KEGG   ENZYME: 2.3.3.6
Entry
EC 2.3.3.6                  Enzyme                                 

Name
2-ethylmalate synthase;
(R)-2-ethylmalate 2-oxobutanoyl-lyase (CoA-acetylating);
2-ethylmalate-3-hydroxybutanedioate synthase;
propylmalate synthase;
propylmalic synthase
Class
Transferases;
Acyltransferases;
Acyl groups converted into alkyl groups on transfer
Sysname
acetyl-CoA:2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)
Reaction(IUBMB)
acetyl-CoA + H2O + 2-oxobutanoate = (R)-2-ethylmalate + CoA [RN:R00998]
Reaction(KEGG)
R00998
Substrate
acetyl-CoA [CPD:C00024];
H2O [CPD:C00001];
2-oxobutanoate [CPD:C00109]
Product
(R)-2-ethylmalate [CPD:C02488];
CoA [CPD:C00010]
Comment
Also acts on (R)-2-(n-propyl)-malate. Formerly wrongly included with EC 2.3.3.7 3-ethylmalate synthase.
History
EC 2.3.3.6 created 1983 as EC 4.1.3.33, transferred 2002 to EC 2.3.3.6
Pathway
ec00620  Pyruvate metabolism
Reference
1  [PMID:6052435]
  Authors
Strassman M, Ceci LN.
  Title
A study of acetyl-CoA condensation with alpha-keto acids.
  Journal
Arch Biochem Biophys 119:420-8 (1967)
DOI:10.1016/0003-9861(67)90473-0
Other DBs
ExplorEnz - The Enzyme Database: 2.3.3.6
IUBMB Enzyme Nomenclature: 2.3.3.6
ExPASy - ENZYME nomenclature database: 2.3.3.6
BRENDA, the Enzyme Database: 2.3.3.6
CAS: 9024-01-5

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Pathway (2)   
   KEGG PATHWAY (2)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (4)   
   KEGG REACTION (1)   
   KEGG RCLASS (3)   
All databases (11)   

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KEGG   REACTION: R00998
Entry
R00998                      Reaction                               

Name
acetyl-CoA:2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming);
(R)-2-ethylmalate 2-oxobutanoyl-lyase (CoA-acylating)
Definition
(R)-2-Ethylmalate + CoA <=> Acetyl-CoA + H2O + 2-Oxobutanoate
Equation
Comment
multi-step reaction
Reaction class
RC00004  C00010_C00024
RC00067  C00109_C02488
RC02754  C00024_C02488
Enzyme
Pathway
rn00620  Pyruvate metabolism
Other DBs
RHEA: 23043

  All links  
Ontology (1)   
   KEGG BRITE (1)   
Pathway (2)   
   KEGG PATHWAY (2)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (5)   
   KEGG ENZYME (1)   
   KEGG RCLASS (3)   
   SABIO-RK (1)   
All databases (13)   

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