KEGG   ENZYME: 1.1.1.281
Entry
EC 1.1.1.281                Enzyme                                 
Name
GDP-4-dehydro-6-deoxy-D-mannose reductase;
GDP-4-keto-6-deoxy-D-mannose reductase [ambiguous];
GDP-6-deoxy-D-lyxo-4-hexulose reductase;
Rmd;
GDP-6-deoxy-D-mannose:NAD(P)+ 4-oxidoreductase (D-rhamnose-forming);
GDP-6-deoxy-alpha-D-mannose:NAD(P)+ 4-oxidoreductase (D-rhamnose-forming)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
GDP-alpha-D-rhamnose:NAD(P)+ 4-oxidoreductase
Reaction(IUBMB)
GDP-alpha-D-rhamnose + NAD(P)+ = GDP-4-dehydro-alpha-D-rhamnose + NAD(P)H + H+ [RN:R03397 R03399]
Reaction(KEGG)
R03397 R03399
Substrate
GDP-alpha-D-rhamnose [CPD:C03117];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
GDP-4-dehydro-alpha-D-rhamnose [CPD:C01222];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
This enzyme differs from EC 1.1.1.187, GDP-4-dehydro-D-rhamnose reductase, in that the only product formed is GDP-alpha-D-rhamnose. D-Rhamnose is a constituent of lipopolysaccharides of Gram-negative plant and human pathogenic bacteria.
History
EC 1.1.1.281 created 2004
Pathway
ec00051  Fructose and mannose metabolism
ec00541  Biosynthesis of various nucleotide sugars
ec01100  Metabolic pathways
Orthology
K15856  GDP-4-dehydro-6-deoxy-D-mannose reductase
Genes
YPBYPTS_1054
YPQDJ40_1349
YPUBZ21_253
YPRBZ20_1036
YPCBZ23_529
YASN0H69_17385
XALXALC_2707(rmd)
XVAC7V42_18455
XINQ7W82_05940
PDDMNQ95_09680
LCPLC55x_4380
LGULG3211_4185
LEZGLE_4243
LEMLEN_0958
LYARDV84_11810
LSYH8L67_09155
LUEDCD74_08535
THESFHQ07_06210
TCNH9L16_07610
TBVH9L17_06870
DYGDYGSA30_16510(rmd)
LAEOL2Y97_04270
PAEPA5454(rmd)
PAEVN297_5642
PAEIN296_5642
PAUPA14_72000(rmd)
PAGPLES_58491(rmd)
PAFPAM18_5576(rmd)
PNCNCGM2_6231(rmd)
PAEBNCGM1900_6309(rmd)
PDKPADK2_29015
PSGG655_28685
PRPM062_28735
PAEPPA1S_29460
PAERPA1R_gp3389
PAEMU769_29965
PAELT223_29925
PAESSCV20265_6187
PAEUBN889_06061(rmd)
PAEGAI22_04525
PAECM802_5640
PAEOM801_5507
SECHB18_08485
PCQPcP3B5_01740(rmd)
PMUIG4G71_02280
PAPPSPA7_6244
PPAAB7D75_28305
PPJRK21_03607
PSTPSPTO_1007
PSYRN018_21315
PSAVPSA3335_07955
PCIPCH70_01440
PAVLBKM03_05930
PCABJGS08_04655
PCOFPOR16_19790
PTREI9H09_04235
PASTN015_26065
PLIJKQP88_00690
PFEPSF113_5885(rmd)
PFOPfl01_5681
PMANOU5_3478
