| Entry |
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| Name |
mannosyl-3-phosphoglycerate synthase;
MPG synthase;
GDP-mannose:3-phosphoglycerate 3-alpha-D-mannosyltransferase
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| Class |
Transferases;
Glycosyltransferases;
Hexosyltransferases
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| Sysname |
GDP-mannose:3-phospho-D-glycerate 3-alpha-D-mannosyltransferase
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| Reaction(IUBMB) |
GDP-mannose + 3-phospho-D-glycerate = GDP + 2-(alpha-D-mannosyl)-3-phosphoglycerate [RN: R05768]
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| Reaction(KEGG) |
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| Substrate |
GDP-mannose [CPD: C00096];
3-phospho-D-glycerate [CPD: C00197]
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| Product |
GDP [CPD: C00035];
2-(alpha-D-mannosyl)-3-phosphoglycerate [CPD: C11516]
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| Comment |
Requires Mg2+. The enzyme is absolutely specific for GDPmannose and 3-phosphoglycerate, and transfers the mannosyl group with retention of configuration. In the hyperthermophilic archaeon Pyrococcus horikoshii, the mannosyl-3-phosphoglycerate formed is subsequently dephosphorylated by a specific phosphatase, EC 3.1.3.70 (mannosyl-3-phosphoglycerate phosphatase), producing mannosylglycerate.
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| History |
EC 2.4.1.217 created 2002
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| Pathway |
| ec00051 | Fructose and mannose metabolism |
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| Orthology |
| K05947 | mannosyl-3-phosphoglycerate synthase |
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| Genes |
» show all
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| Reference |
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| Authors |
Empadinhas N, Marugg JD, Borges N, Santos H, da Costa MS |
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| Title |
Pathway for the synthesis of mannosylglycerate in the hyperthermophilic archaeon Pyrococcus horikoshii. Biochemical and genetic characterization of key enzymes. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.4.1.217 |
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