KEGG   ENZYME: 1.7.1.10
Entry
EC 1.7.1.10                 Enzyme                                 

Name
hydroxylamine reductase (NADH);
hydroxylamine reductase;
ammonium dehydrogenase;
NADH-hydroxylamine reductase;
N-hydroxy amine reductase;
hydroxylamine reductase (NADH2);
NADH2:hydroxylamine oxidoreductase
Class
Oxidoreductases;
Acting on other nitrogenous compounds as donors;
With NAD+ or NADP+ as acceptor
Sysname
ammonium:NAD+ oxidoreductase
Reaction(IUBMB)
NH3 + NAD+ + H2O = hydroxylamine + NADH + H+ [RN:R00143]
Reaction(KEGG)
R00143
Substrate
NH3 [CPD:C00014];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Product
hydroxylamine [CPD:C00192];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Also acts on some hydroxamates.
History
EC 1.7.1.10 created 1972 as EC 1.6.6.11, transferred 2002 to EC 1.7.1.10
Pathway
ec00910  Nitrogen metabolism
ec01100  Metabolic pathways
Reference
1  [PMID:4311180]
  Authors
Bernheim ML.
  Title
The hydroxylamine reductase of mitochondria.
  Journal
Arch Biochem Biophys 134:408-13 (1969)
DOI:10.1016/0003-9861(69)90300-2
Reference
2  [PMID:4298499]
  Authors
Bernheim ML, Hochstein P.
  Title
Reduction of hydroxylamine by rat liver mitochondria.
  Journal
Arch Biochem Biophys 124:436-42 (1968)
DOI:10.1016/0003-9861(68)90349-4
Reference
3
  Authors
Wang, R. and Nicholas, D.J.D.
  Title
Some properties of nitrite and hydroxylamine reductases from Derxia gummosa.
  Journal
Phytochemistry 25:2463-2469 (1986)
Other DBs
ExplorEnz - The Enzyme Database: 1.7.1.10
IUBMB Enzyme Nomenclature: 1.7.1.10
ExPASy - ENZYME nomenclature database: 1.7.1.10
BRENDA, the Enzyme Database: 1.7.1.10
CAS: 9032-06-8

KEGG   REACTION: R00143
Entry
R00143                      Reaction                               

Name
ammonia:NAD+ oxidoreductase;
NADH:hydroxylamine oxidoreductase
Definition
Ammonia + NAD+ + H2O <=> Hydroxylamine + NADH + H+
Equation
Comment
not using NADH directly, but electron-transferring (ec 1.7.99.1, see R00284)
Reaction class
RC00001  C00003_C00004
RC02797  C00014_C00192
Enzyme
1.7.1.10        1.7.99.1
Pathway
rn00910  Nitrogen metabolism
rn01100  Metabolic pathways
Orthology
K05601  hydroxylamine reductase [EC:1.7.99.1]
K15864  nitrite reductase (NO-forming) / hydroxylamine reductase [EC:1.7.2.1 1.7.99.1]
Other DBs
RHEA: 20584

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