KEGG ENZYME: 2.4.1.217

ENZYME: 2.4.1.217

Entry

EC 2.4.1.217                Enzyme

Name

mannosyl-3-phosphoglycerate synthase;
MPG synthase;
GDP-mannose:3-phosphoglycerate 3-alpha-D-mannosyltransferase

Class

Transferases;
Glycosyltransferases;
Hexosyltransferases

Sysname

GDP-mannose:3-phospho-D-glycerate 3-alpha-D-mannosyltransferase

Reaction(IUBMB)

GDP-mannose + 3-phospho-D-glycerate = GDP + 2-(alpha-D-mannosyl)-3-phosphoglycerate [RN:R05768]

Reaction(KEGG)

R05768

Substrate

GDP-mannose [CPD:C00096];
3-phospho-D-glycerate [CPD:C00197]

Product

GDP [CPD:C00035];
2-(alpha-D-mannosyl)-3-phosphoglycerate [CPD:C11516]

Comment

Requires Mg2+. The enzyme is absolutely specific for GDPmannose and 3-phosphoglycerate, and transfers the mannosyl group with retention of configuration. In the hyperthermophilic archaeon Pyrococcus horikoshii, the mannosyl-3-phosphoglycerate formed is subsequently dephosphorylated by a specific phosphatase, EC 3.1.3.70 (mannosyl-3-phosphoglycerate phosphatase), producing mannosylglycerate.

History

EC 2.4.1.217 created 2002

Pathway

ec00051

Fructose and mannose metabolism

ec01100

Metabolic pathways

Orthology

K05947

mannosyl-3-phosphoglycerate synthase

Genes

NCR:

NCU05700

NTE:	NEUTE1DRAFT100267(NEUTE1DRAFT_100267)

SMP:	10807906(SMAC4_02065)

PAN:	PODANSg2537

PBEL:

QC761_700490

PPSD:

QC762_700490

PPSP:

QC763_700490

PPSA:

QC764_700490

TTT:	THITE_2120465

MTM:	MYCTH_2303166

CTHR:

CTHT_0072260

RTHE:

98122212(VTJ83DRAFT_1411)

PPEI:

PpBr36_05480

PGRI:

PgNI_02833

TMN:	UCRPA7_732

CFJ:	CFIO01_04083

CLUP:

CLUP02_12643

ELA:	UCREL1_10936

PNO:	SNOG_14776

PTE:

PTT_11203

PTRR:

6341735(PtrM4_098340)

ARAB:

EKO05_0010263

SLOM:

PXH66_02990(mpgS)

AAQW:

K1X11_020565(mpgS)

PPHT:

GA004_05175(mpgS)

CLIT:

OQ292_03145(mpgS)

PRHO:

PZB74_17250(mpgS)

TPEL:

P0M28_29720(mpgS)

CNQ:	PZB72_02575(mpgS)

RSR:	T7867_17300(mpgS)

RMR:

Rmar_0502

RMG:	Rhom172_0500

RLO:	GQ464_016260(mpgS)

ACTN:

L083_6965

ACTR:

Asp14428_60620

AFS:

AFR_36880

PLAB:

C6361_25375

PLAT:

C6W10_13480

PFLA:

Pflav_085120

PSUU:

Psuf_048030

PRY:	Prubr_39070

NHY:	JQS43_18785

CCAZ:

COUCH_07620(mpgS)

DET:	DET1363(mpgSP)

DEH:

cbdbA1314

DEB:	DehaBAV1_1174

DEV:	DhcVS_1144

DMC:

btf_1241

DMD:

dcmb_1222

DMG:	GY50_1201(mngA)

DMX:	X792_06380

DMY:	X793_06240

DMZ:	X794_05800

DUC:	UCH007_11250

DLY:	Dehly_0877

DEW:	DGWBC_0701

DFO:	Dform_01049

DETH:

HX448_06860

DLF:	V8247_00245

TTH:

TT_C0588

TTJ:	TTHA0954(TTHA0954)

TTS:	Ththe16_0950

TTL:	TtJL18_1098

MHD:	Marky_0082

MTEE:

MTTB_02910

MFV:

Mfer_0544

APO:	Arcpr_0588

AVE:	Arcve_0995 Arcve_1326

PFU:

PF0591

PFI:

PFC_02085

PHO:	PH0927(PH0927)

PAB:

PAB0816

PYN:

PNA2_1454

PYA:	PYCH_06950

PYS:

Py04_0855

PYC:	TQ32_02365

TGA:

TGAM_0817

TSI:

TSIB_0251

TBA:	TERMP_00005

THA:

TAM4_785

TLT:

OCC_09696

THS:

TES1_0131

TNU:

BD01_0152

THV:	ADU37_CDS01910

TCH:	CHITON_0969

TCE:	A3L02_00525

TBS:	A3L01_01795

THH:	CDI07_01770

TTD:	A3L14_03245

TRL:	A3L10_04690

THY:	A3L12_01820

THEI:

K1720_04380(mpgS)

TAGG:

NF865_01535(mpgS)

PPAC:

PAP_01435

MJK:	N2V74_02575(mpgS) N2V74_03285(mpgS)

APE:	APE_0889.1(mpgs)

ACJ:	ACAM_0578(mpgs)

SMR:

Smar_0498

SHC:	Shell_0304

TCS:	IMZ38_06980(mpgS)

PDL:	Pyrde_0369

PABI:

PABY_00960(mpgS)

NGA:	Ngar_c16030(mngA1) Ngar_c27190(mngA2)

NVN:	NVIE_006110(mngA)

NEV:

NTE_01978

TAA:	NMY3_00972 NMY3_02751

NFN:	NFRAN_0350(mngA) NFRAN_1965(mngA)

NCV:	NCAV_1295(mngA)

» show all

Reference

1 [PMID:11562374]

Authors

Empadinhas N, Marugg JD, Borges N, Santos H, da Costa MS

Title

Pathway for the synthesis of mannosylglycerate in the hyperthermophilic archaeon Pyrococcus horikoshii. Biochemical and genetic characterization of key enzymes.

Journal

J Biol Chem 276:43580-8 (2001)
DOI:10.1074/jbc.M108054200

Sequence

[pho:PH0927]

Other DBs

ExplorEnz - The Enzyme Database:

2.4.1.217

IUBMB Enzyme Nomenclature:

2.4.1.217

ExPASy - ENZYME nomenclature database:

2.4.1.217

BRENDA, the Enzyme Database:

2.4.1.217

CAS:	393512-63-5

All links

Gene (114)   
   MGENES (84)   
   RefGene (30)   
Protein sequence (552)   
   UniProt (255)   
   SWISS-PROT (4)   
   RefSeq(pep) (267)   
   PDBSTR (26)   
DNA sequence (567)   
   RefSeq(nuc) (379)   
   GenBank (103)   
   EMBL (85)   
3D Structure (13)   
   PDB (13)   
Protein domain (3)   
   InterPro (2)   
   Pfam (1)   
All databases (1249)   

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