KEGG   ENZYME: 2.1.1.354Help
Entry
EC 2.1.1.354                Enzyme                                 

Name
[histone H3]-lysine4 N-trimethyltransferase;
KMT2A (gene name);
KMT2B (gene name);
KMT2C (gene name);
KMT2D (gene name);
KMT2E (gene name);
KMT2F (gene name);
KMT2G (gene name);
KMT2H (gene name);
KMT3C (gene name);
KMT3D (gene name);
KMT3E (gene name);
KMT7 (gene name);
PRDM7 (gene name);
PRDM9 (gene name);
MLL1 (gene name);
MLL2 (gene name);
MLL3 (gene name);
MLL4 (gene name);
MLL5 (gene name);
SETD1A (gene name);
ASH1L (gene name);
SMYD1 (gene name);
SMYD2 (gene name);
SMYD3 (gene name);
SET7/9 (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:[histone H3]-L-lysine4 N6-methyltransferase
Reaction(IUBMB)
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine4 = 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine4 (overall reaction);
(1a) S-adenosyl-L-methionine + a [histone H3]-L-lysine4 = S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine4;
(1b) S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine4 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine4;
(1c) S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine4 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine4
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
[histone H3]-L-lysine4;
[histone H3]-N6-methyl-L-lysine4;
[histone H3]-N6,N6-dimethyl-L-lysine4
Product
S-adenosyl-L-homocysteine [CPD:C00021];
[histone H3]-N6,N6,N6-trimethyl-L-lysine4;
[histone H3]-N6-methyl-L-lysine4;
[histone H3]-N6,N6-dimethyl-L-lysine4
Comment
This entry describes several enzymes that successively methylate the L-lysine4 residue of histone H3 (H3K4), ultimately generating a trimethylated form. These modifications influence the binding of chromatin-associated proteins. In most cases the trimethylation of this position is associated with gene activation. Unlike the other enzymes, KMT7 catalyses only monomethylation.
History
EC 2.1.1.354 created 1976 as EC 2.1.1.43, modified 1982, modified 1983, part transferred 2019 to EC 2.1.1.354
Pathway
ec00310  Lysine degradation
ec01100  Metabolic pathways
Orthology
K06101  [histone H3]-lysine4 N-trimethyltransferase ASH1L
K09186  [histone H3]-lysine4 N-trimethyltransferase MLL1
K09187  [histone H3]-lysine4 N-trimethyltransferase MLL2
K09188  [histone H3]-lysine4 N-trimethyltransferase MLL3
K09189  [histone H3]-lysine4 N-trimethyltransferase MLL5
K11422  [histone H3]-lysine4 N-trimethyltransferase SETD1
K11426  [histone H3]-lysine4/36 N-trimethyltransferase SMYD
K11431  [histone H3]-lysine4 N-trimethyltransferase SETD7
K14959  [histone H3]-lysine4 N-trimethyltransferase MLL4
K20796  [histone H3]-lysine4 N-trimethyltransferase PRDM7/9
K22748  [histone H3]-lysine4 N-trimethyltransferase ATXR3
Genes
HSA: 11105(PRDM7) 150572(SMYD1) 23067(SETD1B) 4297(KMT2A) 55870(ASH1L) 55904(KMT2E) 56950(SMYD2) 56979(PRDM9) 58508(KMT2C) 64754(SMYD3) 8085(KMT2D) 80854(SETD7) 9739(SETD1A) 9757(KMT2B)
PTR: 100610362(KMT2D) 107971434(ASH1L) 451587(KMT2A) 455959(KMT2B) 457729(SMYD2) 457870(SMYD3) 459386(SMYD1) 461944(PRDM9) 463640(KMT2E) 463875(KMT2C) 468101(SETD1A) 473295(SETD1B) 737682(SETD7)
PPS: 100971786(SMYD2) 100972983(SETD1A) 100979249(KMT2B) 100979709(ASH1L) 100981554(SETD7) 100982828(KMT2E) 100983230(SMYD1) 100984332(KMT2A) 100985657(SETD1B) 100990317(SMYD3) 100992231(KMT2C) 100993054(PRDM9) 100995808(KMT2D)
GGO: 101124677(SETD1B) 101126745(SETD1A) 101129366(KMT2A) 101134264(ASH1L) 101134599(KMT2C) 101135995(PRDM7) 101136369(PRDM9) 101136477(SETD7) 101139923(KMT2B) 101144774(KMT2D) 101144971(KMT2E) 101145998(SMYD3) 101146341(SMYD1) 101147890(SMYD2)
PON: 100172280(SMYD1) 100173903(KMT2E) 100432076(SETD1A) 100435324(SETD1B) 100439269(SMYD3) 100439693(PRDM9) 100439768(SMYD2) 100440639(PRDM7) 100441102(KMT2A) 100441715(KMT2D) 100442005(KMT2B) 100449956(SETD7)
NLE: 100579604(SMYD3) 100580011(ASH1L) 100583589(PRDM9) 100584028(SETD1B) 100586637(KMT2D) 100594433(KMT2B) 100600051(KMT2E) 100602268(SETD1A) 100602353(SETD7) 100603309(SMYD2) 100603551(SMYD1) 100604245(KMT2A) 100607151(KMT2C) 100607333(PRDM7)
MCC: 695034(PRDM9) 697233(KMT2E) 698950(SMYD1) 700426(SETD7) 703402(SMYD3) 703717(SETD1B) 705511(KMT2A) 709375(SMYD2) 710795(KMT2D) 712416(SETD1A) 716753(KMT2C) 717778(ASH1L) 718835(KMT2B)
MCF: 101866311(KMT2A) 101867084(ASH1L) 101926094(KMT2E) 102115861(KMT2B) 102120149(SMYD3) 102120758(SMYD1) 102123137(SETD1B) 102123773(KMT2D) 102126119(PRDM7) 102128002(KMT2C) 102134166(SETD1A) 102136354(PRDM9) 102140141(SETD7) 102141885(SMYD2) 107128203
CSAB: 103215061(PRDM9) 103223879(ASH1L) 103226692(KMT2E) 103227268(KMT2C) 103230106(SMYD2) 103230910(SMYD3) 103231168(SETD1A) 103233507(PRDM7) 103234531(KMT2B) 103236281(SETD7) 103238253(KMT2D) 103239290(SETD1B) 103241358(SMYD1) 103248594(KMT2A)
RRO: 104654337(SETD7) 104659604(ASH1L) 104661596(SETD1A) 104665589(KMT2A) 104666361(SETD1B) 104667085(KMT2B) 104669844(SMYD2) 104674171(SMYD1) 104674292(PRDM7) 104675848(KMT2E) 104676513(SMYD3) 104677903 104678716(KMT2C) 104679726(KMT2D)
RBB: 108512323(KMT2B) 108515913 108518888(SMYD1) 108522758(SETD7) 108523124(KMT2C) 108523384(SETD1B) 108526582(SETD1A) 108526806(ASH1L) 108527467(SMYD2) 108528557(SMYD3) 108528969(PRDM7) 108531292(KMT2E) 108536375(KMT2A) 108543918(KMT2D)
CJC: 100388751(SMYD1) 100389921(KMT2E) 100391138(KMT2A) 100392519(SMYD3) 100393607(ASH1L) 100398610(SETD1B) 100399648(PRDM7) 100401397(KMT2C) 100404005(SMYD2) 100407541(KMT2B) 100408425(KMT2D) 100414241(SETD7) 100415635(SETD1A)
SBQ: 101029847(KMT2A) 101033099(KMT2E) 101034359(KMT2B) 101037539(KMT2D) 101039502(SMYD3) 101042903(SETD1A) 101043413(SMYD1) 101043552(KMT2C) 101045177(SETD1B) 101046051(ASH1L) 101047679(SETD7) 101048329 101049466 101050442(SMYD2)
MMU: 12180(Smyd1) 192195(Ash1l) 208043(Setd1b) 213389(Prdm9) 214162(Kmt2a) 226830(Smyd2) 231051(Kmt2c) 233904(Setd1a) 381022(Kmt2d) 69188(Kmt2e) 69726(Smyd3) 73251(Setd7) 75410(Kmt2b)
MCAL: 110290320(Smyd3) 110291461(Ash1l) 110291535(Setd7) 110294014(Kmt2e) 110295015(Setd1b) 110295273(Kmt2c) 110296132(Smyd1) 110297666(Kmt2b) 110298244(Setd1a) 110298532(Smyd2) 110301786(Kmt2a) 110310214(Kmt2d) 110312704
MPAH: 110312745(Setd1b) 110313856(Kmt2e) 110316198(Kmt2c) 110316349(Smyd1) 110317687(Setd1a) 110320364(Setd7) 110320636(Ash1l) 110321293(Smyd3) 110322084(Smyd2) 110327485(Kmt2a) 110334561(Kmt2d) 110338243 110338314(Kmt2b)
RNO: 100359816(Setd1b) 100362634(Kmt2d) 102550344(Kmt2b) 289372(Smyd2) 297333(Smyd1) 310638(Ash1l) 311968(Kmt2e) 315606(Kmt2a) 365155(Prdm9) 498295(Smyd3) 502710(Kmt2c) 689954(Setd7)
MUN: 110541941 110545142(Setd7) 110545334(Setd1b) 110547438(Kmt2d) 110548961(Ash1l) 110549115(Kmt2a) 110550986(Kmt2b) 110552814(Kmt2e) 110553406(Smyd2) 110557574(Smyd3) 110559772 110559774 110561122(Prdm9) 110562254(Smyd1) 110564205 110564208
CGE: 100750575(Kmt2b) 100752747(Prdm9) 100753294(Setd1b) 100753962(Setd1a) 100754103(Ash1l) 100756731(Kmt2e) 100760424(Kmt2a) 100761694(Smyd2) 100764840(Smyd3) 100765465(Kmt2d) 100766221(Smyd1) 100767175(Setd7) 100767367(Kmt2c)
NGI: 103726333(Setd1a) 103727065(Smyd2) 103729965(Kmt2b) 103732191(Kmt2e) 103737043(Smyd1) 103739104(Setd1b) 103742349(Prdm9) 103742371(Setd7) 103745326(Kmt2c) 103746872(Smyd3) 103748298(Kmt2a) 103750570(Kmt2d) 103750808(Ash1l)
HGL: 101698086 101698170(Kmt2c) 101699273(Kmt2b) 101701112 101702850(Setd1b) 101709197(Setd1a) 101712321(Kmt2e) 101715832(Setd7) 101716671(Kmt2a) 101718411(Kmt2d) 101718535(Smyd1) 101720447(Smyd2) 101722574(Smyd3) 101723836(Ash1l)
CCAN: 109674462 109675706(Smyd3) 109682842(Setd1a) 109684282(Kmt2e) 109685268(Kmt2c) 109686401(Setd1b) 109688014(Ash1l) 109689598(Kmt2b) 109689973(Kmt2a) 109691464(Setd7) 109694824(Kmt2d) 109695167 109700578(Smyd1) 109700718(Smyd2) 109702113 109702114
OCU: 100339782 100344249(SMYD2) 100347516(SMYD3) 100347618(SETD1B) 100347837(SETD7) 100353483(KMT2B) 100353688(KMT2C) 100353733(KMT2A) 100353840(KMT2E) 100354139(SETD1A) 100354541(ASH1L) 100355437(SMYD1) 100357052(KMT2D) 100358830(PRDM7) 100358832 103347079
TUP: 102469443(ASH1L) 102470517(SETD7) 102473382(KMT2A) 102474223(SETD1B) 102477772(KMT2B) 102478405(SETD1A) 102479012(KMT2C) 102480722(KMT2D) 102483069(KMT2E) 102483290(SMYD3) 102493552(SMYD1) 102496135(PRDM9) 102496151(SMYD2)
CFA: 100688666(KMT2B) 475758(SMYD1) 475895(KMT2E) 476079(SETD7) 479417(KMT2A) 480026(SMYD2) 480101(SMYD3) 480128(ASH1L) 486257(SETD1B) 486558(KMT2D) 489916(SETD1A) 611094(KMT2C)
VVP: 112916198(KMT2C) 112916807(SMYD1) 112918925(ASH1L) 112920160(KMT2A) 112921101(KMT2D) 112921783(SMYD2) 112923542(SMYD3) 112924552 112925373(KMT2E) 112928324(KMT2B) 112929256(SETD1A) 112934919(SETD7) 112935175(SETD1B)
AML: 100465228(KMT2C) 100466350(SMYD3) 100466490(SMYD2) 100468393(KMT2E) 100469094(KMT2B) 100469373(PRDM7) 100472168(SETD7) 100474237(ASH1L) 100478541(SETD1B) 100479447(KMT2D) 100482700(SETD1A) 100483766(SMYD1) 100484220(KMT2A) 109490334
UMR: 103657933(SETD1A) 103658074(SETD7) 103660985(KMT2C) 103661268(SETD1B) 103662507(KMT2A) 103666923(SMYD3) 103668369(ASH1L) 103671476(SMYD1) 103672523(SMYD2) 103673975(PRDM7) 103674714(KMT2E) 103675622(KMT2D) 103682560(KMT2B)
UAH: 113241427(KMT2C) 113242840(SMYD1) 113244759(KMT2B) 113245266(ASH1L) 113251646(PRDM7) 113255688(SETD7) 113257661(KMT2D) 113258804(KMT2E) 113259992(KMT2A) 113262691(SMYD2) 113262946(SMYD3) 113266937(SETD1B) 113267709(SETD1A)
ORO: 101362332(KMT2E) 101362407(SETD1B) 101362745(ASH1L) 101363392 101363669(KMT2A) 101364358(SMYD1) 101365628(KMT2C) 101368440(SETD7) 101369213(KMT2D) 101370290(KMT2B) 101371861(SMYD2) 101376995(SETD1A) 101383043(PRDM7) 101384991(SMYD3)
