# OC Root 2nd 3rd 4th 5th PC Gene/Definition OC.276633 Archaea.248 Euryarchaeota.13735 - - pto.913 pto:PTO0913 2-isopropylmalate synthase; K01649 2-isopropylmalate synthase [EC:2.3.3.13] OC.276633 Archaea.248 Euryarchaeota.13735 Ferroplasma.1519 - fac.942 fac:FACI_IFERC01G0949 hypothetical protein; K01649 2-isopropylmalate synthase [EC:2.3.3.13] OC.276633 Archaea.248 Euryarchaeota.13735 Ferroplasma.1519 - fai.1707 fai:FAD_1836 hcs; homocitrate synthase; K01649 2-isopropylmalate synthase [EC:2.3.3.13] OC.276633 Archaea.248 Crenarchaeota.2298 - - iag.1480 iag:Igag_1565 2-isopropylmalate synthase; K01649 2-isopropylmalate synthase [EC:2.3.3.13] OC.276633 Archaea.248 Crenarchaeota.2298 - - pfm.1637 pfm:Pyrfu_1692 isopropylmalate/citramalate/homocitratesynthase; K01649 2-isopropylmalate synthase [EC:2.3.3.13] OC.276633 Archaea.248 Crenarchaeota.2298 - - pdl.1897 pdl:Pyrde_1931 2-isopropylmalate synthase; K01649 2-isopropylmalate synthase [EC:2.3.3.13] OC.276633 Archaea.248 Crenarchaeota.2298 Pyrobaculum.447 - pai.1333 pai:PAE1993 2-isopropylmalate synthase (leuA) with possible unusual start codon; K01649 2-isopropylmalate synthase [EC:2.3.3.13] OC.276633 Archaea.248 Crenarchaeota.2298 Pyrobaculum.447 - pis.1742 pis:Pisl_1814 2-isopropylmalate synthase; K01649 2-isopropylmalate synthase [EC:2.3.3.13] OC.276633 Archaea.248 Crenarchaeota.2298 Pyrobaculum.447 - pcl.1550 pcl:Pcal_1604 2-isopropylmalate synthase; K01649 2-isopropylmalate synthase [EC:2.3.3.13] OC.276633 Archaea.248 Crenarchaeota.2298 Pyrobaculum.447 - pas.1983 pas:Pars_2063 2-isopropylmalate synthase; K01649 2-isopropylmalate synthase [EC:2.3.3.13] OC.276633 Archaea.248 Crenarchaeota.2298 Pyrobaculum.447 - pyr.284 pyr:P186_0235 isopropylmalate/citramalate/homocitrate synthase; K01649 2-isopropylmalate synthase [EC:2.3.3.13] OC.276633 Archaea.248 Crenarchaeota.2298 Pyrobaculum.447 - pog.105 pog:Pogu_0061 Isopropylmalate/homocitrate/citramalate synthase; K01649 2-isopropylmalate synthase [EC:2.3.3.13] OC.276633 Archaea.248 Crenarchaeota.2298 Pyrobaculum.447 - tne.809 tne:Tneu_0832 isopropylmalate/citramalate/homocitrate synthase; K01649 2-isopropylmalate synthase [EC:2.3.3.13] OC.276633 Archaea.248 Crenarchaeota.2298 Pyrobaculum.447 - pyw.870 pyw:PYWP30_00915 2-isopropylmalate synthase; K01649 2-isopropylmalate synthase [EC:2.3.3.13] OC.276633 Archaea.248 Crenarchaeota.2298 - - cma.1121 cma:Cmaq_1171 isopropylmalate/citramalate/homocitrate synthase; K01649 2-isopropylmalate synthase [EC:2.3.3.13] OC.276633 Archaea.248 Crenarchaeota.2298 Thermoproteus.296 - tuz.1278 tuz:TUZN_1312 isopropylmalate/citramalate/homocitrate synthase; K01649 2-isopropylmalate synthase [EC:2.3.3.13] OC.276633 Archaea.248 Crenarchaeota.2298 Thermoproteus.296 - ttn.148 ttn:TTX_0134 