KEGG   ENZYME: 1.1.99.7
Entry
EC 1.1.99.7                 Enzyme                                 

Name
lactate---malate transhydrogenase;
malate-lactate transhydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With unknown physiological acceptors
Sysname
(S)-lactate:oxaloacetate oxidoreductase
Reaction(IUBMB)
(S)-lactate + oxaloacetate = pyruvate + malate [RN:R01447]
Reaction(KEGG)
R01447
Substrate
(S)-lactate [CPD:C00186];
oxaloacetate [CPD:C00036]
Product
pyruvate [CPD:C00022];
malate [CPD:C00149]
Comment
Catalyses hydrogen transfer from C3 or C4 (S)-2-hydroxy acids to 2-oxo acids. It contains tightly bound nicotinamide nucleotide in its active centre. This prosthetic group cannot be removed without denaturation of the protein.
History
EC 1.1.99.7 created 1972
Pathway
ec00620  Pyruvate metabolism
ec01100  Metabolic pathways
Reference
1  [PMID:4289051]
  Authors
Allen SH.
  Title
The isolation and characterization of malate-lactate transhydrogenase from Micrococcus lactilyticus.
  Journal
J Biol Chem 241:5266-75 (1966)
Reference
2  [PMID:4333516]
  Authors
Allen SH, Patil JR.
  Title
Studies on the structure and mechanism of action of the malate-lactate transhydrogenase.
  Journal
J Biol Chem 247:909-16 (1972)
Other DBs
ExplorEnz - The Enzyme Database: 1.1.99.7
IUBMB Enzyme Nomenclature: 1.1.99.7
ExPASy - ENZYME nomenclature database: 1.1.99.7
BRENDA, the Enzyme Database: 1.1.99.7
CAS: 9077-15-0

KEGG   REACTION: R01447
Entry
R01447                      Reaction                               

Name
(S)-Lactate:oxaloacetate oxidoreductase
Definition
(S)-Lactate + Oxaloacetate <=> (S)-Malate + Pyruvate
Equation
Reaction class
RC00031  C00036_C00149
RC00044  C00022_C00186
Enzyme
Pathway
rn00620  Pyruvate metabolism
rn01100  Metabolic pathways
Other DBs
RHEA: 10987

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