KEGG ENZYME: 2.4.1.269

ENZYME: 2.4.1.269

Entry

EC 2.4.1.269 Enzyme

Name

mannosylglycerate synthase

Class

Transferases;
Glycosyltransferases;
Hexosyltransferases

Sysname

GDP-alpha-D-mannose:D-glycerate 2-alpha-D-mannosyltransferase

Reaction(IUBMB)

GDP-alpha-D-mannose + D-glycerate = GDP + 2-O-(alpha-D-mannopyranosyl)-D-glycerate [RN:R09666]

Reaction(KEGG)

R09666

Substrate

GDP-alpha-D-mannose [CPD:C00096];
D-glycerate [CPD:C00258]

Product

GDP [CPD:C00035];
2-O-(alpha-D-mannopyranosyl)-D-glycerate [CPD:C11544]

Comment

Rhodothermus marinus can also form mannosylglycerate via a two-step pathway catalysed by EC 2.4.1.217 (mannosyl-3-phosphoglycerate synthase) and EC 3.1.3.70 (mannosyl-3-phosphoglycerate phosphatase) [1]. Depending on experimental conditions mannosylglycerate synthase is more or less specific for the GDP-mannose and D-glycerate [1,2].

History

EC 2.4.1.269 created 2011

Pathway

ec00051

Fructose and mannose metabolism

ec01100

Metabolic pathways

Orthology

K18818

mannosylglycerate synthase

Genes

RMR:

Rmar_1220

RMG:	Rhom172_1264

Reference

1 [PMID:10585410]

Authors

Martins LO, Empadinhas N, Marugg JD, Miguel C, Ferreira C, da Costa MS, Santos H

Title

Biosynthesis of mannosylglycerate in the thermophilic bacterium Rhodothermus marinus. Biochemical and genetic characterization of a mannosylglycerate synthase.

Journal

J Biol Chem 274:35407-14 (1999)
DOI:10.1074/jbc.274.50.35407

Sequence

[rmr:Rmar_1220]

Reference

2 [PMID:15951819]

Authors

Flint J, Taylor E, Yang M, Bolam DN, Tailford LE, Martinez-Fleites C, Dodson EJ, Davis BG, Gilbert HJ, Davies GJ

Title

Structural dissection and high-throughput screening of mannosylglycerate synthase.

Journal

Nat Struct Mol Biol 12:608-14 (2005)
DOI:10.1038/nsmb950