KEGG   ENZYME: 2.4.1.63
Entry
EC 2.4.1.63                 Enzyme                                 

Name
linamarin synthase;
uridine diphosphoglucose-ketone glucosyltransferase;
uridine diphosphate-glucose-ketone cyanohydrin beta-glucosyltransferase;
UDP glucose ketone cyanohydrin glucosyltransferase;
UDP-glucose:ketone cyanohydrin beta-glucosyltransferase;
uridine diphosphoglucose-ketone cyanohydrin glucosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-glucose:2-hydroxy-2-methylpropanenitrile beta-D-glucosyltransferase
Reaction(IUBMB)
UDP-glucose + 2-hydroxy-2-methylpropanenitrile = UDP + linamarin [RN:R03625]
Reaction(KEGG)
R03625;
(other) R04948 R10037
Substrate
UDP-glucose [CPD:C00029];
2-hydroxy-2-methylpropanenitrile [CPD:C02659]
Product
UDP [CPD:C00015];
linamarin [CPD:C01594]
Comment
The enzyme glucosylates the cyanohydrins of butanone and pentan-3-one as well as that of acetone.
History
EC 2.4.1.63 created 1972
Pathway
ec00460  Cyanoamino acid metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Reference
1  [PMID:5417265]
  Authors
Hahlbrock K, Conn EE.
  Title
The biosynthesis of cyanogenic glycosides in higher plants. I. Purification and properties of a uridine diphosphate-glucose-ketone cyanohydrin beta-glucosyltransferase from Linum usitatissimum L.
  Journal
J Biol Chem 245:917-22 (1970)
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.63
IUBMB Enzyme Nomenclature: 2.4.1.63
ExPASy - ENZYME nomenclature database: 2.4.1.63
BRENDA, the Enzyme Database: 2.4.1.63
CAS: 37277-68-2

KEGG   REACTION: R03625
Entry
R03625                      Reaction                               

Name
UDPglucose:2-hydroxy-2-methylpropanenitrile beta-D-glucosyltransferase
Definition
UDP-glucose + Acetone cyanohydrin <=> UDP + Linamarin
Equation
Comment
UGT85K2/K3/K4/K5
Reaction class
RC00005  C00015_C00029
RC00262  C01594_C02659
Enzyme
Pathway
rn00460  Cyanoamino acid metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K16266  cyanohydrin UDP-glucosyltransferase [EC:2.4.1.-]
Other DBs
RHEA: 20012

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