KEGG ENZYME: 1.1.1.281

ENZYME: 1.1.1.281

Entry

EC 1.1.1.281                Enzyme

Name

GDP-4-dehydro-6-deoxy-D-mannose reductase;
GDP-4-keto-6-deoxy-D-mannose reductase [ambiguous];
GDP-6-deoxy-D-lyxo-4-hexulose reductase;
Rmd;
GDP-6-deoxy-D-mannose:NAD(P)+ 4-oxidoreductase (D-rhamnose-forming);
GDP-6-deoxy-alpha-D-mannose:NAD(P)+ 4-oxidoreductase (D-rhamnose-forming)

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

GDP-alpha-D-rhamnose:NAD(P)+ 4-oxidoreductase

Reaction(IUBMB)

GDP-alpha-D-rhamnose + NAD(P)+ = GDP-4-dehydro-alpha-D-rhamnose + NAD(P)H + H+ [RN:R03397 R03399]

Reaction(KEGG)

R03397 R03399

Substrate

GDP-alpha-D-rhamnose [CPD:C03117];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]

Product

GDP-4-dehydro-alpha-D-rhamnose [CPD:C01222];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

This enzyme differs from EC 1.1.1.187, GDP-4-dehydro-D-rhamnose reductase, in that the only product formed is GDP-alpha-D-rhamnose. D-Rhamnose is a constituent of lipopolysaccharides of Gram-negative plant and human pathogenic bacteria.

History

EC 1.1.1.281 created 2004

Pathway

ec00051

Fructose and mannose metabolism

ec00541

Biosynthesis of various nucleotide sugars

ec01100

Metabolic pathways

Orthology

K15856

GDP-4-dehydro-6-deoxy-D-mannose reductase

Genes

YPB:

YPTS_1054

YPQ:

DJ40_1349

YPU:

BZ21_253

YPR:

BZ20_1036

YPC:

BZ23_529

YAS:	N0H69_17385

XAL:	XALC_2707(rmd)

XVA:	C7V42_18455

XIN:	Q7W82_05940

PDD:	MNQ95_09680

LCP:	LC55x_4380

LGU:	LG3211_4185

LEZ:

GLE_4243

LEM:

LEN_0958

LYA:	RDV84_11810

LSY:	H8L67_09155

LUE:	DCD74_08535

THES:

FHQ07_06210

TCN:	H9L16_07610

TBV:	H9L17_06870

DYG:	DYGSA30_16510(rmd)

LAEO:

L2Y97_04270

PAE:	PA5454(rmd)

PAEV:

N297_5642

PAEI:

N296_5642

PAU:	PA14_72000(rmd)

PAG:	PLES_58491(rmd)

PAF:	PAM18_5576(rmd)

PNC:	NCGM2_6231(rmd)

PAEB:

NCGM1900_6309(rmd)

PDK:	PADK2_29015

PSG:	G655_28685

PRP:	M062_28735

PAEP:

PA1S_29460

PAER:

PA1R_gp3389

PAEM:

U769_29965

PAEL:

T223_29925

PAES:

SCV20265_6187

PAEU:

BN889_06061(rmd)

PAEG:

AI22_04525

PAEC:

M802_5640

PAEO:

M801_5507

SECH:

B18_08485

PCQ:	PcP3B5_01740(rmd)

PMUI:

G4G71_02280

PAP:	PSPA7_6244

PPAA:

B7D75_28305

PPJ:	RK21_03607

PST:	PSPTO_1007

PSYR:

N018_21315

PSAV:

PSA3335_07955

PCI:	PCH70_01440

PAVL:

BKM03_05930

PCAB:

JGS08_04655

PCOF:

POR16_19790

PTRE:

I9H09_04235

PAST:

N015_26065

PLIJ:

KQP88_00690

PFE:	PSF113_5885(rmd)

PFO:	Pfl01_5681

PMAN:

OU5_3478

PKR:	AYO71_00205

PBA:	PSEBR_a5628

PPUU:

PputUW4_01530

PDR:	H681_00575

PCH:	EY04_29645

PCZ:	PCL1606_00120

PCP:	JM49_00325

PSES:

PSCI_5345

PSEM:

TO66_31495

PKE:	DLD99_28840

PGY:	AWU82_06540

PBZ:	GN234_18540

PATA:

JWU58_00740

PZE:	HU754_000880

PPII:

QL104_10135

PTZ:	HU718_000865

PHV:	HU739_017845

PASG:

KSS96_21040

PAZE:

KSS91_08605

PIE:	HU724_000850

PGF:	J0G10_00830

PSII:

NF676_27390

PFIT:

KJY40_00810

PNB:	NK667_27595

PKJ:	Q1W70_10455

PCUC:

PSH97_28260

PRHZ:

CRX69_26140

PSKU:

KUIN1_08900

PSHS:

JJN09_20005

PHEF:

PSH57_28915

PLIS:

NN484_06715

PCAA:

V6L78_11760

PSWO:

SD196_00435

PTHV:

CE140_28355

PALL:

UYA_23050

PZD:	KQ248_07510

ACX:	Achr_26730

PDEN:

F1C79_25075

HASM:

QAO71_04745

PALC:

A0T30_02620

ASIP:

AQUSIP_18140(rmd)

MMOB:

F6R98_01275

HTR:	EPV75_08920

APRS:

BI364_12375

EPS:	L0Y14_14445

MME:	Marme_2111

BSAN:

CHH28_01970

ENW:	MJO57_17180

AQL:	BXU06_15900

MAER:

DAI18_08270

REU:	Reut_A0719

BMA:

BMA2297

BMV:	BMASAVP1_A0531

BML:	BMA10229_A1069

BMN:	BMA10247_2175

BMAZ:

BM44_1066

BMAL:

DM55_1487

BMAE:

DM78_2667

BMAQ:

DM76_1465

BMAI:

DM57_1072

BMAF:

DM51_1938

BMAB:

BM45_2463

BPS:	BPSL2797(wcbK)

BPM:	BURPS1710b_3293(wcbK)

BPL:	BURPS1106A_3279

BPD:	BURPS668_3244

BPR:	GBP346_A3422

BPSE:

BDL_2648

BPSM:

BBQ_512

BPSU:

BBN_640

BPSD:

BBX_1046

BPZ:	BP1026B_I0513(wcbK)

BPQ:	BPC006_I3327

BPK:

BBK_2133

BPSH:

DR55_1721

BPSA:

BBU_2765

BPSO:

X996_1361

BUT:

X994_3359

BTHA:

DR62_530

BSTL:

BBJ41_08345

PCOS:

C2747_01690

PLG:	NCTC10937_04677(gmd_1)

TVL:	FAZ95_17380

PVAC:

HC248_00496(rmd)

VPE:	Varpa_0776

VAM:	C4F17_15435

HHT:	F506_01240

CFU:	CFU_1116(rmd)

CARE:

LT85_3694

CPRA:

CPter91_3974

OAL:	NB647_07525

NET:

Neut_0156

DOE:	DENOEST_3930(rmd)

MBAT:

BN1208_0921(wcbK)

SLAC:

SKTS_36170(rmd)

DAJ:	VX159_03705

REN:	EF513_04490

MOP:	Mesop_2616

MAM:	Mesau_05024

MERD:

EB233_24835

MMEI:

LRP31_12195

MESJ:

MJ8_19860

MESU:

LHFGNBLO_005358

PHT:	BLM14_22615

ALEG:

CFBP4996_24270

RJG:	CCGE525_26930

RLS:	HB780_25405

RFV:	RFYW14_04607

PDES:

FE840_018905

BAUT:

QA635_39080

RPA:	TX73_020475

RPD:

RPD_1646

RPE:

RPE_4260

RPT:

Rpal_4473

RPX:	Rpdx1_4326

RHOR:

ONR75_25225

RHOL:

RBJ75_13405

NHA:

Nham_2781

VGO:	GJW-30_1_00102(rmd)

TRB:	HB776_03030

TARV:

FIU28_19030

BOP:	AXW83_22490

BOSE:

RMR04_27240

AZC:

AZC_0053

MRD:	Mrad2831_1050 Mrad2831_3464

MET:

M446_5188

MOR:	MOC_1268 MOC_3977

MPHY:

MCBMB27_00644 MCBMB27_00801 MCBMB27_02951

MEE:	DA075_19405

METD:

C0214_18365

METX:

A3862_14145 A3862_25325

METS:

DK389_04280

MMES:

MMSR116_25040 MMSR116_30875

MTAD:

M6G65_05335 M6G65_05720 M6G65_20570

MFUJ:

ABC766_03840 ABC766_22035

MENS:

LOK46_05515 LOK46_18380

BBAR:

RHAL1_00379

RVA:

Rvan_2460

BLAG:

BLTE_16230(rmd)

MSC:

BN69_2011

MBRY:

B1812_17900

MROS:

EHO51_15185

MHEY:

H2LOC_014770

MPAR:

F7D14_06745

MIWA:

SS37A_01050

MESZ:

LNB28_09430

MECI:

RVU70_08015

MTW:	CQW49_16720

MECQ:

MSC49_13800

PLEO:

OHA_1_01728(rmd)

HDI:	HDIA_0149(rmd_1)

AALM:

LUX29_06815

AUB:	LXB15_15305

ACUT:

MRB58_13375

CAUL:

KCG34_18335

BSB:	Bresu_3279

BRG:	A4249_12990

BDM:	EQG53_06295

BGOE:

IFJ75_18540

BFQ:	JX001_02515

BREA:

HZ989_04000

BREN:

KKHFBJBL_02536(rmd)

RSU:

NHU_00140

RHM:	B5V46_02120

PGV:	SL003B_2556

HNE:

HNE_0794

ZMN:

Za10_0101

ZMI:

ZCP4_0102

ZMC:	A265_00102(rfbE)

ZMR:	A254_00102(rfbE)

ZMP:	Zymop_1692

SNAP:

PQ455_06375

SPRS:

EGM87_12005

GOX:	GOX1292 GOX1611

GOH:

B932_0830

GOY:	GLS_c13770 GLS_c17320

GAL:	A0U94_14000

GTI:	FXF46_06825

GSP:	IGS75_09465

GFA:	MKW11_06770

GBE:	GbCGDNIH1_1716

GBH:	GbCGDNIH2_1716

GBC:	GbCGDNIH3_1716

GBS:	GbCGDNIH4_1716

KBA:	A0U89_02310

LCK:	HN018_20315

RAP:

RHOA_5432

ACR:

Acry_0507

AMV:	ACMV_05820(rmd)

ACIM:

GT370_03245

RGI:	RGI145_01425

ROS:	CTJ15_19565

RMUC:

FOB66_18950

RMT:	IAI58_04410

AOZ:	HUE56_00500

AZS:	E6C72_30875

AZP:	E6C67_04310

SKT:	IGS68_03080

SMUC:

JL100_003195

SROE:

JL101_002965

MAGQ:

MGMAQ_1159

AFR:

AFE_3291

AFE:	Lferr_2889

ACU:

Atc_0208

AFI:	Acife_1159 Acife_2355

AFJ:	AFERRID_14960

AFP:	K1Y48_08195

AFH:	GL267_004235

HWI:	A0Z60_06610

HPUL:

NCTC13154_01560(gmd)

SDIZ:

WCY31_11325

CJJ:	CJJ81176_1426(wcbK)

CJN:	ICDCCJ07001_1357

CJS:	CJS3_1519(wcbK)