FCA: 101081435(SMYD2) 101084095(KMT2C) 101084945(KMT2E) 101085009(PRDM7) 101086114(ASH1L) 101089231(SMYD3) 101090288(KMT2A) 101091070(SETD1A) 101091191(SETD7) 101095247(SMYD1) 101095268(KMT2D) 101096419(SETD1B) 101098760(KMT2B)
PTG: 102949117(KMT2E) 102949463(SMYD3) 102953445(SETD7) 102956940(KMT2A) 102962859(KMT2D) 102964154(KMT2C) 102964982(KMT2B) 102968240(SMYD2) 102969005(SETD1A) 102969379(ASH1L) 102970032(SMYD1) 102970685(SETD1B) 102971819(PRDM7)
PPAD: 109245496(PRDM7) 109249058(KMT2D) 109249505(SETD7) 109251114(SMYD3) 109251503(KMT2B) 109252401(KMT2C) 109254457(SMYD2) 109256230(ASH1L) 109258968(SETD1A) 109264245(SMYD1) 109268101(KMT2E) 109277797(SETD1B) 109278556(KMT2A)
AJU: 106966460(KMT2A) 106966796(SMYD2) 106967594(SETD1B) 106968611(SMYD3) 106969329(KMT2D) 106974745(KMT2B) 106976180(SETD7) 106978140(SMYD1) 106978485(KMT2E) 106979084(SETD1A) 106981535(ASH1L) 106984461(KMT2C) 106985288(PRDM7)
BTA: 100139638 100190914(PRDM9) 100851938 506805(KMT2D) 508330(KMT2A) 514102(SETD1B) 515928(SETD7) 516002(PRDM7) 520584 537404(SMYD1) 539121(KMT2E) 540563(ASH1L) 615229(SMYD2) 616050(SMYD3) 782887(SETD1A) 785776(KMT2B) 789336(KMT2C)
BOM: 102267186(KMT2C) 102268887(KMT2D) 102269320(KMT2B) 102270977(SMYD1) 102271291 102273734(SMYD2) 102275046(ASH1L) 102279495(SETD1A) 102280025(KMT2A) 102280610(SETD1B) 102281278(KMT2E) 102281809(SETD7) 102282730 102287417(SMYD3)
BIU: 109553548(ASH1L) 109554959 109554963 109557366(KMT2E) 109558041(KMT2C) 109559148(KMT2D) 109561910 109566148(SMYD1) 109569413(KMT2A) 109570555(SMYD3) 109570591(SMYD2) 109570912(SETD1B) 109571070(SETD7) 109572325(KMT2B) 109578511(SETD1A)
BBUB: 102392548(SMYD3) 102393219(SETD1B) 102394548(SETD7) 102396938(KMT2C) 102398212(KMT2E) 102400596(KMT2B) 102401126(KMT2A) 102401677(SETD1A) 102401706(KMT2D) 102403578 102406655 102408066(SMYD1) 102413004 102415367(ASH1L) 102416088(SMYD2) 112582202 112582680 112582838
CHX: 102168698(KMT2D) 102169033(KMT2A) 102169548(KMT2E) 102170478(SETD1A) 102171177(SMYD3) 102172292(KMT2B) 102177044(PRDM9) 102179971(SETD1B) 102181925(KMT2C) 102183791(PRDM9) 102185413(ASH1L) 102185508 102187140(SMYD1) 102189783(SMYD2) 102191824(SETD7)
OAS: 101101875 101101916(KMT2A) 101102409(SMYD2) 101103509(SETD1B) 101103705 101104086(KMT2B) 101105467(SETD1A) 101108731(SMYD1) 101115617(KMT2C) 101115990(SETD7) 101116161(SMYD3) 101118592 101119775(ASH1L) 101120741(KMT2D) 101120895 101121766(KMT2E) 114116628
SSC: 100155920(ASH1L) 100156137(SETD1B) 100294702(SMYD1) 100294706(SMYD2) 100294707(SMYD3) 100511747(SETD1A) 100514805(KMT2C) 100520742(KMT2B) 100620538(PRDM7) 100623006(KMT2A) 100626704(SETD7) 100628131(KMT2E) 110260656(KMT2D)
CFR: 102506865(SETD7) 102507730(KMT2C) 102509980(SETD1A) 102510314(PRDM7) 102510601(ASH1L) 102513005(SMYD1) 102514543(KMT2E) 102514741(SMYD3) 102515223(KMT2D) 102515785(SMYD2) 102517824(KMT2A) 102520520(KMT2B) 102521372(SETD1B) 102523091 106728486
CDK: 105087090(SETD7) 105088051(KMT2B) 105088782(ASH1L) 105090168(KMT2A) 105093021(KMT2E) 105098689(KMT2C) 105099293(SMYD2) 105099491(SMYD3) 105102557(SETD1B) 105102789(SETD1A) 105103813(KMT2D) 105104177(SMYD1) 105106131(PRDM7)
BACU: 103002011(KMT2E) 103002269(SETD7) 103004413(KMT2D) 103004433(KMT2C) 103008957(SETD1A) 103010622(SETD1B) 103014183(KMT2A) 103015601(KMT2B) 103015822(ASH1L) 103018045(SMYD3) 103018379(SMYD1) 103018911(PRDM7) 103020103(SMYD2)
LVE: 103068531(KMT2A) 103070332(SMYD1) 103071598(SETD7) 103073652(KMT2B) 103074842(KMT2E) 103077679(SETD1B) 103078348(KMT2C) 103079757(SETD1A) 103081140(SMYD3) 103082116(KMT2D) 103083457(PRDM7) 103084369 103087473(ASH1L) 103090372(SMYD2)
OOR: 101269640(KMT2D) 101271862(SMYD2) 101276223(KMT2B) 101278571(KMT2A) 101278914(SETD1B) 101281657(SMYD3) 101282114(SETD7) 101283071(SETD1A) 101284649(SMYD1) 101285642(KMT2E) 101288516(KMT2C) 101288541(ASH1L) 101290159(PRDM7)
DLE: 111164613(KMT2E) 111165396(SMYD1) 111166868(KMT2A) 111167169(ASH1L) 111174034(KMT2D) 111176572(KMT2C) 111177545(SMYD3) 111179118(SETD7) 111179685(PRDM7) 111181136(KMT2B) 111182119(SETD1A) 111184680(SMYD2) 111186875(SETD1B)
PCAD: 102974760(PRDM7) 102977910(SETD1B) 102980726(KMT2E) 102980789(SMYD1) 102981445(KMT2A) 102981848(KMT2D) 102986025(SETD7) 102987727(KMT2B) 102988929(KMT2C) 102989011(SMYD3) 102992344(SMYD2) 102992941(SETD1A) 102993773(ASH1L) 112064829 114487551
ECB: 100052774(SMYD2) 100052805(SMYD1) 100053168(PRDM7) 100057386(ASH1L) 100058928(KMT2E) 100058932(KMT2D) 100059267(SMYD3) 100059802(KMT2B) 100063257(SETD7) 100063523(SETD1A) 100064812(KMT2C) 100071238(KMT2A) 100146430(SETD1B)
EPZ: 103541678(SETD1B) 103545551 103546689(KMT2A) 103547270(SETD1A) 103547761(SMYD2) 103548807 103549975(SMYD1) 103551020(SETD7) 103552202(KMT2D) 103552840 103553137(KMT2C) 103560579(KMT2E) 103562021 103566091(KMT2B) 103566688 103567807(PRDM7)
EAI: 106823334(KMT2C) 106825187(KMT2E) 106828486(ASH1L) 106829152(KMT2B) 106831838(SETD1A) 106836860(KMT2D) 106838574(SMYD1) 106838612(SETD7) 106840333(KMT2A) 106842219(SETD1B) 106846818(SMYD2) 106846844(SMYD3)
MYB: 102240554 102244915(SMYD2) 102244965(KMT2D) 102246410(KMT2E) 102246482(SETD7) 102246704(KMT2C) 102246785(KMT2A) 102247786(SMYD3) 102253255(SETD1A) 102255512(SETD1B) 102255643 102256394(ASH1L) 102257900 102258373 102259087(KMT2B) 102262117
MYD: 102751347(SETD1B) 102755932(SMYD1) 102756071(SETD1A) 102758785(KMT2E) 102759674(KMT2C) 102760166(SETD7) 102760582(SMYD2) 102762410(KMT2D) 102764796(ASH1L) 102765569 102765850(PRDM9) 102766910(KMT2A) 102769466(SMYD3) 102771251(KMT2B) 102774259 107182758
MNA: 107524895(KMT2C) 107524924 107528109(KMT2D) 107528337(SMYD3) 107528646(SMYD1) 107530776 107530799 107534917(SETD7) 107539362 107540799(SETD1A) 107541833(SETD1B) 107542284(KMT2E) 107542826 107543372(KMT2B) 107543779(ASH1L) 107546243(SMYD2)
HAI: 109371387 109372008(KMT2B) 109374193(SETD1A) 109376837(SMYD1) 109378226 109378400 109378707 109378765 109379108(SMYD2) 109381405(PRDM7) 109385301(KMT2A) 109386061(SETD1B) 109389650(KMT2C) 109391450 109392049(KMT2E) 109393224(KMT2D) 109393386(ASH1L) 109394201(SETD7)
DRO: 112296748(PRDM7) 112297714(SMYD2) 112301980 112303106(SMYD1) 112303206(KMT2E) 112303918 112303963 112304818(SETD1A) 112308262(KMT2C) 112310608(SETD1B) 112312687(SETD7) 112313830 112314381(KMT2A) 112316652 112316914(ASH1L) 112318232(KMT2D) 112318753(SMYD3) 112320053(KMT2B)
PALE: 102878419(PRDM7) 102879153(SETD1B) 102880671(SMYD1) 102881431(KMT2B) 102883630(SMYD2) 102884674(SETD1A) 102887843(SMYD3) 102888124(ASH1L) 102888384(KMT2E) 102888593(KMT2D) 102889824(PRDM9) 102890289(SETD7) 102893336(KMT2A) 102897550(KMT2C)
RAY: 107497624(KMT2B) 107498661(SMYD3) 107502258(KMT2A) 107503985(SETD1A) 107505913(SMYD1) 107508545 107511501(KMT2E) 107514237(KMT2D) 107515234(SETD1B) 107515339(SETD7) 107516247(PRDM9) 107520298(KMT2C) 107521457(ASH1L) 107521612 107521638(SMYD2)
LAV: 100653681(KMT2A) 100653839(SETD7) 100659534(SMYD3) 100660034(PRDM7) 100662609(SETD1A) 100664734 100666322(PRDM9) 100668468(ASH1L) 100668488(SETD1B) 100669611(KMT2B) 100670013(KMT2D) 100671071(KMT2E) 100672564(SMYD1) 100673765(KMT2C) 100674556(SMYD2) 100676686
MDO: 100013387(SETD1A) 100017118(ASH1L) 100018480(KMT2E) 100019161(KMT2C) 100023305(SMYD2) 100027436(SETD7) 100029674(SMYD1) 100031440(KMT2A) 100617561(KMT2B) 100618514(SETD1B) 100619798(SMYD3) 103099827(KMT2D)
SHR: 100916165(SMYD1) 100920575(KMT2C) 100922144(KMT2E) 100923245 100924557(KMT2A) 100926753 100927672(KMT2B) 100928096(SETD1B) 100928575(KMT2D) 100929261(SETD7) 100929291(SETD1A) 100931585(ASH1L) 100932883(SMYD3) 100934440(SMYD2) 105749741
PCW: 110194047(KMT2D) 110194897(SETD7) 110196348(SMYD1) 110196787(SETD1B) 110201341(KMT2B) 110201406(PRDM9) 110205493(SMYD3) 110206991(KMT2E) 110207193(KMT2A) 110211945(ASH1L) 110222694(SMYD2) 110223143(SETD1A) 110223876(KMT2C)
OAA: 100074286(KMT2C) 100074411(SETD1B) 100077208(KMT2E) 100078649(SMYD1) 100079176(SMYD2) 100081674(SETD7) 100082753(SMYD3) 100086068(KMT2A) 100090957(SETD1A) 103165316(KMT2B) 103168045(ASH1L)
GGA: 373960(SMYD1) 414897(KMT2A) 416851(SETD1B) 417712(KMT2E) 420437(KMT2C) 421361(SMYD2) 421489(SMYD3) 422443(SETD7) 425064(ASH1L) 425846(KMT2D)
MGP: 100538978(SMYD2) 100539732(ASH1L) 100540662(KMT2A) 100541967(SETD7) 100544670(SETD1B) 100545169(KMT2C) 100545555(KMT2E) 100548953(SMYD1) 104909329 104915798
CJO: 107308762(KMT2C) 107311083(SMYD2) 107311243(SMYD3) 107313101(SETD7) 107314020(SMYD1) 107321274(SETD1B) 107324133(KMT2A) 107324503(ASH1L) 107325180(KMT2E) 107325738(KMT2D)
NMEL: 110387546(KMT2A) 110387902(ASH1L) 110389135(KMT2D) 110392363(KMT2E) 110393789(KMT2C) 110395863(SMYD3) 110396134(SMYD2) 110397503(SETD7) 110398544(SMYD1) 110406578(SETD1B)
APLA: 101790791(SMYD2) 101796266(KMT2C) 101797321(KMT2A) 101800254(SETD7) 101800831(SMYD1) 101801343(SMYD3) 101803072(SETD1B) 101805084(KMT2E)
ACYG: 106031413(SETD1B) 106031578(SMYD2) 106033933(SMYD1) 106039772(KMT2A) 106040965(SETD7) 106043274(KMT2E) 106046952(KMT2C) 106047718(KMT2D) 106048498(ASH1L) 106049693(SMYD3)
TGU: 100219723(SMYD3) 100219994(SETD7) 100225647(SETD1B) 100226399(KMT2E) 100226907(KMT2D) 100227193(KMT2C) 100229714(ASH1L) 100230154(SMYD1) 100230503(SMYD2) 100231049(KMT2A)
LSR: 110468513(SETD7) 110470458(KMT2A) 110471483(ASH1L) 110471750(SETD1B) 110472726(KMT2E) 110473308(SMYD1) 110479948(SMYD2) 110480395(KMT2D) 110481707(SMYD3) 110484559(KMT2C)
SCAN: 103813061(KMT2C) 103813524(KMT2E) 103817699(SMYD3) 103818319(SETD1B) 103821549(SMYD2) 103822533(SETD7) 103822784(KMT2A) 103823501(SMYD1) 103823951(ASH1L) 103824625(KMT2D)
GFR: 102031396(KMT2C) 102032923(SMYD2) 102034037(KMT2D) 102036439(KMT2A) 102037071(SMYD1) 102037758(SMYD3) 102040049(SETD1B) 102040515(SETD7) 102042927(ASH1L) 102045471(KMT2E) 106632190
