KEGG   ENZYME: 1.2.1.64Help
Entry
EC 1.2.1.64                 Enzyme                                 

Name
4-hydroxybenzaldehyde dehydrogenase (NAD+);
p-hydroxybenzaldehyde dehydrogenase (ambiguous);
4-hydroxybenzaldehyde dehydrogenase (ambiguous)
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
4-hydroxybenzaldehyde:NAD+ oxidoreductase
Reaction(IUBMB)
4-hydroxybenzaldehyde + NAD+ + H2O = 4-hydroxybenzoate + NADH + 2 H+ [RN:R01293]
Reaction(KEGG)
R01293;
(other) R07667
Show
Substrate
4-hydroxybenzaldehyde [CPD:C00633];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Product
4-hydroxybenzoate [CPD:C00156];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The bacterial enzyme (characterized from an unidentified denitrifying bacterium) is involved in an anaerobic toluene degradation pathway. The plant enzyme is involved in formation of 4-hydroxybenzoate, a cell wall-bound phenolic acid that plays a major role in plant defense against pathogens. cf. EC 1.2.1.96, 4-hydroxybenzaldehyde dehydrogenase (NADP+).
History
EC 1.2.1.64 created 2000, modified 2015
Pathway
ec00623  Toluene degradation
ec00627  Aminobenzoate degradation
ec01120  Microbial metabolism in diverse environments
Reference
1  [PMID:2722739]
  Authors
Bossert ID, Whited G, Gibson DT, Young LY.
  Title
Anaerobic oxidation of p-cresol mediated by a partially purified methylhydroxylase from a denitrifying bacterium.
  Journal
J Bacteriol 171:2956-62 (1989)
DOI:10.1128/JB.171.6.2956-2962.1989
Reference
2  [PMID:17658659]
  Authors
Sircar D, Mitra A
  Title
Evidence for p-hydroxybenzoate formation involving enzymatic phenylpropanoid side-chain cleavage in hairy roots of Daucus carota.
  Journal
J Plant Physiol 165:407-14 (2008)
DOI:10.1016/j.jplph.2007.05.005
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.64
IUBMB Enzyme Nomenclature: 1.2.1.64
ExPASy - ENZYME nomenclature database: 1.2.1.64
UM-BBD (Biocatalysis/Biodegradation Database): 1.2.1.64
BRENDA, the Enzyme Database: 1.2.1.64
CAS: 61229-72-9

KEGG   REACTION: R01293Help
Entry
R01293                      Reaction                               

Name
4-hydroxybenzaldehyde:NAD+ oxidoreductase
Definition
4-Hydroxybenzaldehyde + NAD+ + H2O <=> 4-Hydroxybenzoate + NADH + H+
Equation
Reaction class
RC00001  C00003_C00004
RC00075  C00156_C00633
Enzyme
1.2.1.28        1.2.1.64
Pathway
rn00623  Toluene degradation
rn00627  Aminobenzoate degradation
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
Orthology
K00141  benzaldehyde dehydrogenase (NAD) [EC:1.2.1.28]
Other DBs
RHEA: 20308

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