PKRAYO71_00205
PBAPSEBR_a5628
PPUUPputUW4_01530
PDRH681_00575
PCHEY04_29645
PCZPCL1606_00120
PCPJM49_00325
PSESPSCI_5345
PSEMTO66_31495
PKEDLD99_28840
PGYAWU82_06540
PBZGN234_18540
PATAJWU58_00740
PZEHU754_000880
PPIIQL104_10135
PTZHU718_000865
PHVHU739_017845
PASGKSS96_21040
PAZEKSS91_08605
PIEHU724_000850
PGFJ0G10_00830
PSIINF676_27390
PFITKJY40_00810
PNBNK667_27595
PKJQ1W70_10455
PCUCPSH97_28260
PRHZCRX69_26140
PSKUKUIN1_08900
PSHSJJN09_20005
PHEFPSH57_28915
PLISNN484_06715
PCAAV6L78_11760
PSWOSD196_00435
PTHVCE140_28355
PALLUYA_23050
PZDKQ248_07510
ACXAchr_26730
PDENF1C79_25075
HASMQAO71_04745
PALCA0T30_02620
ASIPAQUSIP_18140(rmd)
MMOBF6R98_01275
HTREPV75_08920
APRSBI364_12375
EPSL0Y14_14445
MMEMarme_2111
BSANCHH28_01970
ENWMJO57_17180
AQLBXU06_15900
MAERDAI18_08270
REUReut_A0719
BMABMA2297
BMVBMASAVP1_A0531
BMLBMA10229_A1069
BMNBMA10247_2175
BMAZBM44_1066
BMALDM55_1487
BMAEDM78_2667
BMAQDM76_1465
BMAIDM57_1072
BMAFDM51_1938
BMABBM45_2463
BPSBPSL2797(wcbK)
BPMBURPS1710b_3293(wcbK)
BPLBURPS1106A_3279
BPDBURPS668_3244
BPRGBP346_A3422
BPSEBDL_2648
BPSMBBQ_512
BPSUBBN_640
BPSDBBX_1046
BPZBP1026B_I0513(wcbK)
BPQBPC006_I3327
BPKBBK_2133
BPSHDR55_1721
BPSABBU_2765
BPSOX996_1361
BUTX994_3359
BTHADR62_530
BSTLBBJ41_08345
PCOSC2747_01690
PLGNCTC10937_04677(gmd_1)
TVLFAZ95_17380
PVACHC248_00496(rmd)
VPEVarpa_0776
VAMC4F17_15435
HHTF506_01240
CFUCFU_1116(rmd)
CARELT85_3694
CPRACPter91_3974
OALNB647_07525
NETNeut_0156
DOEDENOEST_3930(rmd)
MBATBN1208_0921(wcbK)
SLACSKTS_36170(rmd)
DAJVX159_03705
RENEF513_04490
MOPMesop_2616
MAMMesau_05024
MERDEB233_24835
MMEILRP31_12195
MESJMJ8_19860
MESULHFGNBLO_005358
PHTBLM14_22615
ALEGCFBP4996_24270
RJGCCGE525_26930
RLSHB780_25405
RFVRFYW14_04607
PDESFE840_018905
BAUTQA635_39080
RPATX73_020475
RPDRPD_1646
RPERPE_4260
RPTRpal_4473
RPXRpdx1_4326
RHORONR75_25225
RHOLRBJ75_13405
NHANham_2781
VGOGJW-30_1_00102(rmd)
TRBHB776_03030
TARVFIU28_19030
BOPAXW83_22490
BOSERMR04_27240
AZCAZC_0053
MRDMrad2831_1050 Mrad2831_3464
METM446_5188
MORMOC_1268 MOC_3977
MPHYMCBMB27_00644 MCBMB27_00801 MCBMB27_02951
MEEDA075_19405
METDC0214_18365
METXA3862_14145 A3862_25325
METSDK389_04280
MMESMMSR116_25040 MMSR116_30875
MTADM6G65_05335 M6G65_05720 M6G65_20570
MFUJABC766_03840 ABC766_22035