FAB: 101806346(KMT2C) 101807006(SMYD2) 101807375(SETD7) 101812652(SETD1B) 101812878(KMT2E) 101813917(KMT2A) 101818086(KMT2D) 101819907(ASH1L) 101821319(SMYD3) 101822247(SMYD1)
PHI: 102099277(KMT2C) 102100454(KMT2D) 102101401(SMYD2) 102102416(SMYD1) 102103515(KMT2A) 102106186(SETD7) 102107307(SMYD3) 102108338(KMT2E) 102113028(ASH1L) 102114734(SETD1B) 106628993
PMAJ: 107198594(KMT2D) 107202071(SMYD2) 107202430(SMYD3) 107203381(SETD7) 107203527(SMYD1) 107204272(KMT2E) 107211664(SETD1B) 107214385(KMT2A) 107214568(ASH1L) 107216349(KMT2C)
CCAE: 111923252(KMT2E) 111925501(KMT2C) 111926193(SMYD2) 111926986 111927591 111928311(SMYD1) 111928908(SETD7) 111936709(SETD1B) 111939213(KMT2A) 111939443(ASH1L) 111940566
CCW: 104683547(ASH1L) 104684478(SMYD3) 104685633(SMYD2) 104686428(KMT2C) 104686872(KMT2E) 104688830(SETD1B) 104690813(SMYD1) 104692048(KMT2A) 104697344(SETD7)
ETL: 114055005(SETD1B) 114056306(KMT2A) 114058383(SETD7) 114060528(KMT2E) 114060897(SMYD2) 114062389(KMT2C) 114065339(SMYD3) 114066019 114067206(SMYD1) 114069574(ASH1L) 114071069(KMT2D) 114072229 114073002
FPG: 101911864(SETD1B) 101913546(ASH1L) 101916525(KMT2D) 101917176(KMT2C) 101917301(SETD7) 101919056(SMYD1) 101919125(SMYD3) 101919912(KMT2E) 101922729(KMT2A) 101923412(SMYD2)
FCH: 102047191(KMT2C) 102047542(KMT2E) 102049111 102051296(SETD1B) 102053523(SETD7) 102056587(ASH1L) 102057033(SMYD1) 102057924(SMYD2) 102058880(SMYD3) 102059401(KMT2A)
CLV: 102083945(SETD1B) 102084453(KMT2A) 102086496(SMYD1) 102087865(SETD7) 102088613(SMYD2) 102088903(KMT2E) 102090928(ASH1L) 102091442(KMT2D) 102092665(SMYD3) 102097963(KMT2C)
EGZ: 104122745(SETD1B) 104123317 104126982(SMYD1) 104128583(KMT2E) 104130998(KMT2C) 104131533(SMYD3) 104132856(SMYD2) 104134673(SETD7) 104134854(ASH1L) 104135262 104135361(KMT2A)
NNI: 104010731(KMT2E) 104011458(SMYD3) 104014894(KMT2C) 104015980(SETD7) 104016208(KMT2A) 104017938 104018532(SMYD1) 104019711(SMYD2) 104020487(ASH1L) 104020788(SETD1B)
ACUN: 113477175(KMT2C) 113477910(SMYD3) 113478725(SMYD2) 113479169(SMYD1) 113479515(SETD7) 113485968(SETD1B) 113488577(KMT2A) 113488743(ASH1L) 113490163(KMT2E)
PADL: 103913294(ASH1L) 103914561(SETD1B) 103914598(SMYD3) 103915639(KMT2C) 103916551(KMT2A) 103920580(KMT2E) 103920974(SETD7) 103922130(SMYD2) 103923505(SMYD1)
AAM: 106484901(SMYD1) 106485191(KMT2A) 106485306(KMT2C) 106485538(SMYD3) 106485892(KMT2E) 106490428(SMYD2) 106491857(SETD7) 106494341(ASH1L) 106495668(SETD1B) 106497500(KMT2D)
ASN: 102368053(SMYD1) 102372997(ASH1L) 102373099(KMT2D) 102374512(SETD7) 102375642(KMT2E) 102378568(SETD1B) 102379342(KMT2C) 102381556(SMYD3) 102382195(KMT2B) 102383161(SMYD2) 102385246(KMT2A) 102387237(SETD1A)
AMJ: 102560006(KMT2D) 102560388(KMT2E) 102567474(KMT2C) 102568755(SETD7) 102571713(ASH1L) 102571979 102572253(KMT2A) 102574091(SETD1B) 102575326(SMYD2) 102575695(SMYD1) 102576362(SMYD3) 102576444(SETD1A) 106739435 109281961
PSS: 102445204 102446823 102448089(SETD1B) 102448117(ASH1L) 102449156(SMYD1) 102450509(KMT2D) 102454598(KMT2E) 102455968 102456582(SMYD3) 102459016(KMT2C) 102460627 102460633(SETD1A) 102461265(SMYD2) 102461649(SETD7) 102463628(KMT2A)
CMY: 102931937(KMT2B) 102932627 102933355(KMT2E) 102933435(SMYD2) 102934693(SETD1B) 102936055(SMYD1) 102937004(SETD1A) 102937036(SMYD3) 102941272(KMT2A) 102943205(SETD7) 102943662(ASH1L) 102944171 102948345(KMT2C)
CPIC: 101930966(SETD7) 101934288(KMT2D) 101934563 101935009(KMT2E) 101936901(SETD1A) 101939661(SETD1B) 101939705 101941687(KMT2A) 101942050(ASH1L) 101947848 101948178(SMYD2) 101950574(KMT2B) 101951595(SMYD1) 101951981(SMYD3) 101953918(KMT2C)
ACS: 100551939(setd7) 100553183(kmt2e) 100554175(kmt2d) 100556055(kmt2c) 100556600(kmt2b) 100557667(smyd2) 100560745(kmt2a) 100561699(smyd1) 100563888(ash1l) 103279564(setd1a) 103279992 103280931(setd1b) 107982259
PVT: 110071916(KMT2C) 110073660(SETD7) 110075080(KMT2D) 110076069(SMYD3) 110079453(KMT2A) 110080953(KMT2E) 110081037(ASH1L) 110083882(SETD1B) 110086348(SMYD1) 110086418(SETD1A) 110086747 110087176(SMYD2) 110089900(KMT2B)
PBI: 103049419 103051289(KMT2D) 103051962(KMT2E) 103052345(SMYD3) 103054198(SMYD2) 103054534(SETD1A) 103055134(PRDM9) 103056555(SETD7) 103058624(SMYD1) 103058696(KMT2B) 103060233(ASH1L) 103063162(SETD1B) 103065683 103067762(KMT2A)
PMUR: 107284778(KMT2A) 107286389(KMT2D) 107286731 107286738 107286983(SETD1B) 107287999(KMT2B) 107289289(SMYD2) 107289708 107290222(SETD1A) 107292628 107293153(SETD7) 107297020(ASH1L) 107298635(KMT2E) 107301328 107302384(SMYD1) 107303312(KMT2C)
PMUA: 114582254(SMYD1) 114582823(SETD1A) 114585722(KMT2A) 114586200(SETD1B) 114586229(ASH1L) 114587663 114594456(SMYD3) 114594675(SMYD2) 114603572(KMT2B) 114604135(SETD7) 114605818(KMT2E) 114607001(KMT2C)
GJA: 107105569(SMYD1) 107105838(KMT2D) 107106655(SETD1A) 107106688 107108065(SMYD3) 107108169(KMT2B) 107109138 107110772(SETD7) 107112539(KMT2A) 107113725(KMT2E) 107115893(SETD1B) 107119617(ASH1L) 107121665(SMYD2) 107123156 107123162(KMT2C)
XTR: 100135006(kmt2a) 100144721(kmt2b) 100145429(smyd1) 100486829(kmt2c) 100487270(setd1a) 100494109(kmt2d) 100494527(smyd3) 100495522(smyd2) 613102(setd7) 779539(kmt2e) 780106(setd1b)
NPR: 108783805(SMYD2) 108784343(KMT2C) 108787262(SETD1B) 108787486(SMYD3) 108787523(SETD7) 108791395(KMT2D) 108794233(ASH1L) 108794984(KMT2A) 108795231(KMT2E) 108796886(SMYD1) 108799776(KMT2B) 108800988(SETD1A)
DRE: 100536523(kmt2d) 321245(smyd1a) 325395(kmt2e) 393876(prdm9) 436729(setd7) 541423(smyd2a) 556535(setd1a) 557048(kmt2a) 560793(kmt2ca) 560856(kmt2ba) 563799(ash1l) 566825(kmt2bb) 567970(setd1ba) 568616(smyd2b) 569027(smyd1b) 569507(smyd3) 571274(setd1bb)
NFU: 107372442(kmt2b) 107373342(setd1b) 107374212 107375014(smyd1) 107377597(smyd2) 107378515(setd1a) 107379592(ash1l) 107380358(kmt2a) 107381186 107381206(smyd3) 107383945(kmt2c) 107386366(kmt2e) 107387053(setd7) 107387683(znf286a) 107390885(kmt2d) 107393824 107393825 107394125 107394561 107394636
LCM: 102347272(KMT2C) 102349685(SMYD1) 102349988(KMT2E) 102350182(SETD7) 102351078(SETD1A) 102354014(KMT2D) 102354331 102354519(SMYD2) 102354605 102357046(KMT2A) 102357625 102361515(SMYD3) 102363172(SETD1B) 102367246(ASH1L)
CMK: 103172000 103176975(kmt2e) 103180354(kmt2a) 103181297(setd7) 103181513(smyd1) 103181738(smyd3) 103184390(setd1b) 103186165(smyd2) 103189259(kmt2d) 103189435(kmt2c) 103189436 103191129
DME: Dmel_CG13761(Smyd3) Dmel_CG3848(trr) Dmel_CG40351(Set1) Dmel_CG8651(trx) Dmel_CG8887(ash1)
DSI: Dsimw501_GD11928(Dsim_GD11928) Dsimw501_GD12268(Dsim_GD12268) Dsimw501_GD16408(Dsim_GD16408) Dsimw501_GD20433(Dsim_GD20433) Dsimw501_GD28104(Dsim_GD28104) Dsimw501_GD29063(Dsim_GD29063)
CEL: CELE_C26E6.9(set-2) CELE_R06F6.4(set-14) CELE_T12D8.1(set-16) CELE_T12F5.4(lin-59) CELE_T22A3.4(set-18) CELE_ZC8.3(set-30)
CBR: CBG03016(Cbr-set-14) CBG12017(Cbr-lin-59) CBG14580(Cbr-set-30) CBG18244(Cbr-set-16) CBG24752(Cbr-set-18)
ATH: AT1G43245 AT2G17900(SDG37) AT2G19640(ASHR2) AT4G15180(SDG2) AT5G06620(SDG38)
LJA: Lj0g3v0111689.1(Lj0g3v0111689.1) Lj0g3v0111689.2(Lj0g3v0111689.2) Lj0g3v0252639.1(Lj0g3v0252639.1) Lj0g3v0252639.2(Lj0g3v0252639.2) Lj0g3v0308279.1(Lj0g3v0308279.1) Lj0g3v0308279.2(Lj0g3v0308279.2) Lj0g3v0308279.3(Lj0g3v0308279.3) Lj1g3v0764540.1(Lj1g3v0764540.1) Lj1g3v0764540.2(Lj1g3v0764540.2) Lj2g3v2985910.1(Lj2g3v2985910.1) Lj2g3v2985910.2(Lj2g3v2985910.2) Lj2g3v2985910.3(Lj2g3v2985910.3) Lj3g3v2888370.1(Lj3g3v2888370.1) Lj3g3v2888370.2(Lj3g3v2888370.2) Lj4g3v0165060.1(Lj4g3v0165060.1) Lj4g3v0166140.1(Lj4g3v0166140.1)
DOSA: Os03t0704200-01(Os03g0704200) Os04t0423600-01(Os04g0423600) Os08t0180100-01(Os08g0180100) Os08t0205300-01(Os08g0205300) Os10t0410700-01(Os10g0410700)
ATS: 109736528(LOC109736528) 109741969(LOC109741969) 109747984(LOC109747984) 109776439(LOC109776439) 109778416(LOC109778416)
OLU: OSTLU_15174(SDG3512) OSTLU_32372(SDG3514) OSTLU_88595(SDG3527) OSTLU_92854(SDG3513)
SCE: YHR119W(SET1)
KMX: KLMA_30450(SET6) KLMA_60252(SET1)
NCS: NCAS_0B07030(NCAS0B07030) NCAS_0C01270(NCAS0C01270)
NDI: NDAI_0B04360(NDAI0B04360) NDAI_0K01280(NDAI0K01280)
TPF: TPHA_0I01480(TPHA0I01480)
TBL: TBLA_0C05500(TBLA0C05500)
TDL: TDEL_0A06370(TDEL0A06370) TDEL_0B05100(TDEL0B05100)
KAF: KAFR_0F00700(KAFR0F00700) KAFR_0H02340(KAFR0H02340)
SLB: AWJ20_424(SET6) AWJ20_608(SET1)
NCR: NCU01206(set-1) NCU01932(set-3) NCU02962
NTE: NEUTE1DRAFT125465(NEUTE1DRAFT_125465) NEUTE1DRAFT144212(NEUTE1DRAFT_144212) NEUTE1DRAFT150707(NEUTE1DRAFT_150707)
NHE: NECHADRAFT_123121(SDG2103) NECHADRAFT_49470(SDG2101) NECHADRAFT_74600(SDG2107)
ANG: ANI_1_1490164(An18g06840) ANI_1_1754144(An16g04950) ANI_1_2518094(An11g09860)
PBN: PADG_03985 PADG_06078 PADG_11427(PADG_02444)
SPO: SPBP8B7.07c(set6) SPCC306.04c(set1)
CNE: CND03610
CNB: CNBD2720
ABP: AGABI1DRAFT102088(AGABI1DRAFT_102088) AGABI1DRAFT120631(AGABI1DRAFT_120631) AGABI1DRAFT41599(AGABI1DRAFT_41599) AGABI1DRAFT76762(AGABI1DRAFT_76762)
ABV: AGABI2DRAFT120820(AGABI2DRAFT_120820) AGABI2DRAFT209673(AGABI2DRAFT_209673) AGABI2DRAFT211045(AGABI2DRAFT_211045) AGABI2DRAFT223832(AGABI2DRAFT_223832)
EHI: EHI_092690(175.t00011)
PYO: PY17X_1133200(PY04885)
PCB: PCHAS_113130(PC000913.02.0)
CPV: cgd7_5090
SMIN: v1.2.013565.t1(symbB.v1.2.013565.t1) v1.2.019699.t1(symbB.v1.2.019699.t1) v1.2.029529.t3(symbB.v1.2.029529.t3) v1.2.035053.t1(symbB.v1.2.035053.t1)
 » show all
Taxonomy
Reference
1  [PMID:12453419]
  Authors
Nakamura T, Mori T, Tada S, Krajewski W, Rozovskaia T, Wassell R, Dubois G, Mazo A, Croce CM, Canaani E
  Title
ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation.