CJER:

H730_08150

CJQ:	UC78_1367(rmd_2)

CJW:	PJ18_07310

CJR:	CJE1611(wcbK)

CJD:	JJD26997_1763

CJZ:	M635_02860

CJX:	BN867_14030

CLR:	UPTC16701_0315

CLM:	UPTC16712_0313

CLN:	UPTC3659_0325

CCF:

YSQ_01730

CAMR:

CAQ16704_0314

CSM:	CSUB8521_0326

CHV:	CHELV3228_0213

CCUN:

CCUN_1156

CLX:

CLAN_0158

CAMZ:

CVIC12175_0180

COJ:

CORN_0312

CUX:	CUP3940_1436

CNV:	CNZW441b_0359

CVU:	CVULP_0234

CDEV:

CIGN_0118

TAMM:

GEAMG1_2508

PSEF:

PSDVSF_07520

DOV:	DSCO28_03330

DWD:	DSCW_50670(rfbB)

MXA:	MXAN_5328(rmd)

MSD:	MYSTI_05892

MFB:	MFUL124B02_31580

MLAN:

JY572_37490

MYM:	A176_001583

CCX:	COCOR_02240(rmd)

MFU:	LILAB_34470

MMAS:

MYMAC_005188

PPAK:

JY651_04885

SUR:	STAUR_6036(rmd)

PBRU:

LZC95_14190

PRUE:

LVJ94_14335

PALJ:

LZC94_28025

TRO:

trd_0916

STI:

Sthe_1123

BVO:	Pan97_02120(rmd)

BREM:

PSR63_10020

TTF:

THTE_3576

PLH:	VT85_25320(rmd_3)

GES:	VT84_32605(rmd_2)

GOG:	C1280_12470

GMS:	SOIL9_61690

TIM:	GMBLW1_14760

LRS:	PX52LOC_03147

FTJ:

FTUN_0673

ULI:	ETAA1_19690(rmd)

TSPH:

KIH39_19790

IPA:

Isop_0504

SACI:

Sinac_0262

PBOR:

BSF38_03321(rmd_3)

AGV:	OJF2_00280(rmd_1)

TPLA:

ElP_70320(rmd_4)

PBAP:

Pla133_24840(rmd)

VAI:	BU251_02255

LIL:	LA_0235(rfbB)

LIE:	LIF_A0204(rfbB)

LIC:	LIC_10203(rmd)

LIS:	LIL_10203(rfbB1)

LBJ:

LBJ_0170

LBL:

LBL_2913

LBI:	LEPBI_I3261

LBF:

LBF_3148

LST:

LSS_04696

LAJ:	A0128_01075

LMAY:

DPV73_04570

LKM:	EFP84_11920

LWL:	FHG68_01110

LKB:	LPTSP3_g34060(rfbB_2)

LNO:	MAL08_01050

LKR:	FH602_06560

LMIL:

AB3N58_15105

LIOW:

AB3N60_16480

LGOR:

AB3N59_00870

LMGO:

AB3N62_16390

LCIN:

AB3N61_01000

TSA:	AciPR4_1238

TPSC:

RBB77_18765

ABAC:

LuPra_05853(rmd)

LUB:	TBR22_A48280

GEX:	GETHOR_16780

GEP:	Q9293_00430

MSEA:

METESE_02540

FSU:	Fisuc_2243

FSC:	FSU_2786(rmd)

GAU:

GAU_1969

GPH:	GEMMAAP_10230

GGR:	HKW67_04485

GBA:

J421_3572

PSPC:

Strain318_001836

FEI:	K9M53_05440

FLP:	LK994_03645

MMAB:

HQ865_06420

CAMU:

CA2015_3251

HYZ:	AXW84_10635

HTB:	MTX78_04920

HVL:	MUN86_04770

CTUR:

LNP04_06330

NALL:

PP769_12635

NNEO:

PQG83_03480

LPAK:

GDS87_03105

PSYO:

PB01_03670

TEI:	QS257_18565 QS257_18570

BBE:	BBR47_17540

BFM:	BP422_03945

BCHS:

JNE38_09525

BPAB:

PSE45_08690

BHUI:

LOK74_08520

BBOR:

RFB14_13695

BREH:

HP435_09260

PJD:	Pjdr2_3512

PMS:	KNP414_03315 KNP414_06543

PMQ:	PM3016_3535 PM3016_6150

PMW:	B2K_18235 B2K_31225

PLV:	ERIC2_c02840(gmd)

PSON:

JI735_05780

PSWU:

SY83_13105

PCX:	LPB68_14475

PLUT:

EI981_25875

PPRT:

ET464_03300

PALO:

E6C60_3795

PCEL:

HUB94_07815

PTHI:

NDS46_22630

PDY:	QJQ58_25285 QJQ58_29620

PELG:

ACJ7K1_23120

ANX:	ACH33_01790

COHN:

KCTCHS21_54750 KCTCHS21_55810(rfbB)

CHEB:

HH215_19395

COHL:

J4772_32735

AFX:	JZ786_22515

ACUR:

JZ785_22290

FFE:	LSG31_04330

CGEL:

psyc5s11_31690(gca)

CCL:	Clocl_3957

RCH:

RUM_03120

CFEM:

HCR03_09585

STH:

STH1372

DAI:	Desaci_4421

DED:	DHBDCA_p1070

DEC:	DCF50_p1140

DRU:	Desru_3675

AACX:

DEACI_0201

PHOS:

ABFY19_13065

SAY:	TPY_1421 TPY_2530

SAP:	Sulac_2236 Sulac_3283

BPEN:

NQ488_00275

CBAF:

JS518_12155

BPB:	bpr_I0151(gmd1) bpr_I0396

BLUI:

Blut17040_12340

CHYL:

CE91St63_29530(gca)

LGG:	QJR73_01660

KIB:	RBB56_12655 RBB56_12735

KSI:	V6984_18470

HHJ:	NQ487_03980

CLE:	Clole_3815

CEW:	EKH84_00475

SOVA:

SOV_09050(rmd)

SACV:

SPACI_042530(rmd_1)

CALK:

HUE98_16880

EYY:	EGYY_07230(Gmd)

RTS:	CE91St31_13150(gca)

MTU:	Rv0112(gca)

MTV:

RVBD_0112

MTC:

MT0121

MRA:	MRA_0118(gca)

MTF:	TBFG_10113

MTB:	TBMG_00113

MTK:	TBSG_00113

MTZ:	TBXG_000113

MTI:	MRGA423_00730

MTE:	CCDC5079_0098

MTUR:

CFBS_0121(gca)

MTL:	CCDC5180_0098

MTO:	MTCTRI2_0115(gca)

MTD:	UDA_0112(gca)

MTN:	ERDMAN_0130(gca)

MTJ:	J112_00620

MTUB:

MT7199_0114(gca)

MTUC:

J113_00800

MTUE:

J114_00620

MTX:	M943_00620

MTUH:

I917_00860

MTUL:

TBHG_00112

MTUT:

HKBT1_0121(gca)

MTUU:

HKBT2_0121(gca)

MTQ:	HKBS1_0121(gca)

MBO:	BQ2027_MB0116(gca)

MBB:	BCG_0145(gca)

MBT:	JTY_0116(gca)

MBM:	BCGMEX_0116(gca)

MBK:	K60_001250

MBX:

BCGT_3909

MAF:	MAF_01130(gca)

MMIC:

RN08_0130

MCE:	MCAN_01151(gca)

MCQ:	BN44_10135(gca)

MCV:	BN43_10130(gca)

MCX:	BN42_10151(gca)

MCZ:	BN45_10128(gca)

MORY:

MO_000122

MAIC:

MAIC_46420(rmd)

MTS:

MTES_0931

MIH:	BJP65_06395 BJP65_14830

MWA:	E4K62_03120

MRG:	SM116_05850

DCP:	RN607_02060

NMAR:

HPC71_18470

NOCR:

OSR43_18760

PLK:	CIK06_06155

DAUR:

Daura_25160

NAB:	B1sIIB91_05480

ABAI:

IMCC26256_111953

RXY:

Rxyl_0568

AFO:

Afer_0745

ATQ:	GH723_12295

AQZ:	KSP35_08645

IAM:	HC251_09120

IMA:	PO878_13500

DHI:	LH044_20025

PMH:	P9215_14361

KOV:	K9N68_31465

NSH:

GXM_02821

RRS:	RoseRS_1853 RoseRS_3655 RoseRS_4076

RCA:	Rcas_0917 Rcas_3281

CAU:	Caur_1970 Caur_2686

CHL:	Chy400_2124 Chy400_2903

CAG:	Cagg_0939 Cagg_2042

HAU:	Haur_3742 Haur_4820

CALL:

OZ401_001251

TTR:

Tter_1710

CAP:	CLDAP_16990

PBF:	CFX0092_A0151(rmd)

THUG:

KNN16_09480

PMET:

G4Y79_14310

VAB:

WPS_29120

TRA:

Trad_2861

ACO:	Amico_1359

AMIZ:

RBH88_03100

TLI:

Tlie_1236

AMO:	Anamo_1479 Anamo_1883

FUL:	C4N20_11210

LOT:	AXF11_05710

LSZ:	JCM16776_1906 JCM16776_1907

LRUG:

AB8B22_00175

SBE:	RAAC3_TM7C01G0307

SBAG:

UW38_C0001G0732

FSH:	Q2T83_18055

TMG:	US01_C0001G0477

MIB:	UY43_C0001G0736

MCHK:

MchiMG62_18220

MPI:

Mpet_1407

MANQ:

L1994_11640

HALY:

HYG82_08675

FLT:	Sv326_1260

LOKI:

Lokiarch_35700(rmd)

LOB:	NEF87_004320

AGW:	QT03_C0001G0689

» show all

Reference

1 [PMID:11096116]

Authors

Kneidinger B, Graninger M, Adam G, Puchberger M, Kosma P, Zayni S, Messner P

Title

Identification of two GDP-6-deoxy-D-lyxo-4-hexulose reductases synthesizing GDP-D-rhamnose in Aneurinibacillus thermoaerophilus L420-91T.

Journal

J Biol Chem 276:5577-83 (2001)
DOI:10.1074/jbc.M010027200

Sequence

[ag:AAS55712]

Reference

2 [PMID:11856318]

Authors

Maki M, Jarvinen N, Rabina J, Roos C, Maaheimo H, Renkonen R

Title

Functional expression of Pseudomonas aeruginosa GDP-4-keto-6-deoxy-D-mannose reductase which synthesizes GDP-rhamnose.

Journal

Eur J Biochem 269:593-601 (2002)
DOI:10.1046/j.0014-2956.2001.02688.x

Sequence

[pae:PA5454]

Other DBs

ExplorEnz - The Enzyme Database:

1.1.1.281

IUBMB Enzyme Nomenclature:

1.1.1.281

ExPASy - ENZYME nomenclature database:

1.1.1.281

BRENDA, the Enzyme Database:

1.1.1.281

All links

Gene (7940)   
   MGENES (6777)   
   RefGene (1163)   
Protein sequence (558)   
   UniProt (389)   
   SWISS-PROT (2)   
   RefSeq(pep) (167)   
DNA sequence (13643)   
   RefSeq(nuc) (11364)   
   GenBank (1236)   
   EMBL (1043)   
Protein domain (3)   
   InterPro (3)   
All databases (22144)   

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