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Drug Identifiers

The KEGG DRUG D number is an identifier to distinguish drugs as chemical substances, which is used to integrate approved drugs in Japan, USA and Europe. The D numbers are linked to drug classifications, such as WHO's ATC classification. In KEGG MEDICUS all drug products in the USA (and in Japan in the Japanese version) are given D numbers and organized in the following hierarchy.
Drug classification (ATC code, etc.)
Chemical substance (KEGG D number)
Drug label (DailyMed setId)
Drug product (NDC)


KEGG D number
Represents the chemical structure (or the chemical component of a mixture).
A KEGG object identifier consisting of the prefix D followed by a five-digit number.
(Example) D01441 Imatinib mesylate (Gleevec)

ATC code
WHO's Anatomical Therapeutic Chemical Classification.
A five-level classification system.
(Example)
L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L01 ANTINEOPLASTIC AGENTS
L01X OTHER ANTINEOPLASTIC AGENTS
L01XE Protein kinase inhibitors
L01XE01 Imatinib

DailyMed setId
A unique identifier for the FDA labels (package inserts) in the DailyMed database.
Consisting of 36 characters including four hyphens.
(Example) 211ef2da-2868-4a77-8055-1cb2cd78e24b GLEEVEC (Novartis)

NDC (National Drug Code)
A unique three-segment number for human drugs in the USA.
Consisting of the labeler code, the product code and the package code.
(Product example) 0078-0401 GLEEVEC
(Package example) 0078-0401-34 GLEEVEC 90 TABLET in 1 BOTTLE

Note that only the first two segments of the NDC code are used in KEGG MEDICUS.


Last updated: October 5, 2012