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EXPRESSION
for
Database: All databases - Search term: notch
Ontology
GO
0003137
[GO]
obsolete Notch signaling pathway involved in heart induction
0003270
[GO]
Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation
0005112
[GO]
Notch binding
0007219
[GO]
Notch signaling pathway
0007220
[GO]
Notch receptor processing
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Pathway
KEGG PATHWAY
map04330
Notch signaling pathway
Network
KEGG NETWORK
N00086
Notch signaling pathway
N00087
NOTCH-overexpression to Notch signaling pathway
N00380
HPV E6 to Notch signaling pathway
N00381
HPV E6 to Notch signaling pathway
N00382
HPV E6 to Notch signaling pathway
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KEGG VARIANT
4851v1
NOTCH1 overexpression
4851v2
NOTCH1 mutation
4853v1
NOTCH2 mutation
4854v1
NOTCH3 mutation
4855v1
NOTCH4 overexpression
Chemical substance
KEGG COMPOUND
C22528
Notch intracellular domain; NICD
Gene
KEGG ORTHOLOGY
K02599
NOTCH1; Notch 1
K20994
NOTCH2; Notch 2
K20995
NOTCH3; Notch 3
K20996
NOTCH4; Notch 4
K24463
DNER; delta and Notch-like epidermal growth factor-related receptor
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KEGG GENES
hsa:4853
K20994 Notch 2 | (RefSeq) NOTCH2, AGS2, HJCYS, hN2; notch receptor 2
hsa:100996717
K24466 Notch homolog 2 N-terminal-like protein | (RefSeq) NOTCH2NLC, ETM6, N2N, NIID, NOTCH2NL, NOTCH2NLA, OPDM3; notch 2 N-terminal like C
hsa:23251
K24829 major intrinsically disordered Notch2-binding receptor 1 | (RefSeq) MINAR1, KIAA1024, UBTOR; membrane integral NOTCH2 associated receptor 1
hsa:65989
K24462 protein delta homolog 2 | (RefSeq) DLK2, DLK-2, EGFL9; delta like non-canonical Notch ligand 2
hsa:182
K06052 jagged-1 | (RefSeq) JAG1, AGS, AGS1, AHD, AWS, CD339, CMT2HH, DCHE, HJ1, JAGL1; jagged canonical Notch ligand 1
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KEGG MGENES
T30004:id07290
K20995 Notch 3 | F1-T_1981.1_B_pred_4_+_1840_1904_0_P
T30004:id09765
K26273 protein strawberry notch | F1-T_3025.1_A_pred_2_-_1156_1694_2_P
T30004:id27982
K26273 protein strawberry notch | F1-T_12572.1_A_pred_2_-_451_1114_1_P
T30007:id18035
K26273 protein strawberry notch | F2-W_6387.1_B_pred_1_+_1_1103_1_P
T30008:id44829
K02599 Notch 1 | F2-X_063L01.b_B_pred_1_-_1_258_0_P
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REFGENE
RG001:000016481
K02599 Notch 1 | OM-RGC.v1.000016481; TARA_100_SRF_0.22-3_scaffold357611_1_gene380235
RG001:000018501
K02599 Notch 1 | OM-RGC.v1.000018501; TARA_034_DCM_<-0.22_scaffold82921_2_gene67699
RG001:000018518
K02599 Notch 1 | OM-RGC.v1.000018518; TARA_093_DCM_0.22-3_scaffold35906_1_gene29036
RG001:000021330
K02599 Notch 1 | OM-RGC.v1.000021330; TARA_052_DCM_0.22-1.6_scaffold355882_1_gene314054
RG001:000028403
K02599 Notch 1 | OM-RGC.v1.000028403; TARA_100_SRF_0.22-3_scaffold293099_2_gene263438
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NCBI-GENE
60681241
[NCBI-Gene]
ASB66_RS05980; strawberry notch family protein
61054988
[NCBI-Gene]
C8D77_RS28785; strawberry notch family protein
89573917
[NCBI-Gene]
V7S97_RS07665; strawberry notch C-terminal domain-containing protein
66893306
[NCBI-Gene]
I8G32_RS11545; strawberry notch family protein
102619181
[NCBI-Gene]
LOC102619181; notchless protein homolog
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ENSEMBL
ENSAPOG00000000105
[Ensembl]
jagged canonical Notch ligand 1a [Source:ZFIN;Acc:ZDB-GENE-011128-2]
ENSAPOG00000003185
[Ensembl]
strawberry notch homolog 2 [Source:HGNC Symbol;Acc:HGNC:29158]