MENSLOK46_05515 LOK46_18380
BBARRHAL1_00379
RVARvan_2460
BLAGBLTE_16230(rmd)
MSCBN69_2011
MBRYB1812_17900
MROSEHO51_15185
MHEYH2LOC_014770
MPARF7D14_06745
MIWASS37A_01050
MESZLNB28_09430
MECIRVU70_08015
MTWCQW49_16720
MECQMSC49_13800
PLEOOHA_1_01728(rmd)
HDIHDIA_0149(rmd_1)
AALMLUX29_06815
AUBLXB15_15305
ACUTMRB58_13375
CAULKCG34_18335
BSBBresu_3279
BRGA4249_12990
BDMEQG53_06295
BGOEIFJ75_18540
BFQJX001_02515
BREAHZ989_04000
BRENKKHFBJBL_02536(rmd)
RSUNHU_00140
RHMB5V46_02120
PGVSL003B_2556
HNEHNE_0794
ZMNZa10_0101
ZMIZCP4_0102
ZMCA265_00102(rfbE)
ZMRA254_00102(rfbE)
ZMPZymop_1692
SNAPPQ455_06375
SPRSEGM87_12005
GOXGOX1292 GOX1611
GOHB932_0830
GOYGLS_c13770 GLS_c17320
GALA0U94_14000
GTIFXF46_06825
GSPIGS75_09465
GFAMKW11_06770
GBEGbCGDNIH1_1716
GBHGbCGDNIH2_1716
GBCGbCGDNIH3_1716
GBSGbCGDNIH4_1716
KBAA0U89_02310
LCKHN018_20315
RAPRHOA_5432
ACRAcry_0507
AMVACMV_05820(rmd)
ACIMGT370_03245
RGIRGI145_01425
ROSCTJ15_19565
RMUCFOB66_18950
RMTIAI58_04410
AOZHUE56_00500
AZSE6C72_30875
AZPE6C67_04310
SKTIGS68_03080
SMUCJL100_003195
SROEJL101_002965
MAGQMGMAQ_1159
AFRAFE_3291
AFELferr_2889
ACUAtc_0208
AFIAcife_1159 Acife_2355
AFJAFERRID_14960
AFPK1Y48_08195
AFHGL267_004235
HWIA0Z60_06610
HPULNCTC13154_01560(gmd)
SDIZWCY31_11325
CJJCJJ81176_1426(wcbK)
CJNICDCCJ07001_1357
CJSCJS3_1519(wcbK)
CJERH730_08150
CJQUC78_1367(rmd_2)
CJWPJ18_07310
CJRCJE1611(wcbK)
CJDJJD26997_1763
CJZM635_02860
CJXBN867_14030
CLRUPTC16701_0315
CLMUPTC16712_0313
CLNUPTC3659_0325
CCFYSQ_01730
CAMRCAQ16704_0314
CSMCSUB8521_0326
CHVCHELV3228_0213
CCUNCCUN_1156
CLXCLAN_0158
CAMZCVIC12175_0180
COJCORN_0312
CUXCUP3940_1436
CNVCNZW441b_0359
CVUCVULP_0234
CDEVCIGN_0118
TAMMGEAMG1_2508
PSEFPSDVSF_07520
DOVDSCO28_03330
DWDDSCW_50670(rfbB)
MXAMXAN_5328(rmd)
MSDMYSTI_05892
MFBMFUL124B02_31580
MLANJY572_37490
MYMA176_001583
CCXCOCOR_02240(rmd)
MFULILAB_34470
MMASMYMAC_005188
PPAKJY651_04885
SURSTAUR_6036(rmd)
PBRULZC95_14190
PRUELVJ94_14335
PALJLZC94_28025
TROtrd_0916
STISthe_1123
BVOPan97_02120(rmd)
BREMPSR63_10020
TTFTHTE_3576
PLHVT85_25320(rmd_3)
GESVT84_32605(rmd_2)
GOGC1280_12470
GMSSOIL9_61690
TIMGMBLW1_14760
LRSPX52LOC_03147
FTJFTUN_0673
ULIETAA1_19690(rmd)
TSPHKIH39_19790
IPAIsop_0504
SACISinac_0262
PBORBSF38_03321(rmd_3)
AGVOJF2_00280(rmd_1)
