KEGG   ENZYME: 1.1.1.132
Entry
EC 1.1.1.132                Enzyme                                 

Name
GDP-mannose 6-dehydrogenase;
guanosine diphosphomannose dehydrogenase;
GDP-mannose dehydrogenase;
guanosine diphosphomannose dehydrogenase;
guanosine diphospho-D-mannose dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
GDP-D-mannose:NAD+ 6-oxidoreductase
Reaction(IUBMB)
GDP-D-mannose + 2 NAD+ + H2O = GDP-D-mannuronate + 2 NADH + 2 H+ [RN:R00880]
Reaction(KEGG)
R00880
Substrate
GDP-D-mannose [CPD:C00096];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Product
GDP-D-mannuronate [CPD:C00976];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Also acts on the corresponding deoxynucleoside diphosphate derivative as a substrate.
History
EC 1.1.1.132 created 1972
Pathway
ec00051  Fructose and mannose metabolism
ec00520  Amino sugar and nucleotide sugar metabolism
ec01100  Metabolic pathways
Orthology
K00066  GDP-mannose 6-dehydrogenase
Genes
PAE: PA3540(algD)
PAEV: N297_3663(algD)
PAEI: N296_3663(algD)
PAU: PA14_18580(algD)
PAP: PSPA7_1605(algD)
PAG: PLES_14931(algD)
PAF: PAM18_1446(algD)
PNC: NCGM2_4665(algD)
PAEB: NCGM1900_2744(algD)
PDK: PADK2_06665
PSG: G655_07100
PRP: M062_18755
PAEP: PA1S_07720
PAER: PA1R_gp1358
PAEM: U769_07195
PAEL: T223_07435
PAES: SCV20265_1523
PAEU: BN889_03910(algD)
PAEG: AI22_26185
PAEC: M802_3660(algD)
PAEO: M801_3528(algD)
PMY: Pmen_1031 Pmen_1678
PMK: MDS_1082
PRE: PCA10_11880(algD) PCA10_38230(algD)
PALC: A0T30_11805
PCQ: PcP3B5_50680(algD)
PPU: PP_1288(algD)
PPF: Pput_4437
PPG: PputGB1_4561
PPW: PputW619_0889
PPT: PPS_4403
PPB: PPUBIRD1_4273
PPI: YSA_03091
PPX: T1E_3168(algD)
PPUH: B479_22150
PPUT: L483_27235
PPUN: PP4_08000(algD)
PPUD: DW66_4794
PFV: Psefu_3880
PMON: X969_21685
PMOT: X970_21320
PMOS: O165_013045 O165_018560
PPJ: RK21_00119
PST: PSPTO_1243(algD)
PSB: Psyr_1063
PSYR: N018_20355
PSP: PSPPH_1118(algD)
PAMG: BKM19_008085
PCI: PCH70_10130
PAVL: BKM03_07020
PVD: CFBP1590__4277(algD)
PFL: PFL_1024(algD)
PPRC: PFLCHA0_c10440(algD)
PPRO: PPC_1062
PFO: Pfl01_0960(algD)
PFS: PFLU_0990(algD)
PFE: PSF113_4752
PFC: PflA506_0970(algD)
PFN: HZ99_11915
PPZ: H045_01690
PFB: VO64_4071
PMAN: OU5_2447
PTV: AA957_09045
PCG: AXG94_09975
PVR: PverR02_05230
PAZO: AYR47_12230
POI: BOP93_04735
PFW: PF1751_v1c09480(algD)
PFF: PFLUOLIPICF703390
PFX: A7318_04290
PEN: PSEEN3453(algD-2) PSEEN4535(algD)
PBA: PSEBR_a4590
PBC: CD58_24305