  Journal
Mol Cell 10:1119-28 (2002)
  Sequence
[hsa:4297]
Reference
2  [PMID:12540855]
  Authors
Xiao B, Jing C, Wilson JR, Walker PA, Vasisht N, Kelly G, Howell S, Taylor IA, Blackburn GM, Gamblin SJ
  Title
Structure and catalytic mechanism of the human histone methyltransferase SET7/9.
  Journal
Nature 421:652-6 (2003)
DOI:10.1038/nature01378
  Sequence
[hsa:80854]
Reference
3  [PMID:15235609]
  Authors
Hamamoto R, Furukawa Y, Morita M, Iimura Y, Silva FP, Li M, Yagyu R, Nakamura Y
  Title
SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells.
  Journal
Nat Cell Biol 6:731-40 (2004)
DOI:10.1038/ncb1151
  Sequence
[hsa:64754]
Reference
4  [PMID:27129774]
  Authors
Blazer LL, Lima-Fernandes E, Gibson E, Eram MS, Loppnau P, Arrowsmith CH, Schapira M, Vedadi M
  Title
PR Domain-containing Protein 7 (PRDM7) Is a Histone 3 Lysine 4 Trimethyltransferase.
  Journal
J Biol Chem 291:13509-19 (2016)
  Sequence
[hsa:11105]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.354
IUBMB Enzyme Nomenclature: 2.1.1.354
ExPASy - ENZYME nomenclature database: 2.1.1.354
BRENDA, the Enzyme Database: 2.1.1.354

KEGG   ENZYME: 2.1.1.355Help
Entry
EC 2.1.1.355                Enzyme                                 

Name
[histone H3]-lysine9 N-trimethyltransferase;
KMT1A (gene name);
KMT1B (gene name);
KMT1C (gene name);
KMT1D (gene name);
KMT1E (gene name);
KMT1F (gene name);
MT8 (gene name);
SUV39H1 (gene name);
G9A (gene name);
EHMT1 (gene name);
PRDM2 (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:[histone H3]-L-lysine9 N6-methyltransferase
Reaction(IUBMB)
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 = 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9 (overall reaction);
(1a) S-adenosyl-L-methionine + a [histone H3]-L-lysine9 = S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine9;
(1b) S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine9 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine9;
(1c) S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine9 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
[histone H3]-L-lysine9;
[histone H3]-N6-methyl-L-lysine9;
[histone H3]-N6,N6-dimethyl-L-lysine9
Product
S-adenosyl-L-homocysteine [CPD:C00021];
[histone H3]-N6,N6,N6-trimethyl-L-lysine9;
[histone H3]-N6-methyl-L-lysine9;
[histone H3]-N6,N6-dimethyl-L-lysine9
Comment
This entry describes several enzymes that successively methylate the L-lysine9 residue of histone H3 (H3K9), ultimately generating a trimethylated form. These modifications influence the binding of chromatin-associated proteins. In general, the methylation of H3K9 leads to transcriptional repression of the affected target genes.
History
EC 2.1.1.355 created 1976 as EC 2.1.1.43, modified 1982, modified 1983, part transferred 2019 to EC 2.1.1.355
Pathway
ec00310  Lysine degradation
ec01100  Metabolic pathways
Orthology
K11419  [histone H3]-lysine9 N-trimethyltransferase SUV39H
K11420  [histone H3]-lysine9 N-trimethyltransferase EHMT
K11421  [histone H3]-lysine9 N-trimethyltransferase SETDB1
K11432  [histone H3]-lysine9 N-trimethyltransferase PRDM2
K18494  [histone H3]-lysine9 N-trimethyltransferase SETDB2
Genes
HSA: 10919(EHMT2) 6839(SUV39H1) 7799(PRDM2) 79723(SUV39H2) 79813(EHMT1) 83852(SETDB2) 9869(SETDB1)
PTR: 107971148(SUV39H1) 452719(SETDB2) 462572(EHMT2) 464891(EHMT1) 466014(SUV39H2) 469125(PRDM2) 469481(SETDB1)
PPS: 100968253(EHMT1) 100972839(SETDB1) 100977497(SUV39H1) 100982469(SUV39H2) 100986951(SETDB2) 100991724(EHMT2) 103782930(PRDM2)
GGO: 101125370(PRDM2) 101126338(SUV39H2) 101139808(EHMT2) 101141713(SETDB2) 101146215(SETDB1) 101146540(SUV39H1) 101151843(EHMT1)
PON: 100172621(SUV39H1) 100431310(SETDB1) 100436926(SUV39H2) 100436958(PRDM2) 100437576(SETDB2) 100449422(EHMT1) 100460372(EHMT2)
NLE: 100581330(SETDB1) 100582767(PRDM2) 100584465(EHMT1) 100591032(SUV39H2) 100593118 100598636(SUV39H1) 100606578(EHMT2)
MCC: 697378(SUV39H2) 706277(SETDB2) 711040(SUV39H1) 715824(EHMT2) 716141(SETDB1) 716295(PRDM2) 721470(EHMT1)
MCF: 101926557(PRDM2) 102117410(SETDB1) 102124788(SETDB2) 102125769(EHMT1) 102134179(SUV39H1) 102136014(SUV39H2) 102139754(EHMT2)
CSAB: 103214423(SETDB2) 103221737(EHMT2) 103225565(PRDM2) 103231938(SUV39H1) 103237926(SUV39H2) 103239544(EHMT1) 103241360 103247223(SETDB1)
RRO: 104660660(SUV39H1) 104662745(SETDB2) 104664471(SUV39H2) 104669606(EHMT1) 104674046(PRDM2) 104678126(EHMT2) 104681064(SETDB1)
RBB: 108517467(SUV39H1) 108519969 108520267(EHMT2) 108530731(SETDB2) 108531071(SUV39H2) 108533259(SETDB1) 108542880(EHMT1)
CJC: 100385110(PRDM2) 100394788(SETDB2) 100398057(EHMT1) 100401369(SUV39H1) 100401513(SUV39H2) 100408867(EHMT2) 100411734(SETDB1)
SBQ: 101040475(SUV39H2) 101042658(SETDB1) 101043411(SETDB2) 101046305(EHMT2) 101052197(SUV39H1) 101054202(PRDM2) 101054241(EHMT1)
MMU: 107303348(Gm45935) 110147(Ehmt2) 110593(Prdm2) 20937(Suv39h1) 239122(Setdb2) 64707(Suv39h2) 77683(Ehmt1) 84505(Setdb1)
MCAL: 110284133(Ehmt2) 110287176(Suv39h1) 110289296(Suv39h2) 110291522(Setdb1) 110293588(Prdm2) 110309030(Setdb2) 110312405(Ehmt1)
MPAH: 110313347(Suv39h1) 110317691(Ehmt1) 110320737(Setdb1) 110322886(Prdm2) 110325326(Setdb2) 110333642(Suv39h2) 110335935(Ehmt2)
RNO: 100361710(Setdb2) 302553(Suv39h1) 313678(Prdm2) 361798(Ehmt2) 362078(Ehmt1) 364785(Suv39h2) 689883(Setdb1)
MUN: 110540015(Setdb2) 110544320 110554698(Suv39h2) 110556467(Prdm2) 110560108(Ehmt2) 110560774(Setdb1) 110561991(Suv39h1) 110565135 110565136 110565639(Ehmt1)
CGE: 100754544(Ehmt1) 100755145(Suv39h2) 100764568(Suv39h1) 100765697(Setdb1) 100769417(Ehmt2) 100773277(Prdm2) 100774155 107979496
NGI: 103724422(Ehmt2) 103727170(Setdb2) 103730089(Setdb1) 103732609(Ehmt1) 103735184(Suv39h2) 103741644(Suv39h1) 103749132 103752332(Prdm2)
HGL: 101696702(Setdb2) 101697232(Ehmt2) 101699104(Ehmt1) 101699822(Prdm2) 101701917(Suv39h2) 101706867(Suv39h1) 101715248(Setdb1)
CCAN: 109681205(Setdb1) 109688969(Ehmt1) 109689573(Ehmt2) 109691104(Setdb2) 109691500(Suv39h2) 109701207(Suv39h1) 109702677(Prdm2)
OCU: 100342335(PHF11) 100348361(EHMT1) 100354725(SUV39H1) 100355131(EHMT2) 100355877(SETDB1) 100358024(SUV39H2) 103352508(PRDM2)
TUP: 102468719(SUV39H1) 102472765 102479735(EHMT2) 102495109(SUV39H2) 102498729(EHMT1) 102499550(PRDM2) 102502264(SETDB1) 102503290(SETDB2)
CFA: 100688431(PRDM2) 474851(EHMT2) 477995(SUV39H2) 483186(SETDB1) 485441(SETDB2) 491224(EHMT1) 491868(SUV39H1)
VVP: 112907242(SUV39H1) 112907769(SETDB1) 112911417(EHMT1) 112913622(EHMT2) 112929764(PRDM2) 112933120(SUV39H2) 112933943(SETDB2)
AML: 100466861(EHMT1) 100468794(EHMT2) 100469547(SUV39H2) 100472595(SUV39H1) 100476962(SETDB2) 100481446(PRDM2) 100482250(SETDB1)
UMR: 103664189(SUV39H2) 103666633(PRDM2) 103667532(SETDB1) 103669105(SUV39H1) 103675323(EHMT1) 103677615(SETDB2) 103682289(EHMT2)
UAH: 113241391(SUV39H2) 113243735(EHMT2) 113246155(SETDB1) 113248390 113248430 113251315 113265922(SUV39H1) 113270485(PRDM2)
ORO: 101364966(PRDM2) 101372094(SETDB1) 101374258(SUV39H2) 101375740(EHMT1) 101376988(EHMT2) 101381146(SUV39H1) 101381937(SETDB2)
FCA: 101082169(PRDM2) 101083571(SUV39H1) 101087111(EHMT1) 101091940(EHMT2) 101094118(SETDB1) 101099218(SUV39H2)
PTG: 102950897(SUV39H1) 102954489(EHMT1) 102962904(SETDB2) 102963752(SUV39H2) 102967892(PRDM2) 102968259(EHMT2) 102970727(SETDB1)
PPAD: 109248069(SUV39H1) 109257028(SETDB1) 109260239(EHMT1) 109260503(EHMT2) 109265964 109273698(SUV39H2) 109274376(PRDM2)
AJU: 106970864(SUV39H1) 106971016(SUV39H2) 106972687 106979835(SETDB1) 106983481(EHMT2) 106988167(PRDM2) 106989056(EHMT1)
BTA: 100138100(SETDB1) 509382(SETDB2) 514062(EHMT2) 523047(SUV39H1) 528606(EHMT1) 536936(SUV39H2) 789222(PRDM2)
BOM: 102264756(SUV39H2) 102271111(EHMT1) 102271191(SUV39H1) 102279999(EHMT2) 102281203(PRDM2) 102287560(SETDB2) 102288279(SETDB1)
BIU: 109555305(SETDB1) 109565691(EHMT1) 109566720(SETDB2) 109567973(SUV39H2) 109570372(PRDM2) 109576929(EHMT2)
BBUB: 102392662(SETDB2) 102395323(EHMT1) 102396138(PRDM2) 102401546(SUV39H1) 102405188(EHMT2) 102408652(SETDB1) 102415169(SUV39H2)
CHX: 102171636(PRDM2) 102174919(SUV39H1) 102176621(SUV39H2) 102178316(EHMT2) 102180982(SETDB1) 102186776(SETDB2) 102189411(EHMT1)
OAS: 101109230(SETDB1) 101110031(SUV39H1) 101115739(EHMT2) 101116064(SETDB2) 101116417(SUV39H2) 101123545(EHMT1) 105601941(PRDM2)
SSC: 100124382(EHMT2) 100157885(SETDB2) 100157920(SETDB1) 100518559(PRDM2) 110258080(EHMT1) 664651(SUV39H2) 767626(SUV39H1)
CFR: 102512057(SETDB1) 102512972(SUV39H1) 102514882(PRDM2) 102514903(SETDB2) 102518579(EHMT2) 102521199(SUV39H2) 102521526(EHMT1)
CDK: 105087443(EHMT2) 105101932(SETDB2) 105102102(EHMT1) 105103196(SETDB1) 105103308(SUV39H1) 105104521(SUV39H2) 105107110(PRDM2)
BACU: 102999710(SUV39H2) 103005831(SUV39H1) 103009894(SETDB1) 103017152(SETDB2) 103017744(EHMT1) 103018553(EHMT2) 103020862(PRDM2)
LVE: 103068757(SETDB2) 103072310(EHMT2) 103073919(SUV39H1) 103076461(SETDB1) 103079038(EHMT1) 103083070(PRDM2) 103084616(SUV39H2) 103088198
OOR: 101269551(PRDM2) 101270688(SETDB1) 101272833(EHMT1) 101275448(SETDB2) 101279239(SUV39H2) 101282385(EHMT2) 101289196(SUV39H1)
DLE: 111169525(SUV39H1) 111169744(SETDB1) 111170699(EHMT2) 111175303 111176964(EHMT1) 111178089(SUV39H2) 111187234(PRDM2)
PCAD: 102974835(PRDM2) 102978732(EHMT1) 102981491 102988226(SUV39H2) 102988363(SUV39H1) 102990347(SETDB2) 102993056(EHMT2) 114486049 114486183
ECB: 100054973(PRDM2) 100056120(SETDB2) 100058869(EHMT1) 100059118(EHMT2) 100059254(SETDB1) 100062108(SUV39H1) 100068891(SUV39H2)
EPZ: 103544360 103544897(SUV39H1) 103547642(SETDB1) 103554163(EHMT1) 103556824(SUV39H2) 103563300(EHMT2) 103563428(SETDB2) 103564688(PRDM2)
EAI: 106822324(EHMT2) 106822761(EHMT1) 106827436(SUV39H1) 106828015(PRDM2) 106829693(SETDB2) 106840452(SUV39H2) 106846522(SETDB1)
MYB: 102243180(SUV39H1) 102245485(EHMT1) 102248401(SETDB2) 102249747(PRDM2) 102257713(SETDB1) 102260054(SUV39H2) 102263672(EHMT2)
