KEGG   ENZYME: 2.5.1.102
Entry
EC 2.5.1.102                Enzyme                                 

Name
geranyl-pyrophosphate---olivetolic acid geranyltransferase;
GOT (ambiguous)
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
geranyl-diphosphate:olivetolate geranyltransferase
Reaction(IUBMB)
geranyl diphosphate + 2,4-dihydroxy-6-pentylbenzoate = diphosphate + cannabigerolate [RN:R10176]
Reaction(KEGG)
R10176
Substrate
geranyl diphosphate [CPD:C00341];
2,4-dihydroxy-6-pentylbenzoate [CPD:C20417]
Product
diphosphate [CPD:C00013];
cannabigerolate [CPD:C20406]
Comment
Part of the cannabinoids biosynthetic pathway of the plant Cannabis sativa. The enzyme can also use neryl diphosphate as substrate, forming cannabinerolate.
History
EC 2.5.1.102 created 2012
Pathway
ec00999  Biosynthesis of various secondary metabolites - part 1
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Reference
1  [PMID:9607329]
  Authors
Fellermeier M, Zenk MH
  Title
Prenylation of olivetolate by a hemp transferase yields cannabigerolic acid, the  precursor of tetrahydrocannabinol.
  Journal
FEBS Lett 427:283-5 (1998)
DOI:10.1016/S0014-5793(98)00450-5
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.102
IUBMB Enzyme Nomenclature: 2.5.1.102
ExPASy - ENZYME nomenclature database: 2.5.1.102
BRENDA, the Enzyme Database: 2.5.1.102

KEGG   REACTION: R10176
Entry
R10176                      Reaction                               

Name
geranyl-diphosphate:olivetolate geranyltransferase
Definition
Geranyl diphosphate + 2,4-Dihydroxy-6-pentylbenzoate <=> Diphosphate + Cannabigerolate
Equation
Reaction class
RC01869  C20406_C20417
Enzyme
Pathway
rn00999  Biosynthesis of various secondary metabolites - part 1
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00894  Cannabidiol biosynthesis, malonyl-CoA => cannabidiol/dronabinol
Other DBs
RHEA: 34130

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