PPUU: PputUW4_04471(algD)
PDR: H681_19425
PSV: PVLB_04235 PVLB_15470
PSK: U771_06125
PKC: PKB_0968(algD)
PCH: EY04_04520
PCZ: PCL1606_50710
PCP: JM49_25125
PFZ: AV641_18510
PLQ: AA042_15150
PALK: PSAKL28_08740 PSAKL28_31810
PPV: NJ69_13830
PSES: PSCI_0721
PSEM: TO66_05210
PSEC: CCOS191_0912(algD1) CCOS191_2029(algD2)
PPSY: AOC04_15730
PSOS: POS17_1030
PKR: AYO71_07540
PFK: PFAS1_06330
PANR: A7J50_0992
PSET: THL1_1268 THL1_3804
PSIL: PMA3_24585
PYM: AK972_0838
PKE: DLD99_05160
PALL: UYA_04885 UYA_15320
PUM: HGP31_04975
POJ: PtoMrB4_26000(algD) PtoMrB4_46190
PGG: FX982_00687
PGY: AWU82_19080 AWU82_29005
AVN: Avin_10970(algD)
AVL: AvCA_10970(algD)
AVD: AvCA6_10970(algD)
ACX: Achr_31180(algD)
PAT: Patl_1531
MSR: AU15_13665
GAG: Glaag_2800
PMES: FX988_01104
HMI: soil367_08790
CEG: D0C16_11005
ABO: ABO_0384(algD)
ALN: AS19_03970
GSN: YC6258_00963
OME: OLMES_2098 OLMES_4477
TAU: Tola_1407
SVA: SVA_1550
REV: HUE57_13005
PLG: NCTC10937_04283(algD)
RFR: Rfer_0673
JAG: GJA_3986(algD)
JAL: BZG29_08185
JAS: FJQ89_25120
JLV: G3257_08340
MNR: ACZ75_11680
MASZ: C9I28_09765
MASY: DPH57_12210
MFLA: GO485_23875
MPLI: E1742_23455
EBA: ebA4268(algD)
AZO: azo3269(algD)
AOA: dqs_3408
ACOM: CEW83_18780
APP: CAP2UW1_0858 CAP2UW1_1431
NIS: NIS_0191
CMED: FE773_08555
CPAF: C6V80_01890
DSA: Desal_3469
DTO: TOL2_C36540(algD)
RHL: LPU83_pLPU83d0171(algD1) LPU83_pLPU83d1236(algD3)
RGR: FZ934_26065
BJA: blr6296(blr6296)
BRA: BRADO7047
BRS: S23_62720
BRC: BCCGELA001_11045
BIC: LMTR13_08410
BRK: CWS35_18850
BRQ: CIT40_06180
BSYM: CIT39_05020
BARH: WN72_18950
MNO: Mnod_5882
METI: DK427_06650
BID: Bind_3885
MPAR: F7D14_18240
MAAD: AZF01_02675
MMED: Mame_02304(algD)
RBM: TEF_19885
DSH: Dshi_1896(algD)
MALG: MALG_02776
CON: TQ29_00725
HAT: RC74_06375
LABR: CHH27_22980
LABP: FJ695_16660
YPAC: CEW88_18640
YAN: AYJ57_24995
SULZ: C1J03_23160
TOM: BWR18_20775
THW: BMG03_12925
THAA: CFI11_06320 CFI11_06490
LIT: FPZ52_00565
PPRU: FDP22_22880
POZ: I0K15_05930
FAQ: G5B39_18330
HDH: G5B40_09200
NAR: Saro_3220
SPHI: TS85_22025
SSAN: NX02_04640
SECH: B18_00665
EGN: BMF35_a0516
ERF: FIU90_00265(algD)
PHZ: CHX26_00290
POT: E2E27_01460
HTQ: FRZ44_03090(algD)
HADH: FRZ61_03380(algD)
BMX: BMS_2990
MSM: MSMEG_5957(algD)
MSG: MSMEI_5797
MSB: LJ00_29460
MSN: LI99_29465
MSH: LI98_29470
MVA: Mvan_1699
MSP: Mspyr1_41390
MNE: D174_24385
MYN: MyAD_23925
MGO: AFA91_10990 AFA91_29875
MTY: MTOK_31270(algD)
ROP: ROP_57960(algD)
TOY: FO059_04060
