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ENTRY	nt06037
Name	Histidine metabolism
Category	Pathway view; Amino acid metabolism
Pathway	hsa00340 Histidine metabolism hsa00670 One carbon pool by folate
Module	hsa_M00045 Histidine degradation, histidine => N-formiminoglutamate => glutamate
Display	drug-target relation   disease type

N01727    His − HAL ⇉ UROC1 ⇉ AMDHD1 → Formimino-Glu     Histidinemia His↗   HAL*     Urocanase deficiency         UROC1* N01728    THF+Formimino-Glu − FTCD → 5-Formimino-THF+Gl..     Formiminotransferase deficiency     FTCD* N01725    Dihydrofolate − DHFR → THF     DHFR deficiency     DHFR* N01726    THF − MTHFD1 → MTHF − MTHFR ⇉ MTR → THF     NTDs     MTHFD1*     NTDs             MTHFR*     NTDs                 MTR* N01729    His − HDC → Histamine     TS     HDC*

		Disease name	Disease category
Histidinemia	H00171	Histidinemia	Inherited metabolic disorder
Urocanase deficiency	H01233	Urocanase deficiency	Inherited metabolic disorder
Formiminotransferase deficiency	H01262	Formiminotransferase deficiency	Inherited metabolic disorder
DHFR deficiency	H01197	Dihydrofolate reductase deficiency	Inherited metabolic disorder
NTDs	H00262	Neural tube defects, folate-sensitive	Congenital malformation
TS	H00862	Tourette syndrome	Mental and behavioural disorder