leuA-2; 2-isopropylmalate synthase 2; K01649 2-isopropylmalate synthase [EC:2.3.3.13] OC.276633 Archaea.248 Crenarchaeota.2298 Vulcanisaeta.1598 - vdi.673 vdi:Vdis_0685 isopropylmalate/citramalate/homocitratesynthase; K01649 2-isopropylmalate synthase [EC:2.3.3.13] OC.276633 Archaea.248 Crenarchaeota.2298 Vulcanisaeta.1598 - vmo.1498 vmo:VMUT_1520 isopropylmalate/citramalate/homocitrate synthase; K01649 2-isopropylmalate synthase [EC:2.3.3.13] OC.276633 Archaea.248 Crenarchaeota.2299 Ignicoccus.1182 - iho.974 iho:Igni_0983 isopropylmalate/citramalate/homocitrate synthase; K01649 2-isopropylmalate synthase [EC:2.3.3.13] OC.276633 Archaea.248 Crenarchaeota.2299 Ignicoccus.1182 - iis.1181 iis:EYM_06375 2-isopropylmalate synthase; K01649 2-isopropylmalate synthase [EC:2.3.3.13] OC.276633 Archaea.248 Crenarchaeota.2299 - - sto.624 sto:STK_05380 leuA; 2-isopropylmalate synthase; K01649 2-isopropylmalate synthase [EC:2.3.3.13] OC.276633 Archaea.248 Crenarchaeota.2299 Sulfolobus.1302 Sulfolobus_acidocaldarius.2141 sai.872 sai:Saci_0940 2-isopropylmalate synthase; K01649 2-isopropylmalate synthase [EC:2.3.3.13] OC.276633 Archaea.248 Crenarchaeota.2299 Sulfolobus.1302 Sulfolobus_acidocaldarius.2141 sacn.902 sacn:SacN8_04560 aksA; trans-homoaconitate synthase; K01649 2-isopropylmalate synthase [EC:2.3.3.13] OC.276633 Archaea.248 Crenarchaeota.2299 Sulfolobus.1302 Sulfolobus_acidocaldarius.2141 sacr.898 sacr:SacRon12I_04550 aksA; trans-homoaconitate synthase; K01649 2-isopropylmalate synthase [EC:2.3.3.13] OC.276633 Archaea.248 Crenarchaeota.2299 Sulfolobus.1302 Sulfolobus_acidocaldarius.2141 sacs.819 sacs:SUSAZ_04310 trans-homoaconitate synthase; K01649 2-isopropylmalate synthase [EC:2.3.3.13] OC.276633 Archaea.248 Crenarchaeota.2299 Sulfolobus.2643 Sulfolobus_solfataricus.1400 sso.2025 sso:SSO2407 leuA-3; 2-isopropylmalate synthase, putative (leuA-3); K01649 2-isopropylmalate synthase [EC:2.3.3.13] OC.276633 Archaea.248 Crenarchaeota.2299 Sulfolobus.2643 Sulfolobus_solfataricus.1400 sol.234 sol:Ssol_0214 isopropylmalate/citramalate/homocitrate synthase; K01649 2-isopropylmalate synthase [EC:2.3.3.13] OC.276633 Archaea.248 Crenarchaeota.2299 Sulfolobus.2643 Sulfolobus_solfataricus.1400 ssoa.232 ssoa:SULA_0206 trans-homoaconitate synthase; K01649 2-isopropylmalate synthase [EC:2.3.3.13] OC.276633 Archaea.248 Crenarchaeota.2299 Sulfolobus.2643 Sulfolobus_solfataricus.1400 ssol.234 ssol:SULB_0207 trans-homoaconitate synthase; K01649 2-isopropylmalate synthase [EC:2.3.3.13] OC.276633 Archaea.248 Crenarchaeota.2299 Sulfolobus.2643 Sulfolobus_solfataricus.1400 ssof.232 ssof:SULC_0206 trans-homoaconitate synthase; K01649 2-isopropylmalate synthase [EC:2.3.3.13] OC.276633 Archaea.248 Crenarchaeota.2299 Sulfolobus.2643 