KEGG   ENZYME: 2.6.1.49
Entry
EC 2.6.1.49                 Enzyme                                 

Name
dihydroxyphenylalanine transaminase;
dopa transaminase;
dihydroxyphenylalanine aminotransferase;
aspartate-DOPP transaminase (ADT);
L-dopa transaminase;
dopa aminotransferase;
glutamate-DOPP transaminase (GDT);
phenylalanine-DOPP transaminase (PDT);
DOPA 2-oxoglutarate aminotransferase;
DOPAATS
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
Sysname
3,4-dihydroxy-L-phenylalanine:2-oxoglutarate aminotransferase
Reaction(IUBMB)
L-dopa + 2-oxoglutarate = 3,4-dihydroxyphenylpyruvate + L-glutamate [RN:R02077]
Reaction(KEGG)
R02077
Substrate
L-dopa [CPD:C00355];
2-oxoglutarate [CPD:C00026]
Product
3,4-dihydroxyphenylpyruvate [CPD:C04045];
L-glutamate [CPD:C00025]
Comment
A pyridoxal-phosphate protein.
History
EC 2.6.1.49 created 1972
Pathway
ec00350  Tyrosine metabolism
ec01100  Metabolic pathways
Reference
1  [PMID:5829872]
  Authors
Fonnum F, Larsen K.
  Title
Purification and properties of dihydroxyphenylalanine transaminase from guinea pig brain.
  Journal
J Neurochem 12:589-98 (1965)
DOI:10.1111/j.1471-4159.1965.tb04251.x
Reference
2  [PMID:17616348]
  Authors
Ranjith NK, Sasikala Ch, Ramana ChV.
  Title
Catabolism of L-phenylalanine and L-tyrosine by Rhodobacter sphaeroides OU5 occurs through 3,4-dihydroxyphenylalanine.
  Journal
Res Microbiol 158:506-11 (2007)
DOI:10.1016/j.resmic.2007.04.008
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.49
IUBMB Enzyme Nomenclature: 2.6.1.49
ExPASy - ENZYME nomenclature database: 2.6.1.49
BRENDA, the Enzyme Database: 2.6.1.49
CAS: 37277-98-8

KEGG   ENZYME: 1.13.12.15
Entry
EC 1.13.12.15               Enzyme                                 

Name
3,4-dihydroxyphenylalanine oxidative deaminase;
3,4-dihydroxy-L-phenylalanine: oxidative deaminase;
oxidative deaminase;
DOPA oxidative deaminase;
DOPAODA
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)
Sysname
3,4-dihydroxy-L-phenylalanine:oxygen oxidoreductase (deaminating)
Reaction(IUBMB)
2 L-dopa + O2 = 2 3,4-dihydroxyphenylpyruvate + 2 NH3 [RN:R08920]
Reaction(KEGG)
R08920
Substrate
L-dopa [CPD:C00355];
O2 [CPD:C00007]
Product
3,4-dihydroxyphenylpyruvate [CPD:C04045];
NH3 [CPD:C00014]
Comment
This enzyme is one of the three enzymes involved in L-dopa (3,4-dihydroxy-L-phenylalanine) catabolism in the non-oxygenic phototrophic bacterium Rubrivivax benzoatilyticus OU5 (and not Rhodobacter sphaeroides OU5 as had been thought [1]), the other two being EC 4.3.1.22 (dihydroxyphenylalanine reductive deaminase) and EC 2.6.1.49 (3,4-dihydroxyphenylalanine transaminase). In addition to L-dopa, the enzyme can also use L-tyrosine, L-phenylalanine, L-tryptophan and glutamate as substrate, but more slowly. The enzyme is inhibited by NADH and 2-oxoglutarate.
History
EC 1.13.12.15 created 2008
Pathway
ec00350  Tyrosine metabolism
ec01100  Metabolic pathways
Reference
1  [PMID:18923551]
  Authors
Ranjith NK, Ramana ChV, Sasikala Ch
  Title
Purification and characterization of 3,4-dihydroxyphenylalanine oxidative deaminase from Rhodobacter sphaeroides OU5.
  Journal
Can J Microbiol 54:829-34 (2008)
DOI:10.1139/w08-071
Other DBs
ExplorEnz - The Enzyme Database: 1.13.12.15
IUBMB Enzyme Nomenclature: 1.13.12.15
ExPASy - ENZYME nomenclature database: 1.13.12.15
BRENDA, the Enzyme Database: 1.13.12.15

KEGG   REACTION: R02077
Entry
R02077                      Reaction                               

Name
3,4-Dihydroxy-L-phenylalanine:2-oxoglutarate aminotransferase
Definition
3,4-Dihydroxy-L-phenylalanine + 2-Oxoglutarate <=> 3-(3,4-Dihydroxyphenyl)pyruvate + L-Glutamate
Equation
Reaction class
RC00006  C00025_C00026  C00355_C04045
Enzyme
Pathway
rn00350  Tyrosine metabolism
rn01100  Metabolic pathways
Other DBs
RHEA: 15276

KEGG   REACTION: R08920
Entry
R08920                      Reaction                               

Name
3,4-dihydroxy-L-phenylalanine:oxygen oxidoreductase (deaminating)
Definition
2 3,4-Dihydroxy-L-phenylalanine + Oxygen <=> 2 3-(3,4-Dihydroxyphenyl)pyruvate + 2 Ammonia
Equation
2 C00355 + C00007 <=> 2 C04045 + 2 C00014
Reaction class
RC00006  C00355_C04045
Enzyme
Pathway
rn00350  Tyrosine metabolism
rn01100  Metabolic pathways
Other DBs
RHEA: 25883

DBGET integrated database retrieval system