KEGG   ENZYME: 1.2.1.53
Entry
EC 1.2.1.53                 Enzyme                                 

Name
4-hydroxyphenylacetaldehyde dehydrogenase;
4-HPAL dehydrogenase
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
Sysname
4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase
Reaction(IUBMB)
4-hydroxyphenylacetaldehyde + NAD+ + H2O = 4-hydroxyphenylacetate + NADH + 2 H+ [RN:R02695]
Reaction(KEGG)
R02695
Substrate
4-hydroxyphenylacetaldehyde [CPD:C03765];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Product
4-hydroxyphenylacetate [CPD:C00642];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
With EC 4.2.1.87 octopamine dehydratase, brings about the metabolism of octopamine in Pseudomonas.
History
EC 1.2.1.53 created 1989
Pathway
ec00350  Tyrosine metabolism
ec01100  Metabolic pathways
Reference
1  [PMID:3034855]
  Authors
Cuskey SM, Peccoraro V, Olsen RH.
  Title
Initial catabolism of aromatic biogenic amines by Pseudomonas aeruginosa PAO: pathway description, mapping of mutations, and cloning of essential genes.
  Journal
J Bacteriol 169:2398-404 (1987)
DOI:10.1128/JB.169.6.2398-2404.1987
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.53
IUBMB Enzyme Nomenclature: 1.2.1.53
ExPASy - ENZYME nomenclature database: 1.2.1.53
BRENDA, the Enzyme Database: 1.2.1.53
CAS: 109456-56-6

KEGG   REACTION: R02695
Entry
R02695                      Reaction                               

Name
4-Hydroxyphenylacetaldehyde:NAD+ oxidoreductase
Definition
4-Hydroxyphenylacetaldehyde + NAD+ + H2O <=> 4-Hydroxyphenylacetate + NADH + H+
Equation
Comment
see R02697 (NADPH)
Reaction class
RC00001  C00003_C00004
RC00080  C00642_C03765
Enzyme
1.2.1.5         1.2.1.29        1.2.1.53
Pathway
rn00350  Tyrosine metabolism
rn01100  Metabolic pathways
Orthology
K00129  aldehyde dehydrogenase (NAD(P)+) [EC:1.2.1.5]
Other DBs
RHEA: 17276

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