| Entry |
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| Name |
2-oxoaldehyde dehydrogenase (NAD+);
alpha-ketoaldehyde dehydrogenase;
methylglyoxal dehydrogenase;
NAD+-linked alpha-ketoaldehyde dehydrogenase;
2-ketoaldehyde dehydrogenase;
NAD+-dependent alpha-ketoaldehyde dehydrogenase
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| Class |
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
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| Sysname |
2-oxoaldehyde:NAD+ 2-oxidoreductase
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| Reaction(IUBMB) |
a 2-oxoaldehyde + NAD+ + H2O = a 2-oxo carboxylate + NADH + H+ [RN: R01337]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
Not identical with EC 1.2.1.49 2-oxoaldehyde dehydrogenase (NADP+).
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| History |
EC 1.2.1.23 created 1972, modified 1986
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| Pathway |
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| Reference |
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| Authors |
Monder C. |
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| Title |
Alpha-keto aldehyde dehydrogenase, an enzyme that catalyzes the enzymic oxidation of methylglyoxal to pyruvate. |
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| Journal |
J Biol Chem 242:4603-9 (1967) |
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| Reference |
|
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| Authors |
Ray M, Ray S. |
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| Title |
On the interaction of nucleotides and glycolytic intermediates with NAD-linked alpha-ketoaldehyde dehydrogenase. |
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| Journal |
J Biol Chem 257:10571-4 (1982) |
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| Reference |
|
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| Authors |
Ray S, Ray M. |
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| Title |
Purification and characterization of NAD and NADP-linked alpha-ketoaldehyde dehydrogenases involved in catalyzing the oxidation of methylglyoxal to pyruvate. |
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| Journal |
J Biol Chem 257:10566-70 (1982) |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 1.2.1.23 |
| ExPASy - ENZYME nomenclature database: | 1.2.1.23 |
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