TPLAElP_70320(rmd_4)
PBAPPla133_24840(rmd)
VAIBU251_02255
LILLA_0235(rfbB)
LIELIF_A0204(rfbB)
LICLIC_10203(rmd)
LISLIL_10203(rfbB1)
LBJLBJ_0170
LBLLBL_2913
LBILEPBI_I3261
LBFLBF_3148
LSTLSS_04696
LAJA0128_01075
LMAYDPV73_04570
LKMEFP84_11920
LWLFHG68_01110
LKBLPTSP3_g34060(rfbB_2)
LNOMAL08_01050
LKRFH602_06560
LMILAB3N58_15105
LIOWAB3N60_16480
LGORAB3N59_00870
LMGOAB3N62_16390
LCINAB3N61_01000
TSAAciPR4_1238
TPSCRBB77_18765
ABACLuPra_05853(rmd)
LUBTBR22_A48280
GEXGETHOR_16780
GEPQ9293_00430
MSEAMETESE_02540
FSUFisuc_2243
FSCFSU_2786(rmd)
GAUGAU_1969
GPHGEMMAAP_10230
GGRHKW67_04485
GBAJ421_3572
PSPCStrain318_001836
FEIK9M53_05440
FLPLK994_03645
MMABHQ865_06420
CAMUCA2015_3251
HYZAXW84_10635
HTBMTX78_04920
HVLMUN86_04770
CTURLNP04_06330
NALLPP769_12635
NNEOPQG83_03480
LPAKGDS87_03105
PSYOPB01_03670
TEIQS257_18565 QS257_18570
BBEBBR47_17540
BFMBP422_03945
BCHSJNE38_09525
BPABPSE45_08690
BHUILOK74_08520
BBORRFB14_13695
BREHHP435_09260
PJDPjdr2_3512
PMSKNP414_03315 KNP414_06543
PMQPM3016_3535 PM3016_6150
PMWB2K_18235 B2K_31225
PLVERIC2_c02840(gmd)
PSONJI735_05780
PSWUSY83_13105
PCXLPB68_14475
PLUTEI981_25875
PPRTET464_03300
PALOE6C60_3795
PCELHUB94_07815
PTHINDS46_22630
PDYQJQ58_25285 QJQ58_29620
PELGACJ7K1_23120
ANXACH33_01790
COHNKCTCHS21_54750 KCTCHS21_55810(rfbB)
CHEBHH215_19395
COHLJ4772_32735
AFXJZ786_22515
ACURJZ785_22290
FFELSG31_04330
CGELpsyc5s11_31690(gca)
CCLClocl_3957
RCHRUM_03120
CFEMHCR03_09585
STHSTH1372
DAIDesaci_4421
DEDDHBDCA_p1070
DECDCF50_p1140
DRUDesru_3675
AACXDEACI_0201
PHOSABFY19_13065
SAYTPY_1421 TPY_2530
SAPSulac_2236 Sulac_3283
BPENNQ488_00275
CBAFJS518_12155
BPBbpr_I0151(gmd1) bpr_I0396
BLUIBlut17040_12340
CHYLCE91St63_29530(gca)
LGGQJR73_01660
KIBRBB56_12655 RBB56_12735
KSIV6984_18470
HHJNQ487_03980
CLEClole_3815
CEWEKH84_00475
SOVASOV_09050(rmd)
SACVSPACI_042530(rmd_1)
CALKHUE98_16880
EYYEGYY_07230(Gmd)
RTSCE91St31_13150(gca)
MTURv0112(gca)
MTVRVBD_0112
MTCMT0121
MRAMRA_0118(gca)
MTFTBFG_10113
MTBTBMG_00113
MTKTBSG_00113
MTZTBXG_000113
MTIMRGA423_00730
MTECCDC5079_0098
MTURCFBS_0121(gca)
MTLCCDC5180_0098
MTOMTCTRI2_0115(gca)
MTDUDA_0112(gca)
MTNERDMAN_0130(gca)
MTJJ112_00620
MTUBMT7199_0114(gca)
MTUCJ113_00800
MTUEJ114_00620
MTXM943_00620
MTUHI917_00860
MTULTBHG_00112
