Entry |
|
Name |
GDP-4-dehydro-6-deoxy-D-mannose reductase;
GDP-4-keto-6-deoxy-D-mannose reductase [ambiguous];
GDP-6-deoxy-D-lyxo-4-hexulose reductase;
Rmd;
GDP-6-deoxy-D-mannose:NAD(P)+ 4-oxidoreductase (D-rhamnose-forming);
GDP-6-deoxy-alpha-D-mannose:NAD(P)+ 4-oxidoreductase (D-rhamnose-forming)
|
Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
|
Sysname |
GDP-alpha-D-rhamnose:NAD(P)+ 4-oxidoreductase
|
Reaction(IUBMB) |
GDP-alpha-D-rhamnose + NAD(P)+ = GDP-4-dehydro-alpha-D-rhamnose + NAD(P)H + H+ [RN: R03397 R03399]
|
Reaction(KEGG) |
|
Substrate |
|
Product |
|
Comment |
This enzyme differs from EC 1.1.1.187, GDP-4-dehydro-D-rhamnose reductase, in that the only product formed is GDP-alpha-D-rhamnose. D-Rhamnose is a constituent of lipopolysaccharides of Gram-negative plant and human pathogenic bacteria.
|
History |
EC 1.1.1.281 created 2004
|
Pathway |
ec00051 | Fructose and mannose metabolism |
ec00520 | Amino sugar and nucleotide sugar metabolism |
ec00541 | O-Antigen nucleotide sugar biosynthesis |
|
Orthology |
K15856 | GDP-4-dehydro-6-deoxy-D-mannose reductase |
|
Genes |
» show all
|
Reference |
|
Authors |
Kneidinger B, Graninger M, Adam G, Puchberger M, Kosma P, Zayni S, Messner P |
Title |
Identification of two GDP-6-deoxy-D-lyxo-4-hexulose reductases synthesizing GDP-D-rhamnose in Aneurinibacillus thermoaerophilus L420-91T. |
Journal |
|
Sequence |
|
Reference |
|
Authors |
Maki M, Jarvinen N, Rabina J, Roos C, Maaheimo H, Renkonen R |
Title |
Functional expression of Pseudomonas aeruginosa GDP-4-keto-6-deoxy-D-mannose reductase which synthesizes GDP-rhamnose. |
Journal |
|
Sequence |
|
Other DBs |
ExPASy - ENZYME nomenclature database: | 1.1.1.281 |
|