KEGG   ENZYME: 2.6.1.23
Entry
EC 2.6.1.23                 Enzyme                                 

Name
4-hydroxyglutamate transaminase;
4-hydroxyglutamate aminotransferase;
4-hydroxy-L-glutamate:2-oxoglutarate aminotransferase
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
Sysname
erythro-4-hydroxy-L-glutamate:2-oxoglutarate aminotransferase
Reaction(IUBMB)
erythro-4-hydroxy-L-glutamate + 2-oxoglutarate = (4R)-4-hydroxy-2-oxoglutarate + L-glutamate [RN:R05052]
Reaction(KEGG)
R05052;
(other) R03266
Substrate
erythro-4-hydroxy-L-glutamate [CPD:C05947];
2-oxoglutarate [CPD:C00026]
Product
(4R)-4-hydroxy-2-oxoglutarate [CPD:C05946];
L-glutamate [CPD:C00025]
Comment
The enzyme participates in a degradation pathway of trans-4-hydroxy-L-proline, a compound that contributes to the stability of the collagen triple helix. Oxaloacetate can replace 2-oxoglutarate. This enzyme may be identical with EC 2.6.1.1 aspartate transaminase.
History
EC 2.6.1.23 created 1972, modified 1982, modified 2020
Pathway
ec00330  Arginine and proline metabolism
ec01100  Metabolic pathways
Reference
1  [PMID:13948827]
  Authors
GOLDSTONE A, ADAMS E.
  Title
Metabolism of gamma-hydroxyglutamic acid. I. Conversion to alpha-hydroxy-gamma-ketoglutarate by purified glutamic-aspartic transaminase to rat liver.
  Journal
J Biol Chem 237:3476-85 (1962)
Reference
2  [PMID:14089443]
  Authors
KURATOMI K, FUKUNAGA K, KOBAYASHI Y.
  Title
THE METABOLISM OF GAMMA-HYDROXYGLUTAMATE IN RAT  LIVER. II. A TRANSAMINASE CONCERNED IN GAMMA-HYDROXYGLUTAMATE METABOLISM.
  Journal
Biochim Biophys Acta 78:629-36 (1963)
DOI:10.1016/0006-3002(63)91028-X
Reference
3  [PMID:14170323]
  Authors
MAITRA U, DEEKKER E
  Title
PURIFICATION OF RAT-LIVER GAMMA-HYDROXYGLUTAMATE TRANSAMINASE AND ITS PROBABLE IDENTITY WITH GLUTAMATE-ASPARTATE TRANSAMINASE.
  Journal
Biochim Biophys Acta 81:517-32 (1964)
DOI:10.1016/0926-6569(64)90136-1
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.23
IUBMB Enzyme Nomenclature: 2.6.1.23
ExPASy - ENZYME nomenclature database: 2.6.1.23
BRENDA, the Enzyme Database: 2.6.1.23
CAS: 37277-86-4

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Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (3)   
   KEGG REACTION (2)   
   KEGG RCLASS (1)   
Protein sequence (3)   
   UniProt (3)   
DNA sequence (2)   
   GenBank (1)   
   EMBL (1)   
All databases (18)   

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KEGG   REACTION: R05052
Entry
R05052                      Reaction                               

Name
L-erythro-4-hydroxyglutamate:2-oxoglutarate aminotransferase
Definition
L-erythro-4-Hydroxyglutamate + 2-Oxoglutarate <=> (4R)-4-Hydroxy-2-oxoglutarate + L-Glutamate
Equation
Reaction class
RC00006  C00025_C00026  C05946_C05947
Enzyme
2.6.1.1         2.6.1.23
Pathway
rn00330  Arginine and proline metabolism
rn01100  Metabolic pathways
Orthology
K00811  aspartate aminotransferase, chloroplastic [EC:2.6.1.1]
K00812  aspartate aminotransferase [EC:2.6.1.1]
K00813  aspartate aminotransferase [EC:2.6.1.1]
K11358  aspartate aminotransferase [EC:2.6.1.1]
K14454  aspartate aminotransferase, cytoplasmic [EC:2.6.1.1]
K14455  aspartate aminotransferase, mitochondrial [EC:2.6.1.1]
Other DBs
RHEA: 31238

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Ontology (1)   
   KEGG BRITE (1)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (3)   
   KEGG ENZYME (2)   
   KEGG RCLASS (1)   
Gene (8509)   
   KEGG ORTHOLOGY (6)   
   KEGG GENES (8503)   
All databases (8521)   

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