MYD: 102756540(EHMT1) 102757145(SUV39H2) 102760935(PRDM2) 102763954(SUV39H1) 102765299(SETDB2) 102773684(SETDB1) 102773857(EHMT2)
MNA: 107531408(SETDB2) 107531564 107534821(SUV39H2) 107536199(EHMT1) 107538997(EHMT2) 107539129(SETDB1) 107541392(SUV39H1)
HAI: 109372277(SETDB1) 109373117(EHMT2) 109374812(SUV39H1) 109381271(PRDM2) 109382055(EHMT1) 109387125(SETDB2) 109393823(SUV39H2)
DRO: 112299124(PRDM2) 112302258(EHMT2) 112306260(EHMT1) 112313171 112313537(SETDB1) 112320455(SUV39H2) 112322458(SUV39H1)
PALE: 102879374(EHMT2) 102879589(PRDM2) 102886191(SETDB1) 102891996 102893102(EHMT1) 102894853(SUV39H1) 102898400(SUV39H2)
RAY: 107498490(EHMT2) 107499036(SETDB1) 107503067(EHMT1) 107504834(SUV39H2) 107505354 107510017(SETDB2) 107513143(PRDM2) 107515026(SUV39H1)
MJV: 108389857 108397103(SUV39H2) 108397963(PRDM2) 108400840(EHMT2) 108403560(SETDB2) 108404637 108405374(EHMT1) 108408400(SUV39H1) 108409453(SETDB1)
LAV: 100653780(SUV39H1) 100658021(PRDM2) 100659207(EHMT2) 100660736(EHMT1) 100670438 100673374(SETDB1) 100674328(SUV39H2) 104847199
MDO: 100010516(PRDM2) 100014806(SUV39H2) 100018670(SUV39H1) 100023838(EHMT1) 100025360(EHMT2) 100028710(SETDB2) 100618580(SETDB1)
SHR: 100922258(SUV39H1) 100928904(SETDB1) 100931147(EHMT2) 100932927(EHMT1) 100933751(SUV39H2) 100934863(SETDB2) 100934867(PRDM2)
PCW: 110198885(PRDM2) 110199440(EHMT2) 110201087(SUV39H1) 110205249(EHMT1) 110213411(SETDB2) 110217388(SUV39H2) 110220597(SETDB1)
OAA: 100078328(EHMT1) 100082943(EHMT2) 100083315(SETDB2) 100084051(SUV39H1) 100085175(SUV39H2) 100091318(SETDB1) 100681503(PRDM2)
GGA: 100859816(SETDB1) 112529925 112529927(SUV39H1) 395847(MLLT11) 417250(EHMT1) 418866(SETDB2) 419478(PRDM2) 426314(SUV39H2)
MGP: 100538392(EHMT1) 100539540(SUV39H2) 100542346(SETDB1) 100548070 100550682(SETDB2) 104914188(PRDM2)
CJO: 107307203(SUV39H1) 107308162(SETDB2) 107308165(PHF11) 107319605(SUV39H2) 107321652(EHMT1) 107323354(PRDM2) 107324577(SETDB1)
NMEL: 110387900(SETDB1) 110391539(SUV39H1) 110392282(SUV39H2) 110402348 110406734(EHMT1) 110408674(PRDM2)
APLA: 101790074 101794756(SETDB1) 101795723(PRDM2) 101796000(SUV39H2) 101805087(EHMT1)
ACYG: 106035063(PHF11) 106035084(SETDB2) 106037080(EHMT1) 106040216(PRDM2) 106046190(SUV39H2) 106049268(SETDB1)
LSR: 110469585 110470972(SUV39H2) 110476787(PRDM2) 110476821(SETDB1) 110476956(EHMT1) 110481760(SUV39H1) 110482327
GFR: 102031848(SUV39H2) 102034546(SETDB1) 102036198(EHMT1) 102043625(SETDB2) 102043786(PHF11) 106631968(PRDM2)
FAB: 101806838(EHMT1) 101812782(PRDM2) 101812936(PHF11) 101814584 101816158(SUV39H2)
PHI: 102099526(EHMT1) 102101563(SETDB1) 102103897(PHF11) 102104074(SETDB2) 102106085 102110616(SUV39H1) 102111894(PRDM2) 102114300(SUV39H2) 106629066
PMAJ: 107204624(SUV39H2) 107211503 107212039(EHMT1) 107213672(PRDM2) 107214655(SETDB1)
CCAE: 111923103(SUV39H2) 111935294 111936927(EHMT1) 111938730(PRDM2) 111939473(SETDB1)
CCW: 104688230(EHMT1) 104689965 104693258(PRDM2) 104694491(SUV39H2)
ETL: 114060918 114065121(PRDM2) 114067139(EHMT1) 114067551(SUV39H2) 114071955(SETDB1) 114073290 114073634
FPG: 101912073(SETDB1) 101912234(PHF11) 101912815(SUV39H2) 101914490(PRDM2) 101916063(EHMT1) 101917763(SETDB2)
FCH: 102055212(SETDB1) 102055395 102057247(EHMT1) 102059458(SUV39H2) 106631029(PRDM2)
CLV: 102085960(EHMT1) 102088543 102092575(PRDM2) 102094505(SETDB1) 102098917(SUV39H2)
EGZ: 104124045(EHMT1) 104129700(SETDB1) 104131606(SETDB2) 104131607(PHF11) 104132393(SUV39H2) 104133098(PRDM2)
NNI: 104009017 104010895(PHF11) 104010896(SETDB2) 104014430(SETDB1) 104014630(SUV39H2) 104022219(EHMT1)
ACUN: 113486655(EHMT1) 113487883(PRDM2) 113488725(SETDB1) 113489224(SETDB2) 113489768(SUV39H2)
PADL: 103913457(PHF11) 103913458(SETDB2) 103915032(SUV39H2) 103918059(PRDM2) 103918930(EHMT1) 103919479(SETDB1)
AAM: 106482427(PRDM2) 106485143(SUV39H2) 106489242(PHF11) 106489246(SETDB2) 106493032(EHMT1) 106495416(SETDB1)
ASN: 102371718(PRDM2) 102374916(EHMT1) 102375358(SUV39H2) 102378805(SUV39H1) 102380189 102381770(EHMT2) 102382539(SETDB1)
AMJ: 102558468(SUV39H1) 102561958(PRDM2) 102563656(SUV39H2) 102564850(EHMT1) 102574756(EHMT2) 102575637(SETDB1) 102576351(SETDB2)
CMY: 102932556(PHF11) 102932781(SETDB2) 102933671(EHMT1) 102937045(SUV39H2) 102937828(SETDB1) 102937831(SUV39H1) 102942942(PRDM2)
CPIC: 101931963(SETDB1) 101939547(PRDM2) 101942163(EHMT1) 101945875(SUV39H2) 101947321(EHMT2) 101950077(PHF11) 101950365(SETDB2) 101951503(SUV39H1)
ACS: 100552443(setdb2) 100553897(suv39h1) 100556375(ehmt2) 100565730(ehmt1) 100565799(setdb1) 100567365(prdm2)
PVT: 110072610 110080651(SETDB2) 110080653(PHF11) 110081193(SUV39H1) 110081479(SETDB1) 110088696(EHMT2) 110089799(EHMT1)
PBI: 103049261(EHMT2) 103052540(SUV39H1) 103053131(SETDB1) 103053645 103057390(EHMT1) 103060604(PRDM2) 103067345 107326457(PHF11)
PMUR: 107283956 107284269(SETDB2) 107291380(PRDM2) 107292899(SETDB1) 107295037(EHMT2) 107297347(EHMT1) 107300048(SUV39H1) 107302473
PMUA: 114583936 114586177(SETDB1) 114588136(SUV39H1) 114589035(EHMT1) 114592073(EHMT2) 114593254(SETDB2) 114602405(PRDM2)
GJA: 107105480(EHMT2) 107106223(PRDM2) 107112843(SUV39H1) 107113385(SETDB2) 107118801(EHMT1) 107119301 107119302 107121584(SETDB1)
XLA: 100037174(suv39h2.L) 108696585(prdm2.L) 108698163(ehmt1.L) 108698559(ehmt2.L) 108699889(ehmt1.S) 108700299(suv39h1.S) 108700333(setdb1.S) 108713053(suv39h2.S) 398711(setdb2.S) 431943(suv39h1.L) 432147(setdb1.L) 494709(prdm2.S)
XTR: 100124713(ehmt1) 100124743(setdb2) 100170624(prdm2) 100484992(ehmt2) 100490309(setdb1) 549262(suv39h2)
NPR: 108783946(PRDM2) 108786543(EHMT2) 108788266(SUV39H1) 108789810(SETDB1) 108794066(SUV39H2) 108794390(EHMT1) 108797823(SETDB2)
DRE: 100003615(prdm2a) 100005761(ehmt1a) 326906(suv39h1b) 335153(setdb2) 402830(ehmt1b) 445198(suv39h1a) 553292(setdb1a) 569250(ehmt2) 768131(setdb1b) 797296(prdm2b)
CSEM: 103384853(suv39h1) 103384937 103385671(prdm2) 103388279(setdb1) 103389041 103389803(setdb2) 103394057(ehmt2) 103394578 103397363
SFM: 108918498(prdm2) 108922673(ehmt1) 108923796(setdb1) 108924930 108934780(suv39h1) 108935584(ehmt2) 108937739 108938542
LCM: 102351913 102356699(SETDB1) 102359250(PRDM2) 102359445(EHMT2) 102360554(SUV39H2) 102361297(EHMT1) 102363588(SETDB2) 106705364
CMK: 103173106 103180404(ehmt1) 103181338(prdm2)
RTP: 109911717(setdb2) 109919887(ehmt2) 109921345(suv39h2) 109925832 109926709(ehmt1) 109937263(prdm2)
DME: Dmel_CG12196(egg) Dmel_CG2995(G9a) Dmel_CG43664(Su(var)3-9) Dmel_CG43665(eIF2gamma)
DSI: Dsimw501_GD16494(Dsim_GD16494) Dsimw501_GD24920(Dsim_GD24920)
NVI: 100116736(SUV39H1) 100120014(Setdb1) 100121084(Ehmt1)
BMOR: 101742950 101743644 692623(Su(var)3-9)
CEL: CELE_R05D3.11(met-2)
CBR: CBG18157(Cbr-met-2)
TSP: Tsp_05330
EGL: EGR_06122
ATH: AT1G17770(SUVH7) AT1G73100(SUVH3) AT2G22740(SUVH6) AT2G24740(SDG21) AT2G33290(SUVH2) AT2G35160(SUVH5) AT4G13460(SUVH9) AT5G04940(SUVH1) AT5G13960(SUVH4)
LJA: Lj0g3v0007239.1(Lj0g3v0007239.1) Lj0g3v0128679.1(Lj0g3v0128679.1) Lj0g3v0265609.1(Lj0g3v0265609.1) Lj0g3v0266169.1(Lj0g3v0266169.1) Lj0g3v0269559.1(Lj0g3v0269559.1) Lj0g3v0293009.1(Lj0g3v0293009.1) Lj1g3v3904410.1(Lj1g3v3904410.1) Lj1g3v4059050.1(Lj1g3v4059050.1) Lj2g3v1989010.1(Lj2g3v1989010.1) Lj2g3v1989010.2(Lj2g3v1989010.2) Lj2g3v1989010.3(Lj2g3v1989010.3) Lj2g3v1989020.1(Lj2g3v1989020.1) Lj2g3v1989030.1(Lj2g3v1989030.1) Lj2g3v1989040.1(Lj2g3v1989040.1) Lj2g3v1989040.2(Lj2g3v1989040.2) Lj5g3v2244670.1(Lj5g3v2244670.1) Lj6g3v0156100.1(Lj6g3v0156100.1) Lj6g3v0156120.1(Lj6g3v0156120.1)
DOSA: Os01t0811300-01(Os01g0811300) Os01t0927000-01(Os01g0927000) Os03t0320400-01(Os03g0320400) Os04t0544100-01(Os04g0544100) Os05t0490700-01(Os05g0490700) Os07t0435900-01(Os07g0435900) Os08t0399300-00(Os08g0399300) Os08t0400000-01(Os08g0400000) Os08t0400200-00(Os08g0400200) Os08t0565700-01(Os08g0565700) Os09t0362900-01(Os09g0362900) Os11t0131600-00(Os11g0131600) Os11t0602200-01(Os11g0602200) Os12t0128450-00(Os12g0128450)
ATS: 109741537(LOC109741537) 109741621 109744867(LOC109744867) 109746199(LOC109746199) 109749138(LOC109749138) 109749619(LOC109749619) 109750455(LOC109750455) 109751482(LOC109751482) 109761403(LOC109761403) 109766085(LOC109766085) 109769949(LOC109769949) 109769961(LOC109769961) 109770115 109771886 109774279(LOC109774279) 109777308(LOC109777308) 109782755(LOC109782755)
CRE: CHLREDRAFT_6823(SET3)
VCN: VOLCADRAFT_93418(VSET3)
NCR: NCU04402(dim-5)
NTE: NEUTE1DRAFT121214(NEUTE1DRAFT_121214)
MGR: MGG_06852
SSCK: SPSK_07647
NHE: NECHADRAFT_94199(SDG2104)
MAW: MAC_09094
MAJ: MAA_00272
CMT: CCM_00746
BFU: BCIN_11g02360(BcDIM5)
MBE: MBM_05751
ANI: AN1170.2
ANG: ANI_1_1828074(An08g03380)
ABE: ARB_02816
TVE: TRV_01916
PTE: PTT_11395
ZTR: MYCGRDRAFT_107709(SDG2411)
SPO: SPBC428.08c(clr4)
CNE: CNH00720
CNB: CNBL0680
LBC: LACBIDRAFT_296206(SDG16210)
ABP: AGABI1DRAFT108076(AGABI1DRAFT_108076) AGABI1DRAFT129982(AGABI1DRAFT_129982)
ABV: AGABI2DRAFT146074(AGABI2DRAFT_146074) AGABI2DRAFT180791(AGABI2DRAFT_180791)
DFA: DFA_00949(suvA)
 » show all
Taxonomy
Reference
1  [PMID:11094092]
  Authors
O'Carroll D, Scherthan H, Peters AH, Opravil S, Haynes AR, Laible G, Rea S, Schmid M, Lebersorger A, Jerratsch M, Sattler L, Mattei MG, Denny P, Brown SD, Schweizer D, Jenuwein T
  Title
Isolation and characterization of Suv39h2, a second histone H3 methyltransferase  gene that displays testis-specific expression.
  Journal
Mol Cell Biol 20:9423-33 (2000)
  Sequence
[mmu:20937 64707]
Reference
2  [PMID:11867540]
  Authors
Schotta G, Ebert A, Krauss V, Fischer A, Hoffmann J, Rea S, Jenuwein T, Dorn R, Reuter G
  Title
Central role of Drosophila SU(VAR)3-9 in histone H3-K9 methylation and heterochromatic gene silencing.
  Journal
EMBO J 21:1121-31 (2002)
  Sequence
Reference
3  [PMID:12130538]
  Authors
Tachibana M, Sugimoto K, Nozaki M, Ueda J, Ohta T, Ohki M, Fukuda M, Takeda N, Niida H, Kato H, Shinkai Y
  Title
G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis.
