KEGG    Network variation - Parkinson disease
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ENTRYnt06463
NameParkinson disease
CategoryDisease view; Neurodegenerative disease
Pathwayhsa05012 Parkinson disease
DiseaseH00057 Parkinson disease
Display drug-target relation   disease type
Calcium signaling
N00953    GlutamateGRM1GNAQPLCBIP3ITPRCa2+PKCTRPC3Ca2+
N01032        PRKN*PLCG1IP3ITPRCa2+
N00967    Ca2+(extracellular..VGCCCa2+MCUCa2+(mito)MPTPCYCS=APAF1CASP9(CASP3,CASP7)
N01031    Ca2+(extracellular..SNCA*Ca2+MCUCa2+(mito)MPTPCYCS=APAF1CASP9CASP3
 
Ubiquitin-proteasome system
N01019    UBCH7/8=PRKNalphaSp22
N01020    UBCH7/8PRKN*alphaSp22
N01021    UBCH7/8=PRKNPAELR
N01022    UBCH7/8PRKN*PAELR
N01023    UBCH7/8=PRKNCDCREL1
N01024    UBCH7/8PRKN*CDCREL1
N01025    UBCH7/8=PRKNSYPH1
N01026    UBCH7/8PRKN*SYPH1
N01029    (Protein+UB)26SPeptide
N01030    SNCA*26S
N01027    UB(chain)UCHL1UB(free)
N01028    UB(chain)UCHL1*UB(free)
 
Unfolded protein response (UPR) signaling
N01009        EIF2AK3EIF2S1ATF4DDIT3
N01035    SNCA*BIPEIF2AK3EIF2S1ATF4DDIT3
N01011        ERN1XBP1DDIT3
N01034    SNCA*BIPERN1XBP1
N01015        ATF6(DDIT3,XBP1,HSPA5)
N01033    SNCA*BIPATF6DDIT3
 
Mitophagy
N01052    PINK1PRKNMFN1/2
N01053    PINK1*PRKNMFN1/2
N01054      PRKN*MFN1/2
 
Apoptosis
N00098    (PMAIP1,BBC3,BAD,B..(BCL2,BCL2L1)(BAX,BAK1)CYCS=APAF1CASP9(CASP3,CASP7)
N01051    DJ1*BCL2L1BAX
N01050    PINK1*PRKNBAXCYCS=APAF1CASP9CASP3
N01049      PRKN*BAXCYCS=APAF1CASP9CASP3
N01048      PINK1*(HTRA2,TRAP1)CYCS=APAF1CASP9CASP3
N01047        LRRK2*CYCS=APAF1CASP9CASP3
N01056      FASLGFAS(DAXX+ASK1)JNK
N01057        DJ1*(DAXX+ASK1)JNK
N01417    PQROSTRX1ASK1JNK
 
Dopamine metabolism
N01530    Tyr+BH4THL-DopaDDCDopamineMAODOPAL
N01037    SNCA*THL-Dopa
N01039            PRKN*MAODOPAL
N01040    DopamineVMATDopamine(SV)
N01041    SNCA*VMAT2
 
Oxidative phosphorylation
N00995    NADHCxIQ
N01042    SNCA*CxIQ
N01043    PINK1*CxIQ
N01044    MPP+CxIQ
N01045    RotenoneCxIQ
N00988    SuccinateCxIIQH2
N01402    Mn2+CxIIQH2
N00990    QH2CxIIICytC
N01046    ManebCxIIICytC
 
Microtubule-based transport
N00976      (DCTN+DNAH+DNAI+DN..=(TUBA+TUBB)
N01055    SNCA*(KIF5+KLC)(TUBA+TUBB)
 
Transcription
N01058    DJ1*TP53DUSP1
N00243    (O2-,HO2,H2O2,OH,A..KEAP1NRF2(HMOX1,NQO1,GST,TX..
N01059      DJ1*NRF2TRX1