S02AA13 D00416 ORAVIG FLORID Oropharyngeal candidiasis (OPC) Candida
Ketoconazole J02AB02 D01AC08 G01AF11 D00351 NIZORAL NIZORAL
Tinea (pityriasis) versicolor
Seborrheic dermatitis
Clotrimazole D01AC01 A01AB18 G01AF02 D00282 CLOTRIMAZOLE EMPECID Oropharyngeal candidiasis
Candidiasis (tinea versicolor)
Candida, Malassezia
Econazole D01AC03 G01AF05 D00881 ECOZA PALAVALE Interdigital tinea pedis, tinea cruris, tinea corporis Trichophyton
Isoconazole D01AC05 G01AF07 D01480 ADESTAN Tinea, candidiasis, tinea versicolor
Trichophyton, Candida, Malassezia
Sulconazole D01AC09 D00886 EXELDERM EXELDERM Tinea pedis, tinea cruris, tinea corporis, tinea versicolor Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis
Bifonazole D01AC10 D01775 MYCOSPOR Tinea, candidiasis, tinea versicolor Trichophyton, Candida, Malassezia
Oxiconazole D01AC11 G01AF17 D00885 OXISTAT OKINAZOLE Dermal infections (tinea pedis, tinea cruris, tinea corporis)
tinea (pityriasis) versicolor
Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum
Malassezia furfur
Sertaconazole D01AC14 G01AF19 D08510 ERTACZO Interdigital tinea pedis Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum
Butoconazole G01AF15 D00880 GYNAZOLE 1 Vulvovaginal candidiasis Candida
Lanoconazole D01092 ASTAT Tinea, candidiasis, tinea versicolor Trichophyton, Candida, Malassezia
Neticonazole D01620 ATOLANT Tinea, candidiasis, tinea versicolor Trichophyton, Candida, Malassezia
Luliconazole D01980 LUZU LULICON Interdigital tinea pedis, tinea cruris, tinea corporis Trichophyton rubrum, Epidermophyton floccosum
Triazole (DG01523) Fluconazole J02AC01 D01AC15 D00322 DIFLUCAN DIFLUCAN Vaginal candidiasis, Oropharyngeal and esophageal candidiasis, Cryptococcal meningitis Candida, Cryptococcus
Fosfluconazole D01429 PRODIF Candidiasis, Cryptococcosis Candida, Cryptococcus
Itraconazole J02AC02 D00350 SPORANOX ITRIZOLE Fungal infections (blastomycosis, histoplasmosis, aspergillosis)
Oropharyngeal and esophageal candidiasis
Blastomyces dermatitidis, Histoplasma capsulatum, Aspergillus
Voriconazole J02AC03 D00578 VFEND VFEND Fungal infections (invasive aspergillosis, candida infections, fusarium infections) Aspergillus, Candida, Fusarium
Posaconazole J02AC04 D02555 NOXAFIL Invasive aspergillus, candida infections (oropharyngeal candidiasis) Aspergillus, Candida
Terconazole G01AG02 D00888 TERAZOL Vulvovaginal candidiasis (moniliasis) Candida
Efinaconazole D10021 JUBLIA CLENAFIN Onychomycosis Trichophyton rubrum, Trichophyton mentagrophytes
Allylamine Terbinafine D01AE15 D01BA02 D02219 LAMISIL LAMISIL Onychomycosis Dermatophytes
Naftifine D01AE22 D00883 NAFTIN Interdigital tinea pedis, tinea cruris, and tinea corporis Trichophyton rubrum
Morpholine Amorolfine D01AE16 D01720 PEKIRON Dermatomycosis (tinea, cutaneous candidiasis, tinea versicolor) Trichophyton, Candida, Malassezia
Thiocarbamate Tolnaftate D01AE18 D00381 HI-ALARZIN Trichophytia pompholyciformis, marginated eczema, trichophytia maculovesiculosa, tinea versicolor Trichophyton, Malassezia
Liranaftate D01550 ZEFNART Tinea Trichophyton
Benzylamine Butenafine D01AE23 D01093 MENTAX VOLLEY
Tinea, tinea versicolor Trichophyton, Malassezia
Combination of azole Clotrimazole - betamethasone D07CC01 D10300 LOTRISONE Tinea pedis, tinea cruris, tinea corporis Epidermophyton floccosum, Trichophyton mentagrophytes, Trichophyton rubrum
Nucleic acid synthesis inhibitor Fluoropyrimidine Flucytosine J02AX01 D01AE21 D00323 ANCOBON ANCOTIL Candida infections, Cryptococcus infections Candida, Cryptococcus
Folic acid biosynthesis inhibitor Sulfonamide Sulfanilamide J01EB06 D06BA05 D08543 AVC Vulvovaginitis Candida albicans
Combination of sulfonamide Trimethoprim-sulfamethoxazole J01EE01 D00285 BACTRIM
Carinii pneumonia, Pneumocystis pneumonia Pneumocystis carinii, Pneumocystis jirovecii
Cell wall biosyntehsis inhibitor Echinocandin Caspofungin J02AX04 D02501 CANCIDAS CANCIDAS Fungal infections (Candida infections, esophageal candidiasis, invasive aspergillosis) Candida, Aspergillus
Micafungin J02AX05 D02465 MYCAMINE FUNGUARD Candida infections Candida
Anidulafungin J02AX06 D03211 ERAXIS Candida Infections Candida
Other Salicylic acid D01AE12 S01BC08 D00097 SALICYLIC ACID SALICYLIC ACID Hyperkeratotic skin disorders Torichophyton, Malassezia
Selenium sulfide D01AE13 D11AC03 D05815 SELENIUM SULFIDE Tinea versicolor, seborrheic dermatitis of the scalp, and dandruff Malassezia

Related KEGG pathway maps
Category Title Comment
Metabolic pathway map Steroid biosynthesis Target molecules in ergosterol biosynthesis pathway
Drug structure map Antifungal agents

Last updated: October 9, 2015