  Journal
Genes Dev 16:1779-91 (2002)
  Sequence
[mmu:110147]
Reference
4  [PMID:11959841]
  Authors
Schultz DC, Ayyanathan K, Negorev D, Maul GG, Rauscher FJ 3rd
  Title
SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase  that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins.
  Journal
Genes Dev 16:919-32 (2002)
  Sequence
[hsa:9869]
Reference
5  [PMID:14633678]
  Authors
Kim KC, Geng L, Huang S
  Title
Inactivation of a histone methyltransferase by mutations in human cancers.
  Journal
Cancer Res 63:7619-23 (2003)
  Sequence
[hsa:7799]
Reference
6  [PMID:20084102]
  Authors
Wu H, Min J, Lunin VV, Antoshenko T, Dombrovski L, Zeng H, Allali-Hassani A, Campagna-Slater V, Vedadi M, Arrowsmith CH, Plotnikov AN, Schapira M
  Title
Structural biology of human H3K9 methyltransferases.
  Journal
PLoS One 5:e8570 (2010)
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.355
IUBMB Enzyme Nomenclature: 2.1.1.355
ExPASy - ENZYME nomenclature database: 2.1.1.355
BRENDA, the Enzyme Database: 2.1.1.355

KEGG   ENZYME: 2.1.1.356Help
Entry
EC 2.1.1.356                Enzyme                                 

Name
[histone H3]-lysine27 N-trimethyltransferase;
KMT6A (gene name);
KMT6B (gene name);
EZH1 (gene name);
EZH2 (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:[histone H3]-L-lysine27 N6-methyltransferase
Reaction(IUBMB)
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine27 = 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine27 (overall reaction);
(1a) S-adenosyl-L-methionine + a [histone H3]-L-lysine27 = S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine27;
(1b) S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine27 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine27;
(1c) S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine27 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine27
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
[histone H3]-L-lysine27;
[histone H3]-N6-methyl-L-lysine27;
[histone H3]-N6,N6-dimethyl-L-lysine27
Product
S-adenosyl-L-homocysteine [CPD:C00021];
[histone H3]-N6,N6,N6-trimethyl-L-lysine27;
[histone H3]-N6-methyl-L-lysine27;
[histone H3]-N6,N6-dimethyl-L-lysine27
Comment
This entry describes enzymes that successively methylate the L-lysine27 residue of histone H3 (H3K27), ultimately generating a trimethylated form. These modifications influence the binding of chromatin-associated proteins. The methylation of lysine27 leads to transcriptional repression of the affected target genes. The enzyme associates with other proteins to form a complex that is essential for activity. The enzyme can also methylate some non-histone proteins.
History
EC 2.1.1.356 created 1976 as EC 2.1.1.43, modified 1982, modified 1983, part transferred 2019 to EC 2.1.1.356
Pathway
ec00310  Lysine degradation
ec01100  Metabolic pathways
Orthology
K11430  [histone H3]-lysine27 N-trimethyltransferase EZH2
K17451  [histone H3]-lysine27 N-trimethyltransferase EZH1
Genes
HSA: 2145(EZH1) 2146(EZH2)
PTR: 454697(EZH1) 745437(EZH2)
PPS: 100967877(EZH1) 100971244(EZH2)
GGO: 101126515(EZH1) 101147968(EZH2)
PON: 100171872(EZH1) 100447447(EZH2)
NLE: 100580962(EZH2) 100604860(EZH1)
MCC: 709075(EZH2) 711173(EZH1)
MCF: 102130547(EZH1) 102146280(EZH2)
CSAB: 103227182(EZH2) 103243395(EZH1)
RRO: 104667012(EZH2) 104680126(EZH1)
RBB: 108522307(EZH2) 108526767(EZH1)
CJC: 100394758(EZH2) 100411881(EZH1)
SBQ: 101038203(EZH1) 101051611(EZH2)
MMU: 14055(Ezh1) 14056(Ezh2)
MCAL: 110295592(Ezh2) 110304611(Ezh1)
MPAH: 110315211(Ezh2) 110331872(Ezh1)
RNO: 303547(Ezh1) 312299(Ezh2)
MUN: 110547503(Ezh2) 110550881(Ezh1)
CGE: 100758055(Ezh2) 100760595(Ezh1)
NGI: 103731383(Ezh2) 103735912(Ezh1)
HGL: 101702710(Ezh2) 101723063(Ezh1)
CCAN: 109687337(Ezh1) 109695508(Ezh2)
OCU: 100345157(EZH2) 100351852(EZH1)
TUP: 102485788(EZH1) 102495627(EZH2)
CFA: 475511(EZH2) 480516(EZH1)
VVP: 112910738(EZH1) 112934818(EZH2)
AML: 100466177(EZH2) 100472619(EZH1)
UMR: 103668955(EZH2) 103672584(EZH1)
UAH: 113241452(EZH2) 113265406(EZH1)
ORO: 101369941(EZH2) 101379551(EZH1)
FCA: 101087309(EZH2) 101099602(EZH1)
PTG: 102956220(EZH2) 102961028(EZH1)
PPAD: 109258535(EZH1) 109269218(EZH2)
AJU: 106972615(EZH1) 106981407(EZH2)
BTA: 509106(EZH2) 533087(EZH1)
BOM: 102276653(EZH1) 102287858(EZH2)
BIU: 109557756(EZH2) 109573994(EZH1)
BBUB: 102405899(EZH2) 102407322(EZH1)
CHX: 102189343(EZH1) 102190101(EZH2)
OAS: 101104765(EZH1) 101120745(EZH2)
SSC: 100518394(EZH1) 100625497(EZH2)
CFR: 102515793(EZH2) 102516907(EZH1)
CDK: 105085196(EZH2) 105090473(EZH1)
LVE: 103069623(EZH2) 103073364(EZH1)
OOR: 101280796(EZH2) 101285746(EZH1)
DLE: 111166246(EZH1) 111177205(EZH2)
PCAD: 102994010(EZH2) 102994197(EZH1) 112061879
ECB: 100051290(EZH2) 100052411(EZH1)
EPZ: 103545927 103550351(EZH1) 103553703(EZH2)
EAI: 106826432(EZH1) 106842131(EZH2)
MYB: 102246299(EZH2) 102259730(EZH1)
MYD: 102755313(EZH1) 102768989(EZH2)
MNA: 107523768(EZH2) 107528927(EZH1)
HAI: 109395452(EZH2) 109395755(EZH1)
DRO: 112298572(EZH1) 112308348(EZH2)
PALE: 102879627(EZH1) 102886689(EZH2)
RAY: 107500533(EZH2) 107513838(EZH1)
MJV: 108386069(EZH1) 108386657(EZH2)
LAV: 100664312(EZH2) 100673691(EZH1)
MDO: 100010738(EZH1) 100013390(EZH2)
SHR: 100926678(EZH2) 100932535(EZH1)
PCW: 110198374(EZH1) 110201666(EZH2)
OAA: 100073485(EZH2) 100082851(EZH1)
GGA: 420023(EZH1) 420784(EZH2)
MGP: 100540374(EZH2) 100547448(EZH1)
CJO: 107309835(EZH2) 107325326(EZH1)
NMEL: 110388515(EZH1) 110390789(EZH2)
APLA: 101791765(EZH1) 101793453(EZH2)
ACYG: 106048025(EZH1) 106048735(EZH2)
TGU: 100226728(EZH2) 100227472(EZH1)
LSR: 110471820(EZH1) 110479186(EZH2)
SCAN: 103819367(EZH2) 103821570(EZH1)
GFR: 102035477(EZH1) 102038673(EZH2)
FAB: 101809240(EZH2) 101811414(EZH1)
PHI: 102099930(EZH2) 102103576(EZH1)
PMAJ: 107200653(EZH2) 107215126(EZH1)
CCAE: 111923642(EZH2) 111940096(EZH1)
CCW: 104688925(EZH2) 104697765(EZH1)
ETL: 114063607(EZH1) 114063865(EZH2)
FPG: 101911332(EZH2) 101915579(EZH1)
FCH: 102052374(EZH1) 102055584(EZH2)
CLV: 102093761(EZH2) 102097006(EZH1)
EGZ: 104125781(EZH2) 104134781(EZH1)
NNI: 104009878(EZH1) 104015388(EZH2)
ACUN: 113477549(EZH2) 113489070
PADL: 103916088(EZH2) 103919098(EZH1)
AAM: 106491114(EZH1) 106495267(EZH2)
ASN: 102372569(EZH2) 102383438(EZH1)
AMJ: 102562122(EZH2) 102566481(EZH1)
PSS: 102453330(EZH2) 102463087(EZH1)
CMY: 102932650(EZH2) 102934538(EZH1)
CPIC: 101934118(EZH1) 101937752(EZH2)
ACS: 100559669(ezh1) 100564989(ezh2)
PVT: 110080273(EZH1) 110088673(EZH2)
PBI: 103051581(EZH2) 103052924(EZH1)
PMUR: 107288847(EZH2) 107290401 107302416(EZH1)
TSR: 106547020(EZH2) 106554239(EZH1)
PMUA: 114581626(EZH1) 114607413(EZH2)
GJA: 107119624(EZH2) 107123351(EZH1)
XLA: 100381148(ezh2.S) 108701022(ezh1.L) 108702719(ezh1.S) 399174(ezh2.L)
XTR: 100493532(ezh1) 550047(ezh2)
NPR: 108794364(EZH2) 108796324(EZH1)
DRE: 664754(ezh1) 768133(ezh2)
IPU: 108256455(ezh2) 108279279(ezh1)
PHYP: 113528051(ezh1) 113541351(ezh2)
AMEX: 103027230(ezh2) 103044086(ezh1)
EEE: 113589064(ezh2) 113590056
TRU: 101068728(ezh2) 101070195(ezh1)
LCO: 104923910(ezh1) 104933871(ezh2)
NCC: 104940789(ezh2) 104944052
MZE: 101464777 101474304(ezh1) 112429845(ezh2)
ONL: 100695015(ezh1) 100702594(ezh2)
OLA: 100125823(ezh2) 101166385(ezh1)
XMA: 102218572(ezh2) 102228014(ezh1)
XCO: 114136427(ezh2) 114160264(ezh1)
PRET: 103457011(ezh2) 103468644(ezh1) 103469387
CVG: 107091776(ezh1) 107097879(ezh2)
NFU: 107378461(ezh1) 107383138(ezh2)
KMR: 108243802(ezh1) 108249555(ezh2)
ALIM: 106511331 106528219(ezh1) 106531656(ezh2)
AOCE: 111564547(ezh1) 111570645(ezh2)
CSEM: 103377188(ezh2) 103393149(ezh1) 103399469
LCF: 108884998(ezh2) 108900993(ezh1)
SDU: 111217595(ezh1) 111238320(ezh2)
SLAL: 111647273(ezh2) 111660565(ezh1)
HCQ: 109508596 109521815(ezh2)
BPEC: 110158320(ezh2) 110166859(ezh1)
MALB: 109951056(ezh2) 109964204(ezh1)
ELS: 105013194(ezh1) 105022040(ezh2)
LCM: 102364190(EZH1)
CMK: 103187005(ezh2)
CIN: 100177449
SPU: 585842
APLC: 110990448
DME: Dmel_CG6502(E(z))
DER: 6546346
DSI: Dsimw501_GD12857(Dsim_GD12857)
DSR: 110185151
DPE: 6601386
DMN: 108151423
DWI: 6646360
DAZ: 108614083
DNV: 108652219
MDE: 101887292
LCQ: 111677283
AAG: 5577466
AALB: 109401157
AME: 552235
BIM: 100747000
BTER: 100647736
CCAL: 108631087
OBB: 114880742
SOC: 105197183
MPHA: 105835069
AEC: 105143480
ACEP: 105617407
PBAR: 105425935
VEM: 105559070
DQU: 106746421
CFO: 105250747
LHU: 105670949
PGC: 109855910
OBO: 105285382
PCF: 106792137
NVI: 100113526(E(z))
CSOL: 105367879
TCA: 659759
DPA: 109536169
NVL: 108560889
BMOR: 101739540 101745450(E(Z))
PMAC: 106718913
PRAP: 110995414
HAW: 110375985
TNL: 113498098
API: 100168406
DNX: 107161946
AGS: 114123060
RMD: 113551950
BTAB: 109035984
CLEC: 106666006
ZNE: 110841374
DPTE: 113792645
PTEP: 107455687
CEL: CELE_R06A4.7(mes-2)
CBR: CBG11099(Cbr-mes-2)
BMY: Bm1_55060
TSP: Tsp_01566
PCAN: 112556350
CRG: 105330640
MYI: 110442389
OBI: 106874217
LAK: 106181368
EGL: EGR_02209
EPA: 110249650
AMIL: 114967312
PDAM: 113673889
SPIS: 111323365
DGT: 114531596
HMG: 100201207
AQU: 109587656
ATH: AT1G02580(MEA) AT2G23380(CLF) AT4G02020(SWN)
LJA: Lj0g3v0213049.1(Lj0g3v0213049.1) Lj2g3v1890940.1(Lj2g3v1890940.1) Lj2g3v1890940.2(Lj2g3v1890940.2) Lj5g3v1598420.1(Lj5g3v1598420.1) Lj5g3v1598420.2(Lj5g3v1598420.2) Lj5g3v1598420.3(Lj5g3v1598420.3) Lj5g3v1598420.4(Lj5g3v1598420.4)
SLY: 100134891(EZ1) 100134892(EZ2) 101267964
DOSA: Os03t0307800-01(Os03g0307800) Os06t0275500-01(Os06g0275500)
ATS: 109742834(LOC109742834) 109781663(LOC109781663) 109781665(LOC109781665)
ZMA: 541954(mez1) 541955(mez3) 542659(mez2)
PPP: 112274954
MNG: MNEG_1960
MBE: MBM_04736
PTE: PTT_08614
ZTR: MYCGRDRAFT_71291(SDG2401)
LBC: LACBIDRAFT_312288(SDG16204)
 » show all
Taxonomy
Reference
1  [PMID:12351676]
  Authors
Cao R, Wang L, Wang H, Xia L, Erdjument-Bromage H, Tempst P, Jones RS, Zhang Y
  Title
Role of histone H3 lysine 27 methylation in Polycomb-group silencing.
  Journal
Science 298:1039-43 (2002)
  Sequence
[hsa:2146]
Reference
2  [PMID:12435631]
  Authors
Kuzmichev A, Nishioka K, Erdjument-Bromage H, Tempst P, Reinberg D
  Title
Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein.
