KEGG   ENZYME: 1.1.1.187
Entry
EC 1.1.1.187                Enzyme                                 

Name
GDP-4-dehydro-D-rhamnose reductase;
GDP-4-keto-6-deoxy-D-mannose reductase;
GDP-4-keto-D-rhamnose reductase;
guanosine diphosphate-4-keto-D-rhamnose reductase;
GDP-6-deoxy-D-mannose:NAD(P)+ 4-oxidoreductase;
GDP-6-deoxy-alpha-D-mannose:NAD(P)+ 4-oxidoreductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
GDP-4-dehydro-alpha-D-rhamnose:NAD(P)+ 4-oxidoreductase
Reaction(IUBMB)
(1) GDP-alpha-D-rhamnose + NAD(P)+ = GDP-4-dehydro-alpha-D-rhamnose + NAD(P)H + H+ [RN:R03397 R03399];
(2) GDP-6-deoxy-alpha-D-talose + NAD(P)+ = GDP-4-dehydro-alpha-D-rhamnose + NAD(P)H + H+ [RN:R03396 R03398]
Reaction(KEGG)
Substrate
GDP-alpha-D-rhamnose [CPD:C03117];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
GDP-6-deoxy-alpha-D-talose [CPD:C02977]
Product
GDP-4-dehydro-alpha-D-rhamnose [CPD:C01222];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme, which operates in the opposite direction to that shown, forms a mixture of GDP-alpha-D-rhamnose and its C-4 epimer, GDP-6-deoxy-alpha-D-talose. cf. EC 1.1.1.281, GDP-4-dehydro-6-deoxy-D-mannose reductase and EC 1.1.1.135, GDP-6-deoxy-D-talose 4-dehydrogenase.
History
EC 1.1.1.187 created 1984
Pathway
ec00051  Fructose and mannose metabolism
ec00520  Amino sugar and nucleotide sugar metabolism
Reference
1  [PMID:4386238]
  Authors
Barber GA.
  Title
The synthesis of guanosine 5'-diphosphate D-rhamnose by enzymes of a higher plant.
  Journal
Biochim Biophys Acta 165:68-75 (1968)
DOI:10.1016/0304-4165(68)90189-X
Reference
2  [PMID:4398966]
  Authors
Winkler NW, Markovitz A.
  Title
Guanosine diphosphate-4-keto-D-rhamnose reductase. A non-stereoselective enzyme.
  Journal
J Biol Chem 246:5868-76 (1971)
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.187
IUBMB Enzyme Nomenclature: 1.1.1.187
ExPASy - ENZYME nomenclature database: 1.1.1.187
BRENDA, the Enzyme Database: 1.1.1.187
CAS: 9075-56-3

KEGG   REACTION: R03397
Entry
R03397                      Reaction                               

Name
GDP-6-deoxy-D-mannose:NAD+ 4-oxidoreductase
Definition
GDP-6-deoxy-D-mannose + NAD+ <=> GDP-4-dehydro-6-deoxy-D-mannose + NADH + H+
Equation
Comment
NADP+ (see R03399)
Reaction class
RC00001  C00003_C00004
RC00182  C01222_C03117
Enzyme
1.1.1.187       1.1.1.281
Pathway
rn00051  Fructose and mannose metabolism
rn00520  Amino sugar and nucleotide sugar metabolism
rn00541  O-Antigen nucleotide sugar biosynthesis
rn01100  Metabolic pathways
Orthology
K15856  GDP-4-dehydro-6-deoxy-D-mannose reductase [EC:1.1.1.281]
Other DBs
RHEA: 13828

KEGG   REACTION: R03399
Entry
R03399                      Reaction                               

Name
GDP-6-deoxy-D-mannose:NADP+ 4-oxidoreductase
Definition
GDP-6-deoxy-D-mannose + NADP+ <=> GDP-4-dehydro-6-deoxy-D-mannose + NADPH + H+
Equation
Comment
NAD+ (see R03397)
Reaction class
RC00001  C00005_C00006
RC00182  C01222_C03117
Enzyme
1.1.1.187       1.1.1.281
Pathway
rn00051  Fructose and mannose metabolism
rn00520  Amino sugar and nucleotide sugar metabolism
rn00541  O-Antigen nucleotide sugar biosynthesis
rn01100  Metabolic pathways
Orthology
K15856  GDP-4-dehydro-6-deoxy-D-mannose reductase [EC:1.1.1.281]
Other DBs
RHEA: 13832

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