Sulfolobus_islandicus.1339 sia.211 sia:M1425_0200 isopropylmalate, Fcitramalate, or Fhomocitrate synthase; K01649 2-isopropylmalate synthase [EC:2.3.3.13] OC.276633 Archaea.248 Crenarchaeota.2299 Sulfolobus.2643 Sulfolobus_islandicus.1339 sim.210 sim:M1627_0200 isopropylmalate/citramalate/Fhomocitrate synthase; K01649 2-isopropylmalate synthase [EC:2.3.3.13] OC.276633 Archaea.248 Crenarchaeota.2299 Sulfolobus.2643 Sulfolobus_islandicus.1339 sid.224 sid:M164_0219 isopropylmalate/citramalate/homocitrate synthase; K01649 2-isopropylmalate synthase [EC:2.3.3.13] OC.276633 Archaea.248 Crenarchaeota.2299 Sulfolobus.2643 Sulfolobus_islandicus.1339 siy.238 siy:YG5714_0204 isopropylmalate/citramalate/homocitrate synthase; K01649 2-isopropylmalate synthase [EC:2.3.3.13] OC.276633 Archaea.248 Crenarchaeota.2299 Sulfolobus.2643 Sulfolobus_islandicus.1339 sin.2399 sin:YN1551_2807 isopropylmalate/citramalate/homocitrate synthase; K01649 2-isopropylmalate synthase [EC:2.3.3.13] OC.276633 Archaea.248 Crenarchaeota.2299 Sulfolobus.2643 Sulfolobus_islandicus.1339 sii.254 sii:LD85_0204 isopropylmalate/citramalate/homocitrate synthase; K01649 2-isopropylmalate synthase [EC:2.3.3.13] OC.276633 Archaea.248 Crenarchaeota.2299 Sulfolobus.2643 Sulfolobus_islandicus.1339 sih.221 sih:SiH_0206 isopropylmalate/citramalate/homocitrate synthase; K01649 2-isopropylmalate synthase [EC:2.3.3.13] OC.276633 Archaea.248 Crenarchaeota.2299 Sulfolobus.2643 Sulfolobus_islandicus.1339 sir.213 sir:SiRe_0199 isopropylmalate/citramalate/homocitrate synthase; K01649 2-isopropylmalate synthase [EC:2.3.3.13] OC.276633 Archaea.248 Crenarchaeota.2299 Sulfolobus.2643 Sulfolobus_islandicus.1339 sic.207 sic:SiL_0192 Isopropylmalate/homocitrate/citramalate synthase; K01649 2-isopropylmalate synthase [EC:2.3.3.13] OC.276633 Archaea.248 Crenarchaeota.2299 Metallosphaera.368 - mse.626 mse:Msed_0623 2-isopropylmalate synthase; K01649 2-isopropylmalate synthase [EC:2.3.3.13] OC.276633 Archaea.248 Crenarchaeota.2299 Metallosphaera.368 - mcn.1467 mcn:Mcup_1480 trans-homoaconitate synthase; K01649 2-isopropylmalate synthase [EC:2.3.3.13] OC.276633 Archaea.248 Crenarchaeota.2299 Metallosphaera.368 - mhk.482 mhk:DFR87_02845 homoaconitate hydratase; K01649 2-isopropylmalate synthase [EC:2.3.3.13] OC.276633 Archaea.248 Crenarchaeota.2299 Acidianus.2056 - aho.2154 aho:Ahos_2201 isopropylmalate/citramalate/homocitrate synthase; K01649 2-isopropylmalate synthase [EC:2.3.3.13] OC.276633 Archaea.248 Crenarchaeota.2299 Acidianus.2056 - aman.635 aman:B6F84_03100 homoaconitate hydratase; K01649 2-isopropylmalate synthase [EC:2.3.3.13] OC.276633 Archaea.248 Crenarchaeota.2299 Acidianus.2056 - asul.597 asul:DFR86_03100 homoaconitate hydratase; K01649 2-isopropylmalate synthase [EC:2.3.3.13]