  Journal
Genes Dev 16:2893-905 (2002)
  Sequence
[hsa:2146]
Reference
3  [PMID:15231737]
  Authors
Kirmizis A, Bartley SM, Kuzmichev A, Margueron R, Reinberg D, Green R, Farnham PJ
  Title
Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27.
  Journal
Genes Dev 18:1592-605 (2004)
  Sequence
[hsa:2146]
Reference
4  [PMID:17200670]
  Authors
Schlesinger Y, Straussman R, Keshet I, Farkash S, Hecht M, Zimmerman J, Eden E, Yakhini Z, Ben-Shushan E, Reubinoff BE, Bergman Y, Simon I, Cedar H
  Title
Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo  methylation in cancer.
  Journal
Nat Genet 39:232-6 (2007)
  Sequence
[hsa:2146]
Reference
5  [PMID:19026780]
  Authors
Shen X, Liu Y, Hsu YJ, Fujiwara Y, Kim J, Mao X, Yuan GC, Orkin SH
  Title
EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency.
  Journal
Mol Cell 32:491-502 (2008)
  Sequence
[mmu:14055 14056]
Reference
6  [PMID:21317239]
  Authors
Ezhkova E, Lien WH, Stokes N, Pasolli HA, Silva JM, Fuchs E
  Title
EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair.
  Journal
Genes Dev 25:485-98 (2011)
  Sequence
[mmu:14055 14056]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.356
IUBMB Enzyme Nomenclature: 2.1.1.356
ExPASy - ENZYME nomenclature database: 2.1.1.356
BRENDA, the Enzyme Database: 2.1.1.356

KEGG   ENZYME: 2.1.1.358Help
Entry
EC 2.1.1.358                Enzyme                                 

Name
[histone H3]-dimethyl-L-lysine36 N-methyltransferase;
KMT3A (gene name);
SETD2 (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:[histone H3]-N6,N6-dimethyl-L-lysine36 N6-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine36 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine36
Reaction(KEGG)
(other) R04867
Show
Substrate
S-adenosyl-L-methionine [CPD:C00019];
[histone H3]-N6,N6-dimethyl-L-lysine36
Product
S-adenosyl-L-homocysteine [CPD:C00021];
[histone H3]-N6,N6,N6-trimethyl-L-lysine36
Comment
The enzyme, found in metazoa, methylates a dimethylated L-lysine36 residue of histone H3 (H3K36), which has been methylated previously by EC 2.1.1.357, [histone H3]-lysine36 N-dimethyltransferase. The homologous enzyme from yeast catalyses all three methylations (see EC 2.1.1.359, [histone H3]-lysine36 N-trimethyltransferase).
History
EC 2.1.1.358 created 1976 as EC 2.1.1.43, modified 1982, modified 1983, part transferred 2019 to EC 2.1.1.358
Pathway
ec00310  Lysine degradation
ec01100  Metabolic pathways
Orthology
K11423  [histone H3]-dimethyl-L-lysine36 N-methyltransferase
Genes
HSA: 29072(SETD2)
PTR: 460331(SETD2)
PPS: 100993006(SETD2)
GGO: 101132140(SETD2)
PON: 100433116(SETD2)
NLE: 100584442(SETD2)
MCC: 711825(SETD2)
MCF: 102121581(SETD2)
CSAB: 103227561(SETD2)
RRO: 104671311(SETD2)
RBB: 108517641(SETD2)
CJC: 100411953(SETD2)
SBQ: 101034613(SETD2)
MMU: 235626(Setd2)
MCAL: 110301050(Setd2)
MPAH: 110328077(Setd2)
RNO: 316013(Setd2)
MUN: 110554986(Setd2)
CGE: 100765637(Setd2)
NGI: 103732034(Setd2)
HGL: 101719404(Setd2)
CCAN: 109689467 109689470(Setd2)
TUP: 102477917(SETD2)
CFA: 476643(SETD2)
VVP: 112912390(SETD2)
AML: 100466135(SETD2)
UMR: 103675118(SETD2)
UAH: 113256807(SETD2)
ORO: 101365495(SETD2)
FCA: 101085029(SETD2)
PTG: 102955436(SETD2)
PPAD: 109247730(SETD2)
AJU: 106969033(SETD2)
BTA: 539860(SETD2)
BOM: 102266643(SETD2)
BIU: 109575988(SETD2)
BBUB: 102393639(SETD2)
CHX: 102183113(SETD2)
OAS: 101114649(SETD2)
SSC: 100623101(SETD2)
CFR: 102512396(SETD2)
CDK: 105103636(SETD2)
BACU: 102997833(SETD2)
LVE: 103086894(SETD2)
OOR: 101280364(SETD2) 101282703
DLE: 111174450(SETD2)
ECB: 100064888(SETD2)
EPZ: 103551032(SETD2)
EAI: 106823246(SETD2)
MYB: 102260404(SETD2)
MYD: 102758485(SETD2)
MNA: 107529409(SETD2)
HAI: 109376628(SETD2)
DRO: 112309866(SETD2)
PALE: 102884085(SETD2)
RAY: 107509112(SETD2)
MJV: 108400455(SETD2)
LAV: 100655356(SETD2)
TMU: 101343139
MDO: 100024848(SETD2)
SHR: 100931646(SETD2)
PCW: 110217008(SETD2)
OAA: 114816148(SETD2)
GGA: 420404(SETD2)
MGP: 100539457(SETD2)
CJO: 107308808(SETD2)
NMEL: 110392103 110393293(SETD2)
APLA: 101805218 113842604(SETD2)
ACYG: 106046805(SETD2)
TGU: 100224614(SETD2)
LSR: 110476945(SETD2)
SCAN: 103813035(SETD2)
GFR: 102039322(SETD2)
FAB: 101814785(SETD2)
PHI: 102106397(SETD2)
PMAJ: 107215411(SETD2)
CCAE: 111925482(SETD2)
CCW: 104686490(SETD2)
ETL: 114070402(SETD2)
FPG: 101913975(SETD2)
FCH: 102053248(SETD2)
CLV: 102098192(SETD2)
EGZ: 104123260(SETD2)
NNI: 104019238(SETD2)
ACUN: 113476423(SETD2)
PADL: 103916778(SETD2)
ASN: 102378063(SETD2)
AMJ: 102567964(SETD2)
PSS: 102460966(SETD2)
CMY: 102947543(SETD2)
CPIC: 101947634 101953039(SETD2)
ACS: 100559621(setd2)
PVT: 110069987(SETD2)
PBI: 103055763(SETD2)
PMUR: 107286005(SETD2)
TSR: 106542655(SETD2)
PMUA: 114607160(SETD2)
GJA: 107120098(SETD2)
XLA: 108718681(setd2.L) 108719797(setd2.S)
XTR: 100492810(setd2)
DRE: 794199(setd2)
CCAR: 109063165
IPU: 108267177(setd2)
PHYP: 113542507(setd2)
AMEX: 103039344(setd2)
EEE: 113570706(setd2)
TRU: 101076040(setd2)
LCO: 104940331(setd2)
NCC: 104948745(setd2) 104957630
MZE: 101471514(setd2)
ONL: 100689872(setd2)
OLA: 101163764(setd2)
XMA: 102216591(setd2)
XCO: 114141991(setd2)
PRET: 103478611(setd2)
CVG: 107081814(setd2)
NFU: 107395695(setd2)
KMR: 108241998(setd2)
AOCE: 111572050(setd2)
CSEM: 103388382(setd2)
POV: 109633212(setd2)
LCF: 108891907(setd2)
SDU: 111236791(setd2)
SLAL: 111652786(setd2)
HCQ: 109518019(setd2)
BPEC: 110171513(setd2)
MALB: 109967312(setd2)
SALP: 112076057(setd2)
ELS: 105018749(setd2)
SFM: 108927425(setd2)
PKI: 111850417(setd2)
LCM: 102359121(SETD2)
CMK: 103190896(setd2)
RTP: 109914799(setd2)
SPU: 578079
APLC: 110986919
SKO: 100369661
DME: Dmel_CG1716(Set2)
DER: 6551019
DSI: Dsimw501_GD17127(Dsim_GD17127)
DSR: 110182093
DPE: 6601763
DMN: 108156147
DWI: 6649260
MDE: 101890762
LCQ: 111681651
AAG: 5567362
AME: 100578450
BIM: 100746901
BTER: 100652142
CCAL: 108630194
OBB: 114872234
SOC: 105208079
MPHA: 105837114
AEC: 105144959
ACEP: 105622474
PBAR: 105424427
VEM: 105570676
HST: 105190387
DQU: 106746542
CFO: 105253156
LHU: 105678859
OBO: 105278228
PCF: 106791962
NVI: 100123115(Set2)
CSOL: 105368748
MDL: 103571067
TCA: 662406
DPA: 109538546
NVL: 108569124
BMOR: 101738271
PMAC: 106718844
PRAP: 110997817
HAW: 110373157
TNL: 113493169
PXY: 105386651
BTAB: 109043976
CLEC: 106666752
ZNE: 110839808
FCD: 110842413
TUT: 107365578
DPTE: 113790692
CSCU: 111621622
BMY: Bm1_35965
PCAN: 112572164
MYI: 110448982
OBI: 106877592
LAK: 106152150
SHX: MS3_10863
EPA: 110241079
ADF: 107347448
AMIL: 114957186
PDAM: 113664166
SPIS: 111325620
DGT: 114517689
HMG: 100200309
AQU: 105313292
ATH: AT2G44150(ASHH3) AT3G59960(ASHH4)
CPAP: 110821481
TCC: 18595038
GHI: 107962390
DZI: 111275391
EGR: 104453351
CAM: 101502307
LJA: Lj0g3v0135089.1(Lj0g3v0135089.1) Lj1g3v0887590.1(Lj1g3v0887590.1) Lj2g3v0523280.1(Lj2g3v0523280.1)
RCN: 112190534
PPER: 18771600
ZJU: 107405325
CSV: 101216641
CMO: 103496934
MCHA: 111022963
CMAX: 111468902
CMOS: 111435694
RCU: 8285118
JCU: 105641862
JRE: 109005024
VVI: 100252753
HAN: 110903653
DOSA: Os02t0554000-01(Os02g0554000) Os09t0307800-01(Os09g0307800)
ATS: 109736198(LOC109736198) 109770658(LOC109770658)
ZMA: 100194312 100282875 542662(sdg110a)
VCN: VOLCADRAFT_105059(VASHH1) VOLCADRAFT_65215(VSET2)
OLU: OSTLU_18587(SDG3502)
APRO: F751_5577
DFA: DFA_11423
NGD: NGA_0639500(SETD2)
SPAR: SPRG_03341
 » show all
Taxonomy
Reference
1  [PMID:15798214]
  Authors
Kizer KO, Phatnani HP, Shibata Y, Hall H, Greenleaf AL, Strahl BD
  Title
A novel domain in Set2 mediates RNA polymerase II interaction and couples histone H3 K36 methylation with transcript elongation.
  Journal
Mol Cell Biol 25:3305-16 (2005)
DOI:10.1128/MCB.25.8.3305-3316.2005
Reference
2  [PMID:19332550]
  Authors
Yuan W, Xie J, Long C, Erdjument-Bromage H, Ding X, Zheng Y, Tempst P, Chen S, Zhu B, Reinberg D
  Title
Heterogeneous nuclear ribonucleoprotein L Is a subunit of human KMT3a/Set2 complex required for H3 Lys-36 trimethylation activity in vivo.
  Journal
J Biol Chem 284:15701-7 (2009)
  Sequence
[hsa:29072]
Reference
3  [PMID:22266761]
  Authors
Wagner EJ, Carpenter PB
  Title
Understanding the language of Lys36 methylation at histone H3.
  Journal
Nat Rev Mol Cell Biol 13:115-26 (2012)
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.358
IUBMB Enzyme Nomenclature: 2.1.1.358
ExPASy - ENZYME nomenclature database: 2.1.1.358
BRENDA, the Enzyme Database: 2.1.1.358

KEGG   ENZYME: 2.1.1.359Help
Entry
EC 2.1.1.359                Enzyme                                 

Name
[histone H3]-lysine36 N-trimethyltransferase;
SET2 (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:[histone H3]-L-lysine36 N6-trimethyltransferase
Reaction(IUBMB)
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine36 = 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine36 (overall reaction);
(1a) S-adenosyl-L-methionine + a [histone H3]-L-lysine36 = S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine36;
(1b) S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine36 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36;
(1c) S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine36 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine36
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
[histone H3]-L-lysine36;
[histone H3]-N6-methyl-L-lysine36;
[histone H3]-N6,N6-dimethyl-L-lysine36
Product
S-adenosyl-L-homocysteine [CPD:C00021];
[histone H3]-N6,N6,N6-trimethyl-L-lysine36;
[histone H3]-N6-methyl-L-lysine36;
[histone H3]-N6,N6-dimethyl-L-lysine36
Comment
The enzyme, characterized from yeast, catalyses the successive methylation of lysine36 of histone H3 (H3K36), forming the trimethylated form. These modifications influence the binding of chromatin-associated proteins. The enzyme couples the methylation reactions with transcriptional elongation through an interaction with the large subunit of RNA polymerase II. In mammals this activity is catalysed by two different enzymes, EC 2.1.1.357, [histone H3]-lysine36 N-dimethyltransferase and EC 2.1.1.358, [histone H3]-dimethyl-L-lysine36 N-methyltransferase.
History
EC 2.1.1.359 created 1976 as EC 2.1.1.43, modified 1982, modified 1983, part transferred 2019 to EC 2.1.1.359
Pathway
ec00310  Lysine degradation
ec01100  Metabolic pathways
Orthology
K23700  [histone H3]-lysine36 N-trimethyltransferase
Genes
BOE: 106300603
QSU: 112010221 112037919
SLY: 101265474
SPEN: 107030284
SCE: YJL168C(SET2)
AGO: AGOS_AEL128C
ERC: Ecym_8108
KLA: KLLA0_A06600g
KMX: KLMA_10383(SET2)
LTH: KLTH0F04510g
NCS: NCAS_0I02880(NCAS0I02880)
NDI: NDAI_0B00260(NDAI0B00260)
TPF: TPHA_0A02720(TPHA0A02720)
TBL: TBLA_0J01040(TBLA0J01040)
TDL: TDEL_0G02090(TDEL0G02090)
KAF: KAFR_0F01770(KAFR0F01770)
CAL: CAALFM_C210250CA(SET2)
SLB: AWJ20_4803(SET2)
NCR: NCU00269(set-2)
NTE: NEUTE1DRAFT122301(NEUTE1DRAFT_122301)
MGR: MGG_01661
SSCK: SPSK_04901
NHE: NECHADRAFT_106311(SDG2102)
MAW: MAC_05010
MAJ: MAA_03512
CMT: CCM_07296
BFU: BCIN_10g05250(Bcset2)
MBE: MBM_00950
ANI: AN8825.2
ANG: ANI_1_490154(An17g01825)
ABE: ARB_07003
TVE: TRV_02085
PTE: PTT_20031
ZTR: MYCGRDRAFT_20674(SDG2404)
NPA: UCRNP2_87
SPO: SPAC29B12.02c(set2)
CNE: CNG03810
CNB: CNBG0940
LBC: LACBIDRAFT_318928(SDG16202)
ABP: AGABI1DRAFT123473(AGABI1DRAFT_123473)
ABV: AGABI2DRAFT76781(AGABI2DRAFT_76781)
MGL: MGL_3860
MRT: MRET_0662
SPAR: SPRG_02673
 » show all
Taxonomy
Reference
1  [PMID:11839797]
  Authors
Strahl BD, Grant PA, Briggs SD, Sun ZW, Bone JR, Caldwell JA, Mollah S, Cook RG, Shabanowitz J, Hunt DF, Allis CD
  Title
Set2 is a nucleosomal histone H3-selective methyltransferase that mediates transcriptional repression.