SCO: SCO0382(SCF62.08)
SCB: SCAB_23351
SVL: Strvi_5599
SBH: SBI_09543
SHY: SHJG_7006
SHO: SHJGH_6766
SVE: SVEN_7199
SRC: M271_40840
SALU: DC74_1121
SALL: SAZ_06100
SLV: SLIV_36030(algD)
SVT: SVTN_36100
STRE: GZL_08291
SLD: T261_7968
SPRI: SPRI_2000
STRF: ASR50_26930
SPAV: Spa2297_31800
STRT: A8713_24610
SCLF: BB341_00345
SGS: AVL59_31095
SLS: SLINC_8140
SNR: SNOUR_37270(algD)
SPLU: LK06_025850
STRD: NI25_00640
SSIA: A7J05_09315
SGV: B1H19_04475
SALF: SMD44_08071(algD)
STRO: STRMOE7_01550
SFK: KY5_0166c
SGE: DWG14_01282(algD_2)
SLK: SLUN_34570
SQZ: FQU76_01535
SCYA: EJ357_37150
SKA: CP970_42095
SALW: CP975_03365
SVR: CP971_03305
SFY: GFH48_34990
HEA: HL652_13685
ACH: Achl_2940
TEH: GKE56_16015
NDK: I601_0111(algD)
SRO: Sros_0655
NOA: BKM31_42710
BSD: BLASA_0423(algD)
AMD: AMED_0547(algD)
AMN: RAM_02805
AMM: AMES_0545(algD)
AMZ: B737_0546(algD)
AOI: AORI_0554(algD)
AJA: AJAP_36870(algD)
AMQ: AMETH_0542(ugd)
AMYB: BKN51_36975
AMYY: YIM_21485(algD)
AORI: SD37_38440
PDX: Psed_1848
PMAD: BAY61_02365
HAO: PCC7418_0427
NPU: Npun_F5503
NSH: GXM_00034
CTHE: Chro_0719
STI: Sthe_1134
ROO: G5S37_25645
AHEL: Q31a_57060(algD)
MRI: Mal4_03640(algD)
SDYN: Mal52_06430(algD)
FTJ: FTUN_5650
ABA: Acid345_3792
TRS: Terro_2830
SUS: Acid_0553
BDO: EL88_09425
NKO: Niako_7100
CMR: Cycma_0720
SPIB: G8759_29085
FIB: A6C57_20705
PKO: PKOR_16530
ZGA: ZOBELLIA_1984(algD)
CACI: CLOAM0663
TAM: Theam_0797
NMV: NITMOv2_2630(algD)
 » show all
Reference
1  [PMID:14245351]
  Authors
PREISS J.
  Title
SUGAR NUCLEOTIDE REACTIONS IN ARTHROBACTER. II. BIOSYNTHESIS OF GUANOSINE DIPHOSPHOMANNURONATE.
  Journal
J Biol Chem 239:3127-32 (1964)
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.132
IUBMB Enzyme Nomenclature: 1.1.1.132
ExPASy - ENZYME nomenclature database: 1.1.1.132
BRENDA, the Enzyme Database: 1.1.1.132
CAS: 37250-63-8

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Pathway (6)   
   KEGG PATHWAY (6)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (1950)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (294)   
   KEGG MGENES (1193)   
   RefGene (462)   
Protein sequence (1829)   
   UniProt (1604)   
   SWISS-PROT (6)   
   RefSeq(pep) (207)   
   PDBSTR (12)   
DNA sequence (6134)   
   RefSeq(nuc) (5501)   
   GenBank (333)   
   EMBL (300)   
3D Structure (3)   
   PDB (3)   
Protein domain (8)   
   InterPro (8)   
All databases (9938)   

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