KEGG ENZYME: 1.1.1.132

ENZYME: 1.1.1.132

Entry

EC 1.1.1.132                Enzyme

Name

GDP-mannose 6-dehydrogenase;
guanosine diphosphomannose dehydrogenase;
GDP-mannose dehydrogenase;
guanosine diphosphomannose dehydrogenase;
guanosine diphospho-D-mannose dehydrogenase

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

GDP-D-mannose:NAD+ 6-oxidoreductase

Reaction(IUBMB)

GDP-D-mannose + 2 NAD+ + H2O = GDP-D-mannuronate + 2 NADH + 2 H+ [RN:R00880]

Reaction(KEGG)

R00880

Substrate

GDP-D-mannose [CPD:C00096];
NAD+ [CPD:C00003];
H2O [CPD:C00001]

Product

GDP-D-mannuronate [CPD:C00976];
NADH [CPD:C00004];
H+ [CPD:C00080]

Comment

Also acts on the corresponding deoxynucleoside diphosphate derivative as a substrate.

History

EC 1.1.1.132 created 1972

Pathway

ec00051

Fructose and mannose metabolism

ec00520

Amino sugar and nucleotide sugar metabolism

ec01100

Metabolic pathways

Orthology

K00066

GDP-mannose 6-dehydrogenase

Genes

LARE:

HIV01_005960

PRE:	PCA10_11880(algD) PCA10_38230(algD)

PFUW:

KF707C_11170

POJ:	PtoMrB4_26000(algD) PtoMrB4_46190

PLAL:

FXN65_05555

PAE:	PA3540(algD)

PAEV:

N297_3663(algD)

PAEI:

N296_3663(algD)

PAU:	PA14_18580(algD)

PAG:	PLES_14931(algD)

PAF:	PAM18_1446(algD)

PNC:	NCGM2_4665(algD)

PAEB:

NCGM1900_2744(algD)

PDK:	PADK2_06665

PSG:	G655_07100

PRP:	M062_18755

PAEP:

PA1S_07720

PAER:

PA1R_gp1358

PAEM:

U769_07195

PAEL:

T223_07435

PAES:

SCV20265_1523

PAEU:

BN889_03910(algD)

PAEG:

AI22_26185

PAEC:

M802_3660(algD)

PAEO:

M801_3528(algD)

SECH:

B18_00665

PCQ:	PcP3B5_50680(algD)

PMUI:

G4G71_08975

PNT:	G5B91_26160

PAP:	PSPA7_1605(algD)

PPAA:

B7D75_07435

PPU:	PP_1288(algD)

PPF:

Pput_4437

PPG:	PputGB1_4561

PPW:	PputW619_0889

PPT:

PPS_4403

PPB:	PPUBIRD1_4273

PPI:

YSA_03091

PPX:	T1E_3168(algD)

PPUH:

B479_22150

PPUT:

L483_27235

PPUN:

PP4_08000(algD)

PPUD:

DW66_4794

PFV:	Psefu_3880

PMON:

X969_21685

PMOT:

X970_21320

PPJ:	RK21_00119

PMOL:

CLJ08_08380 CLJ08_22925

PALD:

LU682_024945

PIX:	RIN61_07120

PMOS:

O165_013045 O165_018560

PST:	PSPTO_1243(algD)

PSB:

Psyr_1063

PSYR:

N018_20355

PSP:	PSPPH_1118(algD)

PSAV:

PSA3335_09095

PAMG:

BKM19_008085

PCI:	PCH70_10130

PAVL:

BKM03_07020

PVD:	CFBP1590__4277(algD)

PCAB:

JGS08_19525

PCOF:

POR16_18925

PTRE:

I9H09_05090

PSYI:

MME58_05275

PAST:

N015_05985

PLIJ:

KQP88_04855

PFUV:

NLK61_18730

PFL:	PFL_1024(algD)

PPRC:

PFLCHA0_c10440(algD)

PPRO:

PPC_1062

PFE:	PSF113_4752

PZA:	HU749_024140

PFN:	HZ99_11915

PFO:	Pfl01_0960(algD)

PFS:	PFLU_0990(algD)

PFC:	PflA506_0970(algD)

PPZ:	H045_01690

PFB:

VO64_4071

PMAN:

OU5_2447

PTV:	AA957_09045

PCG:	AXG94_09975

PVR:	PverR02_05230

PAZO:

AYR47_12230

POI:	BOP93_04735

PRX:	HRH33_05805

PMED:

E3Z27_23120

PKR:	AYO71_07540

PMUD:

NCTC8068_04321(algD)

PTOL:

I7845_05045

PMAB:

U0037_04980

PBRE:

QDY63_24165

PFW:	PF1751_v1c09480(algD)

PFF:	PFLUOLIPICF703390

PFX:	A7318_04290

PEN:	PSEEN3453(algD-2) PSEEN4535(algD)

PBA:	PSEBR_a4590

PBC:	CD58_24305

PPUU:

PputUW4_04471(algD)

PDR:	H681_19425

PSV:	PVLB_04235 PVLB_15470

PSK:	U771_06125

PKC:	PKB_0968(algD)

PCH:	EY04_04520

PCZ:	PCL1606_50710

PCP:	JM49_25125

PCHP:

C4K32_1103

PFZ:	AV641_18510

PLQ:	AA042_15150

PALK:

PSAKL28_08740 PSAKL28_31810

PPV:	NJ69_13830

PSES:

PSCI_0721

PSEM:

TO66_05210

PSEC:

CCOS191_0912(algD1) CCOS191_2029(algD2)

PPSY:

AOC04_15730

PSOS:

POS17_1030

PFK:	PFAS1_06330

PANR:

A7J50_0992

PSET:

THL1_1268 THL1_3804

PSIL:

PMA3_24585

PYM:	AK972_0838

PKE:	DLD99_05160

PUM:	HGP31_04975

PGG:	FX982_00687

PGY:	AWU82_19080 AWU82_29005

PSEJ:

HNQ25_10170 HNQ25_19280

PVK:	EPZ47_24330

PEZ:	HWQ56_05050

PBZ:	GN234_24015

PATA:

JWU58_22750

PDW:	BV82_3321 BV82_4690

PZE:	HU754_006270

PMOE:

HV782_005850

PSEP:

C4K39_1041

PPII:

QL104_05175

PVW:	HU752_027430

PTRT:

HU722_0006165

PXA:	KSS93_07790

PSAM:

HU731_021005

PTZ:	HU718_005910

PQI:	KH389_10480 KH389_22245

PSHH:

HU773_022835

PXN:	HU772_004420 HU772_009430

PHV:	HU739_012710

PPRG:

HU725_004085 HU725_014400

PANH:

HU763_020330

PASG:

KSS96_05695

PFAK:

KSS94_04615

PMUY:

KSS95_07475 KSS95_11760

PMAM:

KSS90_04835 KSS90_09905

PAZE:

KSS91_23845

PALV:

KSS97_06295

PCAS:

LOY40_05230

PORY:

EJA05_04800

PWZ:	J7655_04690(algD)

PTK:	EXN22_12380 EXN22_22955

PTW:	TUM18999_50120(algD)

PIE:	HU724_005670

PWY:	HU734_005480

PGF:	J0G10_06075

PCAV:

D3880_05550 D3880_05610

PJU:	L1P09_20850

PIZ:	LAB08_R50410

PPEG:

KUA23_05150

PSII:

NF676_05345

PSIH:

LOY51_04705

PFIT:

KJY40_05935

PASI:

LG197_00315

PKM:	PZ739_23450

PNB:	NK667_22335

PSOA:

PSm6_09920(algD)

PTAI:

ICN73_10950

PKK:	QQ992_23595

PKJ:	Q1W70_05470 Q1W70_21865

PHYG:

JTY93_21615

PHOM:

KJF94_01550 KJF94_13595

PCUC:

PSH97_04640

PTRL:

OU419_22545(algD)

PPAE:

LDL65_16250

PPAO:

K3169_23650

PRHZ:

CRX69_09220

PSJY:

AA098_05025

PSKU:

KUIN1_11040

PSHS:

JJN09_02540

PHEF:

PSH57_05225

PSLP:

BHQ29_07820 BHQ29_17130

PLIS:

NN484_01390

PSNC:

C0058_26885

PFOU:

OZ911_23940

PBEJ:

PSH84_01850

PKV:	QYQ93_05900

PSKP:

KU43P_18940 KU43P_44560

PDEU:

QEP73_14595

PQE:	OSC50_19425

PSDT:

NH234_05830

PCAA:

V6L78_29655

PSIV:

LZ023_33740

PSWO:

SD196_21735(algD)

PMOR:

PMm318_A01820

PTHV:

CE140_22400

PSSX:

DCC84_28260

PAGB:

AWM79_03600

PSNS:

CI807_11825

PMY:	Pmen_1031 Pmen_1678

PMK:

MDS_1082

PALL:

UYA_04885 UYA_15320

PKH:	JLK41_05220(algD)

PTY:	JWV26_01370 JWV26_15965(algD)

PHF:	NLY38_05240(algD) NLY38_16715

PCHE:

QYM18_12805(algD) QYM18_23005(algD)

AVN:	Avin_10970(algD)

AVL:	AvCA_10970(algD)

AVD:	AvCA6_10970(algD)

ACX:	Achr_31180(algD)

EAZ:	JHT90_07865

ENTO:

MTZ49_11930

PDEN:

F1C79_17950

PPHA:

BVH74_05210

PALC:

A0T30_11805

PCAM:

HNE05_07125

MSR:	AU15_13665

MACA:

J2887_18610

GAG:	Glaag_2800

PMES:

FX988_01104

PAT:

Patl_1531

HMI:	soil367_08790

ALKM:

NKI27_00790

CEG:	D0C16_11005

GIL:	NHM04_15470

MNY:	R50073_15990

MEIY:

MIN45_P0136

THIM:

KFB96_07615

TFRI:

Thiofri_03630(algD)

ABO:	ABO_0384(algD)

ALN:	AS19_03970

GSN:	YC6258_00963

OME:	OLMES_2098 OLMES_4477

TAU:

Tola_1407

SVA:

SVA_1550

REV:	HUE57_13005

PLG:	NCTC10937_04283(algD)

RFR:

Rfer_0673

PAQA:

K9V56_012855 K9V56_012880

PAIS:

PFX98_20965

ATER:

MW290_14625

JAG:	GJA_3986(algD)

JAL:	BZG29_08185

JAS:	FJQ89_25120

JLV:	G3257_08340

JRI:	P9875_08610

JAE:	OPV09_08525

MNR:	ACZ75_11680

MASY:

DPH57_12210

MENY:

LSQ66_04000

MASZ:

C9I28_09765

MFLA:

GO485_23875

MPLI:

E1742_23455

TCT:	PX653_13240

PLUE:

EWM63_05620

EHB:	E7V67_006890

MUV:	FIT94_04050

EBA:	ebA4268(algD)

AZO:	azo3269(algD)

AOA:

dqs_3408

ACOM:

CEW83_18780

APP:	CAP2UW1_0858 CAP2UW1_1431

ACOG:

HWD57_11430

AMAX:

ABWH92_04635

ARUI:

G6M88_17210

RHL:	LPU83_pLPU83d0171(algD1) LPU83_pLPU83d1236(algD3)

RGR:	FZ934_26065

RROS:

D4A92_02485 D4A92_22670

RSUL:

N2599_29805

BJA:	blr6296(blr6296)

BRA:

BRADO7047

BRS:

S23_62720

BRC:	BCCGELA001_11045

BIC:	LMTR13_08410

BRK:	CWS35_18850

BRQ:	CIT40_06180

BSYM:

CIT39_05020

BARH:

WN72_18950

BEL:	BE61_69060

BSEP:

HAP48_0031560

BQB:	J4P68_0032835

BAUT:

QA635_27835

BBRA:

QA636_29730

BPAH:

QA639_16165

TARV:

FIU28_16890

MNO:

Mnod_5882

METI:

DK427_06650

MTEZ:

HPT29_006150

BID:

Bind_3885

MPAR:

F7D14_18240

MAAD:

AZF01_02675

MMED:

Mame_02304(algD)

MLUT:

JET14_03725

JAV:	OXU80_00280

RBM:

TEF_19885

LABR:

CHH27_22980

LABP:

FJ695_16660

RPOP:

K1718_15110

ACUT:

MRB58_00060

RUY:	NOR97_20535

DSH:	Dshi_1896(algD)

MALG:

MALG_02776

CON:	TQ29_00725

YPAC:

CEW88_18640

YAN:	AYJ57_24995

SULZ:

C1J03_23160

TOM:	BWR18_20775

THAA:

CFI11_06320 CFI11_06490

RMH:	LVO79_06000

HAT:	RC74_06375

LSAL:

KBK07_17255

TRY:	QF118_01765

THW:	BMG03_12925

TLB:	RPE78_12915

YPHY:

AABB29_07900

YRH:	AABB31_14955

LIT:	FPZ52_00565

PPRU:

FDP22_22880

POZ:	I0K15_05930

CACT:

HZ995_12210

HDH:	G5B40_09200

AMYL:

QBD29_07855

FAQ:	G5B39_18330

NAR:

Saro_3220

SPHI:

TS85_22025

SSAN:

NX02_04640

ACOB:

P0Y56_12580

EGN:	BMF35_a0516

ERF:	FIU90_00265(algD)

ERYT:

KDC96_15245

PHZ:	CHX26_00290

POT:	E2E27_01460

RAP:	RHOA_PB0089(algD)

HTQ:	FRZ44_03090(algD)

HADH:

FRZ61_03380(algD)

SNEA:

NBZ79_19285

NIS:

NIS_0191

CMED:

FE773_08555

CPAF:

C6V80_01890

DVE:	DESUT3_23450(algD)

DSA:	Desal_3469

DTO:	TOL2_C36540(algD)

BMX:

BMS_2990

STI:

Sthe_1134

SLOM:

PXH66_05790

ROO:	G5S37_25645

FPES:

NXS98_06570

AHEL:

Q31a_57060(algD)

SMAM:

Mal15_36880(algD)

MRI:	Mal4_03640(algD)

SDYN:

Mal52_06430(algD)

SCHL:

QJS52_01950

FTJ:

FTUN_5650

ABA:	Acid345_3792

TRS:	Terro_2830

ADIN:

H7849_05985

SUS:

Acid_0553

LUB:	TBR22_A24300(algD)

BDO:	EL88_09425

NKO:	Niako_7100

CMR:	Cycma_0720

EMAI:

KZP23_20245

SPIB:

G8759_29085

SRHO:

HH216_01470

SENF:

GJR95_15585

DSN:	HWI92_00320

FIB:	A6C57_20705

PKO:	PKOR_16530

CLIT:

OQ292_40240

PRHO:

PZB74_20200

TPEL:

P0M28_17740

CNQ:	PZB72_28250

ZGA:	ZOBELLIA_1984(algD)

MLIL:

QLS71_002625

PPON:

MUN68_016515

CACI:

CLOAM0663

TAM:	Theam_0797

NMV:	NITMOv2_2630(algD)

NNEO:

PQG83_09560

PARH:

I5S86_05480

PHEX:

L0M14_20510

LBP:	V1224_13340

HSG:	HPPSJP_3770(rkpK)

MSM:	MSMEG_5957(algD)

MSG:	MSMEI_5797

MSB:	LJ00_29460

MSN:	LI99_29465

MSH:	LI98_29470

MVA:

Mvan_1699

MSP:	Mspyr1_41390

MNE:	D174_24385

MYN:	MyAD_23925

MTY:	MTOK_31270(algD)

MSAR:

MSAR_24600(algD)

MANY:

MANY_49000(algD)

MPOF:

MPOR_19690

MGO:	AFA91_10990 AFA91_29875

MRF:	MJO55_24360

MDF:	K0O62_25565

MAUS:

JN090_07325

MFRE:

EXE63_09795

MFLU:

HZU40_32750

NHU:	H0264_19875

ROP:	ROP_57960(algD)

RKO:	JWS14_31405

RHOY:

QNA09_05105

TOY:	FO059_04060

SCO:	SCO0382(SCF62.08)

SGRF:

SGFS_035730

SCB:	SCAB_23351

SVL:	Strvi_5599

SHY:

SHJG_7006

SHO:	SHJGH_6766

SRC:	M271_40840

SBH:

SBI_09543

SVE:

SVEN_7199

SLV:	SLIV_36030(algD)

SVT:	SVTN_36100

STRE:

GZL_08291

SLD:

T261_7968

SPRI:

SPRI_2000

STRF:

ASR50_26930

SPAV:

Spa2297_31800

STRT:

A8713_24610

SCLF:

BB341_00345

SGS:	AVL59_31095

SALW:

CP975_03365

SGM:	GCM10017557_19510

SGRS:

V9K83_07275

SLS:	SLINC_8140

SNR:	SNOUR_37270(algD)

SALU:

DC74_1121

SALL:

SAZ_06100

SPLU:

LK06_025850

STRD:

NI25_00640

SSIA:

A7J05_09315

SGV:	B1H19_04475

SALF:

SMD44_08071(algD)

STRO:

STRMOE7_01550

SFK:

KY5_0166c

SGE:	DWG14_01282(algD_2)

SLK:	SLUN_34570

SQZ:	FQU76_01535

SCYA:

EJ357_37150

SKA:	CP970_42095

SVR:	CP971_03305

SFY:	GFH48_34990

SBY:	H7H31_29485

SFUG:

CNQ36_29650

STSU:

B7R87_32065

SCHA:

CP983_11050

SGX:	H4W23_37670

SCOE:

CP976_05755

SSPB:

CP982_01460

SHUN:

DWB77_00748(algD)

SCYG:

S1361_04630(algD)

SFEU:

IM697_33530

SROI:

IAG44_00725

SXN:	IAG42_07115

SGJ:	IAG43_29305

SHK:	J2N69_02610

SINE:

KI385_03390

SLF:	JEQ17_08420

SAOV:

G3H79_06935

SDUR:

M4V62_06475

STAA:

LDH80_04755

SLON:

LGI35_03160

STEE:

F3L20_11870

SYUN:

MOV08_38485

SARG:

HKX69_08010

SJN:	RI060_36395

SCYN:

N8I84_34940

SKG:	KJK29_33180

SFP:	QUY26_02885

STRZ:

OYE22_28860

KBU:	Q4V64_06025

SMIB:

SMIR_07815

SCAJ:

O1G22_01465

STRL:

HEP84_37695

STSD:

HEP87_38640

STRV:

EZV63_33750

SMOD:

POD33_22970

STBR:

ABDE16_00175

SGRO:

UBV09_26080

STAC:

ABII15_36555

SSLI:

R2D22_03205

STYI:

C9F11_00600(algD)

SCIT:

V2W30_37045

SSIR:

WAB15_02205

KCH:	O1G21_06125

KCM:	ABWK59_01455

HEA:	HL652_13685

ACH:

Achl_2940

TEH:	GKE56_16015

NDK:	I601_0111(algD)

NOF:	MF408_15695

KSL:	OG809_26460

SRO:

Sros_0655

NOA:	BKM31_42710

NGN:	LCN96_02635

NFS:	OIE67_44765

BSD:	BLASA_0423(algD)

AMD:	AMED_0547(algD)

AMN:

RAM_02805

AMM:	AMES_0545(algD)

AMZ:	B737_0546(algD)

AOI:	AORI_0554(algD)

AJA:	AJAP_36870(algD)

AMQ:	AMETH_0542(ugd)

AMYB:

BKN51_36975

AMYY:

YIM_21485(algD)

AORI:

SD37_38440

AACD:

LWP59_02525

APRT:

MUY14_33840

AROO:

NQK81_20050

ATHM:

L1857_05310

ARHD:

VSH64_40365

AMOG:

QRX60_08495

ACOR:

LCL61_41965

ACAB:

QRX50_04675

ANW:	QP939_09660

AMYD:

K1T34_21425

AMYE:

MJQ72_38830

AMYS:

CVV72_26080

PDX:

Psed_1848

PBRO:

HOP40_15385

PPEL:

H6H00_14920

KUT:	JJ691_61590(algD)

KBR:	Q4V65_17680

PMAD:

BAY61_02365

ACTY:

OG774_25565

HAO:	PCC7418_0427

NPU:	Npun_F5503

NSH:

GXM_00034

CTHE:

Chro_0719

DAH:	DAETH_33720

DMB:	E5F05_17350

SCHV:

BRCON_1950

» show all

Reference

1 [PMID:14245351]

Authors

PREISS J.

Title

SUGAR NUCLEOTIDE REACTIONS IN ARTHROBACTER. II. BIOSYNTHESIS OF GUANOSINE DIPHOSPHOMANNURONATE.

Journal

J Biol Chem 239:3127-32 (1964)

Other DBs

ExplorEnz - The Enzyme Database:

1.1.1.132

IUBMB Enzyme Nomenclature:

1.1.1.132

ExPASy - ENZYME nomenclature database:

1.1.1.132

BRENDA, the Enzyme Database:

1.1.1.132

CAS:	37250-63-8

All links

Gene (1784)   
   MGENES (1322)   
   RefGene (462)   
Protein sequence (1746)   
   UniProt (1423)   
   SWISS-PROT (6)   
   RefSeq(pep) (305)   
   PDBSTR (12)   
DNA sequence (14686)   
   RefSeq(nuc) (11845)   
   GenBank (1461)   
   EMBL (1380)   
3D Structure (3)   
   PDB (3)   
Protein domain (8)   
   InterPro (8)   
All databases (18227)   

Download RDF

DBGET integrated database retrieval system