KEGG    Network variation - Chronic myeloid leukemia
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ENTRYnt06276
NameChronic myeloid leukemia
CategoryDisease view; Cancer
Pathwayhsa05220 Chronic myeloid leukemia
DiseaseH00004 Chronic myeloid leukemia
Display drug-target relation   disease type
ERK signaling
                 D7
 |
N00001    EGFEGFRGRB2SOSRASRAFMEKERKCCND1
   D1,D2,D3,D4,D5,D6
 |
            
N00002      BCR-ABLGRB2SOSRASRAFMEKERK
 
PI3K signaling
N00033    EGFEGFRPI3KPIP3AKTBAD
 D1,D2,D3,D4,D5,D6
 |
          
N00048    BCR-ABL(CRKL+CBL+CRK)PI3KPIP3AKTBAD
 
TGFB signaling
N00063    TGFB(TGFBR2+TGFBR1)(SMAD2,SMAD3)=SMAD4
N00106      AML1-EVI1SMAD3=SMAD4
N00107      EVI1*SMAD3=SMAD4
 
JAK-STAT signaling
N00053    CytokineReceptorJAKSTATPIM1
     D1,D2,D3,D4,D5,D6
 |
    
N00055        BCR-ABLSTAT5BCL2L1
 
Cell cycle
         D7
 |
    
N00066    CDKN2AMDM2TP53CDKN1A(CCND+CDK4/6)RB1E2F
         D7
 |
    
N00067    CDKN2A*MDM2TP53CDKN1A(CCND+CDK4/6)RB1E2F
         D7
 |
    
N00070          CDKN2A*(CCND+CDK4/6)RB1E2F
N00074              RB1*E2F
 
Transcription
N00115    TP53*(CDKN1A,GADD45,BAX..


Drug name
D1D01441Imatinib mesylate (USAN)
D2D06413Nilotinib hydrochloride hydrate (JAN)
D3D06414Dasatinib (USAN)
D4D09728Bosutinib hydrate (JAN)
D5D09951Ponatinib hydrochloride (JAN/USAN)
D6D11404Asciminib hydrochloride (JAN/USAN)
D7D08956Omacetaxine mepesuccinate (USAN)