  Journal
Mol Cell Biol 22:1298-306 (2002)
  Sequence
[sce:YJL168C]
Reference
2  [PMID:12917322]
  Authors
Landry J, Sutton A, Hesman T, Min J, Xu RM, Johnston M, Sternglanz R
  Title
Set2-catalyzed methylation of histone H3 represses basal expression of GAL4 in Saccharomyces cerevisiae.
  Journal
Mol Cell Biol 23:5972-8 (2003)
  Sequence
[sce:YJL168C]
Reference
3  [PMID:16087749]
  Authors
Morris SA, Shibata Y, Noma K, Tsukamoto Y, Warren E, Temple B, Grewal SI, Strahl BD
  Title
Histone H3 K36 methylation is associated with transcription elongation in Schizosaccharomyces pombe.
  Journal
Eukaryot Cell 4:1446-54 (2005)
DOI:10.1128/EC.4.8.1446-1454.2005
  Sequence
Reference
4  [PMID:20048053]
  Authors
Lin LJ, Minard LV, Johnston GC, Singer RA, Schultz MC
  Title
Asf1 can promote trimethylation of H3 K36 by Set2.
  Journal
Mol Cell Biol 30:1116-29 (2010)
  Sequence
[sce:YJL168C]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.359
IUBMB Enzyme Nomenclature: 2.1.1.359
ExPASy - ENZYME nomenclature database: 2.1.1.359
BRENDA, the Enzyme Database: 2.1.1.359

KEGG   ENZYME: 2.1.1.360Help
Entry
EC 2.1.1.360                Enzyme                                 

Name
[histone H3]-lysine79 N-trimethyltransferase;
DOT1L (gene name);
KMT4 (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:[histone H3]-L-lysine79 N6-trimethyltransferase
Reaction(IUBMB)
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine79 = 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine79 (overall reaction);
(1a) S-adenosyl-L-methionine + a [histone H3]-L-lysine79 = S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine79;
(1b) S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine79 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine79;
(1c) S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine79 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine79
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
[histone H3]-L-lysine79;
[histone H3]-N6-methyl-L-lysine79;
[histone H3]-N6,N6-dimethyl-L-lysine79
Product
S-adenosyl-L-homocysteine [CPD:C00021];
[histone H3]-N6,N6,N6-trimethyl-L-lysine79;
[histone H3]-N6-methyl-L-lysine79;
[histone H3]-N6,N6-dimethyl-L-lysine79
Comment
The enzyme successively methylates the L-lysine79 residue of histone H3 (H3K79), ultimately generating a trimethylated form. These modifications influence the binding of chromatin-associated proteins. This is the only known methylation event of a lysine residue within the core region of a histone, as all other such modifications occur at the tail.
History
EC 2.1.1.360 created 1976 as EC 2.1.1.43, modified 1982, modified 1983, part transferred 2019 to EC 2.1.1.360
Pathway
ec00310  Lysine degradation
ec01100  Metabolic pathways
Orthology
K11427  [histone H3]-lysine79 N-trimethyltransferase
Genes
HSA: 84444(DOT1L)
PTR: 455566(DOT1L)
PPS: 100969530(DOT1L)
GGO: 101134931(DOT1L)
PON: 100450564(DOT1L)
NLE: 100606063(DOT1L)
MCC: 710033(DOT1L)
MCF: 101926502(DOT1L)
CSAB: 103233645(DOT1L)
RRO: 104671393(DOT1L)
RBB: 108531435(DOT1L)
CJC: 100407532(DOT1L)
SBQ: 101038132(DOT1L)
MMU: 208266(Dot1l)
MCAL: 110302935(Dot1l)
MPAH: 110326191(Dot1l)
RNO: 362831(Dot1l)
MUN: 110555618(Dot1l)
CGE: 100771005(Dot1l)
NGI: 103737299(Dot1l)
HGL: 101712712(Dot1l)
CCAN: 109689927 109689929(Dot1l)
TUP: 102494943(DOT1L)
CFA: 485073(DOT1L)
VVP: 112935591(DOT1L)
AML: 100464435(DOT1L)
UMR: 103681799(DOT1L)
UAH: 113242759(DOT1L)
ORO: 101366843(DOT1L)
FCA: 101101194(DOT1L)
PTG: 102966497(DOT1L)
PPAD: 109257714(DOT1L)
AJU: 106983698(DOT1L)
BTA: 510442(DOT1L)
BOM: 102280735(DOT1L)
BIU: 109561797(DOT1L)
BBUB: 102405560(DOT1L)
CHX: 102180119(DOT1L)
OAS: 101121261(DOT1L)
SSC: 100738665(DOT1L)
CFR: 102522071(DOT1L) 106729841
CDK: 105103623(DOT1L) 105106057
BACU: 103011331(DOT1L)
LVE: 103083056(DOT1L)
OOR: 101281886(DOT1L)
DLE: 111166180(DOT1L)
PCAD: 102996362(DOT1L)
ECB: 100068506(DOT1L)
EPZ: 103543191 103544492(DOT1L)
EAI: 106834163(DOT1L)
MYB: 102240787(DOT1L)
MYD: 102773641(DOT1L)
MNA: 107534598(DOT1L)
HAI: 109390613(DOT1L)
DRO: 112312198(DOT1L)
PALE: 102893368(DOT1L)
RAY: 107520102(DOT1L)
MJV: 108393233(DOT1L)
LAV: 100661109(DOT1L)
TMU: 101350137
MDO: 100619840(DOT1L)
SHR: 100918350(DOT1L)
PCW: 110223514(DOT1L)
OAA: 100088528(DOT1L)
GGA: 420078(DOT1L)
MGP: 100546682(DOT1L)
CJO: 107325391(DOT1L)
NMEL: 110388996(DOT1L)
APLA: 101804645(DOT1L)
ACYG: 106045654(DOT1L)
TGU: 100222310(DOT1L)
LSR: 110469481(DOT1L)
SCAN: 103821998(DOT1L)
GFR: 102036723(DOT1L)
FAB: 101807609(DOT1L)
PHI: 102108358(DOT1L)
PMAJ: 107215544(DOT1L)
CCAE: 111940168(DOT1L)
CCW: 104696943(DOT1L)
ETL: 114071249(DOT1L) 114071752
FPG: 101911291(DOT1L)
FCH: 102053275(DOT1L)
CLV: 102097756(DOT1L)
EGZ: 104131107(DOT1L)
NNI: 104009661(DOT1L)
ACUN: 113489497(DOT1L)
PADL: 103921169(DOT1L)
ASN: 102368409(DOT1L)
AMJ: 102567829(DOT1L)
PSS: 102455080(DOT1L)
CMY: 102943895(DOT1L)
CPIC: 101947542(DOT1L)
ACS: 103282705(dot1l)
PVT: 110072436(DOT1L) 110072437
PBI: 103061368(DOT1L)
PMUR: 107282186(DOT1L)
TSR: 106548138(DOT1L) 106555419
PMUA: 114588420(DOT1L)
GJA: 107122041(DOT1L)
XLA: 108706873(dot1l.S) 108712856(dot1l.L)
XTR: 100497594(dot1l)
NPR: 108801355
DRE: 559945(dot1l)
IPU: 108270738(dot1l)
PHYP: 113547045(dot1l)
AMEX: 103023208(dot1l)
EEE: 113582386(dot1l)
TRU: 101062350(dot1l)
LCO: 104918483(dot1l)
MZE: 101473918(dot1l)
ONL: 100700031(dot1l)
OLA: 101166952(dot1l)
XMA: 102227320(dot1l)
XCO: 114151376(dot1l)
PRET: 103463635(dot1l)
CVG: 107089710(dot1l)
NFU: 107397320(dot1l)
KMR: 108230786(dot1l)
ALIM: 106515034 106534283(dot1l)
AOCE: 111566583(dot1l)
CSEM: 103376710(dot1l)
LCF: 108877359(dot1l)
SDU: 111232114(dot1l)
SLAL: 111656359(dot1l)
HCQ: 109532198(dot1l)
BPEC: 110174051(dot1l)
MALB: 109973059(dot1l)
SASA: 106584426 106613781(dot1l)
ELS: 105011570(dot1l)
SFM: 108919875(dot1l)
PKI: 111860240(dot1l)
LCM: 102351844(DOT1L)
CMK: 103181918(dot1l)
RTP: 109926363(dot1l)
CIN: 100178360
SPU: 100891935
APLC: 110985151
SKO: 100366496
DME: Dmel_CG42803(gpp)
DER: 6553084
DSI: Dsimw501_GD19874(Dsim_GD19874)
DSR: 110191935
DPE: 6592037
DMN: 108155537
DWI: 6650725
DAZ: 108621847
DNV: 108658160
DHE: 111599591
MDE: 101896384
LCQ: 111675997
AAG: 5579940
AALB: 109414131
AME: 411070
BIM: 100744223
BTER: 100650198
CCAL: 108624642
OBB: 114878501
SOC: 105202538
MPHA: 105837416
AEC: 105144095
ACEP: 105624533
PBAR: 105433651
VEM: 105557690
HST: 105185248
DQU: 106744240
CFO: 105249170
LHU: 105667327
PGC: 109860719
OBO: 105280498
PCF: 106791869
NVI: 100116648(Dot1l)
CSOL: 105366020
MDL: 103568612
TCA: 660658
ATD: 109595466
NVL: 108567082
BMOR: 101736339
PMAC: 106708949
PRAP: 110994938
HAW: 110380490
TNL: 113496303
API: 100168129
DNX: 107162006
RMD: 113550627
BTAB: 109040566
ZNE: 110835135
FCD: 110859850
PVM: 113817809
TUT: 107359774
DPTE: 113794923
PTEP: 107437400
CEL: CELE_F54F7.7(dot-1.2) CELE_F55G7.2(dot-1.4) CELE_W06D11.4(dot-1.3) CELE_Y39G10AR.18(dot-1.1)
BMY: Bm1_56955
TSP: Tsp_05196
PCAN: 112573676
CRG: 105340311
MYI: 110440609
LAK: 106164636
SHX: MS3_09541
EGL: EGR_04863
EPA: 110244289
ADF: 107340719
AMIL: 114963056
PDAM: 113673214
SPIS: 111325641
DGT: 114530231
HMG: 100211036
AQU: 109584002
SCE: YDR440W(DOT1)
ERC: Ecym_4091
KMX: KLMA_40588(DOT1)
NCS: NCAS_0F01220(NCAS0F01220)
NDI: NDAI_0H01750(NDAI0H01750)
TPF: TPHA_0D02550(TPHA0D02550)
TBL: TBLA_0D01440(TBLA0D01440) TBLA_0E03030(TBLA0E03030)
TDL: TDEL_0A04190(TDEL0A04190)
KAF: KAFR_0I00880(KAFR0I00880)
CAL: CAALFM_C306300WA(DOT1)
SLB: AWJ20_173(DOT1)
NCR: NCU06266
NTE: NEUTE1DRAFT146228(NEUTE1DRAFT_146228)
SMP: SMAC_00083(putative dot1)
MGR: MGG_05254
SSCK: SPSK_07317
MAW: MAC_04133
MAJ: MAA_08905
CMT: CCM_06781
BFU: BCIN_08g04180(Bcdot1)
MBE: MBM_01079
ANI: AN0091.2
ANG: ANI_1_296084(An09g02720)
ABE: ARB_04392
TVE: TRV_03181
PTE: PTT_12191
ZTR: MYCGRDRAFT_23780(DOT2401)
CNE: CNK02230
CNB: CNBK1310
ABP: AGABI1DRAFT32345(AGABI1DRAFT_32345)
ABV: AGABI2DRAFT190074(AGABI2DRAFT_190074)
MGL: MGL_1909
MRT: MRET_1896
SPAR: SPRG_11639
 » show all
Taxonomy
Reference
1  [PMID:12123582]
  Authors
Feng Q, Wang H, Ng HH, Erdjument-Bromage H, Tempst P, Struhl K, Zhang Y
  Title
Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET  domain.
  Journal
Curr Biol 12:1052-8 (2002)
  Sequence
[hsa:84444]
Reference
2  [PMID:12080090]
  Authors
Ng HH, Feng Q, Wang H, Erdjument-Bromage H, Tempst P, Zhang Y, Struhl K
  Title
Lysine methylation within the globular domain of histone H3 by Dot1 is important  for telomeric silencing and Sir protein association.
  Journal
Genes Dev 16:1518-27 (2002)
  Sequence
[sce:YDR440W]
Reference
3  [PMID:12628190]
  Authors
Min J, Feng Q, Li Z, Zhang Y, Xu RM
  Title
Structure of the catalytic domain of human DOT1L, a non-SET domain nucleosomal histone methyltransferase.
  Journal
Cell 112:711-23 (2003)
  Sequence
[hsa:84444]
Reference
4  [PMID:18285465]
  Authors
Steger DJ, Lefterova MI, Ying L, Stonestrom AJ, Schupp M, Zhuo D, Vakoc AL, Kim JE, Chen J, Lazar MA, Blobel GA, Vakoc CR
  Title
DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells.
  Journal
Mol Cell Biol 28:2825-39 (2008)
  Sequence
[hsa:84444]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.360
IUBMB Enzyme Nomenclature: 2.1.1.360
ExPASy - ENZYME nomenclature database: 2.1.1.360
BRENDA, the Enzyme Database: 2.1.1.360

DBGET integrated database retrieval system