| Entry |
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| Name |
GDP-4-dehydro-6-deoxy-D-mannose reductase;
GDP-4-keto-6-deoxy-D-mannose reductase [ambiguous];
GDP-6-deoxy-D-lyxo-4-hexulose reductase;
Rmd;
GDP-6-deoxy-D-mannose:NAD(P)+ 4-oxidoreductase (D-rhamnose-forming);
GDP-6-deoxy-alpha-D-mannose:NAD(P)+ 4-oxidoreductase (D-rhamnose-forming)
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| Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
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| Sysname |
GDP-alpha-D-rhamnose:NAD(P)+ 4-oxidoreductase
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| Reaction(IUBMB) |
GDP-alpha-D-rhamnose + NAD(P)+ = GDP-4-dehydro-alpha-D-rhamnose + NAD(P)H + H+ [RN: R03397 R03399]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
This enzyme differs from EC 1.1.1.187, GDP-4-dehydro-D-rhamnose reductase, in that the only product formed is GDP-alpha-D-rhamnose. D-Rhamnose is a constituent of lipopolysaccharides of Gram-negative plant and human pathogenic bacteria.
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| History |
EC 1.1.1.281 created 2004
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| Pathway |
| ec00051 | Fructose and mannose metabolism |
| ec00520 | Amino sugar and nucleotide sugar metabolism |
| ec00541 | O-Antigen nucleotide sugar biosynthesis |
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| Orthology |
| K15856 | GDP-4-dehydro-6-deoxy-D-mannose reductase |
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| Genes |
» show all
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| Reference |
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| Authors |
Kneidinger B, Graninger M, Adam G, Puchberger M, Kosma P, Zayni S, Messner P |
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| Title |
Identification of two GDP-6-deoxy-D-lyxo-4-hexulose reductases synthesizing GDP-D-rhamnose in Aneurinibacillus thermoaerophilus L420-91T. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Maki M, Jarvinen N, Rabina J, Roos C, Maaheimo H, Renkonen R |
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| Title |
Functional expression of Pseudomonas aeruginosa GDP-4-keto-6-deoxy-D-mannose reductase which synthesizes GDP-rhamnose. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 1.1.1.281 |
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