ENSAPOG00000003196
[Ensembl]
strawberry notch homolog 1 (Drosophila) [Source:ZFIN;Acc:ZDB-GENE-080522-2]
ENSAPOG00000006582
[Ensembl]
notchless homolog 1 (Drosophila) [Source:ZFIN;Acc:ZDB-GENE-050522-321]
ENSAPOG00000007996
[Ensembl]
membrane integral NOTCH2 associated receptor 2 [Source:HGNC Symbol;Acc:HGNC:33914]
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HGNC
19889
[HGNC]
NLE1; notchless homolog 1
21113
[HGNC]
DLK2; delta like non-canonical Notch ligand 2
22973
[HGNC]
SBNO1; strawberry notch homolog 1
24456
[HGNC]
DNER; delta/notch like EGF repeat containing
2907
[HGNC]
DLK1; delta like non-canonical Notch ligand 1
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BRC-DNA
HGY090921
[BRC-DNA]
IRAL027F01; Plasmid clone of human NOTCH2NL cDNA
HGY103888
[BRC-DNA]
IRAL059L24; Plasmid clone of human NOTCH2NL cDNA
HGY066938
[BRC-DNA]
IRAK167F18; Plasmid clone of human NOTCH2 cDNA
HGX056431
[BRC-DNA]
IRAK141B07; Plasmid clone of human NOTCH4 cDNA with CMV promoter
HGX055757
[BRC-DNA]
IRAK139G13; Plasmid clone of human NOTCH2NL cDNA with CMV promoter
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Protein sequence
UNIPROT
CHAC1_HUMAN
[UniProt]
[Q9BUX1] RecName: Full=Glutathione-specific gamma-glutamylcyclotransferase 1 {ECO:0000303|PubMed:27913623}; Short=Gamma-GCG 1 {ECO:0000303|PubMed:27913623}; EC=4.3.2.7 {ECO:0000269|PubMed:27913623}; AltName: Full=Blocks Notch protein {ECO:0000303|Pu • • •
CHAC1_MOUSE
[UniProt]
[Q8R3J5] RecName: Full=Glutathione-specific gamma-glutamylcyclotransferase 1 {ECO:0000303|PubMed:23070364}; Short=Gamma-GCG 1 {ECO:0000303|PubMed:23070364}; EC=4.3.2.7 {ECO:0000269|PubMed:23070364}; AltName: Full=Blocks Notch protein {ECO:0000303|Pu • • •
CHAC1_RAT
[UniProt]
[B3STU3] RecName: Full=Glutathione-specific gamma-glutamylcyclotransferase 1 {ECO:0000250|UniProtKB:Q9BUX1}; Short=Gamma-GCG 1 {ECO:0000250|UniProtKB:Q9BUX1}; EC=4.3.2.7 {ECO:0000250|UniProtKB:Q9BUX1}; AltName: Full=Blocks Notch protein {ECO:0000250 • • •
DNER_HUMAN
[UniProt]
[Q8NFT8] RecName: Full=Delta and Notch-like epidermal growth factor-related receptor; Flags: Precursor;
DNER_MOUSE
[UniProt]
[Q8JZM4] RecName: Full=Delta and Notch-like epidermal growth factor-related receptor; AltName: Full=Brain EGF repeat-containing transmembrane protein; Flags: Precursor;
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REFSEQ
XP_065203542
[NCBI]
[XP_065203542] neurogenic locus notch homolog protein 1-like isoform X1 [Planococcus citri].
XP_065190725
[NCBI]
[XP_065190725] neurogenic locus notch homolog protein 4-like [Sycon ciliatum].
WP_345936692
[NCBI]
[WP_345936692] strawberry notch-like NTP hydrolase domain-containing protein [Tistrella sp. BH-R2-4].
XP_064865067
[NCBI]
[XP_064865067] protein strawberry notch homolog 2-like isoform X3 [Oncorhynchus nerka].
XP_065267141
[NCBI]
[XP_065267141] delta and Notch-like epidermal growth factor-related receptor [Emys orbicularis].
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DNA sequence
REFSEQ
XM_029646275
[NCBI]
[XM_029646275] PREDICTED: Oncorhynchus nerka major intrinsically disordered NOTCH2-binding receptor 1-like (LOC115117776), mRNA.
XM_029661273
[NCBI]
[XM_029661273] PREDICTED: Oncorhynchus nerka notchless homolog 1 (Drosophila) (nle1), transcript variant X2, mRNA.
XM_065457117
[NCBI]
[XM_065457117] PREDICTED: Gordionus sp. m RMFG-2023 notchless protein homolog 1-like (LOC135922683), mRNA.
XM_065268363
[NCBI]
[XM_065268363] PREDICTED: Paramisgurnus dabryanus neurogenic locus notch homolog protein 1-like (LOC135749714), mRNA.
