KEGG   ENZYME: 1.4.3.14
Entry
EC 1.4.3.14                 Enzyme                                 

Name
L-lysine oxidase;
L-lysine alpha-oxidase;
L-lysyl-alpha-oxidase
Class
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With oxygen as acceptor
Sysname
L-lysine:oxygen 2-oxidoreductase (deaminating)
Reaction(IUBMB)
L-lysine + O2 + H2O = 6-amino-2-oxohexanoate + NH3 + H2O2 [RN:R00447]
Reaction(KEGG)
R00447
Substrate
L-lysine [CPD:C00047];
O2 [CPD:C00007];
H2O [CPD:C00001]
Product
6-amino-2-oxohexanoate [CPD:C03239];
NH3 [CPD:C00014];
H2O2 [CPD:C00027]
Comment
Also acts, more slowly, on L-ornithine, L-phenylalanine, L-arginine and L-histidine.
History
EC 1.4.3.14 created 1981
Pathway
ec00310  Lysine degradation
ec00960  Tropane, piperidine and pyridine alkaloid biosynthesis
ec01100  Metabolic pathways
Reference
1  [PMID:6101334]
  Authors
Kusakabe H, Kodama K, Kuninaka A, Yoshino H, Misono H, Soda K.
  Title
A new antitumor enzyme, L-lysine alpha-oxidase from Trichoderma viride. Purification and enzymological properties.
  Journal
J Biol Chem 255:976-81 (1980)
Reference
2  [PMID:12460113]
  Authors
Lukasheva EV, Berezov TT.
  Title
L-Lysine alpha-oxidase: physicochemical and biological properties.
  Journal
Biochemistry (Mosc) 67:1152-8 (2002)
DOI:10.1023/a:1020967408229
Other DBs
ExplorEnz - The Enzyme Database: 1.4.3.14
IUBMB Enzyme Nomenclature: 1.4.3.14
ExPASy - ENZYME nomenclature database: 1.4.3.14
BRENDA, the Enzyme Database: 1.4.3.14
CAS: 70132-14-8

KEGG   REACTION: R00447
Entry
R00447                      Reaction                               

Name
L-lysine:oxygen 2-oxidoreductase (deaminating)
Definition
L-Lysine + Oxygen + H2O <=> 6-Amino-2-oxohexanoate + Ammonia + Hydrogen peroxide
Equation
Reaction class
RC00006  C00047_C03239
RC02755  C00007_C00027
Enzyme
Pathway
rn00310  Lysine degradation
rn00960  Tropane, piperidine and pyridine alkaloid biosynthesis
rn01100  Metabolic pathways
Other DBs
RHEA: 14440

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