MTUTHKBT1_0121(gca)
MTUUHKBT2_0121(gca)
MTQHKBS1_0121(gca)
MBOBQ2027_MB0116(gca)
MBBBCG_0145(gca)
MBTJTY_0116(gca)
MBMBCGMEX_0116(gca)
MBKK60_001250
MBXBCGT_3909
MAFMAF_01130(gca)
MMICRN08_0130
MCEMCAN_01151(gca)
MCQBN44_10135(gca)
MCVBN43_10130(gca)
MCXBN42_10151(gca)
MCZBN45_10128(gca)
MORYMO_000122
MAICMAIC_46420(rmd)
MTSMTES_0931
MIHBJP65_06395 BJP65_14830
MWAE4K62_03120
MRGSM116_05850
DCPRN607_02060
NMARHPC71_18470
NOCROSR43_18760
PLKCIK06_06155
DAURDaura_25160
NABB1sIIB91_05480
ABAIIMCC26256_111953
RXYRxyl_0568
AFOAfer_0745
ATQGH723_12295
AQZKSP35_08645
IAMHC251_09120
IMAPO878_13500
DHILH044_20025
PMHP9215_14361
KOVK9N68_31465
NSHGXM_02821
RRSRoseRS_1853 RoseRS_3655 RoseRS_4076
RCARcas_0917 Rcas_3281
CAUCaur_1970 Caur_2686
CHLChy400_2124 Chy400_2903
CAGCagg_0939 Cagg_2042
HAUHaur_3742 Haur_4820
CALLOZ401_001251
TTRTter_1710
CAPCLDAP_16990
PBFCFX0092_A0151(rmd)
THUGKNN16_09480
PMETG4Y79_14310
VABWPS_29120
TRATrad_2861
ACOAmico_1359
AMIZRBH88_03100
TLITlie_1236
AMOAnamo_1479 Anamo_1883
FULC4N20_11210
LOTAXF11_05710
LSZJCM16776_1906 JCM16776_1907
LRUGAB8B22_00175
SBERAAC3_TM7C01G0307
SBAGUW38_C0001G0732
FSHQ2T83_18055
TMGUS01_C0001G0477
MIBUY43_C0001G0736
MCHKMchiMG62_18220
MPIMpet_1407
MANQL1994_11640
HALYHYG82_08675
FLTSv326_1260
LOKILokiarch_35700(rmd)
LOBNEF87_004320
AGWQT03_C0001G0689
 » show all
Reference
1  [PMID:11096116]
  Authors
Kneidinger B, Graninger M, Adam G, Puchberger M, Kosma P, Zayni S, Messner P
  Title
Identification of two GDP-6-deoxy-D-lyxo-4-hexulose reductases synthesizing GDP-D-rhamnose in Aneurinibacillus thermoaerophilus L420-91T.
  Journal
J Biol Chem 276:5577-83 (2001)
DOI:10.1074/jbc.M010027200
  Sequence
Reference
2  [PMID:11856318]
  Authors
Maki M, Jarvinen N, Rabina J, Roos C, Maaheimo H, Renkonen R
  Title
Functional expression of Pseudomonas aeruginosa GDP-4-keto-6-deoxy-D-mannose reductase which synthesizes GDP-rhamnose.
  Journal
Eur J Biochem 269:593-601 (2002)
DOI:10.1046/j.0014-2956.2001.02688.x
  Sequence
[pae:PA5454]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.281
IUBMB Enzyme Nomenclature: 1.1.1.281
ExPASy - ENZYME nomenclature database: 1.1.1.281
BRENDA, the Enzyme Database: 1.1.1.281

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