Entry
Name
2-ethylmalate synthase;
(R)-2-ethylmalate 2-oxobutanoyl-lyase (CoA-acetylating);
2-ethylmalate-3-hydroxybutanedioate synthase;
propylmalate synthase;
propylmalic synthase
Class
Transferases;
Acyltransferases;
Acyl groups converted into alkyl groups on transfer
BRITE hierarchy
Sysname
acetyl-CoA:2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)
Reaction(IUBMB)
acetyl-CoA + H2O + 2-oxobutanoate = (R)-2-ethylmalate + CoA [RN:
R00998 ]
Reaction(KEGG)
Substrate
Product
Comment
Also acts on (R)-2-(n-propyl)-malate. Formerly wrongly included with EC
2.3.3.7 3-ethylmalate synthase.
History
EC 2.3.3.6 created 1983 as EC 4.1.3.33, transferred 2002 to EC 2.3.3.6
Pathway
Reference
Authors
Strassman M, Ceci LN.
Title
A study of acetyl-CoA condensation with alpha-keto acids.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 2.3.3.6
ExPASy - ENZYME nomenclature database: 2.3.3.6
BRENDA, the Enzyme Database: 2.3.3.6