XM_065226526
[NCBI]
[XM_065226526] PREDICTED: Ochlerotatus camptorhynchus strawberry notch (sno), transcript variant X3, mRNA.
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INSDC
OK953560
[GenBank]
[EMBL]
[DDBJ]
[OK953560] Heteropsis elisi voucher ZFMK:BN-SZS-00375 notch e1 p2 gene, partial cds.
OL229147
[GenBank]
[EMBL]
[DDBJ]
[OL229147] Exoplisia cadmeis voucher MCZ:PDV-94-T014 notch e1 part1 gene, partial cds.
OK953244
[GenBank]
[EMBL]
[DDBJ]
[OK953244] Cogia hippalus voucher MGCL:LEP-40097 notch e1 p2 gene, partial cds.
OK953810
[GenBank]
[EMBL]
[DDBJ]
[OK953810] Propapias sipariana voucher MGCL:LEP-61255 notch e1 p2 gene, partial cds.
OL229063
[GenBank]
[EMBL]
[DDBJ]
[OL229063] Kakumia ideoides voucher MCZ:RD-98-U133 notch e1 part1 gene, partial cds.
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3D Structure
PDB
3L95
[PDB-RCSB]
[PDBe]
[PDBj]
CRYSTAL STRUCTURE OF THE HUMAN NOTCH1 NEGATIVE REGULATORY REGION (NRR) BOUND TO THE FAB FRAGMENT OF AN ANTAGONIST ANTIBODY
5FMA
[PDB-RCSB]
[PDBe]
[PDBj]
HUMAN NOTCH 1, EGF 4-7
8OR5
[PDB-RCSB]
[PDBe]
[PDBj]
SOLUTION NMR STRUCTURE OF NOTCH1 TMD
1OT8
[PDB-RCSB]
[PDBe]
[PDBj]
STRUCTURE OF THE ANKYRIN DOMAIN OF THE DROSOPHILA NOTCH RECEPTOR
2RQZ
[PDB-RCSB]
[PDBe]
[PDBj]
STRUCTURE OF SUGAR MODIFIED EPIDERMAL GROWTH FACTOR-LIKE REPEAT 12 OF MOUSE NOTCH-1 RECEPTOR
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Protein domain
INTERPRO
IPR000800
[InterPro]
[Notch_dom] Notch domain
IPR008297
[InterPro]
[Notch] Notch
IPR009626
[InterPro]
[MINAR1-like_C] Major intrinsically disordered Notch2-binding receptor 1-like, C-terminal
IPR010660
[InterPro]
[Notch_NOD_dom] Notch, NOD domain
IPR011651
[InterPro]
[Notch_ligand_N] Notch ligand, N-terminal domain
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PFAM
DNER_C
[Pfam]
[PF19330] Delta and Notch-like EGF-related receptor C-terminus
Helicase_C_4
[Pfam]
[PF13871] C-terminal domain on Strawberry notch homologue
MNNL
[Pfam]
[PF07657] N terminus of Notch ligand C2-like domain
NOD
[Pfam]
[PF06816] NOTCH protein
NODP
[Pfam]
[PF07684] NOTCH protein
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PROSITE
LNR
[ExPASy]
[PS50258] LNR (Lin-12/Notch) repeat profile.
NCBI-CDD
241298
[NCBI-CDD]
[cd01268] PTB_Numb, Numb Phosphotyrosine-binding (PTB) domain. Numb is a membrane associated adaptor protein which plays critical roles in cell fate determination. Numb proteins are involved in control of asymmetric cell division and cell fate choic • • •
239079
[NCBI-CDD]
[cd02339] ZZ_Mind_bomb, Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E • • •
349877
[NCBI-CDD]
[cd03881] M28_Nicastrin, M28 Zn-peptidase nicastrin, a main component of gamma-secretase complex. Peptidase M28 family, nicastrin subfamily. Nicastrin is a main component of the gamma-secretase complex, which also contains presenilin, Pen-2 and Aph- • • •
467193
[NCBI-CDD]
[cd06709] PDZ_SYNJ2BP-like, PDZ domain of synaptojanin-2-binding protein (SYNJ2BP), and related domains. PDZ (PSD-95 (Postsynaptic density protein 95), Dlg (Discs large protein), and ZO-1 (Zonula occludens-1)) domain of SYNJ2BP, and related domains. • • •
185747
[NCBI-CDD]
[cd09234] V_HD-PTP_like, Protein-interacting V-domain of mammalian His-Domain type N23 protein tyrosine phosphatase and related domains. This family contains the V-shaped (V) domain of mammalian His-Domain type N23 protein tyrosine phosphatase (HD-P • • •
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DBGET
integrated database retrieval system